Intake Of Biscuits Research Articles

Synbiotic Biscuit Potential Reducing Blood Sugar Levels In Wistar White Rats

Nutraceuticals, or functional foods, are foods that have been altered or designed to have certain nutritional or physiological effects. Synbiotic biscuit represents an effort in the development of functional food products. A synbiotic biscuit contains both prebiotic ingredients and probiotic bacteria. Created with Lactobacillus acidophilus and a composite flour mix of sweet potatoes, banana corm, and black soybeans, this synbiotic biscuit offers a synergistic combination of probiotics and prebiotics potentially lowering blood glucose levels. This study investigates the impact of the Glycemic Index (GI), Glycemic Load (GL), and the relationship between the quantity of synbiotic biscuits consumed and the reduction of blood glucose levels in Wistar rats. The descriptive approach was utilized as the experimental method, followed by correlation and regression analysis. The experiment used standard meal consumption as a negative control, metformin 45 mg/kg body weight intake as a positive control, synbiotic biscuit 5 g in 10 ml aquades intake, and synbiotic biscuit 10 g in 10 ml aquades intake were employed in the experiment. The study demonstrated a relationship between the intake of synbiotic cookies and blood glucose levels in Wistar rats. The synbiotic biscuits showed that GI and GL at 65.38 and 13.38, respectively. After 15 days of feeding synbiotic biscuit 10 g in 10 ml per day, body weight increased to 216.33 g, and blood glucose levels decreased to 96.97 mg/dl. Total L. acidophilus was discovered in rat faeces at a concentration of 6.56 log CFU/g.

Anorectic effect of COR659 in a rat model of overeating.

COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The present study was designed to assess whether the ability of COR659 to diminish these addictive-like, food-motivated behaviours extended to a rat model of overeating palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour feeding session with highly palatable, calorie-rich Danish butter cookies. Even though satiated, rats overconsumed cookies. COR659 (0, 2.5, 5, and 10 mg/kg, i.p.) was administered before the start of the cookie-feeding session. Treatment with all 3 doses of COR659 produced a substantial decrease in intake of cookies and calories from cookies. These results extend the anorectic profile of COR659 to overconsumption of a highly palatable food and intake of large amounts of unnecessary calories.

Nutritional, Sensory, and Microbial Quality of Cookies Produced by Partial Replacement of Wheat Flour with Plantain (Musa paradisiaca) and Cocoyam (Colocasia esculenta) Flours

Nutritional, sensory, texture, and microbiological load analyses were made of cookies consisting of a partial replacement of wheat flour with plantain (Musa paradisiaca) or cocoyam (Colocasia esculenta) flour. There were slight differences in the amounts of protein, fat, and carbohydrate. Accordingly, the nutritional values per 100 g of the cookies correspond to 10-14% protein and 19-21% energy of the recommended daily allowance. In contrast, cookies containing either cocoyam or plantain flour have 20% and 30% more fiber, respectively, compared to cookies containing wheat flour alone. Similarly, plantain and cocoyam cookies’ iron and zinc contents were, respectively, 1-16% and 2-9% more than ( p < 0.05 ) the control. The levels of aerobic plate count in the cookies were lower than recommended thresholds for such food products. Those cookies containing 20% and 40% of either plantain or cocoyam flour had comparable sensory, texture, and color quality compared to the control. The effect of intake of plantain and cocoyam cookies is likely to eliminate population mineral deficiencies, particularly iron, and zinc. These results underline the potential of enabling food security crops such as plantain and cocoyam in sustaining cookies production, utilization, nutritional value, and the role of such crops in addressing food and nutrition insecurity.

