Intelligence Quotient Level Research Articles

Flexing the emotional muscle: Investigating how team reflexibility shapes performance via emotional intelligence

In team settings, the development of reflexibility and emotional intelligence significantly influences performance outcomes. Identifying these relationships is crucial for optimizing team dynamics and achieving superior results. Present research investigates the relationship between team reflexivity and team performance through the mediating role of Emotional Intelligence. Team reflexibility affects team performance positively and developing emotional intelligence skills improves team performance. SPSS and AMOS software was used to analyze the data and the hypothesis was tested using structural equation modeling (SEM) and data obtained from 317 IT company employees in Coimbatore, India. The outcomes of the study provide both practical and theoretical insights for IT company employees to increase team performance through flexible and emotional intelligence skills. Employees with a high level of Intelligence Quotient (IQ) are insufficient for today's business. To be successful, workers must have a certain level of Emotional Intelligence (EI). Employees with a high EI tend to have better relationships and connections, higher performance due to collaboration, and a more positive and peaceful workplace. This research gives managers and leaders an in-depth understanding of highly reflective teams, which will allow them to be more inventive while also altering their emotional abilities to perform better and retain the organization in the long run.

Comparative Analysis of Mixed Reality and PowerPoint in Education: Tailoring Learning Approaches to Cognitive Profiles.

The term immersive technology refers to various types of technologies and perspectives that are constantly changing and developing. It can be used for different purposes and domains such as education, healthcare, entertainment, arts, and engineering. This paper aims to compare the effectiveness of immersive technologies used in education, namely mixed reality, generated with Microsoft HoloLens 2, with traditional teaching methods. The experiment involves comparing two groups of students who received different training methods: the first group saw a PowerPoint slide with an image of the human muscular system, while the second group saw a 3D hologram of the human body that showed the same muscle groups as in the PowerPoint (PPT). By integrating the Intelligence Quotient (IQ) levels of the participants as a predictive variable, the study sought to ascertain whether the incorporation of mixed reality technology could significantly influence the learning outcomes and retention capabilities of the learners. This investigation was designed to contribute to the evolving pedagogical landscape by providing empirical evidence on the potential benefits of advanced educational technologies in diverse learning environments. The main finding of this study indicates that while MR has potential, its effectiveness is closely tied to its interactivity. In cases where the content remains static and non-interactive, MR does not significantly enhance in-formation retention compared to traditional PPT methods. Additionally, the study highlights that instructional strategies should be adapted to individual cognitive profiles, as the technology type (MR or PPT) alone does not significantly impact learning outcomes when the information presented is identical.

Gambaran Intelligence Quotient (IQ) Di MTs N 1 Karanganyar

Individuals have important factors that influence them. Intelligence is the term referred to by scientists. Intelligence can be said to be an individual's ability, dexterity, shrewdness and ingenuity. Individuals compete to become intelligent humans, because only with intelligence can individuals become successful. Intelligence Quotient (IQ) or commonly called intellectual intelligence, is an individual's ability to think that is innate from birth which allows individuals to act in a certain way, as well as an ability that can be measured in a test. This research method is a correlational quantitative approach. The population of this research is all prospective students of class VII MTS N 1 Karanganyar, Gondangrejo for the 2025/2025 academic year in 7 rooms totaling 164 students. The research sample was prospective class VII students at MTs N 1 Karanganyar, totaling 110 students. The data collection method was carried out using psychological test tools, namely TIKI-M (Indonesian Collective Intelligence Test) and documentary. The data analysis used is descriptive analysis. Based on the results of data analysis and research discussion, it can be concluded that the mean level of intelligence quotient (IQ) of MTS N 1 Karanganyar prospective students for the 2024/2025 academic year is 107, which is included in the average category. Based on the frequency distribution of intellectual intelligence, it can be seen that the level of intellectual intelligence of MTS N 1 Karanganyar prospective students is 68.18% at the average level, 27.27% is at the above average level, and as much as 4.54% is at a superior level.

