Meat Intake Research Articles

The association of red and processed meat with gestational diabetes mellitus: Results from 2 Canadian birth cohort studies.

Red and processed meat is considered risk factors of gestational diabetes mellitus (GDM), but the evidence is inconclusive. We aimed to examine the association between red and processed meat intake and odds of GDM among South Asian and White European women living in Canada. This is a cross-sectional analysis of pregnant women from two birth cohorts: SouTh Asian biRth cohorT (START; n = 976) and Family Atherosclerosis Monitoring In earLY life (FAMILY; n = 581). Dietary intake was assessed using a validated 169-item semi-quantitative food-frequency questionnaire (FFQ). Multivariate logistic regression models were used to examine the associations between gestational diabetes and: 1) total red and processed meat; 2) unprocessed red meat; 3) processed meat and GDM after adjustment for potential confounders. There were 241 GDM cases in START and 91 in FAMILY. The median total red and processed meat intake were 1.5 g/d (START) and 52.8 g/d (FAMILY). In START, the multivariable-adjusted odds ratio (OR) showed neither lower nor higher intakes of unprocessed red meat (p-trend = 0.68), processed meat (p-trend = 0.90), or total red and processed meat (p-trend = 0.44), were associated with increased odds of GDM, when compared with medium intake. Similar results were observed in FAMILY except for processed meat intake [OR = 0.94 (95% CI 0.47-1.91), for medium versus low and OR = 1.51 (95% CI 0.77-2.29) for medium versus high; p-trend = 0.18] after adjusting for additional dietary factors such as the diet quality score, total fiber, saturated fat and glycemic load. Medium compared with low or high red and processed meat intake is not associated with GDM in White Europeans and South Asians living in Canada.

Immunotherapy with biodegradable nanoparticles encapsulating the oligosaccharide galactose-alpha-1,3-galactose enhance immune tolerance against alpha-gal sensitization in a murine model of alpha-gal syndrome.

IgE antibodies against the mammalian oligosaccharide allergen galactose-α-1,3-galactose (αGal) can result in a severe allergic disease known as alpha-gal syndrome (AGS). This syndrome, acquired by tick bites that cause αGal sensitization, leads to allergic reactions after ingestion of non-primate mammalian meat and mammalian-derived products that contain αGal. Allergen-specific immunotherapies for this tickborne allergic syndrome are understudied, as are the immune mechanisms of allergic desensitization that induce clinical tolerance to αGal. Here, we reveal that prophylactic administration of αGal glycoprotein-containing nanoparticles to mice prior to tick protein-induced αGal IgE sensitization blunts the production of Th2 cytokines IL-4, IL-5, and IL-13 in an αGal-dependent manner. Furthermore, these effects correlated with suppressed production of αGal-specific IgE and hypersensitivity reactions, as measured by reduced basophil activation and histamine release and the systemic release of mast cell protease-1 (MCPT-1). Therapeutic administration of two doses of αGal-containing nanoparticles to mice sensitized to αGal had partial efficacy by reducing the Th2 cytokine production, αGal-specific IgE production, and MCPT-1 release without reducing basophil activation or histamine release. These data identify nanoparticles carrying encapsulated αGal glycoprotein as a potential strategy for augmenting αGal-specific immune tolerance and reveal diverse mechanisms by which αGal nanoparticles modify immune responses for established αGal-specific IgE-mediated allergic reactions.

Paragonimiasis.

Paragonimiasis is a zoonotic disease caused by lung flukes of the genus Paragonimus. Humans usually become infected by eating freshwater crabs or crayfish containing encysted metacercariae of these worms. However, an alternative route of infection exists: ingestion of raw meat from a mammalian paratenic host. Adult worms normally occur in pairs in cysts in the lungs from which they void their eggs via air passages. The pulmonary form is typical in cases of human infection due to P. westermani, P. heterotremus, and a few other species. Worms may occupy other sites in the body, notably the brain, but lung flukes have made their presence felt in almost every organ. Ectopic paragonimiasis is particularly common when infection is due to members of the P. skrjabini complex. Human paragonimiasis occurs primarily in the tropics and subtropics of Asia, Africa, and the Americas, with different species being responsible in different areas (Table 6.1).

