Integral Index Research Articles

Determining the Level of Emotional Intelligence of Future Cynologists

The purpose of the paper is to investigate the essence of emotional intelligence (EI) as an important component for future cynologists’ fruitful work in the sphere of rehabilitation of people who have been affected by the war consiquences. The authors studied the scientific literature on EI and its role in “Human-Human” and “Human-Animal” interactions in the working sphere. The authors determined the existing EI level of students who have Cynology as their major, outlined the theoretic and empiric outcomes, and stated recommendations for improving future cynologists’ professional training. Methodology. The empirical survey had a sample of 36 respondents. They were second-year students aged 18-21, 20 were male, and 16 were female. It was conducted by means of Google Forms on the basis of “Methodology of emotional intelligence diagnosis” by N. Hall (adapted) with subsequent processing and analysis of the results. Results. The study of the literature revealed that EI is of crucial importance for future cynologists’ professional fulfillment as it is responsible for the emotional regulation of their behavior, self-motivation, empathy, etc. However, empirically, it was found out that the EI of the respondents had not been sufficiently developed, as 68% of the respondents had a low level of EI integrative index, 22% of the students had the medium level of EI integrative index. Solely 10% of the respondents were recorded to have a high-level EI integrative index. Conclusions. The outcomes of the study revealed that most respondents do not have sufficient EI development, but they have the potential to enhance it. The authors insist on the organization of special educational courses and training to develop the ability of future cynologists to understand their own emotions and the emotions of other people, emotional behavior management, self-motivation, etc.

Issues of assessing the standard of living of the population in the regions of Russia

The article provides an overview of existing methods for assessing the level and quality of life of the population of the regions. A system of indicators has been formed to assess the standard of living, covering the level of poverty, inflation, unemployment, real incomes and food costs in the structure of consumer spending. The methodology was tested on the example of the regions of the Volga Federal District, the study period: 20202022. Regions were grouped according to the value of the integral index of living standards, regions with very high, high, medium, low and very low values of the integral indicator were identified. It is concluded that the standard of living is decreasing against the background of regional differentiation and the need to form a system of measures by public authorities aimed at improving the level and quality of life of the population. The practical significance of the results obtained is that they can be useful for making informed decisions in the field of regional policy and economics.

Assessing the development of a human-centered economy in Russia: A methodological approach

Aim. To build and sub stantiate the author’s methodology for assessing the development of human-centered economy. In view of the insufficiency of theoretical and empirical research in the field of formation and development of economy for human beings, the demand for this scientific research is actualized in order to better meet human needs.Objectives. To develop a methodology for assessing the development of human-centered economy; to test it on the example of the Russian Federation (RF), including Russian regions.Methodology. The methodological basis of the study was formed by the provisions of the theory of human-centered economy. The methods used include normalization, linear scaling, and “series of information criteria” methods. Visualization of the obtained results was carried out on the basis of spatial modeling software package GeoDA. The information base was the data of the Federal State Statistics Service (Rosstat), the Unified Interdepartmental Information and Statistical System, the Ministry of Labor and Social Protection of the Russian Federation, the Ministry of Culture of the Russian Federation, the Ministry of Science and Higher Education of the Russian Federation, the Ministry of Sports of the Russian Federation, Rospatent for 2018-2022.Results. The methodology for calculating the integral index of human-centered economy development has been developed. It was calculated by integrating 87 specific indices and eight subindices. The process of research revealed that this economic system is at the initial stages of development with isogressive-regressive trajectory, has insignificantly developed constituent components in the form of creative and cognitive spheres.Conclusions. The proposed methodology provides a basis for further scientific research in similar studies, as well as for the formation of targeted measures to support the challenging spheres of human activity and human-centered economy as a whole.

Nonlinear integral backstepping control based on particle swarm optimization for a grid-connected variable wind energy conversion system during voltage dips