Evaluation of Sleep EEG Changes in Paediatric Patients with Language Dysfunction: A Follow Up Study

Abstract Background Several case reports and studies have described an association between sleep epileptiform discharges and language dysfunctions. This has been partly confirmed in studies that have investigated the effect of this epileptiform discharges on neurocognitive function. Objectives To screen for sleep-potentiated epileptiform discharges in children with language dysfunction (language delay or regression) and to evaluate the effect of treatment of these epileptiform discharges on language dysfunction. Methods The study was conducted on 93 children with language delay or language regression. Patients were recruited from the pediatric neurology clinic, pediatric outpatient clinic, phoniatrics outpatient clinic and the inpatient neurology ward at the Ain Shams University Children’s hospital, Cairo, Egypt in the period between February 2020 and November 2021. A 90- minute sleep electroencephalography, intelligence quotient level and language age were done for all patients included in the study. Children who had an active electroencephalography with uncontrolled clinical seizures or persistently epileptogenic activity without clinical seizures received treatment according to type of activity then after 6 months they were subjected to follow up electroencephalographyand assessment of intelligence quotient level and language age. Results The enrolled patients were divided into two groups: Group (1) including 28 (30%) patients with either or both of epileptogenic activity and clinical seizures and group (2) including 65 (70%) patients without either epileptogenic activity or clinicalseizures. We found 24 (85.7 %) children in group 1 had clinical seizures with median age of onset 2.5 years (range from 1-8 years). Further in the first group, 21 (85.7 %) of children showed presence ofepileptogenic activity with 10 (47.6 %) of children showed spike and slow wave, 6 (28.6 %) showed sharp wave, 3 (14.3 %) showed continuous spike and wave during slow wave sleep (CSWS), 2 (9.5 %) children showed sharp and slow wave. In our study, levetiracetam was given as first line treatment in patients with active seizures. An add-on therapy was given in patients who were not controlled on one antiepileptic drug. A follow up 90 minutes sleep electroencephalography was done and showed a highly significant reduction in epileptogenic activity with a p value of < 0.001. A follow up language test and intelligence quotient level score were done and showed a highly significant improvement with p value of (0.001 and 0.009) respectively. Conclusion Epileptiform activities with or without epilepsy in children may alter normal language function. Treatment of these epileptogenic activity affect improvement of this language dysfunction. Trial registration: ClinicalTrials.gov I.D: NCT05487521.

Impact of Cognitive Intervention on Neurocognitive Development of Schoolchildren Exposed to Lead in a Semi-Urban Community in Mexico.

A quasi-experimental study with a control group was conducted in children aged 7 to 12years from 2 communities in Morelos, Mexico. Blood lead levels were determined, and the neurocognitive function was assessed pre- and postintervention with the Wechsler Intelligence Scale for Children and Children's Auditory Verbal Learning Test-2. A cognitive intervention was conducted at the school. The difference-in-differences method adjusted for variables known as priori and evaluated the impact of cognitive intervention. The differences-in-differences models indicated a significant average increase in scores on the Verbal Comprehension Index (9.58 points), Processing Speed Index (5.33 points), intelligence quotient (5.63 points) level of learning (7.66 points), interference trial (10.12 points), immediate memory span (7.98 points), and recognition accuracy (1.18 points) subtests after the cognitive intervention. The results suggest that cognitive intervention improves neurocognitive development in schoolchildren exposed to Pb.

Dermatoglyphic pattern is an Indicator for Assessing the Intelligence Quotient (IQ) of Medical Undergraduates in A North Indian Medical College

