Integration Of Visual Information Research Articles

Biobehavioural analysis of the vestibular system and posture control in patients with cervicogenic dizziness. A cross-sectional study

BackgroundCervicogenic dizziness is a musculoskeletal disorder mainly characterised by dizziness and disequilibrium associated with neck pain. The pathophysiology is unclear and the neurophysiological basis remains to be ascertained. The aim of this study is to compare the vestibulo-ocular reflex and postural control between patients with cervicogenic dizziness and asymptomatic subjects, and to assess the association between debilitating dizziness and other psychosocial variables. Materials and methodsA total of 20 patients and 22 asymptomatic subjects were selected. Vestibulo-ocular reflex was assessed by performing the head impulse test. Computerised dynamic posturography was used to evaluate the postural control by means of the sensory organisation test. In addition, subjects self-reported their degree of disability due to dizziness, cervical disability, kinesiophobia, and state of anxiety and depression. ResultsThere were no differences in the vestibulo-ocular reflex (P>.05). However, we found differences with a medium-to-large effect size (d>0.60) in variables related to proprioception and visual information integration; the former variable set was related to disability due to dizziness. Disability due to dizziness presents strong-to-moderate associations with cervical disability, kinesiophobia, and anxiety. ConclusionOur data rule out changes in the vestibular system in cervicogenic dizziness, but they do point to proprioceptive impairment. According to our results, the association between dizziness-related disability and other psychosocial factors in cervicogenic dizziness is very relevant for clinical medicine and for future research projects.

Neuronal Representation of the Saccadic Timing Signals in Macaque Lateral Intraparietal Area.

Primates frequently make saccades direct fovea on interesting objects to receive acute visual information. However, saccade displaces the images on retina and disrupts the visual constancy. One possible mechanism to retain visual constancy is by integrating the presaccadic and postsaccadic visual information right at the time of saccade, which makes the timing of saccade crucial. So far, the saccadic timing signals have been found only in the subcortical regions, for example, the cerebellum and superior colliculus, but not in the neocortex. Here we report 2 types of saccadic timing signals in macaque lateral intraparietal area (LIP). First, many presaccadic response neurons started to decline activity either right around the start (saccade-on-decay) or the end (saccade-off-decay) of saccades. Notably, the time difference between saccade-off-decay and saccade-on-decay was highly correlated with the mean duration of saccades but not with the individual ones, and both saccade-off-decay and saccade-on-decay were better aligned with saccade end than saccade start-reflecting prediction. Second, the peak activity plateau of a group of postsaccadic response neurons was highly correlated with the actual duration of saccade-reflecting reality. While the predicted timing signals might facilitate the integration of visual information across saccades in LIP, the actual duration signals might calibrate the prediction errors.

On the effects of multimodal information integration in multitasking

There have recently been considerable advances in our understanding of the neuronal mechanisms underlying multitasking, but the role of multimodal integration for this faculty has remained rather unclear. We examined this issue by comparing different modality combinations in a multitasking (stop-change) paradigm. In-depth neurophysiological analyses of event-related potentials (ERPs) were conducted to complement the obtained behavioral data. Specifically, we applied signal decomposition using second order blind identification (SOBI) to the multi-subject ERP data and source localization. We found that both general multimodal information integration and modality-specific aspects (potentially related to task difficulty) modulate behavioral performance and associated neurophysiological correlates. Simultaneous multimodal input generally increased early attentional processing of visual stimuli (i.e. P1 and N1 amplitudes) as well as measures of cognitive effort and conflict (i.e. central P3 amplitudes). Yet, tactile-visual input caused larger impairments in multitasking than audio-visual input. General aspects of multimodal information integration modulated the activity in the premotor cortex (BA 6) as well as different visual association areas concerned with the integration of visual information with input from other modalities (BA 19, BA 21, BA 37). On top of this, differences in the specific combination of modalities also affected performance and measures of conflict/effort originating in prefrontal regions (BA 6).

Manipulating the fidelity of lower extremity visual feedback to identify obstacle negotiation strategies in immersive virtual reality.