The effect of snakehead fish (Channa striata) cookies supplementation on fetal growth and birth outcomes: A randomized clinical trial

BACKGROUND: An estimated 15–20% of all births worldwide are low birth weight (LBW). In Indonesia, the LBW incidence reached more than 10% in 2013. Improved maternal nutrition is needed by providing high-calorie-protein supplementation for pregnant women to prevent intrauterine growth retardation and LBW. OBJECTIVES: To observe the effect of snakehead fish (Channa striata) cookies supplementation during pregnancy on fetal growth and birth outcomes. METHODS: A total of 50 pregnant women were included in this randomized clinical trial study and were randomly allocated into two groups: treatment and controls. Subjects in the treatment group received supplementation of snakehead fish cookies during pregnancy until giving birth as much as 75 g per day, while subjects in the control group received standard cookies. The snakehead fish cookies underwent a formulation process and were tested for nutrient content and microbial contamination to ensure safety before being given to the subjects. Fetal growth was monitored monthly using 2-dimensional ultrasonography. RESULTS: The average intake of cookies did not differ between the two groups (Control 69.6 (16.8)% vs Snakehead fish 64.6 (15.3)%, p = 0.278). There were no significant differences in fetal estimated fetal weight, biparietal diameter, abdominal circumference, femur length, birth weight, and birth length between the treatment and control groups (p > 0.05). However, the fetal growth measurements on the subjects who consumed snakehead fish cookies were practically higher than those who ate standard cookies. CONCLUSION: The snakehead fish cookies did improve the fetal growth measurements but the results were not significantly different when compared to standard cookies.

Dietary Intake and Health Status of Elderly Patients With Type 2 Diabetes Mellitus: Cross-sectional Study Using a Mobile App in Primary Care

BackgroundHealthy dietary intake reduces the risk of complications of diabetes mellitus. Using assessment methods helps to understand these circumstances, and an electronic application may optimize this practice.ObjectiveIn this study, we aimed to (1) assess the dietary intake and health status of elderly patients with type 2 diabetes mellitus (T2DM) in primary care, (2) use a mobile app as a tool for data collection and analysis in the context of primary care, and (3) verify the perceptions of multidisciplinary health professionals regarding app use.MethodsFirst, we developed a mobile app comprised of the questions of the Food and Nutrition Surveillance System (SISVAN) of Brazil, which includes a food frequency questionnaire of food categories with a recall of the previous 7 days. Thereafter, we used the app to collect data on the health status and dietary intake of 154 participants, aged 60-96 years, diagnosed with T2DM, and under treatment in primary care centers in the northern region of Rio Grande do Sul, Brazil. We also collected participants’ demographic, anthropometric, biochemical, and lifestyle variables. The associations between dietary intake and other variables were tested using chi-square tests with a 5% significance level. Regarding the app, we assessed usability and acceptance with 20 health professionals.ResultsBetween August 2018 and December 2018, participants had an intake in line with recommended guidelines for raw salads (57.1%), fruits (76.6%), milk products (68.2%), fried foods (72.7%), savory biscuits (60.4%), cookies or sweets (72.1%), and sugary drinks (92.9%) Meanwhile, the consumption of beans (59.7%), pulses and cooked vegetables (73.4%), and processed meat products (59.7%) was not in line with the guidelines. There were statistically significant differences in meeting the recommended guidelines among participants of different genders (P=.006 and P=.035 for the intake of fried foods and sugary drinks, respectively), place of residence (P=.034 for the intake of cookies and sweets), family history of diabetes (P<.001 for the intake of beans), physical activity engagement (P=.003 for the intake fresh fruits), history of smoking (P=.001 for the intake of raw salads), and presence of coronary disease (P=.050 for the intake of pulses and cooked vegetables). The assessment of usability resulted in a mean score of 71.75 points. Similarly, the assessment of the 15 acceptance questions revealed high scores, and the qualitative questions revealed positive perceptions.ConclusionsWe identified that most participants complied with recommended intake guidelines for 7 of 10 categories in the SISVAN guidelines. However, most participants were overweight and had nutritional and clinical disorders, which justifies further investigations in this population. The app was well-rated by health professionals and considered a useful and promising tool for collecting and analyzing data in primary care settings.

