Design outcomes in the Medical Building Projects (MBPs) must satisfy the demand of the medical staff and stakeholders. However, they often do not have the relevant engineering expertise, so the design team is prone to misunderstandings when communicating with them using traditional two-dimensional (2D) Computer-Aided Design (CAD) drawings. The medical staff may not readily visualize and understand the design and then provide feedback to the designer through professional medical requirements or advice, which results in the need to redesign and carry out additional work during the design phase, thus delaying the progress of the MBPs. To address these challenges, this study aims to develop an integrated system based on BIM, advanced rendering engines, and VR technology for use in non-immersive and immersive VR environments. Moreover, in this study, the integrated system was applied to the infection-building project of the People's Hospital of Qingbaijiang District, Chengdu City, and semi-structured interviews were distributed to 16 engineers, designers, contractors, and medical staff who had been involved in the whole project to validate the practicality and effectiveness of the integrated system. The results indicate that this system integration is an efficient visual communication and simulation tool in medical design. Key advantages include enhanced communication efficiency between the design team and medical stakeholders, improved visual interaction, and streamlined decision-making processes within a 3D VR/BIM environment. The successful implementation of this integrated system is expected to significantly aid design teams and stakeholders in effectively managing medical design tasks in future projects.