Integration Of Data Sources Research Articles

Traffic Flow Prediction Using Novel Spatial-Temporal Multi-Head Attention Graph Convolution Networks

For urban development, accurate traffic flow prediction is crucial. Traffic flow prediction data can be used for optimizing public transportation systems, reducing congestion, planning road networks, and improving overall city infrastructure management. Despite numerous spatiotemporal methods used to forecast traffic flow, information aggregation at each site neither produce optimal results, because of the use non-Euclidean distance data. For more accurate results of traffic flow prediction, we propose a spatial-temporal multi-head attention graph convolution network (STMAGCN). It extracts temporal features using temporal convolutional layers and enriches nodes with spatial attention and multi-head attention mechanisms. By combining them, we can extract space characteristics more effectively. We also introduce a novel graph structure construction method that employs graph-based transformations to convert non-connected data points into a comprehensive graph structure, facilitating the effective application of our STMAGCN. This approach improves the predictive efficiency and accuracy of our model by ensuring seamless integration of disparate data sources. Experimental results indicate that the preferential extraction of spatiotemporal data significantly enhances traffic flow prediction accuracy. Compared with the latest models, our performance on the California Department of Transportation Performance Measurement System (PeMS) PeMS04 and PeMS08 datasets shows a slight improvement, with an average increase of 16.8%. Additionally, the average improvement in time is approximately 445.95%.

AI-Driven Predictive Analysis for Urban Traffic Management: A Novel Approach

Urban traffic management remains one of the most complex challenges of modern cities, with congestion, inefficiencies, and accidents costing billions of dollars annually and contributing significantly to pollution and stress. Current traffic management systems are often reactive rather than predictive, responding to congestion and incidents after they occur. This paper introduces a novel AI-driven predictive analysis framework for urban traffic management that leverages advanced machine learning (ML) algorithms and real-time data inputs. The system aims to not only manage existing traffic efficiently but to predict congestion, optimize traffic flows, and enhance computer safety proactively. We explore the integration of multiple data sources—such as GPS data, traffic cameras, IoT sensors, and social media feeds—into a cohesive AI model that learns and evolves. The goal is to create a fully autonomous traffic management system that adjusts dynamically to urban changes, improving overall city mobility, sustainability, and quality of life.

Perioperative risk scores: prediction, pitfalls, and progress.

Perioperative risk scores aim to risk-stratify patients to guide their evaluation and management. Several scores are established in clinical practice, but often do not generalize well to new data and require ongoing updates to improve their reliability. Recent advances in machine learning have the potential to handle multidimensional data and associated interactions, however their clinical utility has yet to be consistently demonstrated. In this review, we introduce key model performance metrics, highlight pitfalls in model development, and examine current perioperative risk scores, their limitations, and future directions in risk modelling. Newer perioperative risk scores developed in larger cohorts appear to outperform older tools. Recent updates have further improved their performance. Machine learning techniques show promise in leveraging multidimensional data, but integrating these complex tools into clinical practice requires further validation, and a focus on implementation principles to ensure these tools are trusted and usable. All perioperative risk scores have some limitations, highlighting the need for robust model development and validation. Advancements in machine learning present promising opportunities to enhance this field, particularly through the integration of diverse data sources that may improve predictive performance. Future work should focus on improving model interpretability and incorporating continuous learning mechanisms to increase their clinical utility.

Predictive Models for the Implementation of Targeted Reproductive Management in Multiparous Cows on Automatic Milking Systems

