ObjectiveTo investigate the feasibility of post-stroke interventions using a motivational instructional design model with occupational and swallowing therapies and the model's potential physical and mental health effects. DesignAn open-label, single-arm, feasibility study on the Attention, Relevance, Confidence, and Satisfaction (ARCS) model. SettingTwo convalescent rehabilitation wards. ParticipantsTwenty-five patients with stroke (19 males; mean age 62.4 ± 11.9 years; 61.9 ± 36.8 days from the first stroke) were recruited. InterventionsTwelve participants received a motivational approach based on the ARCS model during occupational therapy (OT group), and 13 received it during swallowing therapy (ST group). The intervention lasted 40–60 min daily, 5 days weekly, for 4 weeks. Main Outcome MeasuresThe primary outcomes included the drop-out rate, an adverse event, and the participants’ acceptability of the intervention. Paretic arm function was assessed in the OT group, swallowing ability in the ST group, and activities of daily living, depressive symptoms, and apathy in both groups. ResultsNo participants dropped out of the intervention or experienced an adverse event. Twenty-one participants (84%) were satisfied with the intervention, and 19 (76%) hoped to continue receiving it. The OT group showed statistically significant improvements in paretic arm function and activities of daily living for the OT group (Cohen's r = 0.68–0.77), whereas the ST group improved in swallowing ability, activities of daily living, and depressive symptoms (Cohen's r = 0.62–0.85). ConclusionsThe interventions using the motivational instructional model with occupational and swallowing therapies were feasible and could improve post-stroke paretic arm function, swallowing ability, and activities of daily living after stroke.