Double-fed induction generator (DFIG) wind turbines connected to the grid are particularly subject to grid problems such as voltage dips. Because of this, it might be challenging to maintain system stability and prevent system disconnections when using a Proportional-Integral (PI) Controller to operate this system. This paper applies the Integral Backstepping Control for the wind power plant system connected to the power grid. The Integral Backstepping is a nonlinear and recursive method that employs the Lyapunov theory to ensure the system's stability. The best selection of gain values for the Lyapunov function guarantees improved system control. These gains are frequently adjusted using the trial-and-error strategy, which is time-consuming and inefficient. This technique becomes more complex when many parameters need to be determined. It also limits the system's performance and restricts this nonlinear approach's advantages. The objective is to apply the particle swarm optimization for computing several constant values of the nonlinear approach by minimizing an integral absolute error criterion index. The weighted sum of errors is employed to solve the multiple objective problems. The proposed controller tracks the maximum power point, maintains the voltage of the DC-Link constant, and controls active and reactive power. The robustness of this method is verified in critical conditions, including system parameter variation and asymmetrical and symmetrical grid faults. The simulation findings highlight the effectiveness and robustness of the combination of Integral Backstepping with Particle Swarm Optimization in terms of reducing response time from 10.6 (ms) to 2 (ms), canceling static error, and improving overshoot compared to the vector control based on PI regulator. Besides, the DC-Link voltage ripples during the asymmetrical grid faults are reduced to ±1 (V) using the suggested controller. The latter can be implemented thanks to advancements in Central Processor Unit technology.

Relationship Between Land Use Transformation and Ecosystem Service Value in the Process of Urban–Rural Integration: An Empirical Study of 17 Prefecture-Level Cities in Henan Province, China

Urban–rural integration, which aims to balance economic growth with sustainable land use, is becoming an increasingly critical strategy for regional development. This study provides crucial insights into the relationship between land use changes and ecosystem service values (ESVs) in rapidly urbanizing areas by analyzing the urban–rural integration process in Henan Province, a typical agricultural province in China. This research investigated the relationship between land use transformation and ESVs in Henan Province, China, from 1990 to 2020. Utilizing land use data and employing the equivalent factor method and elasticity model, we analyzed shifts in land use and their impacts on ecosystem services across 17 prefecture-level cities. Results indicated a gradual improvement in the urban–rural integration development index of Henan Province, particularly after 2000, but with notable disparities among cities. Zhengzhou, the provincial capital, consistently demonstrated high urban–rural integration development index (URII) values, influencing the integration efforts of neighboring cities. Conversely, peripheral cities exhibited lower integration indices. Notable shifts in land use patterns characterized by diverse transfer dynamics distinctively influenced ESVs across regions. Urban sprawl initially exerted substantial impacts on ecosystem services and stabilized over time. Suburbanization impacts peaked in the early and middle stages, while agricultural intensification initially affected ecosystem services, but their effects diminished with increased efficiency. Ecological restoration efforts consistently enhanced ESVs. The findings contribute to a more comprehensive understanding of the dynamic interactions between land use transitions and ecosystem services in the context of urban–rural integration.

Impact of Internet and mobile communication on cyber resilience: A multivariate adaptive regression spline modeling approach

The spread of broadband Internet and the availability of mobile communication services expand access to digital services for businesses and the public alike. However, at the same time, it aggravates the problem of ensuring digital space security, protection against cyber threats, and the fight against cybercrime. This research aims to calculate the index of a country's resilience to cyber-hacking for 143 countries, to divide these countries into groups based on this resilience (high, above-average, average, below-average, and low), compare these results with those obtained on the basis of National Cyber Security Index (NCSI), and to identify the impact of the Internet and mobile communication prevalence in a country on this level. The selection of the countries is based on the availability of statistical data for 2022 in the databases of the Surfshark VPN service, and the International Telecommunication Union. The integral index of a country's resilience to cyber-hacking is calculated through the multiplicative convolution (with weighted geometric mean) of the number of breached accounts, the Internet penetration probability (penetration into users’ data through the Internet), and the breach density per thousand users. The influence of active mobile broadband subscriptions (per 100 inhabitants), mobile broadband basket (% of Gross National Income Per Capita), mobile cellular subscriptions (per 100 inhabitants), and total fixed broadband subscriptions on the integral index of a country's resilience to cyber-hacking is investigated using multivariate adaptive regression spline. According to the calculations, France, Iceland, Montenegro, the United States, and the United Arab Emirates were the least resistant to cyber hacking in 2022. For countries with high, above-average, and below-average levels of resilience to cyber-hacking, the most relevant factor is the number of active mobile broadband subscriptions (per 100 inhabitants). For countries with an average level, it is total fixed broadband subscriptions.

