Insular Areas Research Articles

Running water for the officials, rainwater for the poor: symbolic use and control of water in early modern Ottoman Crete

This paper deals with the issue of water management on the island of Crete from the beginning of the Ottoman–Venetian war in 1645 to the beginning of its Egyptian administration in 1830. Based primarily on information given by Kandiye’s (mod. Herakleion) Shariah court records, but also on a variety of published and unpublished archival material from Turkey, Greece, and France, it explores the socioeconomic aspects of water-resource exploitation in the island’s urban centers, analyzes the involvement of various local and imperial actors in water management, and locates the struggles created in the above-mentioned processes. Through a detailed analysis of the challenges faced by the administration and the population of an insular area with limited water resources, such as Crete, the article tries to take a fresh look at water management on the Ottoman periphery: It redirects the researchers’ focus from heavily-populated cities and large cultivated plains to the examination of smaller regions with no major hydraulic and irrigation networks and puts emphasis on the symbolic use of water in the socioeconomic context of the Ottoman Empire.

Accessibility and Spatial Inequalities in Greece

Accessibility suggests a major issue in rural areas. Remoteness or inaccessibility is known to amplify rural deprivation and suspend sustainable regional development. Many rural areas in Greece suffer from remoteness mainly because of a varying and continuously alternating terrain. A diverse space is shaped by more than 70% mountain areas, hundreds of inhabited islands in an insular area almost the size of the mainland and intense variation in population distribution between the large urban agglomerations and the periphery. In this paper, a geographical remoteness index for Greece is presented that can capture the required scale of analysis and the distinct characteristics of Greek space. The index is localized and evaluated using empirical and theoretical methods and several demographic and network geostatistics. Finally, we examine the relationship of the index and critical socioeconomic variables in order to associate accessibility with spatial inequalities. Spatial regression models are used that uncover the impact of remoteness in certain key development aspects, namely economy, human capital and infrastructures. Potentially, accessibility may be used as an evaluation tool to redirect policies for spatial equity.

Determination of fire risk to assist fire management for insular areas: the case of a small Greek island

Forest fire risk estimation constitutes an essential process to prevent high-intensity fires which are associated with severe implications to the natural and cultural environment. The primary aim of this research was to determine fire risk levels based on the local features of an island, namely, the impact of fuel structures, slope, aspects, as well as the impact of the road network and inhabited regions. The contribution of all the involved factors to forest fires ignition and behavior highlight certain regions which are highly vulnerable. In addition, the influence of both natural and anthropogenic factors to forest fire phenomena is explored. In this study, natural factors play a dominant role compared to anthropogenic factors. Hence essential preventative measures must focus on specific areas and established immediately. Indicative measures may include: the optimal allocation of watchtowers as well as the spatial optimization of mobile firefighting vehicles; and, forest fuel treatments in areas characterized by extremely high fire risk. The added value of this fire prediction tool is that it is highly flexible and could be adopted elsewhere with the necessary adjustments to local characteristics.

Structural and functional alterations in the brain during working memory in medication-naïve patients at clinical high-risk for psychosis.

Several previous studies suggest that clinical high risk for psychosis (CHR) is associated with prefrontal functional abnormalities and more widespread reduced grey matter in prefrontal, temporal and parietal areas. We investigated neural correlates to CHR in medication-naïve patients. 41 CHR patients and 37 healthy controls were examined with 1.5 Tesla MRI, yielding functional scans while performing an N-back task and structural T1-weighted brain images. Functional and structural data underwent automated preprocessing steps in SPM and Freesurfer, correspondingly. The groups were compared employing mass-univariate strategy within the generalized linear modelling framework. CHR demonstrated reduced suppression of the medial temporal lobe (MTL) regions during n-back task. We also found that, consistent with previous findings, CHR subjects demonstrated thinning in prefrontal, cingulate, insular and inferior temporal areas, as well as reduced hippocampal volumes. The present findings add to the growing evidence of specific structural and functional abnormalities in the brain as potential neuroimaging markers of psychosis vulnerability.

The association of protein and carbohydrate intake with successful aging: a combined analysis of two epidemiological studies.