Heavy metals load in chicken meat and its reduction by probiotic strains.

Around the world, poultry meat is a staple of everyday meals. However, chicken flesh is not always as healthy as it looks since it becomes contaminated by pollutants from the environment, especially heavy metals, which can bioaccumulate and magnify, and endanger human health. The current investigation set out to evaluate the degree of contamination in a subset of chicken samples and the potential risks to human health associated with the ingestion of chicken meat. Using atomic absorption spectroscopy, the heavy metal (lead, cadmium, and copper) contents of chicken samples were evaluated. To assess the residual content, 100 samples of chicken meat, 25 of each from the breast, thigh, gizzard, and liver were randomly selected from chicken butchers in Kafr El-Sheikh and El-Gharbia governorate in Egypt. Lead had mean values of 0.27 ± 0.01, 0.34 ± 0.01, 0.55 ± 0.01, and 0.61 ± 0.02 (mg/kg ww), in the examined breast, thigh, gizzards, and liver, respectively. Cadmium, on the other hand, had mean levels (mg/kg ww) of 0.09 ± 0.01, 0.12 ± 0.01, 0.18 ± 0.01, and 0.25 ± 0.01 in the same samples, respectively. The copper residues had mean values (mg/kg ww) of 1.53 ± 0.14, 1.69 ± 0.16, 2.05 ± 0.17, and 2.71 ± 0.22, in the same samples, respectively. Further government efforts are required to reduce environmental pollution and enhance the quality of the El-Gharbia governorate to prevent the accumulation of heavy metals, even though the majority of the samples that were examined fell within the acceptable limits established by the Egyptian Organization for Standardization and Quality Control.

Experimental Protocol to Toxoplasma gondii Detection in Fresh Goat Milk.

Toxoplasma gondii is a zoonotic parasite with global distribution capable of infecting homeothermic animals. Transmission of protozoan to humans includes ingestion of water and raw food contaminated with sporulated oocysts, ingestion of raw or undercooked meat with tissue cysts, and tachyzoites' transplacental transmission. Fresh goat milk intake has already been linked to human toxoplasmosis outbreaks, but little is known about the infectious potential of this biological sample. Accordingly, the aim of the present study is to assess the survival and infectivity of T. gondii tachyzoites in fresh goat milk samples through an experimental protocol to detect this parasite via bioassay carried out with a murine model, DNA amplification, and serology. Swiss Webster mice were inoculated with fresh goat milk samples contaminated with different T. gondii RH strain tachyzoite concentrations per milliliter and stored for different refrigeration times. Animals showing clinical signs compatible to toxoplasmosis were euthanized. Milk samples contaminated with high parasitic loads and kept for a shorter refrigeration time were the most lethal ones. No significant differences were observed between mean death rates recorded for different goat milk contamination concentrations (p = 0.1888), and for the refrigeration time, contaminated milk samples were kept under (p = 0.9440). T. gondii DNA was amplified in all contaminated milk samples, but only one of the surviving mice was serologically positive. Results of the present study have shown T. gondii survival and infectivity in fresh goat milk samples, and it highlights its significant risk for public health. Therefore, molecular methods must be the tests of choice when milk samples are used to assess infection caused by protozoan in goats' dairy products.

Food group intakes and high-sensitivity C-reactive protein among community-dwelling Japanese adults: a cross-sectional study.

