With the arrival of the intelligence era of Industry 4.0, social development has shown complex and diversified characteristics, gradually forming an innovation ecological environment constructed by vertical interaction of multi-layer innovation systems and horizontal collaboration of multiple organizations and departments, which has posed extremely challenging requirements for higher engineering education to cultivate engineering talents with comprehensive engineering qualities who can solve complex engineering problems. However, practical engineering problems may involve a complex knowledge chain of interdisciplinary and multi-disciplinary cross-coupling. Therefore, higher engineering education needs to form a new interdisciplinary and multi-disciplinary integrated engineering innovation talent training system. Based on the characteristics of the mechanical and electronic engineering major, we will reshape and reconstruct the core courses of the mechanical and electronic engineering major. Two core courses are formed: Drive and Measurement and Control I and Drive and Measurement and Control II, with information flow and energy flow as the main lines, following up with the comprehensive practical curriculum system based on the unity of knowledge and practice and ability-oriented thinking, supporting teaching objectives, promoting students’ individual development, and providing guidelines for relevant curriculum reforms.