The ability to successfully navigate obstacles in our environment requires integration of visual information about the environment with estimates of our body's state. Previous studies have used partial occlusion of the visual field to explore how information about the body and impending obstacles are integrated to mediate a successful clearance strategy. However, because these manipulations often remove information about both the body and obstacle, it remains to be seen how information about the lower extremities alone is utilized during obstacle crossing. Here, we used an immersive virtual reality (VR) interface to explore how visual feedback of the lower extremities influences obstacle crossing performance. Participants wore a head-mounted display while walking on treadmill and were instructed to step over obstacles in a virtual corridor in four different feedback trials. The trials involved: (1) No visual feedback of the lower extremities, (2) an endpoint-only model, (3) a link-segment model, and (4) a volumetric multi-segment model. We found that the volumetric model improved success rate, placed their trailing foot before crossing and leading foot after crossing more consistently, and placed their leading foot closer to the obstacle after crossing compared to no model. This knowledge is critical for the design of obstacle negotiation tasks in immersive virtual environments as it may provide information about the fidelity necessary to reproduce ecologically valid practice environments.

Shangri–La: A medical case–based retrieval tool

Large amounts of medical visual data are produced in hospitals daily and made available continuously via publications in the scientific literature, representing the medical knowledge. However, it is not always easy to find the desired information and in clinical routine the time to fulfil an information need is often very limited. Information retrieval systems are a useful tool to provide access to these documents/images in the biomedical literature related to information needs of medical professionals. Shangri–La is a medical retrieval system that can potentially help clinicians to make decisions on difficult cases. It retrieves articles from the biomedical literature when querying a case description and attached images. The system is based on a multimodal retrieval approach with a focus on the integration of visual information connected to text. The approach includes a query–adaptive multimodal fusion criterion that analyses if visual features are suitable to be fused with text for the retrieval. Furthermore, image modality information is integrated in the retrieval step. The approach is evaluated using the ImageCLEFmed 2013 medical retrieval benchmark and can thus be compared to other approaches. Results show that the final approach outperforms the best multimodal approach submitted to ImageCLEFmed 2013.

Personality effects on spatial learning: Comparisons between visual conditions in a weakly electric fish

AbstractRecent research has explored links between cognition and personality, with prominent hypotheses proposing that personality drives consistent individual differences in cognitive function. These hypotheses particularly expect bolder individuals to be faster, but less accurate, as a trade‐off in cognitive function. However, cognitive processes are typically interconnected and defined in more complex terms than simply speed and accuracy. Here, we present evidence that personality‐based differences in learning rates are a result of differences in decision‐making during training in a two‐alternative forced‐choice spatial memory task. This was examined in the mormyrid fish Gnathonemus petersii in the presence of light, where both vision and the electric sense are available, and in the dark, where visibility is limited and fish rely mostly on electrosensing. The species is adapted for the dark to avoid visual predators; thus, the presence of light can induce high‐risk and the dark low‐risk. We show that light conditions had little effect on learning, with bolder fish learning faster both in the light and in the dark conditions. Yet the relationship between learning rates and error rates indicates that the effect on learning is indirectly influenced by accuracy during training. Speed‐accuracy trade‐offs were not found in decision‐making, with bolder individuals deciding faster and more accurately both in the light and in the dark. Only learning strategy was affected by light conditions, with significantly more fish preferring response to place learning in the dark than in the light, where distal cues were not visible. We conclude that other than effects from the integration of visual information, bolder individuals show a consistently greater tendency to explore and find food rewards during training. This affects their decision‐making and in turn their learning performance. We highlight the complexity by which personality‐based effects are exhibited in spatial associative learning.

Visual Ecology and the Development of Visually Guided Behavior in the Cuttlefish.

Cuttlefish are highly visual animals, a fact reflected in the large size of their eyes and visual-processing centers of their brain. Adults detect their prey visually, navigate using visual cues such as landmarks or the e-vector of polarized light and display intense visual patterns during mating and agonistic encounters. Although much is known about the visual system in adult cuttlefish, few studies have investigated its development and that of visually-guided behavior in juveniles. This review summarizes the results of studies of visual development in embryos and young juveniles. The visual system is the last to develop, as in vertebrates, and is functional before hatching. Indeed, embryonic exposure to prey, shelters or complex background alters postembryonic behavior. Visual acuity and lateralization, and polarization sensitivity improve throughout the first months after hatching. The production of body patterning in juveniles is not the simple stimulus-response process commonly presented in the literature. Rather, it likely requires the complex integration of visual information, and is subject to inter-individual differences. Though the focus of this review is vision in cuttlefish, it is important to note that other senses, particularly sensitivity to vibration and to waterborne chemical signals, also play a role in behavior. Considering the multimodal sensory dimensions of natural stimuli and their integration and processing by individuals offer new exciting avenues of future inquiry.