Dietary acculturation of international students in Pune, India: a cross-sectional study.

Dietary acculturation refers to how a migrant group adopts the eating patterns of the host country. It results in changes in dietary behavior, dietary intake, and nutritional status of this vulnerable group. To study dietary acculturation of international students in Pune, India. International students from three Universities in Pune were enrolled. Information on demography, dietary behavior, and dietary intake (using a food frequency questionnaire) was recorded using an interviewer-administered questionnaire. The height and weight of the students were measured using standard, calibrated equipment. The data were analyzed using descriptive and analytical statistics. A total of 100 international students from Iran, Africa, and South Korea were grouped by nationality. Considerable variation was detected in the daily number of meals consumed, skipping meals, portion size changes, packaged food consumption, and supplement intake following migration between the groups. The intake of non-vegetarian food had declined drastically for all groups. However, the specific non-vegetarian item showing the greatest change differed according to the group's nationality. The intake of biscuits and cake had increased among all groups. African students showed an increase of 3.33 kg in body weight following migration. The intake of protein and micronutrients declined for all groups. This study highlights the changes in dietary behavior, dietary intake, and nutritional status of international students of different nationalities following migration to Pune, India. Thus, it emphasizes the need for nutrition interventions in international students in India.

MO904DIETARY PATTERNS IN HEMODIALYSIS PATIENTS: RELATIONSHIP WITH CLINICAL AND NUTRITIONAL PARAMETERS

Abstract Background and Aims Nutritional recommendations for hemodialysis (HD) patients focus on the achievement of a sufficient energy and protein intake without exceeding phosphorus, potassium, sodium and/or fluids intake limits. This study aimed to identify different dietary patterns of HD patients and analyze their relationship with clinical and nutritional parameters. Method This was a longitudinal prospective multicenter study with 582 HD patients from 37 dialysis centers. Dry weight, Kt/V, serum potassium, phosphorus, calcium, sodium, creatinine and C-reactive protein were measured. Dietary intake was obtained using the Food Frequency Questionnaire. Dietary patterns were derived from principal component analysis based on 20 food groups which were adjusted for total energy intake. Linear regression was used to analyze patterns and the variables of interest. All statistical tests were performed using SPSS 26.0 software. A p-value lower than 0.05, was considered statistically significant. Results Patients’ mean age was 67.8±17.7 years and median HD vintage was 65 (43-104) months. Three different dietary patterns were identified: “Western” (31.3% of the patients) with high intake of soft drinks, home-made fried potatoes, caffeinated drinks, red and processed meat, and low intake of fruit and vegetables soup; “Mediterranean” (33.5% of the patients) with high intake of vegetables, beans, fish, olive oil, eggs, and low intake of milk and milk products. Finally, “Low animal protein” (35.2% of the patients) with high intake of whole grain bread, cookies and sweets, vegetables soup and low intake of white bread, rice, pasta and potatoes. Regarding clinical parameters, the Mediterranean pattern was predictor of a higher dry weight (p=0.001), higher creatinine (p=0.032) and lower serum calcium (p=0.024), whereas Western pattern predicted higher phosphorus (p=0.006), sodium (p=0.014) and creatinine (p=0.001). Low animal protein pattern predicted lower creatinine levels (p=0.011). After adjusting for age, gender, presence of diabetes, HD vintage and Kt/V, serum calcium was the only parameter which remained statistical significant within the Mediterranean pattern. Comparing the nutritional parameters studied, the Mediterranean pattern was the strongest predictor of a higher intake of protein (%) (p&amp;lt;0.001), folate (p&amp;lt;0.001), vitamin B12 (p&amp;lt;0.001), vitamin B6 (p&amp;lt;0.001), vitamin C (p&amp;lt;0.001), vitamin D (p&amp;lt;0.001), potassium (p=0.015) and omega 3 fatty acids (p&amp;lt;0.001) and a lower intake of carbohydrates (%) (p&amp;lt;0.001), calcium (p&amp;lt;0.001) and sodium (p=0.006). Conclusion Three different dietary patterns were identified in these HD population. The pattern which was closer to the well-known Mediterranean diet was associated with a better nutritional intake profile, which, at least theoretically, are associated with better clinical outcomes.

