Existing calibration methods for contact parameters of soil discrete elements are primarily based on a single physical property of soil (e.g., natural accumulation angle and shear characteristics). To solve this limitation, a calibration method based on the area difference method was proposed in accordance with the actual operation effect of ridge and furrow opener. The typical clay loam in the middle and lower reaches of the Yangtze River (moisture content of 20.66% ± 1%) was used as the research object. The Hertz–Mindlin with JKR Cohesion contact model was selected, and the static friction factor and rolling friction factor between soil and 65Mn steel were determined by inclined plane mechanics method. Soil tank ridge and furrow opening experiments and quadratic orthogonal rotation combined tests were carried out. MATLAB software was used to carry out polynomial fitting and the constant integral solution to the ridge and the cross-sectional contour data of the furrow obtained from the measured and simulated ridge and furrow opening experiments to establish the regression model of area difference. The optimization function in Design-Expert software was adopted. The optimal parameter combination was obtained by optimizing the regression model with the minimum area difference as the target. Based on the above parameter combination, the relative error of cross-sectional area of the furrow that was obtained by simulation test and soil tank test was 9.15%. Finally, the comparison of the traction resistance of the simulation and the soil tank test at the stable working stage indicated that the relative error between the simulated value and the measured value was 10.4%, which is less than the acceptable error of 15% in general statistics and within a reasonable range. The results showed that the particle movement and mechanical properties of the soil simulation model were basically consistent with the actual soil after parameter optimization and calibration. In this study, a precise discrete element simulation model of the typical clay loam in the middle and lower reaches of the Yangtze River based on the area difference method was constructed, which lays a theoretical basis for later exploration of the interaction mechanism between the typical clay loam and the soil contact components in the middle and lower reaches of the Yangtze River.