Temporal synchrony and audiovisual integration of speech and object stimuli in autism

BackgroundIndividuals with Autism Spectrum Disorders (ASD) have been shown to have multisensory integration deficits, which may lead to problems perceiving complex, multisensory environments. For example, understanding audiovisual speech requires integration of visual information from the lips and face with auditory information from the voice, and audiovisual speech integration deficits can lead to impaired understanding and comprehension. While there is strong evidence for an audiovisual speech integration impairment in ASD, it is unclear whether this impairment is due to low level perceptual processes that affect all types of audiovisual integration or if it is specific to speech processing. MethodHere, we measure audiovisual integration of basic speech (i.e., consonant-vowel utterances) and object stimuli (i.e., a bouncing ball) in adolescents with ASD and well-matched controls. We calculate a temporal window of integration (TWI) using each individual’s ability to identify which of two videos (one temporally aligned and one misaligned) matches auditory stimuli. The TWI measures tolerance for temporal asynchrony between the auditory and visual streams, and is an important feature of audiovisual perception. ResultsWhile controls showed similar tolerance of asynchrony for the simple speech and object stimuli, individuals with ASD did not. Specifically, individuals with ASD showed less tolerance of asynchrony for speech stimuli compared to object stimuli. In individuals with ASD, decreased tolerance for asynchrony in speech stimuli was associated with higher ratings of autism symptom severity. ConclusionsThese results suggest that audiovisual perception in ASD may vary for speech and object stimuli beyond what can be accounted for by stimulus complexity.

Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study

PurposeTo investigate the altered intrinsic functional connectivity (iFC) of the primary visual cortex (V1) in primary angle-closure glaucoma (PACG) patients before and after surgery using resting-state functional MRI.Materials and MethodsTwenty-five preoperative PACG (pre-PACG) patients and 25 well-matched healthy controls (HCs) were included in this study, and 9 PACG patients were assessed again at least 3 months after treatment (post-PACG). We generated the iFC maps of the seed regions in the centers of the left and right V1 and conducted group comparisons. Then, the relationships between the altered iFC coefficients and clinical variables were investigated in the pre-PACG patients.ResultsCompared with the HCs, the pre-PACG patients showed decreased iFC between the left V1 and right V2 (covering the cuneus, calcarine and lingual gyrus) and increased iFC between the left V1 and left temporal-parietal region, left frontal opercula-insula-basal ganglia region, right insula-basal ganglia region, and right inferior parietal lobule (P < 0.01, corrected). Compared with the pre-PACG patients, the post-PACG patients showed increased iFC between the left V1 and bilateral V2, and between the left V1 and left or right postcentral gyrus; in addition, they showed decreased iFC between the left V1 and the dorsal-attention and frontoparietal-control networks. In the pre-PACG patients, visual activity (VA) was positively correlated with increased iFC between the left V1 and the left temporal-parietal region or the right inferior parietal lobule. Similar patterns of alterations were observed in the right V1-iFC in both the pre- and post-PACG patients.ConclusionsThe primary findings have demonstrated a gradual decrease in visual information integration in the left V1-V2 pathway and VA-related functional compensation in the pre-PACG patients, generating further evidence of functional restoration in post-PACG patients.

Parietal Association Area and Motion Information Processing

Motion perception plays an important role in everyday life. The investigation of the neural mechanisms underlying the distinguishing of the direction of motion has broadly expanded our understanding of the neural mechanisms of not only visual motion processing but also how integration of visual information is linked with intentional behavior. The lateral intraparietal (LIP) cortex is a crucial area involved in perceptual decision making and oculomotor planning. Here, I have reviewed the neural mechanisms underlying visual motion processing and describe how intentional behavior results from motion information.