Healthy dietary patterns have been linked to lower levels of chronic inflammation. The present study aimed to investigate the associations between food group intakes and high-sensitivity C-reactive protein (hsCRP) among community-dwelling adults. Cross-sectional. Three areas in Japan (Shiga, Fukuoka, or Kyushu and Okinawa). The present analysis included 13 648 participants (5126 males and 8522 females; age range, 35-69 years) who had been enrolled in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Food group intakes were estimated using a FFQ. Multiple linear regression was used to examine associations between the quartiles of each energy-adjusted food group intake and log-transformed hsCRP. The following concentration ratios of hsCRP after comparing the highest and lowest quartiles of food group intake were significant: in males, 1·12 (95 % CI 1·02, 1·22) for processed meat, 1·13 (95 % CI 1·03, 1·24) for fish and 0·83 (95 % CI 0·76, 0·90) for nuts; in females, 0·89 (95 % CI 0·81, 0·97) for bread, 1·11 (95 % CI 1·03, 1·19) for processed meat, 0·86 (95 % CI 0·80, 0·92) for vegetables, 1·19 (95 % CI 1·11, 1·29) for fruit, 0·90 (95 % CI 0·84, 0·97) for nuts and 0·88 (95 % CI 0·82, 0·95) for green tea. Processed meat and nut intakes were associated with higher and lower hsCRP levels, respectively, in both sexes. However, for several food groups, including fish and fruit, previous findings from dietary pattern analyses were not supported by the present analyses at the food group level.

Biomarkers of food intake and their relevance to metabolic syndrome.

Metabolic syndrome (MetS) constitutes a prevalent risk factor associated with non communicable diseases such as cardiovascular disease and type 2 diabetes. A major factor impacting the etiology of MetS is diet. Dietary patterns and several individual food constituents have been related to the risk of developing MetS or have been proposed as adjuvant treatment. However, traditional methods of dietary assessment such as 24 h recalls rely greatly on intensive user-interaction and are subject to bias. Hence, more objective methods are required for unbiased dietary assessment and efficient prevention. While it is accepted that some dietary-derived constituents in blood plasma are indicators for certain dietary patterns, these may be too unstable (such as vitamin C as a marker for fruits/vegetables) or too broad (e.g. polyphenols for plant-based diets) or reflect too short-term intake only to allow for strong associations with prolonged intake of individual food groups. In the present manuscript, commonly employed biomarkers of intake including those related to specific food items (e.g. genistein for soybean or astaxanthin and EPA for fish intake) and novel emerging ones (e.g. stable isotopes for meat intake or microRNA for plant foods) are emphasized and their suitability as biomarker for food intake discussed. Promising alternatives to plasma measures (e.g. ethyl glucuronide in hair for ethanol intake) are also emphasized. As many biomarkers (i.e. secondary plant metabolites) are not limited to dietary assessment but are also capable of regulating e.g. anti-inflammatory and antioxidant pathways, special attention will be given to biomarkers presenting a double function to assess both dietary patterns and MetS risk.

From hamburgers to holidays: Modelling the climate change impact of reducing meat consumption according to UK consumer preferences

The climate impact of food is rapidly gaining attention. Studies focus on global and national impacts, marginalising the role and preferences of individual consumers. Diet is highly personal and for changes to be widely adopted they should be consistent with peoples' lifestyles, preferences, tastes, and knowledge. We construct global scenarios of reducing meat consumption and model their carbon mitigation potential to 2050. We conduct a simple survey to explore UK consumers' preferences for different approaches to reducing meat consumption, which are used to develop scenarios, and units for communicating the associated portion sizes and emissions savings. Results from our survey suggest that modest reductions in meat consumption are more resonant (e.g., eating three portions per week) rather than absolutes (becoming vegan for one month) or abstractions (consuming 170 cal of meat per day). Similarly, tangible analogies such as number of airline flights are preferred over raw emissions abated. We find that reducing meat intake to recommended healthy levels (92 cal per day) and avoiding ruminant meat could almost halve production-phase GHG emissions from the food system. Our survey illustrates how such information can be rephrased for more engaging communication: “reducing your meat intake to three times per week is equivalent to avoiding six short-haul return flights each year”.

A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults.

