Intelligence Scale For Children Research Articles

7912 Children's Neurodevelopmental Outcomes at School-Age After Conception with Hysterosalpingography Using Iodinated Contrast Media

Abstract Disclosure: S. Keestra: None. C. Kooper: None. N. van Welie: None. K. Dreyer: Grant Recipient; Self; research grants from Guerbet. Speaker; Self; travel and speaker fees Guerbet. R. van Eekelen: None. T. Roseboom: None. J. Oosterlaan: None. B. Mol: Consulting Fee; Self; Organon Laboratories, Norgine, Merck. Grant Recipient; Self; Merck. Stock Owner; Self; ObsEva. M. Finken: None. V. Mijatovic: Grant Recipient; Self; Guerbet, Merck, Ferring Pharmaceuticals. Speaker; Self; Guerbet, Merck, Ferring Pharmaceuticals. M. Königs: None. Thyroid hormone sufficiency in pregnancy is vital for children's neurodevelopment. Exposure to iodine excess can cause transient disruption of thyroid hormone synthesis through the Wolff-Chaikoff effect. Iodinated contrast media are commonly utilized in hysterosalpingography (HSG) as part of female fertility work-up. When conception occurs shortly after HSG with iodinated contrast, a temporary reduction of maternal and/or foetal thyroid hormone synthesis could jeopardize children's neurodevelopment. We compared the neurodevelopmental outcomes of 6-9-year-old children (n=69) conceived <6 months after HSG with 5-10 ml of oil-based contrast (iodine content: 480mg/ml) or water-based contrasts (iodine content: 250mg/ml) in the follow-up of a nationwide randomised controlled trial (H2Oil trial; Netherlands; 2012-2014; NCT05168228). A community sample of naturally-conceived children (n=44) with similar age, sex and parental education was used as a comparison group (NTR9574). Primary outcomes were intelligence (Wechsler’s Intelligence Scale for Children V), behaviour questionnaires for parents and teachers (Strengths and Difficulties Questionnaire (SDQ); Strengths and Weaknesses of ADHD Symptoms And Normal behaviour (SWAN)), and academic performance. Secondary outcomes were neurocognitive domains assessed in computerized tasks focussing on Processing & Control, Verbal Memory, Visual Memory, Verbal Working Memory, Visual Working Memory, and Visuomotor Integration (Emma Toolbox for Neurocognitive Functioning). We adjusted linear regression models for age, sex, and parental education, applying FDR correction for multiple comparisons. Additional analysis looked at children conceived within 4 weeks, 4-12 weeks, or >12 weeks after HSG. Children conceived <6 months after HSG had lower performance on intelligence tests (-6.81; 95%CI -10.97 to -2.65; p=0.02) and the neurocognitive domain Processing & Control (-0.52; 95%CI-0.84 to -0.19; p=0.02), with processing speed and consistency affected. No differences were found for other neurocognitive domains, behaviour or academic performance. In comparison to naturally-conceived children, children conceived <4 weeks after HSG had lower performance on intelligence tests, but there was no difference for children conceived 4-12 weeks and >12 weeks after HSG. Replication studies with higher power are needed to further evaluate the safety of iodinated contrast media use periconception, including their effects on thyroid function and children's neurodevelopment. Closer monitoring and treatment of thyroid dysfunction in the months following HSG may be warranted. Presentation: 6/1/2024

P-756 Neurodevelopmental outcomes at school-age after conception with hysterosalpingography using iodinated contrast media - follow-up of the nationwide multicentre H2Oil trial