Previous studies have reported associations between levels of protein and carbohydrate intake with several health outcomes. Yet, their effect on successful (or healthy) aging remains unknown. The purpose of the present work was to investigate the association of protein and carbohydrate intake levels with successful aging. A cross-sectional analysis was carried out on the participants of two epidemiological studies; the ATTICA and the MEDIS studies. Anthropometrical, clinical and socio-demographic characteristics, dietary habits, and lifestyle parameters were derived through standard procedures. Successful aging was evaluated using a validated index (SAI) composed of 10 health-related social, lifestyle and clinical characteristics. SAI levels were lower in low protein-high carbohydrate diet group (B = - 0.08, p = 0.04), but higher in high protein-high carbohydrate group (B = 0.06, p = 0.04), as compared to low protein and low carbohydrate diet, in participants living in insular areas. Protein-carbohydrate diet was not associated with SAI (all p's > 0.05) among participants living in urban areas (p for diet-study interaction < 0.001). A high protein diet seems to be beneficial for older islanders in terms of successful aging; stating a hypothesis for a potential diet-environmental interaction that may be related to the quality of foods consumed and, consequently the sources of nutrients.

Distinguishing Adolescents With Conduct Disorder From Typically Developing Youngsters Based on Pattern Classification of Brain Structural MRI.

Background: Conduct disorder (CD) is a mental disorder diagnosed in childhood or adolescence that presents antisocial behaviors, and is associated with structural alterations in brain. However, whether these structural alterations can distinguish CD from healthy controls (HCs) remains unknown. Here, we quantified these structural differences and explored the classification ability of these quantitative features based on machine learning (ML).Materials and Methods: High-resolution 3D structural magnetic resonance imaging (sMRI) was acquired from 60 CD subjects and 60 age-matched HCs. Voxel-based morphometry (VBM) was used to assess the regional gray matter (GM) volume difference. The significantly different regional GM volumes were then extracted as features, and input into three ML classifiers: logistic regression, random forest and support vector machine (SVM). We trained and tested these ML models for classifying CD from HCs by using fivefold cross-validation (CV).Results: Eight brain regions with abnormal GM volumes were detected, which mainly distributed in the frontal lobe, parietal lobe, anterior cingulate, cerebellum posterior lobe, lingual gyrus, and insula areas. We found that these ML models achieved comparable classification performance, with accuracy of 77.9 ∼ 80.4%, specificity of 73.3 ∼ 80.4%, sensitivity of 75.4 ∼ 87.5%, and area under the receiver operating characteristic curve (AUC) of 0.76 ∼ 0.80.Conclusion: Based on sMRI and ML, the regional GM volumes may be used as potential imaging biomarkers for stable and accurate classification of CD.

F163. STRUCTURAL AND FUNCTIONAL ALTERATIONS IN THE BRAIN DURING WORKING MEMORY IN MEDICATION-NAïVE PATIENTS AT CLINICAL HIGH-RISK FOR PSYCHOSIS

BackgroundThe pre-TIPS study in 1994–95 showed that the duration of untreated psychosis (DUP) was long in our region with a mean value of 2.1 years, and median 26 weeks. This set the stage for the TIPS-study (1997–2000), reducing DUP through information campaigns targeted to the general population and other referral agents (GP’s, schools and others) in Rogaland County (Norway). The information campaigns were launched together with a low threshold organization with direct access to an early detection team, for a diagnostic interview and help. The hypothesis was that this could change help seeking behavior, awareness towards psychosis and thus reduce the DUP. The information campaigns and the early detection team were introduced in an early detection(ED) area (Rogaland county, Norway) comparing DUP with two usual-detection control sites in Oslo (Norway) and Roskilde (Denmark). As a result, DUP in the early detection area was reduced from 26 weeks median to 4 weeks median. Symptom and function advantages of early detection and DUP reduction have been demonstrated as being significant throughout the follow-up period. Social and functional outcome have been increasingly emphasized as being key parameters, as these contribute to both quality of life and to financial costs in society. The TIPS program continues to include and follow patients; since the mid 2000’s also young people with ultra-high risk states (Prevention of Psychosis; POP) or substance induced psychoses.Previous ultra-high risk studies suggest that psychotic disorders are associated with structural and functional abnormalities within the frontoparietal circuits and that medication status is a potential confounding factor. We investigated neural correlates to ultra-high risk (UHR) for psychosis in medication-naïve patients.Methods41 CHR patients and 37 healthy controls were examined with 1.5 Tesla MRI, yielding functional scans while performing an N-back task and structural T1-weighted brain images. Functional and structural data underwent automated preprocessing steps in SPM and Freesurfer, correspondingly. The groups were compared employing mass-univariate strategy within the generalized linear modelling framework.ResultsUHR demonstrated reduced suppression of the medial temporal lobe (MTL) regions during n-back task. We also found that, consistent with previous findings, UHR subjects demonstrated thinning in prefrontal, cingulate, insular and inferior temporal areas, as well as reduced hippocampal volumes.DiscussionThe present findings add to the growing evidence of specific structural and functional abnormalities in the brain as potential neuroimaging markers of psychosis vulnerability.