Effect of Galohgor Cookies Intake by Postpartum Mother on Newborn’s Growth

Background: Malnutrition is one of serious public health problems that still need treatment priority. Besides the problem of over-nutrition continues to increase, the problem of under-nutrition has not been resolved properly. Utilization of local food such as galohgor can be an alternative to meet the nutritional needs. Objectives: The present study was aimed to analyze the effect of galohgor cookies intake by postpartum mothers on the newborn’s growth. Methods: The design was quasi-experimental design. There were two groups including the control group (CG) (n = 9) and the intervention group (GG) (n = 9). Postpartum mothers aged 20-35 years (parity between 2 and 5) with normal delivery and had no medical indication were involved in this study. A total of four pieces of cookie (~ 4 g of galohgor powder) were consumed daily from the 1st day until the 40th day after delivery. Anthropometric data (height, body weight, and head circumference) were obtained on day 0, 14 and 40 after delivery. Meanwhile, human milk samples were taken on day 14 and 40 to analyze the levels of human milk insulin-like growth factor-I (IGF-I). Results: The newborns in the GG had significantly heavier weight and larger head circumference than CG on day 14 and 40 after delivery (p &lt;0.05). IGF-I could be maintained by consuming galohgor during postpartum period. However, this study found no differences in body length of both control and intervention group (p&gt; 0.05). Conclusions: Intake of galohgor cookies by postpartum mothers might support the newborn’s growth.

Impulsivity influences food intake in women with generalized anxiety disorder.

Objective:Eating behavior is affected by psychological and neurocognitive factors. However, little is known about this relationship in anxious patients. Our aim was to investigate the associations between impulsivity, inhibitory control, energy-dense food consumption, and body mass index (BMI) in women with generalized anxiety disorder (GAD).Methods:In this cross-sectional study, 51 adult females with GAD answered the Barratt Impulsiveness Scale (BIS-11) and participated in a go/no-go task using food images. Anthropometric measurements were evaluated. A food frequency questionnaire and a snack test were used to study eating behavior. Pearson correlation and multiple linear regression were performed to analyze the variables of interest, adjusted by age.Results:Impulsivity predicted intake of sugar (p = 0.016, 95%CI 0.67-6.05), total fat (p = 0.007, 95%CI 0.62-3.71), and saturated fat (p = 0.004, 95%CI 0.30-1.48). The snack test showed a positive correlation between presence of impulsivity and intake of biscuits (R = 0.296; p = 0.051). Response inhibition to food images in the go/no-go task paradigm did not predict BMI or food intake.Conclusion:Impulsivity was predictive of higher sugar and saturated fat intake in women diagnosed with GAD. Our findings add to the literature regarding the association between neuropsychological factors and food consumption in this specific population.

Reducing Effect of Saikosaponin A, an Active Ingredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating.

Recent lines of experimental evidence have indicated that saikosaponin A (SSA)—a bioactive ingredient of the medicinal plant, Bupleurum falcatum L.—potently and effectively reduced operant self-administration of chocolate and reinstatement of chocolate-seeking behavior in rats. The present study was designed to assess whether the protective properties of SSA on addictive-like, food-related behaviors generalize to a rat model of overeating of palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-h chow-feeding session was followed by a 1-h availability of highly palatable, calorie-rich Danish butter cookies or Oreo chocolate cookies. Even though fed, rats consumed large amounts of cookies; intake of calories from cookies (consumed in 1 h) was even larger than that of calories from chow (consumed in 3 h). SSA (0, 0.25, 0.5, and 1 mg/kg, i.p.) was administered 10 min before cookie presentation. Treatment with SSA resulted in a dose-related decrease in intake of both butter and chocolate cookies. Administration of the cannabinoid CB1 receptor antagonist/inverse agonist, rimonabant (0, 0.3, 1, and 3 mg/kg, i.p.; tested as reference compound), produced a similar reduction in intake of butter cookies. These results (a) contribute to the set-up and validation of a rat model of overeating, characterized by the intake of large amounts of unnecessary calories and (b) provide an additional piece of evidence to the anorectic profile of SSA in rats.

