Studies on Soil Test Crop Response based Integrated Plant Nutrition System (STCR - IPNS) were conducted adopting the Inductive cum Targeted yield model, on Vertic Ustropept of Tamil Nadu, Southern India during 2011 - 2013 in order to develop fertilizer prescriptions through IPNS for the desired yield targets of transgenic cotton under drip fertigation. The basis for making the fertilizer prescriptions viz. nutrient requirement (NR), contribution of nutrients from soil (Cs), fertilizer (Cf) and farmyard manure (Cfym) were computed using the field experimental data. Making use of these basic parameters, the fertilizer prescription equations (FPEs) were developed under NPK alone and under IPNS for the desired yield targets of cotton for a range of soil test values. The quantity of fertilizers contributed by the application of farmyard manure was assessed. The deviation recorded in the achievement of targets aimed was within the range of ± 10 per cent (90 - 110%) proving the validity of the FPEs. Thus the Inductive cum Targeted yield model used to develop fertilizer prescription equations provides a strong basis for soil fertility maintenance consistent with high productivity and efficient nutrient management in Precision Farming for sustainable and enduring Agriculture.