Targeted reproductive management (TRM) aims to improve the fertility efficiency of the dairy herd by applying group-level management strategies based on expected reproductive performance. Key to the utility of TRM is the accuracy with which an animal's reproductive performance can be predicted. Automatic milking systems (AMS) allow for the collection of data relating to milk quantity, quality, and robot visit behavior throughout the transition period. In addition to this, auxiliary data sources such as rumination and activity monitors, as well as historical cow-level data are often readily available. The utility of this data for the prediction of fertility has not been previously explored. The objective of this study was first, to assess the accuracy with which the likelihood of expression of oestrus between 22 and 65 d in milk (DIM) and conception to first insemination between 22 and 80 DIM could be predicted using data collected by AMS from 1 to 21 DIM. Our second objective was to assess the change in model performance following the addition of 2 auxiliary data sources. Using data derived solely from the AMS (RBT data set) a binary random forest classification model was constructed for both outcomes of interest. The performance of these models was compared with models constructed using AMS data in conjunction with 2 auxiliary sources (RBT+ data set). Expression of oestrus was classified with an area under the receiver operator curve (AUC-ROC) of 0.6 and 0.65, conception to first insemination with an AUC-ROC of 0.56 and 0.62 for the RBT and RBT+ data sets respectively. No statistically significant improvement in classification accuracy was achieved by the addition of auxiliary data sources. This is the first study to report the utility of data collected by AMS for the prediction of reproductive performance. Though the performance described is comparable with previously reported models, their utility for the implementation of TRM is limited by poor classification accuracy within key sub-groups. Of note within this study is the failure of the addition of auxiliary data sources to increase the accuracy of prediction over models built using AMS data alone. We discuss the advantages and limitations the integration of additional data sources imposes on model training and deployment and suggest alternative methods to improve performance while preserving model parsimony.

Serum metabolomics improve risk stratification for incident heart failure

Abstract Background The prediction and early detection of heart failure (HF) is vital to reduce its substantial impact on quality of life, survival and healthcare expenditure. Current incident HF risk stratification strategies achieve only modest performance. Moreover, state-of-the-art risk scores focus on commonly acknowledged clinical risk factors, thus necessitating the integration of heterogenous data sources and prioritizing individuals with obvious risk constellations. Purpose Here, we explored the predictive value of serum metabolomics (168 metabolites detected by proton nuclear magnetic resonance (1H-NMR) spectroscopy) for incident HF. Methods Leveraging data of n = 68,311 individuals and > 0.8 million person-years of follow-up from the UK Biobank (UKB) cohort, we (I) evaluated the association of individual metabolites with incident HF via fitting of per-metabolite COX proportional hazards models and (II) trained and validated elastic net (EN) models to predict incident HF using the serum metabolome. Discriminative performance was benchmarked against a comprehensive, well-validated clinical risk score (Pooled Cohort Equations to Prevent HF, PCP-HF). External validation was conducted in the independent FINRISK study. Results Several metabolites were independently associated with incident HF (90/168 adjusting for age and sex, 48/168 adjusting for PCP-HF). Performance-optimized risk models effectively retained key predictors representing highly correlated clusters (≈ 80 % feature reduction). The addition of metabolomics to PCP-HF improved predictive performance (Harrel’s C: 0.768 vs. 0.755, ΔC = 0.013 (95% confidence interval (CI) 0.004 – 0.022), continuous net reclassification improvement (NRI) = 0.287 (95% CI 0.200 – 0.367), relative integrated discrimination improvement (IDI): 17.47 % (95% CI 9.463 - 27.825)). Simplified models only including age, sex and metabolomics performed almost as well as the PCP-HF model (Harrel’s C: 0.745 vs. 0.755, ΔC = 0.010 (95% CI -0.004 - 0.027), continuous NRI: 0.097 (95% CI -0.025 - 0.217), relative IDI: 13.445 % (95% CI -10.608 - 41.454)). Risk and survival stratification was improved by integrating metabolomics. External validation within FINRISK revealed similar patterns using the original model coefficients. Conclusions Serum metabolomics improve the prediction of incident HF risk. Scores obtained from the combination of age, sex and metabolomics exhibit similar predictive power as clinical risk models. Offering serum metabolomics to a middle-aged cohort might significantly improve HF risk stratification, thus facilitating preventive efforts. Via a single blood draw, serum metabolomics displays a highly cost- and time-effective, standardizable, and scalable alternative to clinical risk scores involving physical measurements and history taking in addition to clinical chemistry.Relative performance (test split)ROC & DCA plots (test split)