Introduction: The intelligence quotient (IQ) levels and dermal ridge patterns on the volar surfaces of digits and palms of different individuals may be related because brain developed from 13th to 21st week and during same time-period the dermal groove developed. Neocortex is a higher center for learning and of intelligence, so there is association between Intelligence level and patterns of fingerprints. So, this study was conducted to find out the different dermatoglyphic patterns of fingers and palms and correlate them to the IQ levels of medical undergraduates. Materials and Methods: Fingers and palms prints of both the hands of 150 medical students of 18-24 years were collected with help of ink pad and A4 size of paper. The fingers and palms prints were studied using hand held magnifying lens and their IQ levels assessed using Raven’s Standard Progressive Matrices. Results: The most common finger patterns e.g. single whorl in thumb, ulnar loop in index finger and middle finger of both sides and were found on participants having Grade I Intelligence. More males shown higher IQ and belonged to Class A IQ i.e. grade I and Grade II however in lower IQ the males and females were equally distributed and belonged to Class B i.e. Grade III, IV, V. Most common finger patterns i.e. single whorl in thumb and ulnar loop in index on both right and left side were found in the participants having Grade I & II Intelligence. Conclusion: Students with Grade I and II IQ has higher incidence of whorl followed by loop whereas in participants with IQ level of Grade III onwards, loop was the most common pattern followed by whorl. Asymmetry in patterns on both the side of fingerprint was evident in lower IQ levels. Higher values of mean ‘a-b’ ridge count and mean ‘atd’ angle was higher in individuals with low IQ level. So, it can be concluded that the dermatoglyphic pattern and IQ levels are associated.

FMR1 Protein Expression Correlates with Intelligence Quotient in Both Peripheral Blood Mononuclear Cells and Fibroblasts from Individuals with an FMR1 Mutation

Fragile X syndrome (FXS) is the most common heritable form of intellectual disability and is caused by CGG repeat expansions exceeding 200 (full mutation). Such expansions lead to hypermethylation and transcriptional silencing of the Fragile X messenger ribonucleoprotein 1 (FMR1) gene. As a consequence, little or no FMR1 protein (FMRP) is produced; absence of the protein, which normally is responsible for neuronal development and maintenance, causes the syndrome. Previous studies have demonstrated the causal relationship between FMRP levels and cognitive abilities in peripheral blood mononuclear cells (PBMCs) and dermal fibroblast cell lines of patients with FXS. However, it is arguable whether PBMCs or fibroblast would be the preferred surrogate for measuring molecular markers, particularly FMRP, to represent the cognitive impairment, a core symptom of FXS. To address this concern, CGG repeats, methylation status, FMR1 mRNA and FMRP levels were measured in both PBMCs, and fibroblasts derived from 66 individuals. The findings indicated a strong association between FMR1 mRNA expression levels and CGG repeat numbers in PBMCs of premutation males after correcting for methylation status. Moreover, FMRP expression levels from both PBMCs and fibroblasts of male participants with a hypermethylated full mutation and with mosaicism demonstrated significant association between the intelligence quotient (IQ) levels and FMRP levels, suggesting that PBMCs may be preferable for FXS clinical studies, due to their greater accessibility.

Influence of parental education on the intelligence quotient profiles and socially adaptive behavior of school-age children with autism spectrum disorder in eastern China.

Intelligence quotient (IQ) and adaptive behavior are the influencing factors of autism spectrum disorder (ASD) in children entering mainstream schools. This study explored the association between parental education level, IQ, and adaptive behavior in ASD groups. A total of 257 school-age ASD children were enrolled in our study from January 2017 to June 2021. Their parents completed a standard demographic form, including age at autism diagnosis, gender, school placement, and parents' educational background. The Chinese version of the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) was completed by a certified assessor for each enrolled child. Parents were interviewed on adaptive behavior using the Chinese version of the Adaptive Behavior Assessment System, Second Edition (ABAS-II). The average IQ of school-age ASD children was 76.88 (standard deviation (SD)=22.62) and boys had higher IQ levels than girls. The IQ was positively correlated with age. The General Adaptive Composite (GAC) score was 82.47 (SD=15.86) and adaptive behavior did not increase with age. ASD children who attended mainstream schools had better adaptive behavior profiles than other children. The mother's education level showed a significant correlation with the IQ and adaptive behavior of autistic children, while the father's education level did not. Consequently, better training and support for parents may help autistic children enter mainstream schools, with adaptive training being the most urgently required skill for parents.