Биологическая активность горных почв Западного Кавказа после сведения леса

A study of a set of indicators characterizing the ecological state of forest soils in the mountains of the North-Western Caucasus under broad-leaved and mixed forests has been conducted. The aim of the study has been to assess changes in the biological activity of soils of different genesis after deforestation. The objects of the study have been rendzina, gray forest and gray forest-steppe soils of forest and disturbed ecosystems of the Republic of Adugeya at altitudes from 500 to 1635 m above sea level. Logging plots of different ages (from 10 to 40 years old) after deforestation have been considered. The analyzed indicators have included: the content of total and active carbon, the activity of soil enzymes (catalase, invertase, dehydrogenase, urease, phosphatase), the number of bacteria, as well as an integral index of the biological properties of the soil. The correlation of these indicators with hydrothermal conditions, density of soil structure, penetration resistance, medium reaction, hydrolytic acidity, total absorbed bases and other soil parameters has been evaluated. The level of biological activity of soils in logging areas in the low mountains of Adygea depends on the relief and the timing of restoration after deforestation. Even after several decades of restoration of woody vegetation on the slopes of 12–15° there is no complete return of biological activity to the values of Greyic Phaeozem Eutric of the background forest area. 40 years after logging, the integral index of biological properties of gray forest soil is still 17 % lower than in the control plot. The biological activity of post-forest soils can change in three main directions. On steep slopes, with severe disturbance of the soil and vegetation cover due to the operation of heavy machinery, the integral index of the biological properties of soils decreases by 25–40 % or more without a tendency to recovery. At an average level of disturbance in plots with slight slopes, after an initial decrease, the soils are restored to control values. Restorative successions with intensive development of herbaceous flora and the turf process with slight disturbance can lead to an increase in biological activity above the control values in just 2–3 years. Comprehensive biodiognostic studies using an integral index of the biological state of the soil have revealed, in general, increased stability of low-mountain terrain soils (gray forest and forest-steppe) compared to the soils of the middle mountains of Adygea (rendzina soils). The main degradation factor that reduces the biological activity of soils disturbed by logging is erosion.

Refugees' integration and emotional distress over the course of 9 months.

High prevalence rates of mental disorders are reported in refugees due to experiencing substantial pre-, peri-, and post-migration stress. While long-term studies indicated that emotional distress of refugees either stagnates or ameliorates over time, long-term research on refugees' integration and its' interaction with emotional distress is limited. The examined long-term predictors for refugees' emotional distress and integration in this study were, amongst others, severe physical abuse in childhood, residence status and length of stay. The sample included 46 refugees, 91.3% male, mean age 20.8 years. Trained psychologists screened for emotional distress with the use of the Refugee Health Screener in a semi-structured interview. Integration progress was screened using the Integration Index with the subdimensions psychological, economic, political, social, linguistic and navigational integration. Longitudinal differences for emotional distress and integration sub-dimensions were evaluated by sign tests and t-tests. The longitudinal course of integration was evaluated with a Mixed ANOVA. Further, two hierarchical regression analyses were performed to analyze longitudinal predictors of emotional distress and integration. Overall, emotional distress decreased, and integration increased over time. In particular, the sub-dimensions of social, economic, and linguistic integration increased significantly over time. Two regression analyses determined significant predictors of (a) emotional distresst1 (adjusted R2 = 0.46): psychotherapy (ß = 0.35, p = 0.020), emotional distresst0 (ß = 0.34, p = 0.031), and integrationt0 (ß = -0.29, p = 0.043), and one significant predictor of (b) integrationt1 (adjusted R2 = 0.70): integrationt0 (ß = 0.89, p < 0.001). This is the first study to longitudinally examine the Integration Index with all subdimensions. Over the course of 9 months refugees' overall integration, and the sub-dimensions of social, economic, and linguistic integration increased. Whilst the emotional distress of initially highly distressed refugees ameliorated over the course of nine months, their symptom severity remained clinically significant. Results emphasize the importance of early integration for the long-term development of mental health and integration in refugees. Refugees' emotional distress and integration are intertwined and need to be addressed promptly after refugees' entry into the host country.

General immunologic reactivity of patients with COVID-19 and its relation to gene polymorphism, severity of clinical course of the disease and combination with comorbidities