Abstract Study question How does conception <6 months after hysterosalpingography (HSG) with iodinated contrast media affect the neurodevelopment of the offspring compared to naturally-conceived peers at a school-age? Summary answer Children conceived <6 months after HSG with iodinated contrast media perform lower on intelligence tests and information processing and attention control compared to naturally-conceived peers. What is known already Tubal patency in subfertile women is commonly assessed using hysterosalpingography (HSG), but the potential risks of exposure to high iodine content in contrast media used remains unknown. Exposure to iodine excess can cause transient reduction in thyroid hormone synthesis due to the Wolff-Chaikoff effect. Thyroid hormone sufficiency in early pregnancy is vital for children’s neurodevelopment. When conception occurs shortly after HSG with iodinated contrast, a temporary reduction of maternal and/or foetal thyroid hormone supply could jeopardize children’s neurodevelopment. Study design, size, duration We evaluated neurodevelopmental outcomes of 6–9-year-old children conceived <6 months after HSG with oil-based (iodine content: 480mg/ml) or water-based contrast (iodine content: 240-300mg/ml) in a nationwide randomised controlled trial (H2Oil trial; Netherlands; 2012-2014; NCT05168228). Naturally-conceived children (n = 44) with similar age, sex and parental education were used as a comparison group (NTR9574). We also compared children conceived <4w, 4-12w, >12w after HSG with those conceived naturally. The study took place January 2022 until November 2023. Participants/materials, setting, methods We contacted 140 mothers from the H2Oil trial, 69 children conceived <6m after HSG participated, and parallelly we recruited 44 naturally-conceived children. Primary outcomes were intelligence (Wechsler’s Intelligence Scale for Children V), behavioural functioning (SDQ and SWAN, administered to parents and teachers), and academic performance. Secondary outcomes were neurocognitive function assessed by a battery of computerized tests. We used linear regression adjusted for age, sex, and parental education and applied FDR correction. Main results and the role of chance Compared to naturally conceived children, children conceived <6m after HSG had lower performance on intelligence tests (-6.81; 95%CI-10.97 to -2.65; p = 0.02) and the neurocognitive domain Processing & Control (-0.52; 95%CI-0.84 to -0.19; p = 0.02), with functions relating to information processing speed and consistency affected. No differences were found for other neurocognitive domains, behaviour or academic performance. Considering time between HSG and conception, intelligence scores were lower for children conceived <4w after HSG compared to naturally-conceived peers (-11.47; 95%CI-17.98 to -4.95; p = 0.03), while no significant differences were found for the groups of children conceived 4-12 weeks after HSG (-7.17; 95%CI -12.28 to -2.06; p = 0.10) or > 12 weeks after HSG (-4.20; 95%CI -9.33 to 0.94; p = 0.52). The findings of this study warrant replication in larger independent samples in order to evaluate the long-term neurodevelopment of children conceived after HSG with iodinated contrast media. Limitations, reasons for caution We aimed to recruit 64 children for each group, but our study was not sufficiently powered for small- and medium-sized differences. We did not collect information on the thyroid or iodine status of the mothers following HSG, and there is limited knowledge about pharmacokinetics of iodinated contrast media in humans. Wider implications of the findings Replication studies with are needed to further evaluate the safety of iodinated contrast media use periconception, including their effects on thyroid function and children’s neurodevelopment. Closer monitoring and treatment of thyroid dysfunction in the months following HSG may be warranted. Trial registration number NCT05168228

Diagnostic validity of the fifth Integrated version of IQ scales Wechsler children in students with learning disabilities in Mazandaran province

In this Research, the "diagnostic validity of the fifth integrated version of Wechsler IQ scales for children with learning disabilities in Mazandaran province Students" has been studied. The main question of the research is whether the fifth integrated version of Wechsler Intelligence Scales for children with learning disabilities in Mazandaran province has diagnostic validity. The present research method is in the field of psychometric studies, which is a subset of the methodological research method. The research community includes all students of Mazandaran province who are studying in the first elementary school (first, second and third grade) in the 97-98 academic year and as students with learning disabilities in private and public centres under Coverage of educational-therapeutic services, consisting of 240 students with learning disabilities were selected as the sample size using purposive sampling. The measurement Instrument in this Research is the fifth integrated version of the Wechsler Children's Intelligence Scale, which has good validity and reliability. The statistical model used in the present Research to determine diagnostic validity is the confidence interval method. Finally, the research findings showed that the tests of "Digit Span Forward", " Digit Span Backward" and "sentences recall" in students with learning disabilities have diagnostic validity and can exclude students with learning disabilities from other students.

