The Vietnamese economy is on the rise, but faces a number of problems. One of the most serious is interregional inequality, which is aggravated in the conditions of modern restrictions and international sanctions. The authors of the article show that the nature of interregional inequality in Vietnam and Russia has much in common. Due to the high concentration of financial and investment resources in several territorial points of growth, there is an intensive development of the regions around these points, the rest of the regions to some extent lag the leading regions in economic development. The Vietnamese government has dealt with the problem of significant inter-regional disparities with varying degrees of success. Among the most notable instruments of regional development aimed at reducing inter-regional inequality are international investment projects at the regional level, cross-border cooperation, development of special territories and industrial zones. Considering the common nature of interregional inequality, it is possible for Russia and Vietnam to exchange experience and jointly develop projects aimed at developing a science-based regional policy aimed at reducing interregional inequality.