Accumulating evidence from developmental social-affective neuroscience and educational research reveals striking affordances for adolescents’ academic, psychosocial and neural development of transcendent thinking—the disposition to integrate concrete, context-specific thinking and emotions into deliberations on the abstract, systems-level, ethical and personal implications of information, ideas, and skills. Here, we highlight the coordinated psychological and neural processes by which adolescents leverage transcendent thinking for civic reasoning. From qualitative field data, we argue that civic reasoning in the context of academic learning supports the coordination of conceptual understanding with intellectual agency, identity and communal orientation, leading youth toward process-oriented, rather than outcome-oriented, approaches to learning. From longitudinal interview and neuroimaging data, we argue that civic reasoning drives developmental coordination among brain networks involved in agency, self-awareness, and consciousness; internal reflection, abstraction and narrative; emotional feelings; memory; executive functioning and attention. These brain changes longitudinally predict resilience, identity development, and wellbeing (Gotlieb et al., 2024b). This transdisciplinary research underscores the power of civic reasoning for adolescents’ healthy development into young adulthood, and the benefits of schooling designed to center civic reasoning and personal reflection. In today’s globalized society, civic reasoning may be among the most important core social-emotional dispositions for youth and community thriving. Impact statementCivic reasoning is among the most important capacities youth must develop to sustain a functioning and equitable democratic society, and hence should be among the central aims of education. New research is demonstrating that adolescents’ dispositions toward civic reasoning, and the emotionally motivated transcendent thinking that undergirds it, are associated with a cascade of beneficial brain and psychosocial developmental effects that extend into young adulthood. Organizing adolescent education around civic reasoning and reflection could provide a powerful opportunity to support youths’ deep scholarly learning and psychosocial development in a coordinated way.