How lateral inhibition and fast retinogeniculo-cortical oscillations create vision: A new hypothesis

The role of the physiological processes involved in human vision escapes clarification in current literature. Many unanswered questions about vision include: 1) whether there is more to lateral inhibition than previously proposed, 2) the role of the discs in rods and cones, 3) how inverted images on the retina are converted to erect images for visual perception, 4) what portion of the image formed on the retina is actually processed in the brain, 5) the reason we have an after-image with antagonistic colors, and 6) how we remember space. This theoretical article attempts to clarify some of the physiological processes involved with human vision. The global integration of visual information is conceptual; therefore, we include illustrations to present our theory. Universally, the eyeball is 2.4cm and works together with membrane potential, correspondingly representing the retinal layers, photoreceptors, and cortex. Images formed within the photoreceptors must first be converted into chemical signals on the photoreceptors’ individual discs and the signals at each disc are transduced from light photons into electrical signals. We contend that the discs code the electrical signals into accurate distances and are shown in our figures. The pre-existing oscillations among the various cortices including the striate and parietal cortex, and the retina work in unison to create an infrastructure of visual space that functionally “places” the objects within this “neural” space. The horizontal layers integrate all discs accurately to create a retina that is pre-coded for distance. Our theory suggests image inversion never takes place on the retina, but rather images fall onto the retina as compressed and coiled, then amplified through lateral inhibition through intensification and amplification on the OFF-center cones. The intensified and amplified images are decompressed and expanded in the brain, which become the images we perceive as external vision. SummaryThis is a theoretical article presenting a novel hypothesis about the physiological processes in vision, and expounds upon the visual aspect of two of our previously published articles, “A unified 3D default space consciousness model combining neurological and physiological processes that underlie conscious experience”, and “Functional representation of vision within the mind: A visual consciousness model based in 3D default space.” Currently, neuroscience teaches that visual images are initially inverted on the retina, processed in the brain, and then conscious perception of vision happens in the visual cortex. Here, we propose that inversion of visual images never takes place because images enter the retina as coiled and compressed graded potentials that are intensified and amplified in OFF-center photoreceptors. Once they reach the brain, they are decompressed and expanded to the original size of the image, which is perceived by the brain as the external image.We adduce that pre-existing oscillations (alpha, beta, and gamma) among the various cortices in the brain (including the striate and parietal cortex) and the retina, work together in unison to create an infrastructure of visual space thatfunctionally “places” the objects within a “neural” space. These fast oscillations “bring” the faculties of the cortical activity to the retina, creating the infrastructure of the space within the eye where visual information can be immediately recognized by the brain. By this we mean that the visual (striate) cortex synchronizes the information with the photoreceptors in the retina, and the brain instantaneously receives the already processed visual image, thereby relinquishing the eye from being required to send the information to the brain to be interpreted before it can rise to consciousness.The visual system is a heavily studied area of neuroscience yet very little is known about how vision occurs. We believe that our novel hypothesis provides new insights into how vision becomes part of consciousness, helps to reconcile various previously proposed models, and further elucidates current questions in vision based on our unified 3D default space model. Illustrations are provided to aid in explaining our theory.

An unexpected shoulder competence: The measurement of the extra-corporeal space

The shoulder competence in reaching movement has been known from the time. With this work we wanted to investigate the possible existence of an additional competence of the shoulder with respect to the ability to measure the extracorporeal space, using a new tool known as shoulder proprioceptive rehabilitation tool (SRPT) Observational case-control study on 50 subjects, 25 healthy subjects (HS) and 25 subjects with impingement syndrome (ISS) (2-3 for Neer classification). We proposed to both groups two different tasks using the SRPT: the first one to investigate the integration of visual information and proprioceptive afferents of the shoulder and the second one, inactive and passive modality, to investigate the discriminative proprioceptive capacity of the shoulder eyes closed. The tasks assessed the spatial error made by the shoulder joint in the movement of reaching on sagittal plane. The shoulder showed to have an accurate measurement capability during reaching movement (error of 1.22 cm to 1.55 cmin HS), even with eyes closed. In addition, this ability to measure the extra body space decreased in the impingement group, with a statistically significant difference compared to the healthy group ( P < 0.05 Mann-Whitney test). This difference was not correlated with age, gender, and the intensity of pain. The shoulder has a specific expertise in the measurement of the extracorporeal space during reaching movement that gradually decreased in the impingement syndrome.