Mapping Forest Parameters to Model the Mobility of Terrain Vehicles

This study aims to evaluate the feasibility of using non-contact data collection methods—specifically, UAV (unmanned aerial vehicle)-based and terrestrial laser scanning technologies—to assess forest stand passability, which is crucial for military operations. The research was conducted in a mixed forest stand in the Březina military training area, where the position of trees and their DBHs (Diameter Breast Heights) were recorded. The study compared the effectiveness of different methods, including UAV RGB imaging, UAV-LiDAR, and handheld mobile laser scanning (HMLS), in detecting tree positions and estimating DBH. The results indicate that HMLS data provided the highest number of detected trees and the most accurate positioning relative to the reference measurements. UAV-LiDAR showed better tree detection compared to UAV RGB imaging, though both aerial methods struggled with canopy penetration in densely structured forests. The study also found significant variability in DBH estimation, especially in complex forest stands, highlighting the challenges of accurate tree detection in diverse environments. The findings suggest that while current non-contact methods show promise, further refinement and integration of data sources are necessary to improve their applicability for assessing forest passability in military or rescue contexts.

Site Selection of Large Shopping Malls in Wanbailin District of Taiyuan City

The construction and site selection of shopping malls are directly related to their commercial operation effectiveness and market competitiveness. Some scholars have conducted extensive research in this field, particularly achieving notable results in terms of influencing factors, methodologies, and technological applications for site selection, yet there are still some deficiencies. Traditional site selection methods primarily rely on qualitative analysis and empirical judgment. However, with technological advancements, Geographic Information System technology has gradually been applied to shopping mall site selection. GIS technology enables the integration of multiple data sources, spatial analysis, and visualization, providing a scientific basis for site selection decisions. This article utilizes ArcGIS software to construct an application model for shopping mall site selection in Wanbailin District. Through spatial analysis, eligible areas are identified, achieving a scientific and visual approach to site selection. By considering the main factors affecting the location of large shopping malls in Wanbailin District and using ArcGIS as the basic platform, an application model is built to find the optimal location for building shopping malls. The results show that introducing GIS into mall location planning improves efficiency and accuracy while providing a reliable basis for scientific location.

Enhancing Basic Education Quality through the Implementation of the Regional Medium-Term Development Plan in Oil-Rich Areas

This study investigates the implementation of basic education quality improvement policies in Balikpapan City, a region known for its pivotal role in Indonesia’s oil industry, often referred to as an oil-rich area. The research aims to assess the effectiveness of the Regional Medium-Term Development Plan (2021-2026) in addressing educational quality, considering the city's economic dependence on oil. Adopting a qualitative approach, the study focuses on the Department of Education and Culture in Balikpapan, engaging key informants to evaluate the efficacy of policy implementation. The analysis framework encompasses an evaluation of policy standards, resources, inter-organisational communication, and the characteristics of the implementing agencies. The findings reveal that, while considerable progress has been made in enhancing educational facilities and teacher competencies, challenges persist due to the city’s heavy reliance on the oil sector and its impact on local resources. Furthermore, the study explores the relationship between these challenges and Sustainable Development Goal (SDG) 4 (quality education) by addressing disparities in resource allocation and the city's limited capacity for economic diversification. The research recommends the integration of more diverse data sources, continuous monitoring, and deeper analysis of the social and economic impacts to further improve educational outcomes. Balikpapan's economic context, as an oil-dependent city, significantly influences its ability to implement and sustain effective educational policies, highlighting the necessity for balanced development strategies aligned with broader SDGs.

Spatial Data Infrastructure and Mobile Big Data for Urban Planning Based on the Example of Mikolajki Town in Poland

Spatial Data Infrastructure (SDI) is a decision-making tool that is often used in the area of urban planning. At the same time, many other data sources with great utility potential, such as Big Data, can be identified. The aim of the paper is to present the possibility of using mobile Big Data collections with data from Polish SDI, for the purposes of local spatial planning on the example of the tourist town, Mikolajki in Poland. The publication also focuses on assessing the quality of data, as well as the decision-making process supported by these sources. The draft of the local spatial development plan was verified based on integrated data sources. The results showed that the visualization of Big Data as a heat map may be used in urban tasks and as the thematic layer integrated with vector and raster data sets from the SDI in the geographic information system software. The contribution is the practical example how information about users of mobile devices and some information from behavioral profiles may be analyzed for the purposes of verifying planned land use.

Histopathology in focus: a review on explainable multi-modal approaches for breast cancer diagnosis.

