HomeRadiologyVol. 248, No. 1 PreviousNext Reviews and CommentaryEditorialsWhen Is the Right Time to Conduct a Clinical Trial of a Diagnostic Imaging Technology?Bruce J. Hillman, Constantine A. GatsonisBruce J. Hillman, Constantine A. GatsonisAuthor Affiliations1From the Department of Radiology, the University of Virginia Health System, PO Box 800170, Charlottesville, VA 22908 (B.J.H.); and Center for Statistical Sciences, Program in Public Health, Brown University, Providence, RI (C.A.G.). Received December 21, 2007; final version accepted February 21, 2008.Address correspondence to B.J.H. (e-mail: [email protected]).Bruce J. HillmanConstantine A. GatsonisPublished Online:Jul 1 2008https://doi.org/10.1148/radiol.2481072190MoreSectionsFull textPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In References1 U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Guidance documents. http://www.fda.gov/cder/guidance/index.htm. Accessed December 18, 2007. Google Scholar2 Fryback DG, Thornbury JR. Efficacy of diagnostic imaging. Med Decis Making 1991;11:88–94. Crossref, Medline, Google Scholar3 Gatsonis C. Design of evaluations of imaging technologies: development of a paradigm. Acad Radiol 2000;7:681–683. Crossref, Medline, Google Scholar4 Hillman BJ, Gatsonis C, Schnall MD. The American College of Radiology Imaging Network (ACRIN): a retrospective on 5 years of conducting multi-center trials of radiology and plans for the future. J Am Coll Radiol 2004;1:346–350. Crossref, Medline, Google Scholar5 Ziegler KM, Flamm CR, Aronson N. The Blue Cross Blue Shield Technology Evaluation Center: how we evaluate radiology technologies. J Am Coll Radiol 2005;2:33–38. Crossref, Medline, Google Scholar6 Chalmers TC. The clinical trial. Milbank Mem Fund Q Health Soc 1981;59:324–329. Crossref, Medline, Google Scholar7 Phelps CE, Mushlin AI. Focusing technology assessment using medical decision theory. Med Decis Making 1988;8:279–289. Crossref, Medline, Google Scholar8 Kahan JP, Neu CR, Hammons GT, Hillman BJ. The decision to initiate clinical trials of current medical practices. Publication no. R-3289-NCHSR. Santa Monica, Calif: Rand Corporation, 1985. Google Scholar9 Pisano ED, Gatsonis CA, Yaffe MJ, et al. American College of Radiology Imaging Network Digital Mammographic Imaging Screening Trial: objectives and methodology. Radiology 2005;236:404–412. Link, Google Scholar10 Pisano ED, Gatsonis C, Hendrick E, et al. Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med 2005;353:1773–1783. Crossref, Medline, Google Scholar11 Hillman BJ, Kahan JP. Initiating clinical trials: a case study of breast cancer treatment. Publication no. N-2320/3-NCHSR. Santa Monica, Calif: Rand Corporation, 1985. Google ScholarArticle HistoryPublished in print: 2008 FiguresReferencesRelatedDetailsCited ByEuropean Journal of Nuclear Medicine and Molecular Imaging, Vol. 46, No. 1European Journal of Radiology, Vol. 103Academic Radiology, Vol. 24, No. 8Journal of Biomedical Science, Vol. 23, No. 1Annals of Operations Research, Vol. 230, No. 1Journal of Nuclear Medicine, Vol. 53, No. 5Journal of the American College of Radiology, Vol. 8, No. 2Consensus Interpretation in Imaging Research: Is There a Better Way?1Alexander A. Bankier, , Deborah Levine, , Elkan F. Halpern, , and Herbert Y. Kressel, 1 October 2010 | Radiology, Vol. 257, No. 1European Radiology, Vol. 20, No. 1The AAPS Journal, Vol. 11, No. 2Recommended Articles Implementation of Clinical Artificial Intelligence in Radiology: Who Decides and How?Radiology2022Volume: 0Issue: 0Guidance for Interventional Trials Involving Artificial IntelligenceRadiology: Artificial Intelligence2020Volume: 2Issue: 6Continuous Learning AI in Radiology: Implementation Principles and Early ApplicationsRadiology2020Volume: 297Issue: 1pp. 6-14Machine Learning for Workflow Applications in Screening Mammography: Systematic Review and Meta-AnalysisRadiology2021Volume: 302Issue: 1pp. 88-104Radiology Resident Assessment and Feedback DashboardRadioGraphics2018Volume: 38Issue: 5pp. 1443-1453See More RSNA Education Exhibits Utilization of Imaging in Clinical Trials Under Current FDA GuidelinesDigital Posters2020Coming Out: Making Your Breast Imaging Center LGBT FriendlyDigital Posters2018Embracing EQUIP in Our Daily Mammography Environment: Best Practices and Lessons Learned (The EQUIP Way or the Highway)Digital Posters2018 RSNA Case Collection Acute breast hematomaRSNA Case Collection2020NeurocysticercosisRSNA Case Collection2022Invasive ductal carcinoma as developing asymmetryRSNA Case Collection2021 Vol. 248, No. 1 Supplemental MaterialMetrics Altmetric Score PDF download
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