Abstract Osteoporosis is a skeletal disorder resulting from decreased bone mass that results in increased liability to fractures. Several chronic diseases including dermatological diseases were reported to affect bone mineral density with resulting osteopenia and osteoporosis. Aim of the Study to evaluate the prevalence of osteopenia and osteoporosis in chronic skin diseases. Patients and Methods One hundred patients diagnosed with chronic primary dermatological diseases divided into 4 groups according to dermatological disease were included in the current study. Assessment of BMD by DEXA scan and estimation of serum level of vitamin D were performed. Results In all studied patients, there was no significant association between osteopenia/osteoporosis and studied dermatological diseases or vitamin D levels as T score analysis either lumbar, femoral or forearm in relation to vitamin D status and disease severity. There was significant association of insufficient vitamin D levels with all skin diseases but there was no significant association between T score results and vitamin D status in studied patients. Conclusion The current study revealed that dermatological diseases were associated with insufficient levels of vitamin D.