Análisis bioconductual del sistema vestibular y el control postural en pacientes con mareo cervicogénico. Estudio observacional transversal

BackgroundCervicogenic dizziness is a musculoskeletal disorder mainly characterised by dizziness and disequilibrium associated with neck pain. The pathophysiology is unclear and the neurophysiological basis remains to be ascertained. The aim of this study is to compare the vestibulo-ocular reflex and postural control between patients with cervicogenic dizziness and asymptomatic subjects, and to assess the association between debilitating dizziness and other psychosocial variables. Materials and methodsA total of 20 patients and 22 asymptomatic subjects were selected. Vestibulo-ocular reflex was assessed by performing the head impulse test. Computerised dynamic posturography was used to evaluate the postural control by means of the sensory organisation test. In addition, subjects self-reported their degree of disability due to dizziness, cervical disability, kinesiophobia, and state of anxiety and depression. ResultsThere were no differences in the vestibulo-ocular reflex (P>.05). However, we found differences with a medium-to-large effect size (d>0.60) in variables related to proprioception and visual information integration; the former variable set was related to disability due to dizziness. Disability due to dizziness presents strong-to-moderate associations with cervical disability, kinesiophobia, and anxiety. ConclusionOur data rule out changes in the vestibular system in cervicogenic dizziness, but they do point to proprioceptive impairment. According to our results, the association between dizziness-related disability and other psychosocial factors in cervicogenic dizziness is very relevant for clinical medicine and for future research projects.

A New Neurocognitive Interpretation of Shoulder Position Sense during Reaching: Unexpected Competence in the Measurement of Extracorporeal Space.

Background. The position sense of the shoulder joint is important during reaching. Objective. To examine the existence of additional competence of the shoulder with regard to the ability to measure extracorporeal space, through a novel approach, using the shoulder proprioceptive rehabilitation tool (SPRT), during reaching. Design. Observational case-control study. Methods. We examined 50 subjects: 25 healthy and 25 with impingement syndrome with a mean age [years] of 64.52 +/− 6.98 and 68.36 +/− 6.54, respectively. Two parameters were evaluated using the SPRT: the integration of visual information and the proprioceptive afferents of the shoulder (Test 1) and the discriminative proprioceptive capacity of the shoulder, with the subject blindfolded (Test 2). These tasks assessed the spatial error (in centimeters) by the shoulder joint in reaching movements on the sagittal plane. Results. The shoulder had proprioceptive features that allowed it to memorize a reaching position and reproduce it (error of 1.22 cm to 1.55 cm in healthy subjects). This ability was lower in the impingement group, with a statistically significant difference compared to the healthy group (p < 0.05 by Mann–Whitney test). Conclusions. The shoulder has specific expertise in the measurement of the extracorporeal space during reaching movements that gradually decreases in impingement syndrome.

The Occipital Face Area Is Causally Involved in Facial Viewpoint Perception.

Faces are among the most salient objects we encounter during our everyday activities. Moreover, we are remarkably adept at identifying people at a glance, despite the diversity of viewpoints during our social encounters. Here, we investigate the cortical mechanisms underlying this ability by focusing on effects of viewpoint symmetry, i.e., the invariance of neural responses to mirror-symmetric facial viewpoints. We did this by temporarily disrupting neural processing in the occipital face area (OFA) using transcranial magnetic stimulation. Our results demonstrate that the OFA causally contributes to judgments facial viewpoints and suggest that effects of viewpoint symmetry, previously observed using fMRI, arise from an interhemispheric integration of visual information even when only one hemisphere receives direct visual stimulation.