The high consumption of purine-rich meat is associated with hyperuricemia. However, there is limited evidence linking the consumption of red and processed meat to the genetic risk of hyperuricemia. We investigated the relationship between various combinations of red and processed meat consumption and the polygenic risk scores (PRSs) and the incidence of hyperuricemia in middle-aged Koreans. We analyzed the data from 44,053 participants aged ≥40 years sourced from the Health Examinees (HEXA) cohort of the Korean Genome and Epidemiology Study (KoGES). Information regarding red and processed meat intake was obtained using a semiquantitative food frequency questionnaire (SQ-FFQ). We identified 69 independent single-nucleotide polymorphisms (SNPs) at uric acid-related loci using genome-wide association studies (GWASs) and clumping analyses. The individual PRS, which is the weighted sum of the effect size of each allele at the SNP, was calculated. We used multivariable Cox proportional hazards models adjusted for covariates to determine the relationship between red and processed meat intake and the PRS in the incidence of hyperuricemia. During an average follow-up period of 5 years, 2,556 patients with hyperuricemia were identified. For both men and women, the group with the highest red and processed meat intake and the highest PRS was positively associated with the development of hyperuricemia when compared with the group with the lowest red and processed meat intake and the lowest PRS (hazard ratio [HR], 2.72; 95% confidence interval [CI], 2.10-3.53; P < 0.0001; HR, 3.28; 95% CI, 2.45-4.40; P < 0.0001). Individuals at a high genetic risk for uric acid levels should moderate their consumption of red and processed meat to prevent hyperuricemia.

Burden of ischemic stroke attributable to a high red meat diet in China, 1990-2019: analysis based on the 2019 Global Burden of Disease Study.

The burden of ischemic stroke (IS) linked to high consumption of red meat is on the rise. This study aimed to analyze the mortality and disability-adjusted life years (DALYs) trends for IS attributed to high red meat intake in China between 1990 and 2019 and to compare these trends with global trends. This study extracted data on IS attributed to diets high in red meat in China from 1990 to 2019 from the Global Burden of Disease Study (GBD) database. Key measures, including mortality, DALYs, age-standardized mortality rates (ASMR), and age-standardized DALYs rates (ASDR), were used to estimate the disease burden. The estimated annual percentage change and joinpoint regression models were employed to assess the trends over time. An age-period-cohort analysis was used to assess the contribution of a diet high in red meat to the age, period, and cohort effects of IS ASMR and ASDR. Between 1990 and 2019, deaths and DALYs from IS attributed to a diet high in red meat in China, along with corresponding age-standardized rates, significantly increased. The overall estimated annual percentage change for the total population and across sex categories ranged from 1.01 to 2.08. The average annual percentage changes for overall ASDR and ASMR were 1.4 and 1.33, respectively, with male ASDR and ASMR average annual percentage changes at 1.69 and 1.69, respectively. Contrastingly, female ASDR and ASMR average annual percentage changes were 1.07 and 0.87, respectively. Except for a few periods of significant decrease in females, all other periods indicated a significant increase or nonsignificant changes. Incidence of IS linked to a diet high in red meat rose sharply with age, displaying increasing period and cohort effects in ASDR. Female ASMR period and cohort effect ratios initially increased and then decreased, whereas the male ratio showed an upward trend. This study comprehensively analyzed epidemiological characteristics that indicated a marked increase in mortality and DALYs from IS attributable to high red meat consumption, contrasting with a global downtrend. This increase was more pronounced in males than females. This research provides valuable insights for enhancing IS prevention in China.

Association between processed red meat intake and cardiovascular risk factors in patients with type 2 diabetes: a cross-sectional study from China.