Precision and timeliness in breast cancer detection are paramount for improving patient outcomes. Traditional diagnostic methods have predominantly relied on unimodal approaches, but recent advancements in medical data analytics have enabled the integration of diverse data sources beyond conventional imaging techniques. This review critically examines the transformative potential of integrating histopathology images with genomic data, clinical records, and patient histories to enhance diagnostic accuracy and comprehensiveness in multi-modal diagnostic techniques. It explores early, intermediate, and late fusion methods, as well as advanced deep multimodal fusion techniques, including encoder-decoder architectures, attention-based mechanisms, and graph neural networks. An overview of recent advancements in multimodal tasks such as Visual Question Answering (VQA), report generation, semantic segmentation, and cross-modal retrieval is provided, highlighting the utilization of generative AI and visual language models. Additionally, the review delves into the role of Explainable Artificial Intelligence (XAI) in elucidating the decision-making processes of sophisticated diagnostic algorithms, emphasizing the critical need for transparency and interpretability. By showcasing the importance of explainability, we demonstrate how XAI methods, including Grad-CAM, SHAP, LIME, trainable attention, and image captioning, enhance diagnostic precision, strengthen clinician confidence, and foster patient engagement. The review also discusses the latest XAI developments, such as X-VARs, LeGrad, LangXAI, LVLM-Interpret, and ex-ILP, to demonstrate their potential utility in multimodal breast cancer detection, while identifying key research gaps and proposing future directions for advancing the field.

Data-driven decision-making in public health: The role of advanced statistical models in epidemiology

This paper critically examines the transformative role of data-driven decision-making in public health, focusing on the integration of advanced statistical models in epidemiology. As the volume and complexity of health data increase, leveraging predictive analytics, machine learning, and real-time data integration has become essential for improving public health outcomes. The study explores how these technologies have shifted public health strategies from reactive to proactive approaches, particularly in areas such as disease surveillance, chronic disease management, and health equity. Through comprehensive analysis, the paper identifies key advancements, such as hybrid models that combine traditional epidemiological frameworks with AI, and the integration of multi-modal data sources that enhance predictive accuracy. The findings emphasize the potential of these models to optimize resource allocation, address health disparities, and provide timely interventions. However, challenges such as data quality, algorithmic bias, and the ethical implications of model transparency are highlighted as critical issues requiring ongoing research. The study concludes that for these models to be effectively adopted, there must be a balance between technological innovation and ethical considerations. Recommendations include the need for interdisciplinary collaboration, improved data governance frameworks, and the development of more inclusive models that are generalizable across diverse populations. This research underscores the necessity of combining robust analytical tools with ethical frameworks to enhance the reliability and equity of public health interventions.

1.5 million materials narratives generated by chatbots

The advent of artificial intelligence (AI) has enabled a comprehensive exploration of materials for various applications. However, AI models often prioritize frequently encountered material examples in the scientific literature, limiting the selection of suitable candidates based on inherent physical and chemical attributes. To address this imbalance, we generated a dataset consisting of 1,453,493 natural language-material narratives from OQMD, Materials Project, JARVIS, and AFLOW2 databases based on ab initio calculation results that are more evenly distributed across the periodic table. The generated text narratives were then scored by both human experts and GPT-4, based on three rubrics: technical accuracy, language and structure, and relevance and depth of content, showing similar scores but with human-scored depth of content being the most lagging. The integration of multimodal data sources and large language models holds immense potential for AI frameworks to aid the exploration and discovery of solid-state materials for specific applications of interest.

Named entity recognition and its role in unstructured data analysis

In today's digital world, where vast amounts of unstructured data are generated every day, the ability to efficiently process this information is key for many industries. Unstructured data, which includes text files, emails, video, audio, images, and other forms of media, is the bulk of digital data and requires specialized tools to analyze it. Natural Language Processing (NLP) and Named Entity Recognition (NER) are two key technologies that enable the transformation of unstructured data into structured information that can be used for a variety of applications. Natural Language Processing enables machines to understand, interpret, manipulate and generate human language, opening up possibilities for deep analysis of textual data. This includes identifying key words, phrases, themes, and emotional nuances in texts. NER, as an important component of Natural Language Processing, specializes in identifying and classifying named entities in the text into certain categories, such as names of persons, organizations, locations, dates, times, and others. This allows you to automate the processes of sorting, categorizing and analyzing information. However, working with Natural Language Processing and Named Entity Recognition faces a number of challenges. The large volume and variety of data make it difficult to collect, store and analyze it. Lack of standardization can lead to problems with interoperability and integration of different data sources. In addition, there are challenges related to the recognition of named entities, in particular, distinguishing between the same names belonging to different persons and understanding the context in which the names are used. Despite these challenges, the outlook for Natural Language Processing and Named Entity Recognition looks bright, with continued innovations in artificial intelligence and machine learning promising to improve the accuracy and efficiency of these technologies in the future.