The aim of the study is to identify and evaluate the general immunological reactivity of patients with COVID-19 and its relationship with gene polymorphism, severity of the clinical course of the disease and combination with comorbidities. A cohort study was conducted involving 204 patients with COVID-19 diagnosed with community-acquired pneumonia of mild, moderate, and severe degrees who also had comorbidities: endocrinopathies (46 patients), cardiovascular diseases (82 patients), and comorbidities of the ENT organs, connective tissue, gastrointestinal tract, chronic kidney disease (CKD), which were grouped into the group "other comorbidities (76 patients). Among the patients there were 51.97% (106) women and 48.03% (98) men. The average age of patients was 55.93±8.75 years. The polymorphism of the NOS3 (rs2070744), FGB (rs1800790) and TMPRSS2 (rs12329760) genes was determined by real-time polymerase chain reaction (qualitative determination). The overall immunological reactivity was detected and evaluated based on the analysis of 14 integral leukocyte indices: leukocyte shift index, absolute leukocyte count/erythrocyte sedimentation rate (ESR) ratio index, lymphocyte-granulocyte index, lymphocyte index, immunological resistance and reactivity index, and others. The overall immunological reactivity of the body of patients with coronavirus infection increases in the presence of the wild-type T-allele of the eNOS gene (rs2070744) in the patient's genotype, especially the CC genotype, by 21.98-57.89% (p≤0.029-0.001), against the background of a decrease in the index of nonspecific reactivity and the ratio of agranulocytes to ESR – by 23.0 (p=0.039) and 15.74% (p=0.044), indicating the onset of specific immunological reactions in the active infectious process. Carriers of the mutational A-allele of the FGB gene (rs1800790) and the TT genotype of the TMPRSS2 gene (rs12329760) showed higher immune reactivity and resistance, which was significantly confirmed by the level of increase in immune reactivity by 6.31-17.21% (p=0.007) and 22.05-35.78% (p≤0.06-0.004), respectively, against the background of a slightly higher rate of allergy (especially in owners of the AG genotype of the FGB gene – by 68.18%, PAG=0.017), a higher ratio of agranulocytes and ESR – by 18.30-21.84% (p≤0.008-0.007) and 19.46-31.07% (p=0.023), with a higher ratio of lymphocytes and eosinophils – by 13.35-19.20% (p≤0.002-0.001). The influence of the wild-type T-allele of the eNOS gene (rs2070744), the A-allele of the FGB gene (rs1800790) and the TT genotype of the TMPRSS2 gene (rs12329760) on the immunological reactivity of the body of a patient with coronavirus infection was revealed.

You Are Safe Here: Community Sponsorship Policy and Refugee Integration in the UK

Abstract Globally, resettlement is considered one of the most durable solutions for refugees. The UK has introduced a Community Sponsorship Scheme that enables communities to resettle refugee families providing them with enhanced integration support aided by volunteers. This paper investigates the nature of integration support that sponsored refugees receive utilising the analytical framework of UK’s Indicators of Integration (IoI). Data was collected from interviews with refugee adults resettled in diverse and less diverse areas. Our findings illustrate the importance of support given by volunteer groups to enable access to resources and connections. We establish that there is much potential for sponsorship programmes to add value to refugee support suggesting that the current expansion of sponsorship from its Canadian roots may help facilitate refugee integration. However, further research is needed to uncover the long-term experiences of sponsored refugees and to compare their outcomes to those of forced migrants arriving via different mechanisms.

Evaluation of ecological health of Hainan Island inshore waters in the South China Sea based on preliminary fish biotic integrity index (Actinopterygii and Elasmobranchii)

The well-being of marine ecosystems significantly influences biodiversity and ecological equilibrium amidst pressing challenges such as overfishing, water pollution, and climate change. Drawing upon data from two fishery stock surveys conducted in the inshore waters of Hainan Island in 2022, this study undertook a comprehensive evaluation of the marine ecosystem’s health status in the region. Employing the Fish Index of Biological Integrity (F-IBI) analysis method, coupled with an examination of the structural and functional aspects of the fish community, our research sheds light on the prevailing conditions. Our study revealed a spatial dichotomy within the fish communities of the study area and delineated them into two distinct groups: the northwestern and southeastern ones, with evident disparities in community structure between the two. By employing indicator screening and calculation, we segmented the fish health index in the inshore waters of Hainan Island into five tiers. Despite discernible anthropogenic influences, the ecological health of these waters remained generally robust. Notably, the mean F-IBI of fall (56.30) significantly exceeded that of spring (48.16) (P &amp;lt; 0.01). Furthermore, regarding spatial distribution, the ecological well-being of the southeastern waters surpassed that of the northwestern and Qionghzhou Strait waters. This study represents a pioneer endeavor to apply ecological health assessment methodologies towards informing resource management and conservation strategies for the inshore fisheries of Hainan Island. By furnishing a scientific foundation, our research contributes to the pursuit of sustainable marine ecological development within this locale.