Wild mushroom food custom in the insular area of southwest Japan

Wild mushroom food custom in the insular area of southwest Japan

Motor signatures of emotional reactivity in frontotemporal dementia

Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However, the pathophysiology of emotional reactivity in these diseases has not been elucidated. We studied facial electromyographic responses during emotion identification on viewing videos of dynamic facial expressions in 37 patients representing canonical frontotemporal dementia syndromes versus 21 healthy older individuals. Neuroanatomical associations of emotional expression identification accuracy and facial muscle reactivity were assessed using voxel-based morphometry. Controls showed characteristic profiles of automatic imitation, and this response predicted correct emotion identification. Automatic imitation was reduced in the behavioural and right temporal variant groups, while the normal coupling between imitation and correct identification was lost in the right temporal and semantic variant groups. Grey matter correlates of emotion identification and imitation were delineated within a distributed network including primary visual and motor, prefrontal, insular, anterior temporal and temporo-occipital junctional areas, with common involvement of supplementary motor cortex across syndromes. Impaired emotional mimesis may be a core mechanism of disordered emotional signal understanding and reactivity in frontotemporal dementia, with implications for the development of novel physiological biomarkers of socio-emotional dysfunction in these diseases.

Variación temporal de la diversidad taxonómica y rasgos funcionales de los macroinvertebrados acuáticos en ríos temporales en la isla de Providencia, Colombia

Intermittent streams in Colombia are located principally in dry forest zones and are important in maintaining the hydrological cycle and sustaining biodiversity and the water supply for local human populations. Some aspects of the functioning of these systems are not known in detail, especially in insular areas. This study describes the changes in the species composition, diversity, and some functional traits of macroinvertebrates related to discharge fluctuations in three intermittent streams on Old Providence Island. Sampling was performed during dry and rainy seasons. Ten (10) and 50 functional traits categories were selected, including trophic, physiological, morphological, behavioral and life cycle characteristics. A principal component analysis confirmed a strong seasonality associated with changes in electric conductivity, alkalinity, and dissolved oxygen. Sixty genus-level morphotypes were identified, with highest diversity in the Chironomidae (Diptera). According to a Canonical Correspondence Analysis, Chironomus , Pyrgophorus , Haitia and Dero were associated with high values in electrical conductivity, dissolved oxygen, and total hardness. With respect to functional traits, during dry season mechanisms for resisting specialized to resist the desiccation (cocoon or diapause), asexual reproduction, seasonal short life cycles, preferences for litter microhabitat, and trophic habit scrapers redominated, such as Ancylidae , Dero, Anopheles , Microvelia and Neritina . During rainy season bodies protected with shells or cases, seasonal long life cycles, and trophic collectors were found, such as Macrobrachium , Polypedilum, Helicopsyche, Beardius and Chironomus . In conclusion, hydrological conditions affect the taxonomic and functional structure of the macroinvertebrates, and some physiological traits and life histories are essential for persistence in temporal environments.

Brain Perfusion Correlates of Apathy in Alzheimer's Disease.