Temporal framing in apparent motion perception cycles with a 12Hz (alpha) rhythm

Visual perception is periodic and structured in recurrent temporal frames. However, it is unclear whether these cycles simply reflect fluctuations of visual excitability, and/or organize perception into discrete moments of information integration in which two events falling within one frame are more likely to be perceived as causally linked. In 1981, Varela et al. probed temporal framing of perception by presenting two sequential flashes at a constant delay and found these flashes to be perceived as simultaneous or sequential depending on the phase of ongoing alpha (7-13Hz) oscillations. These results are still awaiting replication (VanRullen et al, 2014). We here tested periodicity of visual information integration in two behavioural experiments probing (i) simultaneity and (ii) apparent motion perception in double flash stimuli. We flashed two visual events either sequentially or simultaneously. In experiment 1, two dots were displayed in the left and right visual fields, while participants reported whether the events were perceived as sequential or simultaneous. In experiment 2, the two events consisted of random dot patterns that could be perceived as coherent motion, incoherent motion or glass patterns. These stimulus pairs were presented time-locked to a preceding sound (0-300ms delays), shown to reset the phase of visual brain oscillations (Romei et al., 2012). Spectro-temporal dynamics of behavioural time courses (hits) revealed periodicity in perception. Dots perceived as sequential (Group 1, n=19) and apparent motion perception (Group 2, n=19) showed identical, cyclic patterns in the 12Hz (alpha) frequency band (with a significant phase consistency across participants). In contrast, a cyclic pattern in the 4Hz (theta) band was observed in the control conditions (simultaneously presented stimuli), suggesting that the alpha cycles in visual perception go beyond reflecting fluctuations in visual excitability. These data suggest that perceptual frames in the alpha-band play a key role in spatio-temporal visual information integration.

Functional reorganization of the visual dorsal stream as probed by 3-D visual coherence in Williams syndrome.

Object and depth perception from motion cues involves the recruitment of visual dorsal stream brain areas. In 3-D structure-from-motion (SFM) perception, motion and depth information are first extracted in this visual stream to allow object categorization, which is in turn mediated by the ventral visual stream. Such interplay justifies the use of SFM paradigms to understand dorsal-ventral integration of visual information. The nature of such processing is particularly interesting to be investigated in a neurological model of cognitive dissociation between dorsal (impaired) and ventral stream (relatively preserved) processing, Williams syndrome (WS). In the current fMRI study, we assessed dorsal versus ventral stream processing by using a performance-matched 3-D SFM object categorization task. We found evidence for substantial reorganization of the dorsal stream in WS as assessed by whole-brain ANOVA random effects analysis, with subtle differences in ventral activation. Dorsal reorganization was expressed by larger medial recruitment in WS (cuneus, precuneus, and retrosplenial cortex) in contrast with controls, which showed the expected dorsolateral pattern (caudal intraparietal sulcus and lateral occipital cortex). In summary, we found a substantial reorganization of dorsal stream regions in WS in response to simple visual categories and 3-D SFM perception, with less affected ventral stream. Our results corroborate the existence of a medial dorsal pathway that provides the substrate for information rerouting and reorganization in the presence of lateral dorsal stream vulnerability. This interpretation is consistent with recent findings suggesting parallel routing of information in medial and lateral parts of dorsal stream.

Cortical regions involved in integration of visual information of point-light walker and background motion velocity

Cortical regions involved in integration of visual information of point-light walker and background motion velocity

Domain specificity in integration of visual information across time

Domain specificity in integration of visual information across time

Selective stimulation of neurons in visual cortex enables segregation of slow and fast connections

Organization of the central visual pathway is generally studied from a perspective of feedforward processes. However, there are horizontal connections and also strong feedback from extra striate to visual cortex. Here, we use visual stimuli designed to maximize relative differential involvements of these three main types of connections. The approach relies on differences between stimulation within the classical receptive field (CRF) and that of the surround region. Although previous studies have used similar approaches, they were limited primarily to spatial segregation of neural connections. Our experimental design provides clear segregation of fast and slow components of surround modulation. We assume these are mediated by feedback and horizontal connections, respectively, but other factors may be involved. Our results imply that both horizontal and feedback connections contribute to integration of visual information outside the CRF and provide suppressive or facilitative modulation. For a given cell, modulation may change in strength and sign from suppression to facilitation or the reverse depending on surround parameters. Sub-threshold input from the CRF surround increases local field potential (LFP) power in distinct frequency ranges which differ for suppression and facilitation. Horizontal connections have delayed CRF-surround modulation and are sensitive to position changes in the surround. Therefore, surround information beyond the CRF is initially processed by fast connections which we consider to be feedback, whereas spatially tuned mechanisms are relatively slow and presumably mediated by horizontal connections. Overall, results suggest that convergent fast (feedforward) inputs determine size and structure of the CRFs of recipient cells in visual cortex. And fast connections from extra striate regions (feedback) plus slow-tuned connections (horizontal) within visual cortex contribute to spatial influences of CRF surround activation.