Citizen science tools for engaged research: Waterquality monitoring in remote communities

Remote areas that lack conventional water-provisioning infrastructure often rely on rainwater harvesting, rivers, pans, reservoirs and borehole-extracted water to meet domestic water requirements. These water sources often have poor microbial quality and chemical composition, the quality of which is not routinely monitored. This study explored citizen science as a tool for Engaged Research and Responsible Research and Innovation, detailing the co-creation of a sustained community-based water quality monitoring program in collaboration with communities in villages in Amakhala Game Reserve (Eastern Cape, South Africa). Without access to other water sources, participants predominantly used rainwater for drinking and cooking (80%), while borehole water was mainly used for cleaning and gardening due to its salty or bitter taste. A hydrogen sulphide (H2S) water testing kit was used by the citizen scientists to monitor the water quality. The H2S kits were effective in estimating bacterial contamination, showing a proportional relationship with Colilert® test results conducted in a laboratory. The alignment observed between community-based monitoring results and those derived from scientist-led testing underscores the value of data produced through citizen science initiatives. Sustained participant engagement throughout this research reflected a sense of community empowerment through access to tools that inform their decision-making around water use and treatment as well as investment in the research, indicative of the perceived relevance of the research to community interests. This integration of transdisciplinary data sources holds promise for informing evidence-based decision-making processes, facilitating more effective and contextually informed water management strategies that value and integrate community perspectives alongside scientific insights.

Soil moisture content estimation of drip-irrigated citrus orchard based on UAV images and machine learning algorithm in Southwest China

Soil moisture content (SMC), as a pivotal component in the energy and matter exchange processes within the soil-plant-atmosphere continuum, plays a crucial role in surface water dynamics, energy fluxes, and carbon cycling within ecosystems. The development of remote sensing technology has offered new perspectives for monitoring soil moisture at regional scales. Unmanned aerial vehicles (UAV) equip with multispectral have distinct advantages for vegetation monitoring, including rapidity and cost-effectiveness, which has superior applicability and practicality. Therefore, in a 5a "Daya" late-maturing citrus orchard, the vegetation index (VI) and texture feature (TF) information of citrus canopy based on UAV multi-spectral images were extracted, and soil and plant analyzer development (SPAD) of citrus was collected. These different data sources were integrated into the framework of the random forest algorithm (RF) and genetic algorithm-optimized random forest (GA-RF) to evaluate the accuracy of surface SMC (SSMC) estimation in citrus orchard. The Biswas model was utilized to simulate the root zone SMC (RSMC). The spatiotemporal variations of SMC in citrus orchard were analyzed, and the potential of low-cost sensor-equipped drones in rapidly acquiring spatial and temporal distribution information of SMC at a large regional scale was explored. The results indicated that the GA-RF models outperformed the RF models in estimating citrus orchard SMC (with R2 ranging from 0.502 to 0.949 and RMSE ranging from 0.552 % to 3.166 % for GA-RF, compared to R2 ranging from 0.430 to 0.936 and RMSE ranging from 0.587 % to 3.449 % for the RF). The GA-RF models using VI+SPAD as inputs exhibited the best performance for SMC at depths of 5 cm, 10 cm, 20 cm and 40 cm (SMC5, SMC10, SMC20 and SMC40) across citrus growth stages (R2 ranging from 0.793 to 0.949 at 5 cm, R2 ranging from 0.702 to 0.938 at 10 cm, R2 ranging from 0.714 to 0.927 at 20 cm). In bud bust to flowering, young fruit and fruit maturation stages (stage Ⅰ, ⅠⅠ and ⅠⅤ), all models demonstrated good accuracy in estimating SMC at depth of 10 cm (R2 ranging from 0.567 to 0.908 in stage Ⅰ, with R2 ranging from 0.681 to 0.916 in stage ⅠⅠ and R2 ranging from 0.579 to 0.938 in stage ⅠⅤ). In fruit expansion stage (stage III), the models performed best in predicting SMC5 (R2 ranging from 0.698 to 0.861). The Biswas model was constructed to simulate SMC40 by utilizing the inverted SMC10 and SMC20, thereby generating spatiotemporal distribution maps of SMC at different depths in citrus orchard. The SSMC was susceptible to environmental factors, exhibiting significant spatiotemporal heterogeneity. In summary, this study illustrated that the integration of multiple data sources into GA-RF enhanced the estimation performance of SMC at different growth stages of late-maturing citrus orchard in the Southwest China. Additionally, it enabled the rapid and efficient monitoring of spatiotemporal variations in SMC, providing an effective method and practical foundation for precision irrigation and improved water use efficiency.