Intellectual status and factors influencing the intelligence in children with attention deficit and hyperactive disorder

To study the intellectual level and the factors influencing the intelligence in children aged 6-16 years with attention deficit hyperactivity disorder (ADHD). A retrospective study was conducted on 2 861 children who were diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition between October 2014 and September 2022 at Henan Children's Hospital. The Wechsler Intelligence Scale for Children-Fourth Edition was used to assess the intellectual levels of the ADHD children. Based on intelligence quotient (IQ) scores, the intellectual levels were classified into five categories: borderline (70-79), low average (80-89), average (90-109), high average (110-119), and superior (≥120). The intellectual levels among the children of different genders, grades, and parental education levels were compared. Among the 2 861 ADHD children, 569 (19.89%) were classified as borderline, 846 (29.57%) as low average, 1 304 (45.58%) as average, 111 (3.88%) as high average, and 31 (1.08%) as superior. The boys had lower scores in working memory, processing speed, and overall IQ than the girls (P<0.05). There were significant differences in perceptual reasoning, working memory, processing speed, and overall IQ scores among different grade groups (P<0.05). The scores in language comprehension, perceptual reasoning, working memory, processing speed, and overall IQ were found to be associated with parental education level in ADHD children (P<0.05). The proportion of ADHD children with low average and borderline intellectual levels is relatively high. The IQ level of ADHD children is influenced by gender, grade level and parental education level.

Pathways from maternal depression to child resilience: Socioeconomic, family, and individual factors in the 2004 Pelotas (Brazil) birth cohort.

The negative impacts of maternal depression on child mental health outcomes are well-documented. However, some children show adaptive functioning following exposure to maternal depression, demonstrating resilience. In a large birth cohort from Brazil, a middle-income country, we examined direct and indirect pathways, considering socioeconomic, family, and individual factors, contributing to the development of resilience. Using data from the 2004 Pelotas Birth Cohort (N=4231), we restricted the sample to those exposed to maternal depression up to age 6years (depression present at≥2 out of 5 assessment waves; n=1132; 50% boys). Resilience was defined as scoring below or equal to the mean of the unexposed group on all four problem subscales of the parent-report Strengths and Difficulties Questionnaire at age 11years. We examined pathways from socioeconomic status (SES; measured at birth) to resilience via cognitive stimulation (CS) (at 24 and 48months) and Intelligence quotient (IQ) (at 6years), and from CS to resilience via IQ, using counterfactual mediation. A minority of children exposed to maternal depression showed resilience (12.4%). There was evidence of indirect pathways from SES to resilience via CS (odds ratio (OR)=1.76, 95% confidence interval (CI) 1.02-3.38) and IQ (OR=1.19, 95% CI 1.01-1.42), such that higher SES was associated with resilience via both higher levels of CS and higher IQ, which, in turn, were each positively associated with resilience. Furthermore, there was evidence of a direct (OR=1.86, 95% CI 1.01-3.76) and total effect (OR=1.94, 95% CI 1.05-3.89) of CS on resilience, even after controlling for SES. However, these effects varied depending on how persistent and severe depression was defined. These findings suggest that CS in early childhood may represent a modifiable protective factor for children exposed to maternal depression and a promising intervention target to promote child resilience in the context of maternal depression exposure.

Emotional intelligence, spelling performance and intelligence quotient differences based on the executive function profile of schoolchildren.

The aim of this study was to determine the correlation of intelligence quotient with spelling performance, executive functions and emotional intelligence and to analyse the profiles in executive functions presented by the participants and the differences at the level of intelligence quotient, spelling performance and emotional intelligence. The sample consisted of 125 Spanish primary school students (58 girls and 67 boys) in a rural environment, with a mean age of 10.92 (±.68)years. Intelligence quotient and spelling performance were measured using the BADyG test; executive functions were assessed using the NIH EXAMINER battery and emotional intelligence was assessed using the Bar-On questionnaire. The results show a high correlation of intelligence quotient with spelling performance, executive functions and two emotional intelligence dimensions (adaptability and interpersonal). Two clusters were observed: a high executive functions profile (n = 74, 59.7%), with high scores on all measured variables (working memory, planning, cognitive flexibility, inhibition and verbal fluency), and a low executive functions profile (n = 50, 40.3%) with low scores on all executive functions-related variables. The multivariate analysis of variance (MANCOVA) found variations between the different clusters in the intelligence quotient, spelling performance and interpersonal emotional intelligence variables, showing that students with a higher executive functions profile had a higher intelligence quotient, spelling performance and interpersonal emotional intelligence values. This study could help to better define what kind of teaching methodology favours the development of academic performance in schoolchildren and the connections between important educational aspects such as emotional intelligence and executive functions.