Background and PurposeApathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer's disease (AD). It may have adverse impacts on the progression of AD. However, its neurobiological underpinnings remain unclear. The objective of this study was to investigate differences in regional cerebral blood flow (rCBF) between AD patients with apathy and those without apathy.MethodsSixty-six apathetic AD patients and 66 AD patients without apathy completed Neuropsychiatric Inventory (NPI) and underwent technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) scans. Voxel-wise differences in rCBF between the 2 groups were examined. Association between rCBF and levels of apathy in the apathetic group was also assessed.ResultsAD patients with apathy showed lower rCBF in the bilateral orbitofrontal cortex, left putamen, left nucleus accumbens, left thalamus, and bilateral insula than those without (all p<0.005). Mean perfusion across all significant clusters showed a negative linear correlation with NPI apathy score in AD patients with apathy (β=−0.25; p=0.04).ConclusionsHypoperfusion in the prefrontal, striatal, and insular areas may be neural correlates of apathy in AD patients.

Narrative production in low-educated individuals with Alzheimer’s Disease and its relation to cognitive and brain volume measures

Narrative production in low-educated individuals with Alzheimer’s Disease and its relation to cognitive and brain volume measures

Association Between IDH1 and IDH2 Mutations and Preoperative Seizures in Patients with Low-Grade Versus High-Grade Glioma: A Systematic Review and Meta-Analysis.

Patients with brain tumors, particularly gliomas, commonly present with seizures. Higher incidence of seizure has been reported in low-grade gliomas and tumors located within the temporal and insular area. The association between IDH1 and IDH2 mutations with preoperative seizures in glioma and the magnitude of this association in low-grade versus high-grade gliomas are unclear. To clarify this relationship, a systematic review and meta-analysis was performed. Following accepted guidelines and systematic review recommendations, electronic searches were performed in journal databases up to May 2017. Data were extracted and pooled via meta-analysis. We compared 782 patients with IDH1 and IDH2 mutations with 803 patients with wild-type IDH1 and IDH2 before surgery. There was a significant difference in seizure incidence between the IDH1 mutation group (61.6%) and wild-type IDH1 group (32.1%) (odds ratio 2.76; 95% confidence interval, 1.26-6.02; I2= 73%; P= 0.01). Similar findings were observed in analysis of IDH1 and IDH2 mutations (odds ratio 2.74; 95% confidence interval, 1.74-4.33; I2= 58%; P < 0.0001). The difference remained in both mutation groups (IDH1, IDH1 and IDH2) with grade II gliomas but not with grade III and IV gliomas. Patients with grade II gliomas showed a higher rate of IDH1 and IDH2 mutations and seizures than patients with grade III and IV gliomas. This study demonstrated a significant association of IDH1 and IDH2 mutations with incidence of preoperative seizures. This association was significant only in patients with low-grade glioma (grade II) and not in patients with higher grade gliomas (grade III and IV).

A Radial Glia Fascicle Leads Principal Neurons from the Pallial-Subpallial Boundary into the Developing Human Insula.

The human insular lobe, in the depth of the Sylvian fissure, displays three main cytoarchitectonic divisions defined by the differentiation of granular layers II and IV. These comprise a rostro-ventral agranular area, an intermediate dysgranular area, and a dorso-caudal granular area. Immunohistochemistry in human embryos and fetuses using antibodies against PCNA, Vimentin, Nestin, Tbr1, and Tb2 reveals that the insular cortex is unique in that it develops far away from the ventricular zone (VZ), with most of its principal neurons deriving from the subventricular zone (SVZ) of the pallial-subpallial boundary (PSB). In human embryos (Carnegie stage 16/17), the rostro-ventral insula is the first cortical region to develop; its Tbr1+ neurons migrate from the PSB along the lateral cortical stream. From 10 gestational weeks (GW) onward, lateral ventricle, ganglionic eminences, and PSB grow forming a C-shaped curvature. The SVZ of the PSB gives rise to a distinct radial glia fiber fascicle (RGF), which courses lateral to the putamen in the external capsule. In the RGF, four components can be established: PF, descending from the prefrontal PSB to the anterior insula; FP, descending from the fronto-parietal PSB toward the intermediate insula; PT, coursing from the PSB near the parieto-temporal junction to the posterior insula, and T, ascending from the temporal PSB and merging with components FP and PT. The RGF fans out at different dorso-ventral and rostro-caudal levels of the insula, with descending fibers predominating over ascending ones. The RGF guides migrating principal neurons toward the future agranular, dysgranular, and granular insular areas, which show an adult-like definition at 32 GW. Despite the narrow subplate, and the absence of an intermediate zone except in the caudal insula, most insular subdivisions develop into a 6-layered isocortex, possibly due to the well developed outer SVZ at the PSB, which is particularly prominent at the level of the dorso-caudal insula. The small size of the initial PSB sector may, however, determine the limited surface expansion of the insula, which is in contrast to the exuberant growth of the opercula deriving from the adjacent frontal-parietal and temporal VZ/SVZ.