To explore the association between Processed red meat (PRM) consumption and cardiovascular risk factors in Chinese adults with type 2 diabetes mellitus (T2DM). Dietary survey, physical measurement, and blood biochemical examination were conducted on 316 patients with type 2 diabetes in Bengbu, China from May to July 2019. Possible confounding factors were identified by comparing between-group variability in the baseline table. To eliminate the effect of confounding factors, subgroup analysis was used to explore whether there were differences in the correlation between PRM intake status and the indicators in cardiovascular disease risk factors. A logistic regression model was used to analyze the association between PRM and the risk of abnormal levels of cardiovascular risk factors in T2DM patients. Restricted cubic spline plots were used to analyze the dose-response relationship between PRM intake and the indicators of cardiovascular disease risk factors. A total of 316 subjects were included in the study, of whom 139 (44.0%) were male and 177 (56.0%) were female. In the multiplicative interaction, there was an effect modifier for smoking (Pinteraction = 0.033) on the association between PRM intake and the risk of substandard FPG level control; sex (Pinteraction = 0.035), smoking status (Pinteraction = 0.017), and alcohol consumption (Pinteraction = 0.046) had effect modifying effects on the association between PRM intake and risk of abnormal systolic blood pressure. Sex (Pinteraction = 0.045) had an effect modifier on the association of PRM intake status with the risk of diastolic blood pressure abnormality. In addition, age had an effect modifier on the association of PRM intake status with risk of abnormal triglyceride index (Pinteraction = 0.004) and risk of abnormal HDL index (Pinteraction = 0.018). After adjusting for potential confounding variables, logistic regression showed that the OR for substandard HbA1c control in patients in the highest PRM intake group, T3 (3.4 ~ 57.2 g/d), was 1.620-fold higher than in the lowest intake, i.e., the no-intake group, T1 (0.0 ~ 0.0 g/d; OR = 2.620; 95% CI 1.198 ~ 5.732; p = 0.016). Whereas the OR for abnormal control of systolic blood pressure levels was 1.025 times higher (OR = 2.025; 95% CI 1.033 ~ 3.968; p = 0.040) in patients in the PRM low intake group T2 (0.1 ~ 3.3 g/d) than in the non-intake group T1 (0.0 ~ 0.0 g/d), the OR for substandard control of systolic blood pressure in patients in the highest group T3 (3.4 ~ 57.2 g/d) was 1.166 times higher than in the no-intake group T1 (OR = 2.166; 95% CI 1.007 ~ 4.660; p = 0.048). The OR for abnormal TG levels in patients in the highest PRM intake group T3 (3.4 ~ 57.2 g/d) was 1.095 times higher than in the no-intake group T1 (OR = 2.095; 95% CI 1.076 ~ 4.078; p = 0.030). Restricted cubic spline plots presented a nonlinear dose-response relationship between PRM intake and risk of substandard HbA1c and SBP control (P nonlinear <0.05), and an atypical inverted U-shaped association between PRM intake and TC and LDL-C levels (P nonlinear <0.05). The strength of the associations between PRM intake and the control levels of FPG, DBP, HDL-C, and TG were not statistically significant (p > 0.05). PRM intake was generally low in patients with T2DM, but a nonlinear dose-response relationship between PRM intake and the risk of suboptimal control of HbA1c and SBP, with an atypical inverted U-shaped association with TC and LDL-C levels, was observed. Appropriate control of PRM intake may be important for tertiary prevention of T2DM and cardiovascular disease prevention. We need to better understand these relationships to promote improved cardiometabolism and global health.

Deep Learning Framework for Colorectal Cancer Classification Using ResNet18 Based on Dietary Habits Related to Meat Intake and Cooking Methods

Deep Learning Framework for Colorectal Cancer Classification Using ResNet18 Based on Dietary Habits Related to Meat Intake and Cooking Methods

Microbiota and detrimental protein derived metabolites in colorectal cancer.

Colorectal cancer (CRC) is the third leading cancer in incidence and the second leading cancer in mortality worldwide. There is growing scientific evidence to support the crucial role of the gut microbiota in the development of CRC. The gut microbiota is the complex community of microorganisms that inhabit the host gut in a symbiotic relationship. Diet plays a crucial role in modulating the risk of CRC, with a high intake of red and processed meat being a risk factor for the development of CRC. The production of metabolites derived from protein fermentation by the gut microbiota is considered a crucial element in the interaction between red and processed meat consumption and the development of CRC. This paper examines several metabolites derived from the bacterial fermentation of proteins associated with an increased risk of CRC. These metabolites include ammonia, polyamines, trimethylamine N-oxide (TMAO), N-nitroso compounds (NOC), hydrogen sulphide (H2S), phenolic compounds (p-cresol) and indole compounds (indolimines). These compounds are depicted and reviewed for their association with CRC risk, possible mechanisms promoting carcinogenesis and their relationship with the gut microbiota. Additionally, this paper analyses the evidence related to the role of red and processed meat intake and CRC risk and the factors and pathways involved in bacterial proteolytic fermentation in the large intestine.

