The utilization of plant-based pesticides in grain storage management presents a promising avenue for sustainable pest control. This review paper examines the efficacy, mechanisms of action, and challenges associated with the adoption of botanical alternatives in grain storage facilities. Highlighted are the diverse phytochemical compositions of plant-based pesticides, their low toxicity to non-target organisms, and their compatibility with integrated pest management strategies. Despite their potential benefits, obstacles such as formulation complexities, limited chemical data, and regulatory hurdles hinder their widespread use. Addressing these challenges through collaborative research efforts and regulatory support is crucial to realizing the full potential of plant-based pesticides in grain storage management. By integrating these natural solutions into storage practices, we can promote food security while mitigating environmental and health risks associated with synthetic pesticides.