Effects of isolation on ant assemblages depend on microhabitat

AbstractHow isolation affects biological communities is a fundamental question in ecology and conservation biology. Local diversity (α) and regional diversity (γ) are consistently lower in insular areas. The pattern of species turnover (β diversity) and the influence of isolation on competitive interactions are less predictable. Differences in communities across microhabitats within an isolated patch could contribute to the variability in patterns related to isolation. Trees form characteristically dense and sparse patches (low vs. high isolation) in floating marshes in coastal Louisiana, and canopy and root areas around these trees could support distinct ant communities. Consequently, trees in floating marshes provide an ideal environment to study the effects of isolation on community assemblages in different microhabitats. We sampled ant communities in 120 trees during the summer of 2016. We found ant α diversity was not different between the canopy and roots, and the magnitude and directional effects of isolation on ants were inconsistent between the canopy and root areas. In the roots of sparse sites, ant diversity (α, β, and γ) was lower, species composition was changed, and the signature of interspecific competition was more prominent compared to dense sites. In the canopy, however, significant differences between dense and sparse sites were only detected in α and γ diversity, and ant species co‐occurrence was not significantly different from a random distribution. The inconsistent responses of ants in canopy and root areas to isolation may be due to the differences of species pool size, environmental harshness, and species interactions between strata. In addition, these findings indicate that communities in distinct microenvironments can respond differentially to habitat isolation. We suggest incorporating organisms from different microhabitats into future research to better understand the influence of isolation on the assembly of biological communities.

Fungal Endophyte Communities in Begonia Species from the Brazilian Atlantic Rainforest.

Tropical plants represent hotspots of endophytic fungal species diversity. Based on culture-dependent methods, we evaluated the endophytic fungal communities in leaves of three plant species found in the Brazilian Atlantic Rainforest: Begonia fischeri, Begonia olsoniae, and Begonia venosa. These species are found in two distant sites: a continental region and an insular area. A total of 426 fungal endophytes in 19 genera were isolated in pure culture including Colletotrichum (51.6% of isolates) and Diaporthe (22.5%) as the most abundant, followed by Phyllosticta (3.5%), Neopestalotiopsis (1.8%), Stagonospora (1.8%), and Nigrospora (1.6%) among the genera found in minor abundance. The diversity and composition of fungal taxa differed across plant hosts. Richness and diversity of fungi were higher in B. fischeri in comparison to B. olsoniae and B. venosa. Discriminatory analysis revealed that fungal communities are structured according to hosts, which means that each plant species had its distinct endophytic communities, but dominated by common fungal taxa. This is the first study to report fungal endophytes in begonia leaves and characterize their communities.

Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making.

Rat orbitofrontal cortex (OFC) is located in the dorsal bank of the rhinal sulcus, and is divided into the medial orbital area, ventral orbital area, ventrolateral orbital area, lateral orbital area, dorsolateral orbital area, and agranular insular areas. Over the past 20 years, there has been a marked increase in the number of publications focused on the functions of rat OFC. While collectively this extensive body of work has provided great insight into the functions of OFC, leading to theoretical and computational models of its functions, one issue that has emerged relates to what is defined as OFC because targeting of this region can be quite variable between studies of appetitive behavior, even within the same species. Also apparent is that there is an oversampling and undersampling of certain subregions of rat OFC for study, and this will be demonstrated here. The intent of the Viewpoint is to summarize studies in rat OFC, given the diversity of what groups refer to as "OFC," and to integrate these with the findings of recent anatomical studies. The primary aim is to help discern functions in reward learning and decision-making, clearing the course for future empirical work.

