Institute Grant Research Articles

Randomized phase II trial of encorafenib and cetuximab with or without nivolumab for patients with previously treated, microsatellite stable, BRAFV600E metastatic and/or unresectable colorectal cancer: SWOG S2107.

TPS265 Background: Patients with microsatellite stable (MSS), BRAFV600E metastatic colorectal cancer (mCRC) experience poor survival outcomes. Treatment with the BRAF inhibitor encorafenib (E) and anti-EGFR antibody cetuximab (C) is an approved treatment combination, with a reported overall response rate (ORR) of 20% and median progression-free survival (PFS) of 4.1 months. Anti-PD-1 antibodies like nivolumab (N) are ineffective as monotherapy for patients with MSS, BRAFV600E mCRC. In preclinical models of MSS, BRAFV600E CRC, inhibition of BRAF and EGFR induces a loss of expression of mismatch repair genes and promotes a microsatellite instability-high phenotype, which may prime these tumors for response to immunotherapy. In support of these findings, a single-institution clinical trial of E + C + N for 26 patients with MSS, BRAFV600E mCRC reported an ORR of 50% and median PFS of 7.2 months. We hypothesize that the addition of N to E + C will improve median PFS for patients with MSS, BRAFV600E mCRC. Methods: In this prospective phase II clinical trial (N = 75), patients with previously treated MSS, BRAFV600E mCRC will be randomized 2:1 into 2 arms, respectively: experimental treatment (E + C + N) or standard treatment (E + C). No prior BRAF, EGFR, or immunotherapy agents are allowed. All patients will receive E (300 mg PO daily) and C (500 mg/m2 IV every 14 days), and patients in the experimental arm will receive N (480 mg IV every 28 days). The primary endpoint is PFS. Secondary endpoints include overall survival, best overall response, duration of response, and safety/tolerability. Using a one-sided α = .10 and power 80%, we target an improvement in median PFS from 4.2 to 7.3 months and a hazard ratio of 0.57. Additional patient specimens will be collected for exploratory correlative research. The study activated across the United States in June 2022 and as of September 2022 has enrolled 2 of 75 planned participants. Funding: NIH/National Cancer Institute grants U10CA180888, U10CA180819, U10CA180820, U10CA180821, U10CA180868; and in part by The Hope Foundation for Cancer Research STrS award. Clinical trial information: NCT05308446 .

SOD2 in platelets: with age comes responsibility

SOD2 in platelets: with age comes responsibility

Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia.

Children with acute pneumonia may be vitamin D deficient. Clinical trials have found that prophylactic vitamin D supplementation decreases children's risk of developing pneumonia. Data on the therapeutic effects of vitamin D in acute childhood pneumonia are limited. This is an update of a Cochrane Review first published in 2018. To evaluate the efficacy and safety of vitamin D supplementation as an adjunct to antibiotics for the treatment of acute childhood pneumonia. We searched CENTRAL, MEDLINE, Embase, and two trial registries on 28 December 2021. We applied no language restrictions. We included randomised controlled trials (RCTs) that compared vitamin D supplementation with placebo in children (aged one month to five years) hospitalised with acute community-acquired pneumonia, as defined by the World Health Organization (WHO) acute respiratory infection guidelines. For this update, we reappraised eligible trials according to research integrity criteria, excluding RCTs published from April 2018 that were not prospectively registered in a trials registry according to WHO or Clinical Trials Registry - India (CTRI) guidelines (it was not mandatory to register clinical trials in India before April 2018). Two review authors independently assessed trials for inclusion and extracted data. For dichotomous data, we extracted the number of participants experiencing the outcome and the total number of participants in each treatment group. For continuous data, we used the arithmetic mean and standard deviation (SD) for each treatment group together with number of participants in each group. We used standard methodological procedures expected by Cochrane. In this update, we included three new trials involving 468 children, bringing the total number of trials to seven, with 1601 children (631 with pneumonia and 970 with severe or very severe pneumonia). We categorised three previously included studies and three new studies as 'awaiting classification' based on the research integrity screen. Five trials used a single bolus dose of vitamin D (300,000 IU in one trial and 100,000 IU in four trials) at the onset of illness or within 24 hours of hospital admission; one used a daily dose of oral vitamin D (1000 IU for children aged up to one year and 2000 IU for children aged over one year) for five days; and one used variable doses (on day 1, 20,000 IU in children younger than six months, 50,000 IU in children aged six to 12 months, and 100,000 IU in children aged 13 to 59 months; followed by 10,000 IU/day for four days or until discharge). Three trials performed microbiological diagnosis of pneumonia, radiological diagnosis of pneumonia, or both. Vitamin D probably has little or no effect on the time to resolution of acute illness (mean difference (MD) -1.28 hours, 95% confidence interval (CI) -5.47 to 2.91; 5 trials, 1188 children; moderate-certainty evidence). We do not know if vitamin D has an effect on the duration of hospitalisation (MD 4.96 hours, 95% CI -8.28 to 18.21; 5 trials, 1023 children; very low-certainty evidence). We do not know if vitamin D has an effect on mortality rate (risk ratio (RR) 0.69, 95% CI 0.44 to 1.07; 3 trials, 584 children; low-certainty evidence). The trials reported no major adverse events. According to GRADE criteria, the evidence was of very low-to-moderate certainty for all outcomes, owing to serious trial limitations, inconsistency, indirectness, and imprecision. Three trials received funding: one from the New Zealand Aid Corporation, one from an institutional grant, and one from multigovernment organisations (Bangladesh, Sweden, and UK). The remaining four trials were unfunded. Based on the available evidence, we are uncertain whether vitamin D supplementation has important effects on outcomes of acute pneumonia when used as an adjunct to antibiotics. The trials reported no major adverse events. Uncertainty in the evidence is due to imprecision, risk of bias, inconsistency, and indirectness.