Comparing the Associations of Dietary Patterns Identified through Principal Component Analysis and Cluster Analysis with Colorectal Cancer Risk: A Large Case-Control Study in China.

Examining the association between dietary patterns and colorectal cancer (CRC) risk can provide valuable insights beyond the assessment of individual foods or nutrients. However, there is a lack of in-depth analysis of dietary patterns and CRC risk in Chinese populations, and few studies have compared dietary patterns derived from different posteriori methods with the aim of predicting disease risk. The aim of this study was to derive dietary patterns using both principal component analysis (PCA) and cluster analysis (CA) and to assess their respective associations with CRC risk. A large-scale case-control study was conducted in Guangdong Province, China, including 2799 incident colorectal cancer cases and an equal number of frequency-matched controls. Dietary intake information was gathered through the use of a validated food frequency questionnaire. PCA and CA were used to derive dietary patterns. A multivariable logistic regression model was used to calculate the adjusted odds ratio (aOR) and 95% confidence interval (CI). Four major dietary patterns were identified by PCA. CA identified two dietary patterns, referred to as the "Balanced dietary pattern" and the "Refined grain dietary pattern". Notably, there were significant inverse associations between the milk-egg-nut-soy dietary pattern (aOR, 0.51; 95% CI, 0.42, 0.62), the vegetable-fruit dietary pattern (aOR, 0.61; 95%CI, 0.51, 0.74), and the poultry-fish dietary pattern (aOR, 0.81; 95%CI, 0.68, 0.97) and CRC risk. However, the red meat-preserved food dietary pattern was associated with an increased risk of CRC (aOR, 2.99; 95%CI, 2.43, 3.67). When compared with the Refined grain dietary pattern, the Balanced dietary pattern showed a decreased risk of CRC (aOR, 0.59; 95%CI, 0.52, 0.66). The results from the comparison of the two methods indicate that both CA and PCA derived remarkably similar patterns. The combined use of PCA and CA identified consistent underlying patterns, showing comparable associations with CRC risk. These findings suggest that individuals who prefer dietary patterns characterized by a high intake of red meat, preserved food, and refined grains should be cautious about their increased CRC risk. Conversely, dietary patterns rich in fruits, vegetables, and high-quality protein sources are advisable for the prevention of CRC in the Chinese population.

Dietary Pattern and Its Impact on Nutritional Status of Adolescent Girls among Chepang Community in Raksirang Rural-Municipality of Makawanpur District

Background: Adolescence is a period of transition between childhood and adulthood. An adolescent is defined as individuals in the 10-19year age group. The health and nutritional status of adolescent girls affects their health and their survival in future. Adolescents, particularly girls, are increasingly conscious of their body which leads to low intake of food rich with nutrients. Teenage girls may excessively restrict their energy intake, out of a desire to be thin, which has a serious threat on their nutritional status.Methods: Descriptive cross sectional study design was applied in ward number 5 of Raksirangrural municipality of Makawanpur district usingsemi-structured questionnaire and all adolescent girls (127) of aged 10-19 years were involved as the respondents of the study. The study duration was 7th June to 25th December 2017. The data was entered and analyzed with the help of software SPSS version 16.0. Results: The prevalence of underweight was found to be 27.6%. Study shows the participants consume protective fruits and vegetables group and other fruits and vegetables group in less quantity as comparison to other food groups. Though most of the participants were literate, knowledge on nutrition about 8% had adequate knowledge and 91% had poor knowledge.Conclusions: Nutritional status of adolescent girls of Raksirangrural municipality is found to be poor. The research recommends improving nutritional status and feeding habits especially intake of wheat, meat and yellow fruits focusing on adolescent girls.