Investigating the sensitivity coefficient of the fifth version of the Wechsler children's intelligence scale in students with attention deficit disorder in Tehran cities

In this research, the "examination of the sensitivity coefficient of the fifth version of the Wechsler intelligence scale for children in students with attention deficit disorder in Tehran cities" has been discussed. The current research method is located in the field of psychometric studies, which is a subset of the methodological research method. The research community consists of all the students with attention deficit disorder in Tehran cities who have referred to psychology and counseling centers, who are covered by educational-therapeutic services (having a diagnostic file as attention deficit and using the available targeted sampling method, 120 people were selected as a statistical sample. The measurement tool in this research is the fifth version of the Wechsler IQ scale for children, which has good validity and reliability. The statistical model used in this research to determine the diagnostic validity is the scatter diagram method (Davis method), the confidence interval method, and the sensitivity coefficient method. Finally, the findings of the research showed that all tests of "Working memory" and "processing speed" scales have a sensitivity coefficient. Therefore, the tests of " Working memory" and "processing speed" scales have diagnostic validity and can distinguish students with attention deficit disorder from normal students.

Effect of metabolic control on cognitive functions in children and adolescents with type 1 diabetes mellitus.

Neurocognitive functions of children with type 1 diabetes mellitus (T1D) are reported to be poorer than those of healthy peers. The aim was to investigate the effects of age of onset of diabetes, metabolic control, and type of insulin regimen on neurocognitive functions in children and adolescents with T1D. Forty-seven children aged 6-18 years, with T1D for at least five years, were included. Children with a known psychiatric disorder or chronic diseases other than T1D were excluded. Intelligence via the Wechsler children's intelligence scale (WISC-R), short-term memory via the audio-auditory digits form B (GISD-B) test, visual motor perception via the Bender Gestalt test, and attention via the Moxo continuous attention and performance test, timing, hyperactivity, and impulsivity (Moxo-dCPT) were assessed. Compared with the T1D group, healthy controls had higher scores in terms of verbal intelligence quotient (IQ), performance IQ, and total IQ mean scores on WISC-R (p=0.01, p=0.05 and p=0.01, respectively). On the MOXO-dCPT test, the T1D group had higher impulsivity compared to the control group (p=0.04). Verbal IQ was better in the moderate control group than in the poorer metabolic control (p=0.01). Patients with no history of diabetic ketoacidosis (DKA) had higher performance, verbal and total intelligence scores than the group with history of DKA. Poor metabolic control and a history of DKA in children with T1D adversely affected neurocognitive functions. It would be beneficial to consider the assessment of neurocognitive functions in T1D and to take the necessary precautions in follow-up.

Effectiveness of Musical Training on Reading Comprehension in Elementary School Children. Is There an Associative Cognitive Benefit?

The current study investigated the impact of instrumental music training on reading comprehension, working memory, and executive function in elementary school children in Greece. A series of studies suggested the possibility of a cognitive advantage from instrumental music training. For the purpose of the present study 80, elementary school children were evaluated. The experimental group consisted of 40 students in 5th grade with at least 5 years of music training and the control group consisted of 40 children who did not have any music training. The two groups were examined in working memory measurements of the Wechsler Intelligence Scale for children (WISC-III; Digit and Forward Digit Recall), in Stoop Test, which is an executive function evaluation and reading comprehension test. The reading ability of both group participants was evaluated with the standardized test in the Greek population Test-A. Children with instrumental music training registered higher performances in reading comprehension tests and all cognitive measurements reflecting a possible cognitive advantage compared to participants without music training. The present results attempt to shed light on the possible link between instrumental music training on cognitive abilities and reading comprehension.