Characteristics and Tectonic Implications of the Geomorphic Indices of the Watersheds around the Lijiang–Jinpingshan Fault

The Lijiang–Jinpingshan fault (LJF) is an important secondary boundary fault that obliquely cuts the Sichuan–Yunnan rhombic block. It is of great significance for understanding the tectonic evolution of the Sichuan–Yunnan rhombic block and even the southeastern margin of the Tibet Plateau. Based on a digital elevation model (DEM), this work combines ArcGIS with MATLAB script programs to extract geomorphic indices including slope, the relief degree of the land surface (RDLS), hypsometric integral (HI), and channel steepness index (ksn) of 593 sub–watersheds and strip terrain profiles around the LJF. By analyzing the spatial distribution characteristics of the geomorphic indices and combining the regional lithology and precipitation conditions, the spatial distribution of the geomorphic indices around the study area was analyzed to reveal the implications of the LJF’s activity. The results of this work indicate that (1) the distribution of geomorphic indices around the LJF may not be controlled by climate and lithological conditions, and the LJF is the dominant factor controlling the geomorphic evolution of the region. (2) The spatial distribution patterns of geomorphic indices and strip terrain profiles reveal that the vertical movement of the LJF resulted in a pronounced uplift on its northwest side, with tectonic activity gradually diminishing from northeast to southwest. Furthermore, based on the spatial distribution characteristics of these geomorphic indices, the activity intensity of the LJF can be categorized into four distinct segments: Jianchuan–Lijiang, Lijiang–Ninglang, Ninglang–Muli, and Muli–Shimian. (3) The activity of the LJF obtained from tectonic geomorphology is consistent with the conclusions obtained in previous geological and geodesic studies. This work provides evidence of the activity and segmentation of the LJF in tectonic geomorphology. The results provide insight for the discussion of tectonic deformation and earthquake disaster mechanisms in the southeastern margin of the Tibet Plateau.

INTEGRATIVE INDICATORS OF ENDOGENOUS INTOXICATION, INFLAMMATORY ACTIVITY, AND SPECIFIC REACTIVITY IN PATIENTS WITH COVID-19

The aim of the study is to identify changes in blood laboratory parameters, integrative indicators of endogenous intoxication, inflammation, and specific reactivity in patients with coronavirus disease. Patients and methods. The study included 77 patients with COVID-19, taking into account the inclusion and exclusion criteria. The comparison group consisted of 68 practically healthy people of the corresponding age. Laboratory blood tests were performed, on the basis of which integrative indicators of endogenous intoxication, inflammation and specific reactivity were calculated. Results. The data of the general blood test showed no significant differences between the patients of the groups, the indicators remained within acceptable limits. A slight inflammatory reaction in patients with COVID-19, especially in the period from 3 to 6 months, is confirmed by an increase in the level of endogenous intoxication (LII, LSI, NLRI, HII) in the group of patients compared to healthy individuals. During the same period, there are signs of activation of the cellular immune system in response to the presence of latent bacterial infection or endogenous intoxication, which is confirmed by a decrease in inflammation activity (LGI, LESRI, CI). Reduced indices of nonspecific reactivity (RC, ILYM, AI) confirmed the activation of the cellular immune system, given the decrease in the number of lymphocytes relative to granulocytes. Changes in integrative indices did not depend on the presence of Long-COVID symptoms. In the period from 12 months after the coronavirus disease, the development of autoimmune processes is possible, since there was a tendency to decrease the indices of endogenous intoxication (NLRI, LSI) simultaneously with an increase in the indices of inflammatory activity (LGI, LESRI, TI) and indices of nonspecific reactivity (RC, Ilymph, AI).

GTDI: a game-theory-based integrated drought index implying hazard-causing and hazard-bearing impact change