PREVALENCE AND RISK FACTORS ASSOCIATED WITH HYPERTENSION IN A RURAL MUNICIPALITY, NEPAL

Background: Hypertension is a significant public health concern globally, as it is a major risk factor for cardiovascular diseases and contributes to high mortality rates. This study aimed to assess the prevalence of hypertension and associated risk factors in Gandaki Rural Municipality. Methods: A cross-sectional study was conducted from May 1 to 13, 2022, involving 315 respondents aged 40 years and above. Hypertension and associated factors were assessed using a self-constructed questionnaire, a doctor’s aneroid sphygmomanometer, and a stethoscope. Logistic regression analysis was performed to identify predictors of hypertension. Results: The majority of respondents (27.3%) were aged between 50 and 59 years, with a mean age of 60.65 years (±12.85). The prevalence of hypertension was 41%. Alcohol consumption was reported by 43.2% of respondents, while 28.3% had a smoking habit, 24.1% used smokeless tobacco, 87.6% consumed red meat, and the majority (60.3%) engaged in moderate-intensity activities. Older age (AOR = 5.4; 95% CI = 2.60–11.06), smoking (AOR = 1.8; 95% CI = 1.06-3.19), presence of non-communicable diseases (AOR = 2.0; 95% CI = 1.03-3.70), and overweight (AOR = 2.4; 95%CI = 1.32-4.22) or obesity (AOR = 5.8; 95%CI = 2.50–13.68) were identified as significant risk factors for hypertension. Conclusions: The prevalence of hypertension was found to be almost two-fifths in Gandaki Rural Municipality, emphasizing the need for preventive strategies focusing on modifiable risk factors. These strategies should focus on major risk factors such as promoting physical activity, discouraging tobacco use, increasing fruit consumption, and reducing red meat intake.

Allergy to galactose-α-1,3-galactose (α-gal) – A case report

Introduction: Meat allergy represents 3-15% of food allergies in paediatrics and 3% in adults. Galactose-α-1,3-galactose (α-gal) is an allergen present in non-primate mammals’ meat, responsible for crossed reactions with cetuximab and gelatine. Case description: 62-year-old male patient was sent to an Immunoallergology outpatient clinic for acetylsalicylic acid desensitization. He reported reproducible anaphylactic reactions beginning 3 hours after red meat ingestion. Currently, the patient strictly avoids red meat. The investigation confirmed sensitization to red meat and α-gal. Discussion/Conclusions: α-gal allergy presents some uncommon characteristics: the trigger (oligosaccharide), IgE-mediated reaction with late-onset, and the association with previous tick bites, responsible for primary sensitization. Patients must avoid red meat and tick bites and have an emergency plan with an adrenalin auto-injector.

Nutritional Strategies for Rheumatoid Arthritis: Exploring Pathways to Better Management

Rheumatoid arthritis (RA) is an autoimmune illness that affects the entire body, with the involvement of the joints and gradual bone and cartilage loss. Environmental and genetic factors contribute to the susceptibility to RA. A growing body of research in recent years has indicated that nutrition plays a major impact in both the risk and course of disease. Notably, environmental factors like dust, pollution, infections, and smoking are identified as potential contributors to systemic autoimmunity preceding symptom onset. Amidst this complexity, the role of nutrition emerges as a significant area of interest, with studies indicating potential links between dietary habits and the onset of RA. The article thoroughly investigates the impact of dietary choices on inflammation, drawing attention to the dichotomy of foods with either pro-inflammatory or anti-inflammatory effects. The Western diet, characterized by its high intake of red meat, saturated fats, and refined carbohydrates, is implicated in elevating inflammation, insulin resistance, and obesity, potentially increasing the risk of RA. Further, the intricate relationship between nutrition and inflammatory diseases is explored, emphasizing the impact of specific nutrients on inflammatory processes. Omega-3 and omega-6 fatty acids, crucial for cellular membranes and inflammatory regulation, emerge as potential therapeutic supplements for RA management. Additionally, calorie restriction and antioxidants are identified as influential factors in mitigating inflammation and disease activity in RA patients. The manuscript also examines the effects of various dietary components such as flavonoids, gluten, fasting, vitamin D, and probiotics on RA. Overall, the manuscript presents a comprehensive overview of the intricate relationship between diet and RA, shedding light on the potential avenues for leveraging nutrition as a tool for managing and potentially mitigating the impact of this complex autoimmune condition. Keywords: Inflammation, Rheumatoid Arthritis, Nutritional Therapy, Omega-3 fatty acids, Joint pains, Antioxidants