Abstract P6-11-16: Dysgeusia, weight and eating habits changes in breast cancer patients undergoing chemotherapy: A prospective cohort study

Abstract Background: Dysgeusia is a frequent side effect in breast cancer patients undergoing adjuvant chemotherapy. The effect of dysgeusia on changes in diet and patient weight has been poorly investigated. We evaluated prospectively dysgeusia in a consecutive series of early breast cancer patients (EBCP) with the aim to explore its impact on food selection and weight changes. Patients and methods: From May 2014 to April 2017, 130 consecutive EBCP were enrolled at the Oncology and Breast Units at Spedali Civili in Brescia. Dysgeusia was categorized as present or absent, changes in types and frequencies of food consumptions during chemotherapy were assessed by a specific questionnaire and photography atlas. Evaluations were performed at baseline, after 3 cycles, at the end of chemotherapy plan and during follow-up. Results: all 130 pts were evaluable. Median age was 53 years (range 26-76), median weight 64 Kg (range 45-115), median BMI 23,86 Kg/m2 (range 17,01-35,49), 73 pts (56%) performed physical activity, 57 pts (44%) were abstemious, 22 pts (17%) received neoadjuvant and 108 pts (83%) adjuvant chemotherapy, 25 pts (19%) were treated with antracycline based schemes, 83 (64%) with antracycline and taxane plus or minus trastuzumab, and 22 pts (17%) other regimens. Seventy-three per cent of pts developed dysgeusia during chemotherapy (p=&amp;lt; 0.001), and in 19% this side effect persisted three months after chemotherapy. Dysgeusia was associated with the length of chemotherapy treatment and taxane use. A statistically significant increase of taste alteration was reported for all metallic, sweet, bitter, salted and acid taste (p&amp;lt;0.001). Dysgeusia was more frequent in pts reporting meteorism and fatigue and in pts without oral mucositis (p=0.002). Dysgeusia correlated with a lower intake of bread, cheese, fat salami, butter and wine and a high intake of biscuits and cakes. However, no correlation was observed with weight and BMI changes. Conclusion: Dysgeusia was frequent in EBCP undergoing adjuvant chemotherapy. It directly correlated with fatigue and meteorism and inversely correlated with mucositis. This adverse event had no impact on weight and BMI but significantly influenced food intake with a preference of glucose containing instead of fat containing foods. Acknowledgments: a thank you to Beretta foundation for the costant support to Breast Unit and Oncology Department. Citation Format: Pedersini R, Zanini A, Romelli M, Coccoli V, Guerra M, Bosio S, Schivardi G, Rodella F, Vassalli L, Amoroso V, Claps M, Simoncini EL, Berruti A. Dysgeusia, weight and eating habits changes in breast cancer patients undergoing chemotherapy: A prospective cohort study [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P6-11-16.