Estimation of Intelligence Quotient in Healthy Individuals using Magnetic Resonance Imaging: A Systematic Review

The intelligence quotient (IQ) is typically used to reflect human intelligence. Conventional IQ tests are commonly used to assess an individual’s level of intelligence. However, the reliability of these conventional methods remains controversial as they are vulnerable to bias and often yield inconsistent results. Interestingly, emerging evidence suggested that magnetic resonance imaging (MRI) may be an alternative method to estimate a person’s level of intelligence, as IQ is closely linked with the brain's structure. In this article, we systematically reviewed published studies on the estimation of IQ in healthy individuals using MRI. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was performed in the PubMed database. The literature search focused on studies reporting on brain structures associated with IQ in healthy individuals and the effects of brain structural changes on IQ. 22 studies met the eligibility criteria and were included in this review. Key brain regions associated with IQ are grey matter (GM), white matter (WM), caudate nucleus, left hemisphere, limbic system, frontoparietal (FP) cortices, and default-mode network (DMN). The critical effect of ageing on brain changes and its impact on IQ were also discussed. Overall, the findings suggested that brain structures play a significant role in IQ levels in healthy individuals. This systematic review highlights the potential use of MRI in estimating IQ by examining brain structures. Nonetheless, available MRI studies were limited by methodological issues. Future MRI investigations should include well-characterized groups of females and matched male healthy individuals while considering confounding factors such as types of IQ tests.

IQ as an Indicator of Academic Stress, Study Habits, and Academic Success

Intelligence quotient (IQ) and its impacts have been studied heavily in previous research. However, studies have not yet sufficiently applied IQ to an academic environment, especially in high-school aged students. To fill this gap in the field of study, this study utilized a mixture of qualitative and quantitative methods to measure trends in the behavior of students at different IQ levels and evaluate the strengths and weaknesses of student populations. The study’s participants, comprising of 21 high schoolers, voiced and quantified their opinions on their personal experiences regarding stress, study habits, and academic success. Ultimately, the trends in high IQ and low IQ groups suggest that IQ is a valuable statistic in educational environments which can be used by educators to improve student weaknesses. The exposure of IQ scores in academic settings would provide crucial insight into the behavioral trends of student groups and can make a lasting positive change in education.

Intelligence quotient (IQ) outcome in children with early-treated congenital hypothyroidism: a systematic review and meta-analysis

Background Congenital hypothyroidism (CH) is the most common congenital endocrine disorder in childhood and is one of the most preventable causes of intellectual disability (ID). Late initiation of thyroid hormone substitution therapy has a negative impact on intellectual abilities in CH patients.&#x0D; Objective To compare Intelligence Quotient (IQ) between children with CH who underwent early treatment among the children without CH.&#x0D; Methods We performed online literature searches of ScienceDirect, Pubmed, Cochrane Library, and Google Scholar. We included clinical studies that examined IQ scores in patients with early-treated CH and without CH. Review Manager 5.4 was used to perform the meta-analysis.&#x0D; Results Twelve studies comparing pediatric patients with and without CH were included in this meta-analysis, for a total of 808 patients. Based on data analysis, IQ levels of verbal IQ [mean difference (MD) -9.05; (95%CI -14.51 to -3.59); (P&lt;0.00001)], performance IQ [MD -11.70; (95%CI -17.41 to -5.99); (P&lt;0.00001)], and total IQ [MD -10.78; (95%CI -14.03 to -7.54); (P&lt;0.00001)]. While verbal, performance, total, of the early-treated CH group were within the normal range, they were each significantly lower than those in the non-CH group.&#x0D; Conclusion This meta-analysis reveals that IQ scores in early-treated CH subjects were within normal limits, but significantly lower than that of normal controls.