Red Meat Intake and the Risk of Cardiovascular Diseases: A Prospective Cohort Study in the Million Veteran Program

BackgroundRed meat consumption was associated with an increased risk of cardiovascular disease (CVD) in prospective cohort studies and a profile of biomarkers favoring high CVD risk in short-term controlled trials. However, several recent systematic reviews and meta-analyses concluded with no or weak evidence for limiting red meat intake. ObjectivesTo prospectively examine the associations between red meat intake and incident CVD in an ongoing cohort study with diverse socioeconomic and racial or ethnic backgrounds. MethodsOur study included 148,506 participants [17,804 female (12.0%)] who were free of cancer, diabetes, and CVD at baseline from the Million Veteran Program. A food frequency questionnaire measured red meat intakes at baseline. Nonfatal myocardial infarction and acute ischemic stroke were identified through a high-throughput phenotyping algorithm, and fatal CVD events were identified by searching the National Death Index. ResultsComparing the extreme categories of intake, the multivariate-adjusted relative risks of CVD was 1.18 (95% CI: 1.01, 1.38; P-trend < 0.0001) for total red meat, 1.14 (95% CI: 0.96, 1.36; P-trend = 0.01) for unprocessed red meat, and 1.29 (95% CI: 1.04, 1.60; P-trend = 0.003) for processed red meat. We observed a more pronounced positive association between red meat intake and CVD in African American participants than in White participants (P-interaction = 0.01). Replacing 0.5 servings/d of red meat with 0.5 servings/d of nuts, whole grains, and skimmed milk was associated with 14% (RR: 0.86; 95% CI: 0.83, 0.90), 7% (RR: 0.93; 95% CI: 0.89, 0.96), and 4% (RR: 0.96; 95% CI: 0.94, 0.99) lower risks of CVD, respectively. ConclusionsRed meat consumption is associated with an increased risk of CVD. Our findings support lowering red meat intake and replacing red meat with plant-based protein sources or low-fat dairy foods as a key dietary recommendation for the prevention of CVD.

Effects of pork sausage on intestinal microecology and metabolism in mice.

Processed meat, as an important part of the human diet, has been recognized as a carcinogen by the International Agency for Research on Cancer (IARC). Although numerous epidemiological reports supported the IARC's view, the relevant evidence of a direct association between processed meat and carcinogenicity has been insufficient and the mechanism has been unclear. This study aims to investigate the effects of pork sausage (as a representative example of processed meat) intake on gut microbial communities and metabolites of mice. Microbial communities and metabolites from all groups were analyzed using 16S rRNA gene sequencing and Ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometer (UPLC-Q-TOF/MS), respectively. The levels of Bacteroidetes, Bacteroides, Alloprevotella, Lactobacillus, Prevotella_9, Lachnospiraceae_NK4A136_group, Alistipes, Blautia, Proteobacteria, Firmicutes, Allobaculum, Helicobacter, Desulfovibrio, Clostridium_sensu_stricto_1, Ruminococcaceae_UCG-014, Lachnospiraceae_UCG-006 and Streptococcus (P < 0.05) were obviously altered in the mice fed a pork sausage diet. Twenty-seven metabolites from intestinal content samples and fourteen matabolites from whole blood samples were identified as potential biomarkers from multivariate analysis, including Phosphatidic acid (PA), Sphingomyelin (SM), Lysophosphatidylcholine (LysoPC), Diglyceride (DG), D-maltose, N-acylamides and so forth. The significant changes in these biomarkers demonstrate metabonomic variations in pork sausage treated rats, especially carbohydrate metabolism, lipid metabolism, and amino acid metabolism. The present study provided evidence that a processed meat diet can increase the risk of colorectal cancer and other diseases significantly by altering the microbial community structure and disrupting the body's metabolic pathways. © 2023 Society of Chemical Industry.