The Family Home Environment, Food Insecurity, and Body Mass Index in Rural Children

Family homes are a key setting for developing lifelong eating and physical activity habits, yet little is known about how family home nutrition and physical activity (FNPA) environments influence food insecurity (FI) and childhood obesity, particularly in rural settings. This study examined associations among FNPA, FI, and body mass index (BMI) in rural children. Parents of 186 elementary school-age children completed FNPA and FI surveys. Child anthropometrics were directly measured. Logistic and linear regressions were used to examine associations. Approximately 37% of children were overweight/obese; 43% of families were at risk for FI. Children whose families limited watching TV while eating were less likely to be obese (odds ratio [OR] = 0.56, p = .03) as were children whose families monitored intake of chips, cookies, and candy (OR = 0.54, p = .01). FI was higher in obese than normal weight children (OR = 11.00, p = .003) but only among families not eligible to receive free/reduced-cost school meals. Among eligible families, lower odds of FI were found for those who ate meals together often (OR = 0.31, p = .04) and for those with children frequently enrolled in organized sports/activities (OR = 0.65, p = .04). Findings were not significant after adjusting for multiple comparisons. Results suggest that favorable FNPA factors were associated with healthier BMI and lower odds of FI. Opportunities for healthy eating at home may support rural children's weight health. Additional resources may be necessary to promote food security among low-income families. Future research is warranted to better understand FNPA in relationship to the disproportionate rates of obesity and FI in rural populations.

Effects of a healthier snack on snacking habits and glycated Hb (HbA1c): a 6-week intervention study.

Dietary behaviour modification may change eating habits and reduce the impact of poor nutrition. This study aimed to evaluate the effects of daily consumption of a healthier snack bar on snacking habits and glycated Hb (HbA1c) within a 6-week intervention. In all, twenty-eight participants were randomly allocated to two groups to either consume the bars as the main snack for 6 weeks (n 14) or receipt of the bars was delayed for 6 weeks (n 14) following a stepped-wedge design. All participants had HbA1c concentrations measured at weeks -1, 0, 4, 6, 10 and 12. A short dietary habits questionnaire was self-completed at weeks 0, 6 and 12. Participants consumed the bars they received instead of other snacks, and found that the healthier snack bar was acceptable as part of their daily dietary pattern. Over the 12 weeks, there was a significant reduction in intake of biscuits, cakes and pies (approximately 2 servings/week, P<0·05) in both groups. Fruit juice intake was reduced (approximately 1 serving/week, P=0·029) in the first group. In all, twenty participants (71·4 %) experienced a decrease (n 15) or no change (n 5) in HbA1c (range 0-4 mmol/mol), whereas eight participants experienced an increase in HbA1c (range 0·5-2·5 mmol/mol). There was high compliance with the healthier snack intervention and a trend towards a favourable effect on glucose homoeostasis. Habitual snacking behaviour has the potential to be improved through changes in the food supply, and in the longer term may reduce the impact of poor nutrition on public health.

Contextual cue exposure effects on food intake in restrained eaters

Food cue exposure has been shown to trigger overeating in restrained eaters. To explore the difficulties experienced by these individuals in regulating their food intake, recent investigations have sought to determine the impact of exposure to a low calorie food cue, but with mixed success. This study tested the possibility that contextual differences moderate the impact of exposure to such a food cue among restrained eaters. To this end, we compared the effect of exposure to a low calorie food cue either on its own or together with a high calorie food cue. Specifically, we exposed 122 undergraduate women to a low calorie food cue (pictures of grapes), or to a high calorie food cue (pictures of cookies), or both, and examined the effect of such food-cue exposure on intake of either grapes or cookies. Restrained eaters were identified by their scores on the Revised Restraint Scale (Herman & Polivy, 1980). In line with predictions regarding dieting goal activation, restrained eaters ate less of the given food, either grapes or cookies, following exposure to the grapes cue alone than after exposure to the grapes+cookies cue. Thus the context in which a low calorie food cue is presented (alone, or in combination with a high calorie food cue) may play an important role in how much restrained eaters eat. The findings have implications for the regulation of food intake in restrained eaters.

Intake of cookies made with buriti oil (Mauritia flexuosa) improves vitamin A status and lipid profiles in young rats.