Automating COVID-19 epidemiological situation reports based on multiple data sources, the Netherlands, 2020 to 2023

BackgroundDuring the COVID-19 pandemic, the National Institute for Public Health and the Environment in the Netherlands developed a pipeline of scripts to automate and streamline the production of epidemiological situation reports (epi‑sitrep). The pipeline was developed for the Automation of Data Import, Summarization, and Communication (hereafter called the A-DISC pipeline). ObjectiveThis paper describes the A-DISC pipeline and provides a customizable scripts template that may be useful for other countries wanting to automate their infectious disease surveillance processes. MethodsThe A-DISC pipeline was developed using the open-source statistical software R. It is organized in four modules: Prepare, Process data, Produce report, and Communicate. The Prepare scripts set the working environment (e.g., load packages). The (data-specific) Process data scripts import, validate, verify, transform, save, analyze, and summarize data as tables and figures and store these data summaries. The Produce report scripts gather summaries from multiple data sources and integrate them into a RMarkdown document – the epi‑sitrep. The Communicate scripts send e-mails to stakeholders with the epi‑sitrep. ResultsAs of March 2023, up to ten data sources were automatically summarized into tables and figures by A-DISC. These data summaries were featured in routine extensive COVID-19 epi‑sitreps, shared as open data, plotted on RIVM's website, sent to stakeholders and submitted to European Centre for Disease Prevention and Control via the European Surveillance System -TESSy [38]. DiscussionIn the face of an unprecedented high number of cases being reported during the COVID-19 pandemic, the A-DISC pipeline was essential to produce frequent and comprehensive epi‑sitreps. A-DISC's modular and intuitive structure allowed for the integration of data sources of varying complexities, encouraged collaboration among people with various R-scripting capabilities, and improved data lineage. The A-DISC pipeline remains under active development and is currently being used in modified form for the automatization and professionalization of various other disease surveillance processes at the RIVM, with high acceptance from the participant epidemiologists. ConclusionThe A-DISC pipeline is an open-source, robust, and customizable tool for automating epi‑sitreps based on multiple data sources.

Development of a comprehensive open access "molecules with androgenic activity resource (MAAR)" to facilitate risk assessment of chemicals.

The increasing prevalence of endocrine-disrupting chemicals (EDCs) and their potential adverse effects on human health underscore the necessity for robust tools to assess and manage associated risks. The androgen receptor (AR) is a critical component of the endocrine system, playing a pivotal role in mediating the biological effects of androgens, which are male sex hormones. Exposure to androgen-disrupting chemicals during critical periods of development, such as fetal development or puberty, may result in adverse effects on reproductive health, including altered sexual differentiation, impaired fertility, and an increased risk of reproductive disorders. Therefore, androgenic activity data is critical for chemical risk assessment. A large amount of androgenic data has been generated using various experimental protocols. Moreover, the data are reported in different formats and in diverse sources. To facilitate utilization of androgenic activity data in chemical risk assessment, the Molecules with Androgenic Activity Resource (MAAR) was developed. MAAR is the first open-access platform designed to streamline and enhance the risk assessment of chemicals with androgenic activity. MAAR's development involved the integration of diverse data sources, including data from public databases and mining literature, to establish a reliable and versatile repository. The platform employs a user-friendly interface, enabling efficient navigation and extraction of pertinent information. MAAR is poised to advance chemical risk assessment by offering unprecedented access to information crucial for evaluating the androgenic potential of a wide array of chemicals. The open-access nature of MAAR promotes transparency and collaboration, fostering a collective effort to address the challenges posed by androgenic EDCs.