Association between intelligence quotient scores and body mass index in pediatric multiple sclerosis

The aim of this study is to examine the relationship between body mass index (BMI) and intelligence quotient scores (IQ). The sample included 11 patients with pediatric multiple sclerosis between 8 and 17 years, mean age 14.45 years (SD = 2.69). The BMI was calculated as weight in kilograms divided by the square of height in meters. The Wechsler Intelligence Scale for Children V and the Abbreviated Weschler Intelligence Scale were used to measure total IQ. Average sample BMI and IQ were 24.61 (SD = 5.53) (range: 19–39.4) and 86.63 (SD = 14.79) (range: 66–111), respectively. Results of the Pearson correlation indicated that there was a significant negative association between BMI and IQ, (r = −0.608, p = 0.042). R-squared was 0.370. We discuss if lower IQ lead to BMI gains or whether overweight/obesity lead to intellectual functioning changes. Implication for practice and future research are presented.

The Effectiveness and Safety of Hormonal Combinations of Antiepileptic Drugs in the Treatment of Epileptic Electrical Continuity in Children during Sleep: A Meta-Analysis.

Objective A systematic evaluation of the efficacy of hormones in combination with antiepileptic drugs (AEDs) compared to AEDs alone in the treatment of children with encephalopathy related to status epilepticus during slow sleep (ESES). This study provides an evidence-based approach to the treatment of children with ESES. Materials and Methods To find all relevant studies published before March 2022, we searched PubMed, Embase, Web of Science, Clinical Trials, Cochrane Library, CNKI, and Wanfang databases. We explore the difference between AEDs combined with hormones and AEDs alone for ESES treatment. All outcome data, including Wechsler Intelligence Scale for Children, the effective rate, EEG discharges, and adverse effects rate (AER), were compared using Review Manager 5.3. Results There were 805 patients in this study's seven investigations, including 403 in the experimental group and 402 in the control group. Meta-analysis showed that after treatment, compared with the AEDs alone group, the hormone combined with AEDs. The difference in clinical improvement rate [RR = 1.25, 95% CI (1.15, 1.36), p < 0.00001], electroencephalographic (EEG) discharge improvement rate [RR = 1.31, 95% CI (1.22, 1.41), p < 0.00001], and cognitive intelligence score [SMD = 1.02, 95% CI (0.76, 1.28), p < 0.00001] was statistically significant. The differences were statistically significant in terms of 0.00001; the incidence of adverse reactions was higher in the hormone combined with AEDs group than in the AEDs group alone, and the differences were statistically significant [RR = 4.13, 95% CI (1.06, 16.13), p < 0.01], and all adverse reactions improved or disappeared after discontinuation of the drug. Conclusions The combination of hormones with AEDs for the treatment of epileptic electrical continuity in sleep has advantages over AEDs alone in terms of controlling seizures, improving EEG abnormalities, and improving cognition. The combination of hormones with AEDs has advantages over AEDs alone in controlling seizures, improving EEG abnormalities, and improving cognition and is relatively safe.

Neurocognitive deficits in survivors of childhood acute myeloid leukemia

BackgroundAlthough treatment of acute myeloid leukemia (AML) contains neurotoxic agents, studies investigating neurocognitive outcomes in children with AML are sparse. We evaluated late cognitive effects in children treated with a high-dose cytarabine based regimen, focusing on general intellectual ability and specific neurocognitive domains.MethodsWe evaluated 12 survivors of childhood AML who were treated between 2006 and 2016 and completed the Wechsler Intelligence Scales. One-sample t-tests were used to compare full-scale intelligence quotient (FSIQ) and primary index scores to norms. The overall effect of index scores and subtests was examined with one-way ANOVA. Univariate analyses and multiple regression models examined demographic and clinical characteristics associated with FSIQ.ResultsParticipants who underwent the Wechsler Intelligence Scale for Children demonstrated impairment on working memory index and participants who underwent the Wechsler Adult Intelligence Scale showed low score in the subtests that reflect working memory, whereas they exhibited no statistical differences versus the population means for FSIQ. There were no significant differences in the overall effect of index scores and subtests. On univariate analysis, FSIQ were related to time since diagnosis and age at assessment, and both were significant predictors of FSIQ on multiple linear regression.ConclusionsSurvivors of childhood AML exhibited impairment of working memory, even if their FSIQ was within the normal range. Difficulties in specific cognitive domains are associated with reduced quality of life. It is important to identify survivors who are at risk and provide tailored interventions.