Abstract. Developing an effective and reliable integrated drought index is crucial for tracking and identifying droughts. The study employs game theory to create a spatially variable weight drought index (game-theory-based drought index, GTDI) by combining two single-type indices: an agricultural drought index (standardized soil moisture index, SSMI), which implies drought hazard-bearing conditions, and a meteorological drought index (standardized precipitation evapotranspiration index, SPEI), which implies drought hazard-causing conditions. In addition, the entropy-theory-based drought index (ETDI) is introduced to incorporate a spatial comparison with GTDI to illustrate the rationality of gaming weight integration, as both entropy theory and game theory belong to linear combination methods in the development of the integrated drought index and entropy theory has been applied in related research. Leaf area index (LAI) data are employed to confirm the reliability of GTDI in identifying drought by comparing it with SPEI, SSMI, and ETDI. Furthermore, a comparative analysis is conducted on the temporal trajectories and spatial evolution of the GTDI-identified drought to discuss GTDI's level of advancement in monitoring changes in hazard-causing and hazard-bearing impacts. The results show that GTDI has a very high correlation with single-type drought indices (SPEI and SSMI), and its gaming weight integration is more logical and trustworthy than that of ETDI. As a result, it outperforms ETDI, SPEI, and SSMI in recognizing drought spatiotemporally and is projected to replace single-type drought indices to provide a more accurate picture of actual drought. Additionally, GTDI exhibits the gaming feature, indicating a distinct benefit in monitoring changes in hazard-causing and hazard-bearing impacts. The case studies show that drought events in the Wei River basin are dominated by a lack of precipitation. The hazard-causing index, SPEI, dominates the early stages of a drought event, whereas the hazard-bearing index, SSMI, dominates the later stages. This study surely serves as a helpful reference for the development of integrated drought indices as well as regional drought prevention and monitoring.

8414 Utilization of Cell Free DNA Integrity Index to Differentiate Benign from Malignant Thyroid Nodules

Abstract Disclosure: S. Tarafdar: None. S. Dutta: None. P. Mukhopadhyay: None. N.P. Bhattacharya: None. S. Ghosh: None. Introduction: Recent advances in molecular genetics have evaluated a potential role for plasma cell-free DNA (cfDNA) integrity index as a non-invasive cancer marker. Data on cfDNA integrity in differentiated thyroid cancer is sparse and needs to be investigated further. Aim of the study: The purpose of this study is to investigate the hypothesis that longer DNA strands in plasma may serve as a marker for thyroid cancer. Methods: Patients presenting with thyroid nodules underwent ultrasonography with Thyroid Image Reporting and Data Systems (TIRADS) scoring and FNAC (Bethesda classification).Patients with Bethesda 3, 4, 5, and 6 had surgery and confirmation by histopathology. Patients with Bethesda 2 presenting with compressive symptoms and cosmetic concerns underwent surgery; the remaining patients were considered benign based on clinical follow-up, USG, and FNAC characteristics. Blood sample collected prior to FNAC was used to extract and quantify cfDNA. To assess the integrity index 180/67, 306/67, and 476/67 for the APP gene, we used a quantitative real-time PCR (qPCR) method based on the quantification of four amplicons of varying lengths (67, 180, 306, and 476 bp, respectively). Because culture cells had extremely intact genomic DNA, the genomic DNA obtained from the MDA-T32 papillary thyroid cancer cell line was utilised as a reference to estimate the relative DNA strand integrity in plasma DNA. To determine the (ΔCt) value for 67,180, 306, and 476 bp, the Ct value of the sample was subtracted from that of the MDA-T32 control. Results: A total of 161 subjects were recruited, of these 92 were benign and 69 had differentiated thyroid cancer(confirmed by histopathology). Using the 180/67 bp integrity index benign thyroid nodule patients had significant lower value (median 0.39, 95% CI: 0.33-0.46) compared to patients with differentiated thyroid cancer (median 0.62, 95% CI: 0.56-0.68). A cfDNA integrity index of 180/67 bp could significantly differentiate between benign and malignant thyroid nodules (P&amp;lt;0.001). However, there was no significant difference between malignant and benign thyroid nodules based on the cell free DNA integrity indexes of 306/67 and 476/67. Conclusions: The cfDNA integrity score of 180/67 exhibits potential as a circulating marker for the detection of thyroid nodules and as a means of monitoring cfDNA fragmentation in patients with thyroid cancer. However, further confirmation through prospective trials is necessary. Presentation: 6/3/2024