Potentials of digital twin system for analyzing travel behavior decisions

This review explores the potential of digital twin systems to provide a more holistic representation of travel behavior and support transportation planning and policymaking. The paper introduces the concept of digital twins, their key characteristics, and their applications in various domains, including transportation. It discusses the traditional methods used in travel behavior analysis and their limitations, as well as the potential advantages of digital twin systems, such as the integration of heterogeneous data sources, real-time monitoring and prediction, and the ability to simulate and evaluate various policy scenarios. The review also identifies the key components of digital twin systems, the challenges associated with their implementation, and the current state of research on digital twins and related methods in travel behavior analysis. The paper highlights research gaps and future directions, emphasizing the need for privacy-preserving techniques, real-world case studies, and the integration of digital twins with decision support systems. Finally, the review discusses the broader implications of digital twin systems for transportation planning and policymaking, concluding by emphasizing the need for interdisciplinary collaboration and stakeholder engagement to fully realize the potential of digital twins in analyzing travel behavior decisions and shaping the future of transportation systems.

Data-driven multiscale geomechanical modeling of unconventional shale gas reservoirs: a case study of Duvernay Formation, Alberta, West Canadian Basin

The Duvernay Formation in Canada is one of the major oil and gas source formations in the Western Canadian Sedimentary Basin, located at its deepest point. While it demonstrates promising development potential, challenges arise in the urgent need for integration of geology and engineering models, as well as in optimizing sweet spots, particularly as infill wells and pads become central operational objectives for the shale gas field. A lack of the geomechanical understanding of shale gas reservoirs presents a significant obstacle in addressing these challenges. To overcome this, we implemented data acquisition and prepared historical models and profiles, resulting in an extended high-resolution geological and reservoir property model with a fine grid system. Subsequently, a 3D full-field multi-scale geomechanical model was constructed for the main district by integrating seismic data (100 m), geological structures (km), routine logs (m), core data (cm), and borehole imaging (0.25 m), following a well-designed workflow. The predicted fracturability index (brittleness) ranges from 0.6 to 0.78, and a lower horizontal stress difference (STDIFF) is anticipated in the target formation, Upper Duvernay_D, making it a favorable candidate for hydraulic fracturing treatment. Post-analysis of the multi-disciplinary models and various data types provides guidelines for establishing a specific big database, which serves as the foundation for production performance analysis and aggregate sweet spot analysis. Fourteen geological and geomechanical candidate parameters are selected for the subsequent sweet spot analysis. This study highlights the effectiveness of multi-scale geomechanical modeling as a tool for the integration of multi-disciplinary data sources, providing a bridge between geological understanding and future field development decisions. The workflows also offer a data-driven framework for selecting parameters for sweet spot analysis and production dynamic analysis.

Multimodal Transformers and Their Applications in Drug Target Discovery for Aging and Age-Related Diseases.

Given the unprecedented rate of global aging, advancing aging research and drug discovery to support healthy and productive longevity is a pressing socioeconomic need. Holistic models of human and population aging that account for biomedical background, environmental context, and lifestyle choices are fundamental to address these needs, but integration of diverse data sources and large data sets into comprehensive models is challenging using traditional approaches. Recent advances in artificial intelligence and machine learning, and specifically multimodal transformer-based neural networks, have enabled the development of highly capable systems that can generalize across multiple data types. As such, multimodal transformers can generate systemic models of aging that can predict health status and disease risks, identify drivers, or breaks of physiological aging, and aid in target discovery against age-related disease. The unprecedented capacity of transformers to extract and integrate information from large and diverse data modalities, combined with the ever-increasing availability of biological and medical data, has the potential to revolutionize healthcare, promoting healthy longevity and mitigating the societal and economic impacts of global aging.