Altered functional connectivity in children born very preterm at school age

Children born very preterm are at significant risk of neurodevelopmental impairment. This study sought to identify differences in cognitive function in children born very preterm compared to term-born controls and investigate alteration in white matter microstructure and functional connectivity (FC) based on tract-based spatial statistics (TBSS) and resting-state functional MRI, respectively. At 6 years of age, 36 children born very preterm (< 32 weeks' gestation) without major neurological disabilities and 26 term-born controls were tested using the Wechsler Intelligence Scale for Children, 4th edition, and Child Behavior Checklist. Whole-brain deterministic tractography and FC measurements were performed in both groups. The very preterm group had significantly lower intelligence scores than the term-born controls. The TBSS revealed no significant differences between the two groups, whereas FC was significantly increased between the frontoparietal network and the language network and was significantly decreased between the right salience network nodes in the very preterm group. The altered FC patterns between specific regions of the higher-order networks may reflect underlying deficits in the functional network architecture associated with cognitive function. Further studies are needed to demonstrate a direct connection between FC in these regions and cognitive function.

Effectiveness of the Combined Memory Training Program on Memory Skills and School Achievement of Children with Specific Learning Disorders: A Pilot Randomized Controlled Trial

Introduction: Children with Specific Learning Disorders (SLD) suffer from some cognitive deficits affecting their school achievement. This study investigated the effect of the combined Working Memory Training Program (WMTP) with the Caillou program (the game-like features of computerized cognitive training programs) on memory (as a cognitive function) and academic achievement in children with SLD.Materials and Methods: In this pilot randomized controlled trial study, 30 children with SLD, aged 8-11 years, participated. They were randomly allocated to the intervention and control groups. The intervention group received 20 training sessions in 10 weeks, each lasting 30-45 minutes. The control group only participated in the assessment sessions. The primary outcome was verbal working memory skills assessed by the digit span and letter-number sequencing subtests of the Wechsler Intelligence Scale for Children, the fourth edition (WISC-IV). Also, the grades of science, literature, and mathematics were collected as the secondary outcomes. Children were assessed 3 times: baseline (pre-test), after the intervention (post-test), and 2 months after the intervention (follow-up).Results: Working memory (digit span and letter-number sequencing scores) and mathematics grades were significantly improved in the intervention group, as compared to the control group at the post-test session (P&lt;0.05) and remained in the follow-up session.Conclusion: Although this combined program effectively improves working memory and mathematic grades, further research is suggested for more academic achievement.

Characterizing the neurocognitive profiles of children with moyamoya disease using the Das Naglieri cognitive assessment system

Although cognitive impairment is well-documented in children with moyamoya disease (MMD), selective decline in specific neurocognitive domains remains controversial. The purpose of this study was to characterize the neurocognitive profile of children with MMD using the Das Naglieri Cognitive Assessment System (CAS) and the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV). We analyzed the neurocognitive data of 30 children (median age, 7 years) with MMD who were assessed with the CAS and the WISC-IV before surgery. We focused on the comparison of standard scores and intraindividual differences across domains. The CAS scores significantly varied across four measures (standard scores, p < 0.001; intraindividual differences, p < 0.001). Post-hoc analyses revealed that the standard scores and intraindividual differences for successive processing were significantly lower than those for planning and attention. The WISC-IV scores did not significantly vary among the four measures, although the working memory index was the lowest among the four measures. The within-individual weakness in successive processing, a form of working memory function, may be a distinct characteristic of children with MMD. The CAS may be more sensitive than the WISC-IV for detecting this selective neurocognitive weakness in children with MMD.