8414 Utilization Of Cell Free DNA Integrity Index To Differentiate Benign From Malignant Thyroid Nodules

Abstract Disclosure: S. Tarafdar: None. S. Dutta: None. P. Mukhopadhyay: None. N.P. Bhattacharya: None. S. Ghosh: None. Introduction: Recent advances in molecular genetics have evaluated a potential role for plasma cell-free DNA (cfDNA) integrity index as a non-invasive cancer marker. Data on cfDNA integrity in differentiated thyroid cancer is sparse and needs to be investigated further. Aim of the study: The purpose of this study is to investigate the hypothesis that longer DNA strands in plasma may serve as a marker for thyroid cancer. Methods: Patients presenting with thyroid nodules underwent ultrasonography with Thyroid Image Reporting and Data Systems (TIRADS) scoring and FNAC (Bethesda classification).Patients with Bethesda 3, 4, 5, and 6 had surgery and confirmation by histopathology. Patients with Bethesda 2 presenting with compressive symptoms and cosmetic concerns underwent surgery; the remaining patients were considered benign based on clinical follow-up, USG, and FNAC characteristics. Blood sample collected prior to FNAC was used to extract and quantify cfDNA. To assess the integrity index 180/67, 306/67, and 476/67 for the APP gene, we used a quantitative real-time PCR (qPCR) method based on the quantification of four amplicons of varying lengths (67, 180, 306, and 476 bp, respectively). Because culture cells had extremely intact genomic DNA, the genomic DNA obtained from the MDA-T32 papillary thyroid cancer cell line was utilised as a reference to estimate the relative DNA strand integrity in plasma DNA. To determine the (ΔCt) value for 67,180, 306, and 476 bp, the Ct value of the sample was subtracted from that of the MDA-T32 control. Results: A total of 161 subjects were recruited, of these 92 were benign and 69 had differentiated thyroid cancer(confirmed by histopathology). Using the 180/67 bp integrity index benign thyroid nodule patients had significant lower value (median 0.39, 95% CI: 0.33-0.46) compared to patients with differentiated thyroid cancer (median 0.62, 95% CI: 0.56-0.68). A cfDNA integrity index of 180/67 bp could significantly differentiate between benign and malignant thyroid nodules (P&amp;lt;0.001). However, there was no significant difference between malignant and benign thyroid nodules based on the cell free DNA integrity indexes of 306/67 and 476/67. Conclusions: The cfDNA integrity score of 180/67 exhibits potential as a circulating marker for the detection of thyroid nodules and as a means of monitoring cfDNA fragmentation in patients with thyroid cancer. However, further confirmation through prospective trials is necessary. Presentation: 6/3/2024

Surface fatigue characterization and its enhancement by the engineered ultrasonic rolling process for 300 M ultrahigh strength steel

The fatigue life of surface layer (FSL) is innovatively characterized to accurately capture the effect of surface integrity on the fatigue behavior of the components. The sensitivity of FSL of 300 M ultrahigh strength steel to the surface integrity indexes induced by representative manufacturing processes was analyzed by analytical modeling and fatigue tests from the perspective of engineering fracture mechanics. The ultrasonic surface rolling process (USRP) was introduced to optimize the fatigue limit of 300 M steel, and the improvement in fatigue life was experimentally quantified. Besides, the fracture analysis was conducted to provide the reason why USRP can enhance the fatigue behavior of 300 M steel. The results show that FSL occupies a majority with percentage of over 95 % in the entire fatigue life and a strong relation with the machined surface defects, especially the surface machining marks. The excellent surface finishing effect and high compressive residual stresses induced by engineered USRP could transfer the crack source from surface machining marks into subsurface inclusions, which greatly prolongs the fatigue crack initiation life and thereby the entire fatigue life. To be specific, the fatigue life was elevated by more than 40 times and the fatigue strength was increased by 34.7 % after USRP for the tested 300 M steel.

Анализ положения ведомственных периодических изданий с учетом новых методик ранжирования научных публикаций

The purpose of this work is to conduct a quantitative thematic analysis of published departmental scientific periodicals produced by organizations of the Federal Penitentiary Service of Russia in the context of the implementation of the recommendation of the Higher Attestation Commission (HAC) under the Ministry of Education and Science of Russia dated October 26, 2022 No. 2-pl/1 “On new criteria for applicants for academic degrees of Candidate of Sciences, Doctor of Sciences, to members of dissertation councils”, changes in the methodology for calculating the integral indicator Science Index and subsequent recalculation of bibliometric indicators for all journals. Monitoring of departmental scientific journals included in the List of Higher Attestation Commissions and the results of their categorization in 2023. Methodology: the methodological basis for the research is general scientific methods: integrity, consistency, universal connection, causality, methods of idealization, synthesis, comparative, qualitative, content analysis. Conclusions. The publication of departmental periodicals is one of the factors in the development of departmental science and education. The dynamics of a general increase in the number of journals at the same time does not directly affect the increase in the number of publications included in the List of Higher Attestation Commissions. An increase of 30% in the total number of journals had little effect on the growth of publications included in the List of Higher Attestation Commissions. The proportions of the distribution of departmental publications by category (more than half are classified in the second category) indicate the sustainable development of periodicals. At the same time, only one journal is classified as a leading journal, which clearly causes a desire to strengthen the position of authority among other departmental periodicals. Understanding the level of development of the journal in comparison with publications of the same thematic scope is important for building further editorial policy. It is clear that the development of a sovereign system of scientific assessment, rating, ranking, categorization of scientific periodicals, which began in 2022, is not static and will undergo more than one change in the process of searching for an optimal selection system that ensures the most objective assessment of the publication. Scientific and practical relevance. The choice of a fairly narrow locus of departmental publications demonstrates general trends. There is a direct relationship between categorization and the individual perception by authors and scientists of the prestige of the periodical and the difficulty of publishing research in it. The results of the quantitative and thematic analysis of published departmental scientific periodicals produced by organizations of the Federal Penitentiary Service of Russia, presented in the article, can be useful both to individuals engaged in editorial and publishing activities and to authors building a publishing career.

