In this paper, we mainly consider a time-varying semi-linear integro-differential inclusion with Clarke sub-differential and a non-local initial condition. By a suitable Green function combined with a resolvent operator, we firstly formulate its mild solutions and show that it admits at least one mild solution which can exist in a well-defined ball with a radius big enough. Through constructing a proper functional, we then derive a useful characterization of the approximate controllability for its related linear system in Green function terms, and establish a sufficient condition for the approximate controllability of the time-varying semi-linear integro-differential inclusion. Lastly, we also consider the finite approximate controllability of the time-varying semi-linear integro-differential inclusion via variational method.
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