The Effect of Abnormal Regional Homogeneity and Spontaneous Low-Frequency Brain Activity on Lower Cognitive Ability: A Cross-Sectional Study on Postoperative Children With Tetralogy of Fallot.

Despite intracardiac malformation correction, children with Tetralogy of Fallot (TOF) may still suffer from brain injury. This cross-sectional study was primarily designed to determine the relationship between blood oxygenation level-dependent (BOLD) signal changes after surgery and cognition in school-aged children with TOF. To evaluate the differences between TOF children (n = 9) and healthy children (n = 9), resting-state functional magnetic resonance imaging (rs-fMRI) and the Wechsler Intelligence Scale for Children–Chinese revised edition (WISC-CR) were conducted in this study. The results showed that TOF children had a lower full-scale intelligence quotient (FSIQ, 95.444 ± 5.354, p = 0.022) and verbal intelligence quotient (VIQ, 92.444 ± 4.708, p = 0.003) than healthy children (FSIQ = 118.500 ± 4.330;VIQ = 124.250 ± 4.404), and that significant differences in regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) existed between the two groups. Besides, VIQ had significantly positive correlations with the decreased ALFF value of the middle inferior occipital gyrus (MIOG, beta = 0.908, p = 0.012) after fully adjusting for all covariates. In addition, elevated ReHo values of the left and right precuneus were positively related to ALFF in the MIOG. This study revealed that brain injury substantially influences neural activity and cognition in postoperative TOF children, providing direct evidence of an association between BOLD signal changes and the VIQ and prompting further attention to language development in TOF children.

Version control and crosswalk in cognitive assessment: Transitioning from the fourth to fifth edition of the Wechsler Intelligence Scale for Children (WISC) in children with NCL disorders/Batten disease

Version control and crosswalk in cognitive assessment: Transitioning from the fourth to fifth edition of the Wechsler Intelligence Scale for Children (WISC) in children with NCL disorders/Batten disease

The effectiveness of matching the visual learning style and the brain information processing style in students with dyslexia

Background and Aim: Special learning disorders include a heterogeneous group of children and adults who have problems in the areas of cognitive, academic and communication-social skills, and work. The purpose of this research is to investigate the effectiveness of matching the visual learning style and the brain information processing style in students with dyslexia, boys and girls in the first year of elementary school. Methods: The current research was quasi-experimental and pre-test, post-test, follow-up and control group design. After receiving the code of ethic Among the male and female students in the first, second and third grade of elementary school in Qom and referred to government and non-government disorder centers in the academic year 2018-19, through targeted sampling, 102 people who met the criteria for entering the research were selected and randomly placed in two experimental groups (51 people) and control group (51 people). The treatment sessions were conducted in 16, 45-minute sessions (two sessions per week) using Eishiner's model and walking learning style in the experimental group. In order to collect data from the Wechsler Children's Intelligence Scale, 4th Edition, Checklist for the assessment of the superior side of the brain, Walk Learning Styles Questionnaire, Chapman and Edinburg Hand Excellence Questionnaire, Delacato's brain development table And the analysis of the content of the Persian book of the first grade of elementary school was used with the visual index (the basis of the content of the textbooks is based on three visual, auditory and movement styles). Data using spss 23 software and the statistical method of covariance analysis and GEE (Estimation of generalized equations) and paired t was analyzed. Results: The findings showed that the effect of consonance in the group with the superior right visual style of consonance in the score of orientation, visualization, listening accuracy, visual accuracy, motor accuracy and writing is significant (P&lt;0.05). The effect of consonance in the group with superior left visual style of consonance is significant in visualization score, movement accuracy, writing, orientation, auditory accuracy and visual accuracy. Congruent effect in the group with superior right visual style, there is a significant difference in the score of orientation and motor accuracy. The effect of congruence in the group with incongruent superior right visual style is not significant in the writing score and visualization dimensions, listening accuracy and writing accuracy and total writing score. The effect of congruence in the group with superior left visual style of incongruent in the writing score and its dimensions is significant (P&lt;0.05) and the two-month follow-up of the results showed the stability of the results. Conclusion: Consonant is an effective intervention method on the conflict between superior visual learning style and cerebral information processing style in insufficient writing