The oil extracted from Mauritia flexuosa (buriti) is rich in vitamin A, tocopherols and unsaturated fatty acids. This study evaluated the retinol status, blood glucose levels, lipid profiles, food efficiency rates (FERs), food conversion rates (FCRs) and murine anthropometric parameters of Wistar rats fed cookies made with buriti oil (BOC). The content of β-carotene and monounsaturated fatty acids in the cookies was enhanced (p < 0.05) using buriti oil. Rats fed BOC showed an increase (p < 0.05) in serum and hepatic retinol levels compared to rats fed cookies made with soy oil (SOC - control). Rats fed BOC showed lower (p < 0.05) total and LDL cholesterol than the control; however, no changes in blood glucose levels or murine anthropometric parameters were observed. Serum retinol contents showed a strong correlation (r > 0.8) with hepatic retinol, and both groups of rats showed moderate correlations (r > 0.6 < 0.5) with FERs, FCRs and weight gain. Taken together, these results indicated that buriti is an alternative to increase vitamin A in baked goods, particularly in cookies. Intake of BOC improves lipid profiles and retinol status without affecting blood glucose in young rats.

Factors associated with six-year weight change in young and middle-aged adults in the Young Finns Study

Objective. To examine factors associated with weight change and obesity risk in young and middle-aged adults. Subjects/methods. The Young Finns Study with its 923 women and 792 men aged 24–39 years at baseline were followed for six years. Variables associated with the weight change were investigated with regression models. Results. The average weight change was 0.45 kg/year in women and 0.58 kg/year in men. In women, weight change was steady across all ages. In men, weight changes were more pronounced in younger age groups. In women (weight gain > 2 kg, n = 490), medication for anxiety, low occupational status, high baseline BMI (body mass index), high intake of sweet beverages, high childhood BMI, high salt (NaCl and/or KCl) use, low number of children, low childhood family income, high stature and low level of dependence (a temperament subscale) were associated with increased weight gain (in the order of importance). In men (weight gain > 2 kg, n = 455), high stature, high intake of french fries, low intake of sweet cookies, young age, recent divorce, low intake of cereals, high intake of milk, depressive symptoms, rural childhood origin, high baseline BMI and unemployment were associated with more pronounced weight gain. Sedentarity (screen-time) was associated with weight gain only in young men. Physical activity and genetic risk for high BMI (score of 31 known variants) were not consistently associated with weight change. Conclusions. Socio-economic factors, temperamental and physical characteristics, and some dietary factors are related with weight change in young/middle-aged adults. The weight change occurring in adulthood is also determined by childhood factors, such as high BMI and low family income.

Allopregnanolone preferentially induces energy-rich food intake in male Wistar rats.

Obesity is an increasing problem and identification of the driving forces for overeating of energy‐rich food is important. Previous studies show that the stress and sex steroid allopregnanolone has a hyperphagic effect on both bland food and palatable food. If allopregnanolone induces a preference for more palatable or for more energy‐rich food is not known. The aim of this study was to elucidate the influence of allopregnanolone on food preference. Male Wistar rats were subjected to two different food preference tests: a choice between standard chow and cookies (which have a higher energy content and also are more palatable than chow), and a choice between a low caloric sucrose solution and standard chow (which has a higher energy content and is less palatable than sucrose). Food intake was measured for 1 h after acute subcutaneous injections of allopregnanolone. In the choice between cookies and chow allopregnanolone significantly increased only the intake of cookies. When the standard chow was the item present with the highest caloric load, the chow intake was increased and allopregnanolone had no effect on intake of the 10% sucrose solution. The increased energy intakes induced by the high allopregnanolone dose compared to vehicle were very similar in the two tests, 120% increase for cookies and 150% increase for chow. It appears that in allopregnanolone‐induced hyperphagia, rats choose the food with the highest energy content regardless of its palatability.