Determination of fluoride content in infant food samples by sample stacking capillary electrophoresis-indirect UV detection and the estimation of daily-fluoride-intake

Fluoride ion plays a major role in the decline of the prevalence and severity of dental caries. However, exposure to a high level of fluoride causes dental and skeletal fluorosis and reduced levels of intelligence quotient (IQ) in children. This study reports a rapid, selective, sensitive, and economic capillary electrophoresis-sample stacking technique for fluoride analysis in infant food samples. Indirect UV detection of fluoride was performed by 10 mmol/L chromate in the separation electrolyte and 0.1 mmol/L cetyltrimethylammonium bromide (CTAB) was added to the separation medium as an electroosmotic flow modifier. The buffer pH was adjusted to 9.37. The conductivity of the separation electrolyte was increased with 10 mmol/L Na2SO4 and sample stacking was performed. The injections were administered throughout 200 s duration. The limit of detection of the method was 0.0079 mg/L. The method was applied to 7 various commercially available infant food samples which are in puree and powdered form. The fluoride concentrations ranged from 2.28 – 3.85 µg fluoride/g infant food. The proposed method is suitable for the rapid and sensitive determination of fluoride content in infant formulas, and it is recommended that fluoride content be determined by reliable methods in all commercial infant food samples.

Analisis Hasil Belajar Matematika Siswa Ditinjau dari Intellegence Quotient

This study aims to describe the relationship between mathematics learning outcomes in terms of intelligence quotient (IQ). The subjects of this study were selected based on test results and predetermined categories. The data collection technique used consisted of two tests, namely a math test to find out learning outcomes and an IQ test to measure students' IQ levels. The results showed that the level of the students' IQ affected the learning outcomes obtained. In addition, the results of the interviews show that there are several factors that become obstacles and are often faced by students in learning, including internal and external factors. Internal factors are feeling lazy, not liking math lessons, lack of understanding of the material, and lack of time to practice working on practice questions. The external factors in this study were the unconducive classroom atmosphere which made it difficult for students to focus, the teacher's delivery was difficult to understand, and the lack of motivation and encouragement from the family, such as the presence of parents in student learning.

A STUDY TO ASSESS THE INFLUENCE OF INTELLIGENCE QUOTIENT (IQ), EMOTIONAL QUOTIENT (EQ), ADVERSITY QUOTIENT (AQ), SPIRITUAL QUOTIENT (SQ) ON THE ACADEMIC PERFORMANCE AMONG UNDERGRADUATE STUDENTS

Academic performance is a key criterion use to evaluate the progress of students and it is inuenced by many cognitive and non cognitive factors. The study aims to assess the inuence of Intelligence Quotient (IQ), Emotional Quotient (EQ), Adversity Quotient (AQ) and Spiritual Quotient (SQ) on the academic performance among undergraduate students. A quantitative research approach &amp; non-experimental descriptive survey design was used in the study. Data was collected from 300 students of DMCH College of Nursing, Malakpur, Ludhiana selected by using total enumerative sampling technique. Responses were collected on Test of General Intelligence, The Assessing Emotions Scale, structured Adversity Quotient Scale and Scale for Spiritual Intelligence. Academic performance data was collected from result cards. Data was tabulated and analysis was done by using descriptive &amp; inferential statistics. Results indicated majority of students had average level of IQ, above average level of EQ, were campers, had average level of SQ and belonged to 2nd division. There was statistical signicant positive correlation of intelligence quotient, emotional quotient spiritual quotient with academic performance. No statistical signicant correlation was found between adversity quotient and academic performance.

Prenatal exposure to ambient PM2.5 and its chemical constituents and child intelligence quotient at 6 years of age

