The rapidly increasing importance of technology integration and generative AI in the fashion industry is prompting changes in fashion design education. This study explored a new design methodology utilizing AI for sustainable and future-oriented fashion design education. The methodology involved consulting practitioners to select ChatGPT and Midjourney as AI tools and technology, pedagogy, and content knowledge (TPACK) as the theoretical framework. An AI prompt guide was developed based on specialized books, from which an educational program was created. An experiment with 30 third- and fourth-year fashion design students showed that their overall satisfaction with AI through TPACK was 4 out of 5, suggesting that TPACK enhances students’ creativity and efficiency through generative AI. Prompt guides received a satisfaction score of 4.7, indicating their usefulness for creative and efficient design outputs. AI-powered educational programs, like ChatGPT and Midjourney, also improved student creativity and learning efficiency, with ChatGPT scoring 4.5. However, concerns about technology dependency were noted. This study offers insights into integrating the latest technology into fashion design to improve process efficiency and creative output. This study not only provides a foundation for future research on AI design methodology but also explores practical directions for sustainable design in the fashion industry.