The effectiveness of Psoriaten products in treatment of patients with chronic plaque psoriasis

Objective — to determine the efficacy and tolerability of Psoriaten ointment and Psoriaten dermatocosmetic products in patients with chronic plaque psoriasis. Materials and methods. The study included 67 patients with chronic plaque psoriasis and 32 healthy individuals of a similar age (control group). All patients were examined according to existing standards. The severity of psoriasis was assessed by PASI and BSA indices. The level of anxiety was determined according to the Spielberger scale, the level of neuroticism — according to the L.I. Wasserman scale, the level of depression — according to the Beck scale, the quality of life — according to the Dermatological Life Quality Index (DLQI) and the CQLS integrative index. After the previous standard therapy, patients with chronic plaque psoriasis were divided into two groups. The experimental group included 32 patients who received topical Psoriaten ointment for therapeutic purposes and Psoriaten delicate cleansing gel as a dermatocosmetic skin care product. In case of psoriasis localisation on the scalp, they were additionally prescribed Psoriaten shampoo for 3 months. The control group included 35 patients with psoriasis who did not receive Psoriaten ointment or dermatocosmetic products of the Psoriaten line. Results and discussion. The use of Psoriaten ointment, Psoriaten delicate cleansing gel and Psoriaten shampoo for 3 months ensured a significant decrease in both — BSA index and PASI index in patients with psoriasis, normalization of skin microbiocenosis disorders. Statistically significantly lower situational anxiety, neuroticism and depression and higher life quality were noted in the experimental group, in comparison with the data obtained at enrollment in the study. The obtained data indicate the high effectiveness of combined use of Psoriaten ointment, Psoriaten delicate cleansing gel and Psoriaten shampoo in patients with chronic plaque psoriasis. Conclusions. Psoriasis is accompanied by cutaneous microbiocenosis changes, high personal and situational anxiety, increased neuroticism, tendency to depression and decreased life quality. The use of Psoriaten ointment and products of the Psoriaten dermatocosmetic line in patients with chronic plaque psoriasis is reasonable and appropriate, as it promotes the regression of psoriatic rashes and improves skin microbiocenosis. The results obtained give grounds to recommend the widespread use of Psoriaten ointment and dermatocosmetic products of the Psoriaten line for the treatment of patients with chronic plaque psoriasis, regardless of the standard therapy performed earlier.

Environmental integrity in two areas of the Paragominas stream in the municipality of the same name, Pará, Brazil

One of the negative aspects of urbanization is the anthropogenic impacts and environmental conditions that alter the Habitat Integrity Index (HII) in urban water bodies. These facts can be studied and analyzed using the HII. The objective of this research was to generate data on the Paragominas stream from the C. do Sacramento highway and Residencial Selecta, in order to show the real state of these two environmental variables, in these two locations, which had not been available until now. The methodology applied was exploratory, observational, qualitative, and quantitative. The results obtained showed that in Area 1, the Constantino Pereira do Sacramento Highway, anthropogenic impacts (∑total = 55) and environmental conditions (∑total = 46) caused an average change in habitat integrity (∑total = 47.2%). In Area 2, Residencial Selecta, 518 m from PA 125, anthropogenic impacts (∑total = 31) caused changes in environmental conditions (∑total = 29), especially in land use and occupation with vegetation suppression, which significantly altered habitat integrity (∑total = 28.6%). Therefore, it can be concluded that urbanization and the construction of marginal residential areas on water bodies cause changes in the habitat of animals and plants, although it still maintains one of the four environmental services: bathing.