Based on analysis of municipal solid waste (MSW) in Shanghai city, a related integrated treatment process of MSW was studied. MSW was classified into organic, combustible, recyclable and other parts. The designed integrated treatment process includes mixed waste sorting, anaerobic digestion of the biodegradability organic waste, RDF production systems of combustible waste and deodorizing system. Organic MSW is digested under anaerobic conditions and produce biogas for power generation for electricity plant. The residue can be used to prepare organic and inorganic fertilizer; Combustible MSW has low water, high calorific value and can be prepared RDF; The recyclable trash (plastic, metal) are on sale. Other MSW is land filled. The designed integrated treatment process may provide a route to solve the problems of MSW in Shanghai.