Come together: human-avatar on-line interactions boost joint-action performance in apraxic patients.

Limb apraxia (LA) is a high-order motor disorder linked to left-hemisphere damage. It is characterized by defective execution of purposeful actions upon delayed imitation, or verbal command when the actions are performed in isolated, non-naturalistic, conditions. Whether interpersonal interactions provide social affordances that activate neural resources different from those requested by individual action execution, which may improve LA performance, is unknown. To fill this gap, we measured interaction performance, behavioral and kinematic indexes of left-brain damaged patients with/without LA in a social reach-to-grasp task involving two different degrees of spatio-temporal interactivity with an avatar. We found that LA patients’ impairment in coordinating with the virtual partner was abolished in highly interactive conditions (where patients selected their actions on-line based on the behavior of the virtual partner) with respect to low interactive conditions (where actions were selected beforehand based on abstract instructions). Voxel-based-Lesion-Symptom-Mapping indicated that impairments in low-interactive conditions were underpinned by lesions of premotor, motor and insular areas, and of the basal ganglia. Our approach expands current understanding of the behavioral and neural correlates of interactive motor performance by highlighting the important role of social affordances, and provides novel, potentially important, views on rehabilitation of higher-order motor cognition disorders.

Neural Activity Patterns in the Human Brain Reflect Tactile Stickiness Perception.

Our previous human fMRI study found brain activations correlated with tactile stickiness perception using the uni-variate general linear model (GLM) (Yeon et al., 2017). Here, we conducted an in-depth investigation on neural correlates of sticky sensations by employing a multivoxel pattern analysis (MVPA) on the same dataset. In particular, we statistically compared multi-variate neural activities in response to the three groups of sticky stimuli: A supra-threshold group including a set of sticky stimuli that evoked vivid sticky perception; an infra-threshold group including another set of sticky stimuli that barely evoked sticky perception; and a sham group including acrylic stimuli with no physically sticky property. Searchlight MVPAs were performed to search for local activity patterns carrying neural information of stickiness perception. Similar to the uni-variate GLM results, significant multi-variate neural activity patterns were identified in postcentral gyrus, subcortical (basal ganglia and thalamus), and insula areas (insula and adjacent areas). Moreover, MVPAs revealed that activity patterns in posterior parietal cortex discriminated the perceptual intensities of stickiness, which was not present in the uni-variate analysis. Next, we applied a principal component analysis (PCA) to the voxel response patterns within identified clusters so as to find low-dimensional neural representations of stickiness intensities. Follow-up clustering analyses clearly showed separate neural grouping configurations between the Supra- and Infra-threshold groups. Interestingly, this neural categorization was in line with the perceptual grouping pattern obtained from the psychophysical data. Our findings thus suggest that different stickiness intensities would elicit distinct neural activity patterns in the human brain and may provide a neural basis for the perception and categorization of tactile stickiness.

Aberrant patterns of brain cerebral blood flow in Chinese han first-episode drug-naïve depressive patients with and without a family history of depression.

A positive family history plays a key role in the brain pathology of depression patients and previous research has confirmed that disturbed mood maintenance may be related to abnormal regional cerebral blood flow (rCBF). However, little is known about whether the rCBF is different between depression patients with and without family histories. To address this question, we examined the rCBF in drug-naïve, first-episode depression patients with and without family histories of depression using a 3D pseudo-continuous arterial spin-labelling technique. We found that decreased rCBF was predominantly observed in the patients without family histories, while decreased and increased rCBF co-existed in patients with family histories. The observed brain regions with altered rCBF were associated with affection processing, such as the prefrontal, occipital and insular areas. However the patterns of rCBF alteration observed in the present study were different from those found in previous studies where patients were compared with healthy controls. Our present findings, together with the findings from previous studies have prompted the need of a long-term follow-up study to characterize the brain features of the developmental trajectory of depression and investigate the targets for precise, personalized treatments.