Differences in Attention Skill between Children with ADHD and Typically Developing Children in Indonesian Primary Schools

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychological developmental disorder in children. ADHD is characterized by inattention, overactivity, and impulsivity. However, the attention skill is not clearly studied in children with ADHD in Indonesia. Objective: The aim of the present study was to investigate the differences in attention skill between children with ADHD and typically developing children (TD), and identify the differences between ADHD subtypes at primary schools in Bandung city Indonesia in terms of the parameter of attention. Methods: This study used the quantitative method. The population of this study was children with ADHD and typically developing (TD) school-age children. The data sampling technique was purposive sampling, consisting of 30 children as a group of ADHD children and 30 children as a group of TD children. The instrument to collect data was Wechsler Intelligence Scale for Children (WISC), Indonesian ADHD Rating Scale (IARS), and The D2 test of attention. The analysis method used t-test and SPSS V.24 for Windows. Results: This study showed significant differences in attention skill performance between children with ADHD and TD children in the variables including the total number of tasks completed, omission, commission, error rate, total amount minus errors or selective attention skill, fluctuation rate and concentration performance. There have been observed significant differences between ADHD subtypes in terms of total number, omission, commission, error rate, total amount minus errors or selective attention skill, and concentration performance. Conclusion: Children with ADHD were found to have lower results than typically developing children in terms of attention skill, inhibiting control, and ability in performance accuracy. Children with ADHD-C subtypes were found to have more inattentive tendencies, hyperactive, and impulsive compared to ADHD-I and ADHD-H. ADHD-C subtype showed more deficits than ADHD-I and ADHD-H in response inhibition and accuracy of performance.

Factor structure of the new Scandinavian WISC-V version: Support for a five-factor model.

The fifth version of Wechsler Intelligence Scale for Children is designed to measure five distinct aspects of intelligence, incorporating a new fluid reasoning index to the four indexes of the previous fourth version. Several factor analyses, however, have failed to support the fifth factor. The Scandinavian version is the only national version not showing clear superiority for the five-factor solution in the Manual. In the present study, we analyze WISC-V protocols from a clinical sample of 237 children tested with the new Scandinavian version. We perform six confirmatory factor analyses (CFA) testing three hierarchical-, two bifactor-, and one correlated candidate factor models. The study shows that the three-factor model does not fit the data, and that all four- and five-factor models showed good fit. The four-factor bifactor model was somewhat better than the five-bifactor and hierarchical models, but the correlated five-factor model was the superior model. Finding support for five-factors in a clinical sample representative of those most probable to be tested with the test, strengthen the claim that also the Scandinavian version measure a distinct fluid factor as intended by the test owners, and thus that clinicians may use the index scores as their main level of analysis. Review of previous CFAs show that the choice of statistical methods for CFA, bifactor or hierarchical/correlated, influence whether second order factor models are better than g-factor models.

Cognitive function and behavioral problems in children born to mothers with preeclampsia: an Indian study