Oxytocin Reduces Reward-Driven Food Intake in Humans

Experiments in animals suggest that the neuropeptide oxytocin acts as an anorexigenic signal in the central nervous control of food intake. In humans, however, research has almost exclusively focused on the involvement of oxytocin in the regulation of social behavior. We investigated the effect of intranasal oxytocin on ingestion and metabolic function in healthy men. Food intake in the fasted state was examined 45 min after neuropeptide administration, followed by the assessment of olfaction and reward-driven snack intake in the absence of hunger. Energy expenditure was registered by indirect calorimetry, and blood was repeatedly sampled to determine concentrations of blood glucose and hormones. Oxytocin markedly reduced snack consumption, restraining, in particular, the intake of chocolate cookies by 25%. Oxytocin, moreover, attenuated basal and postprandial levels of adrenocorticotropic hormone and cortisol and curbed the meal-related rise in plasma glucose. Energy expenditure and hunger-driven food intake as well as olfactory function were not affected. Our results indicate that oxytocin, beyond its role in social bonding, regulates nonhomeostatic, reward-related energy intake, hypothalamic-pituitary-adrenal axis activity, and the glucoregulatory response to food intake in humans. These effects can be assumed to converge with the psychosocial function of oxytocin and imply possible applications in the treatment of metabolic disorders.

Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam

Serum metabolites have been linked to higher risk of chronic diseases but determinants of serum metabolites are not clear. We aimed to investigate the association between habitual diet as a modifiable risk factor and relevant serum metabolites. This cross-sectional study comprised 2380 EPIC-Potsdam participants. Intake of 45 food groups was assessed by food frequency questionnaire and concentrations of 127 serum metabolites were measured by targeted metabolomics. Reduced rank regression was used to find dietary patterns that explain the maximum variation of metabolites. In the multivariable-adjusted model, the proportion of explained variation by habitual diet was ranked as follows: acyl-alkyl-phosphatidylcholines (5.7%), sphingomyelins (5.1%), diacyl-phosphatidylcholines (4.4%), lyso-phosphatidylcholines (4.1%), acylcarnitines (3.5%), amino acids (2.2%) and hexose (1.6%). A pattern with high intake of butter and low intake of margarine was related to acylcarnitines, acyl-alkyl-phosphatidylcholines, lyso-phosphatidylcholines and hydroxy-sphingomyelins, particularly with saturated and monounsaturated fatty acid side chains. A pattern with high intake of red meat and fish and low intake of whole-grain bread and tea was related to hexose and phosphatidylcholines. A pattern consisting of high intake of potatoes, dairy products and cornflakes particularly explained methionine and branched chain amino acids. Dietary patterns related to type 2 diabetes-relevant metabolites included high intake of red meat and low intake of whole-grain bread, tea, coffee, cake and cookies, canned fruits and fish. Dietary patterns characterized by intakes of red meat, whole-grain bread, tea and coffee were linked to relevant metabolites and could be potential targets for chronic disease prevention.

Engagement with a computer game affects lunch memory and later food intake

Distraction while eating can enhance intake of afternoon snacks, perhaps due to the effects of distraction on meal memory. Here we test the hypothesis that greater engagement with a distracter (computer game) will be associated with poorer meal memory and enhanced afternoon snacking compared with either a low involvement distraction or a control condition with no distraction. Using a between subjects design, young women undergraduate students visited the laboratory to eat a fixed lunch while (1) playing a computer game for which they would win money (2) playing a computer without any incentive (3) alone in the absence of distraction. Intake of cookies at a tasting session later that afternoon was measured and participants recalled the order in which they ate lunch items and rated the memory for vividness. All participants ate all of the lunch and rated appetite during lunch did not differ according to condition. Participants ate significantly more cookies and had poorer serial recall of the lunch item order after they had eaten their lunch while playing the computer game for money than when they had eaten their lunch while playing the computer game without an incentive or without any distraction. Vividness of lunch memory was negatively correlated with cookie intake. These results suggest that there is a relationship between distraction at lunch and later food intake provide support for the idea that memory of the previous meal affects future consumption.