There are limited studies on the associations between prenatal exposure to constituents of fine particulate matter (PM2.5) and children’s intelligence quotient (IQ). Our study aimed to explore the associations between prenatal PM2.5 and its six constituents and the IQ levels of 6-year-old children. We included 512 mother-child pairs. We used a satellite-based modelling framework to estimate prenatal PM2.5 and its six constituents (ammonium, sulfate, nitrate, organic carbon, soil dust, and black carbon). We assessed the children’s IQ using the short form of the Wechsler Intelligence Scale. Perceptual Reasoning Index (PRI), Verbal Comprehension Index (VCI), and Full Scale IQ (FSIQ) scores were computed. The multiple informant model (MIM) was applied to explore the trimester specific effects of PM2.5 and its six constituents’ exposure on children’s PRI, VCI, and FSIQ. To examine whether the duration of breastfeeding and physical activity (PA) could modify the effects of PM2.5 on children’s IQ, we stratified the analyses according to the duration of breastfeeding (≤6 and >6 months) and time of outdoor activities after school (≤2 and >2 h/week). The first trimester PM2.5 and its five constituents’ exposures were inversely associated with FSIQ [β = −1.34, 95 % confidence interval [CI] (−2.71, 0.04) for PM2.5] and PRI [β = −2.18, 95 %CI (−3.80, −0.57) for PM2.5] in children. The associations were magnified among boys and those with less outdoor activities or shorter breastfeeding duration. Our results indicate that prenatal PM2.5 and several of its main constituents’ exposure may disrupt cognitive development in children aged 6 years. More PA and longer breastfeeding duration may alleviate the detrimental effects of prenatal PM2.5 exposure on children’s cognitive function.

Noncoding de novo mutations contribute to autism via long-range chromatin interactions

IntroductionThree-dimensional chromatin interactions regulate gene expressions. The significance of de novo mutations (DNMs) in chromatin interactions remains poorly understood for autism spectrum disorder (ASD).ObjectivesTo investigate the genomic architecture of ASD in terms of non-coding de novo mutations and 3-dimensional chromatin interactionsMethodsWe generated 813 whole-genome sequences from 242 Korean simplex families to detect DNMs, and identified target genes which were putatively affected by non-coding DNMs in chromatin interactions.ResultsNon-coding DNMs in chromatin interactions were significantly involved in transcriptional dysregulations related to ASD risk. Correspondingly, target genes showed spatiotemporal expressions relevant to ASD in developing brains and enrichment in biological pathways implicated in ASD, such as histone modification. Regarding clinical features of ASD, non-coding DNMs in chromatin interactions particularly contributed to low intelligence quotient levels in ASD probands. We further validated our findings using two replication cohorts, Simons Simplex Collection (SSC) and MSSNG, and showed the consistent enrichment of non-coding DNM-disrupted chromatin interactions in ASD probands. Generating human induced pluripotent stem cells in two ASD families, we were able to demonstrate that non-coding DNMs in chromatin interactions alter the expression of target genes at the stage of early neural development.ConclusionsTaken together, our findings indicate that non-coding DNMs in ASD probands lead to early neurodevelopmental disruption implicated in ASD risk via chromatin interactions.Disclosure of InterestNone Declared

Association between Intelligence Quotient Dental Anxiety and Oral Health-related Quality of Life in Children: A Cross-sectional Study.

Determining the intelligence quotient (IQ) grades of children help in managing dental anxiety (DA) and maintaining the good oral health-related quality of life (OHRQoL). To assess the association between IQ, DA, and OHRQoL in children aged 10-11 years. This cross-sectional study was carried out among 202 children aged 10-11 years in the Southern part of Tamil Nadu, India. The IQ level, DA, and OHRQoL were measured using Raven's Coloured Progressive Matrices (RCPM), Children's Fear Survey Schedule-Dental Subscale (CFSS-DS), and Child Oral Health Impact Profile Short Form (COHIP-SF) 19, respectively. Chi-squared test and Spearman rank order correlation test were used for analysis. The results revealed a significant negative correlation (p < 0.05; r = -0.239) between IQ and OHRQoL. DA was negatively correlated with IQ (r = -0.093) and OHRQoL (r = -0.065), but it was not statistically significant. The gender-based comparison revealed no significant difference in the distribution of girls and boys within different grades of IQ levels (p = 0.74), DA (p = 0.29), and OHRQoL (p = 0.85). Children with higher IQ showed low OHRQoL scores. DA was negatively correlated with IQ and OHRQoL. Asokan S, PR GP, Mathiazhagan T, et al. Association between Intelligence Quotient Dental Anxiety and Oral Health-related Quality of Life in Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2022;15(6):745-749.