ABSTRACT Studies from high-income countries report associations of preeclampsia (PE) with reduced cognitive function and adverse behavioural outcomes in children. We examined these associations in Indian children aged 5-7 years. Children of mothers with PE (n=74) and without PE (non-PE; n=234) were recruited at delivery at Bharati Hospital, Pune, India. The cognitive performance was assessed using 3 core tests from the Kaufman Assessment Battery and additional tests including Verbal fluency, Kohs block design, and Coding A (from Wechsler Intelligence Scale for Children). The parent-reported Strengths and Difficulties Questionnaire (SDQ) was used to assess children’s behavioral characteristics. Scores were compared between children from PE and non-PE groups, and associations analyzed further using regression models, adjusted for potential confounders. After adjusting for age, sex, socio-economic status and maternal education, children of PE mothers had lower Kohs block design scores (adjusted odds ratio per score category 0.57, [95% CI 0.34-0.96] p=0.034; 0.62 [95%CI (0.36, 1.07), p=0.09 on further adjustment for birth weight and gestation) compared to children of mothers without PE. In the SDQ, there was a lower prevalence of abnormal ‘conduct problem’ scores in PE group than non-PE group (OR=0.33, 95% CI 0.13-0.83, p=0.018, in the fully adjusted model); there were no differences for other behavioral domains. This preliminary study in Indian children suggests that fetal exposure to maternal PE may have an adverse impact on visuo-spatial performance but does not adversely affect behavior. Further studies with larger sample sizes are essential to understand effects of maternal PE on cognitive/behavioral outcomes in children.

Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age.

Background and Objectives: Late long-term outcomes of perinatal asphyxia (PA) in school-age are often unclear. To assess long-term outcomes at an early school age in children who had experienced perinatal hypoxia or asphyxia, where therapeutic hypothermia was not applied. Materials and Methods: The case group children were 8–9-year-old children (n = 32) who were born at full term and experienced hypoxia or asphyxia at birth, where therapeutic hypothermia (TH) was not applied. The control group consisted of 8–9-year-old children (n = 16) born without hypoxia. A structured neurological examination was performed at an early school age. The neuromotor function was assessed using the Gross Motor Function Classification System (GMFCS). Health-related quality-of-life was assessed using the Health Utilities Index (HUI) questionnaire. Intellectual abilities were assessed using the Wechsler Intelligence Scale for Children (WISC). Results: The case group, compared with controls, had significantly (p = 0.002) lower mean [SD] full-scale IQ (87(16.86) vs. 107(12.15)), verbal-scale IQ (89(17.45) vs. 105(11.55)), verbal comprehension index (89(17.36) vs. 105(10.74)), working memory index (89(15.68) vs. 104(11.84)), performance IQ (87(16.51) vs. 108(15.48)) and perceptual organization index (85(15.71) vs. 105(15.93)). We did not find any significant differences in the incidence of disorders of neurological examination, movement abilities and health-related quality of life at an early school age between the case and the control group children. Conclusion: In children who experienced perinatal asphyxia but did not have cerebral paralysis (CP), where therapeutic hypothermia was not applied, cognitive assessment scores at an early school age were significantly lower compared to those in the group of healthy children, and were at a low average level.

ГЕНДЕРНЫЕ ОСОБЕННОСТИ КАЧЕСТВА ЖИЗНИ ДЕТЕЙ МЛАДШЕГО ШКОЛЬНОГО ВОЗРАСТА ПРИ РАЗНОМ КОГНИТИВНОМ РАЗВИТИИ

The current problems of pediatrics are the individual approach and optimization of the quality of life of primary school children. The aim of our research was to study the quality of life among children of primary school age according to their cognitive development and gender and age characteristics. Materials and methods of research: cognitive development was studied using the D. Wechsler Intelligence Scale for Children, the Stanford-Binet intelligence scale and the Torrance Tests of Creative Thinking (TTCT). As a result, 573 primary school children were divided into 2 groups: I with a high cognitive level (82 people) and II with an average level (491 people). The PedsQL 4.0 questionnaire, used by children attending schools in cities of Rostov-on-Don and Lugansk for 4 years, served as a tool for quality of life. Physical, emotional, social functioning, psycho-social health have been studied, as well as an overall quality of life score. More reduced quality of life indicators were found in children with a high cognitive level, with the exception of school functioning. Girls levels of cognition have been found to have lower levels of physical and emotional functioning than boys, but higher levels of social functioning. Conclusions: there is a need to change the way children are taught in gym classes and to provide additional counseling for child psychologists and pediatricians in order to optimize children’s education.