Implementation and expansion of inpatient and ambulatory pharmacist credentialing and privileging at an academic medical center.

This article highlights one academic medical center's effort to implement a complete credentialing and privileging (C&P) process for both inpatient and ambulatory clinical pharmacists. The C&P process offers a recognized method to advance pharmacy practice. Credentialing is defined as a process whereby an individual is deemed qualified in a specific subject matter area. Privileging is the process whereby an institution grants authority to an individual to perform services based on credentials. Federal guidelines permit pharmacists to obtain the same level of privileges as professional medical staff, such as physicians, if relevant state laws allow for the corresponding pharmacist scope of practice. States establish laws and regulations that specify the scope of practice for various types of licensed healthcare professionals, including pharmacists. Many health systems have attempted pharmacist C&P practices in both the inpatient and ambulatory care setting with varying degrees of success and reach. Privileged pharmacists provide established benefits and value to other members of the healthcare team. Oregon Health & Science University (OHSU) pursued C&P for both inpatient and ambulatory clinical pharmacists. Initiation and implementation processes were complex and accompanied by a variety of challenges. OHSU operates with advanced pharmacy practice integrated into the interdisciplinary patient care team. Pharmacist C&P allows pharmacists to demonstrate significant clinical benefits and quality improvement in patient care delivery in both inpatient and ambulatory settings.

Synthetic Feature Generation to Improve Accuracy in Prediction of Credit Limits

Financial institutions use various data mining algorithms to determine the credit limits for individuals using features like age, education, employment, gender, income, and marital status. But, there is still a question of accurate predictability, that is, how accurate can an institution be in predicting risk and granting credit levels. If an institution grants too low of a credit limit/loan for an individual, then the institution may lose business to competitors, but if the institution grants too high of a credit limit/loan, then the institution may lose money if that individual does not repay the credit/loan. The novelty of this work is that it shows how to improve the accuracy in predicting credit limits/loan amounts using synthetic feature generation. By creating secondary groupings and including both the original binning and the synthetic bins, the classification accuracy and other statistical measures like precision and ROC improved substantially. Hence, our research showed that without synthetic feature generation, the classification rates were low, and the use of synthetic features greatly improved the classification accuracy and other statistical measures.

Therapeutic Neovascularization for Refractory Angina-Are We Any Closer?

Therapeutic Neovascularization for Refractory Angina-Are We Any Closer?

Synthetic feature generation to improve accuracyin prediction of credit limits

Financial institutions use various data mining algorithms to determine the credit limits for individuals using featureslike age, education, employment, gender, income, and marital status. But, there is still a question of accuratepredictability, that is, how accurate can an institution be in predicting risk and granting credit levels. If an institutiongrants too low of a credit limit/loan for an individual, then the institution may lose business to competitors, butif the institution grants too high of a credit limit/loan, then the institution may lose money if that individual doesnot repay the credit/loan. The novelty of this work is that it shows how to improve the accuracy in predictingcredit limits/loan amounts using synthetic feature generation. By creating secondary groupings and includingboth the original binning and the synthetic bins, the classification accuracy and other statistical measures likeprecision and ROC improved substantially. Hence, our research showed that without synthetic feature generation,the classification rates were low, and the use of synthetic features greatly improved the classification accuracy andother statistical measures.

Metodika tvorby a zaisťovania chodníčka bipedálnej ľudskej lokomócie

A part of specific methods in criminalistics applied in practice is tracology, used for obtaining and documenting evidence from crime scenes. Tracology deals with various types of evidence, including footprints, tire tracks, and footwear. We must not overlook traces left by lips, teeth, or other parts of the human body. This work describes the creation of a human locomotion pathway on a surface. The pathway is generated by the coloured soles of an individual walking to collect documents. In a real-life scenario, we can envision a situation where a perpetrator steps in the victim's blood and then walks across a carpet, leaving traces in the process. After leaving these traces, a forensic expert can secure and extract necessary information from them. This information may include parameters such as the length of a single step or a pair of steps, which can subsequently be used in mathematical models to estimate the body height of the individual. The presented article focuses on the approach to the field of tracology, which represents a distinct scientific discipline within the realm of criminalistics. Specifically, in this article, our emphasis is on presenting the measurement and data collection process in connection with the resolution of an institutional grant project.

Synthetic feature generation to improve accuracyin prediction of credit limits

Financial institutions use various data mining algorithms to determine the credit limits for individuals using featureslike age, education, employment, gender, income, and marital status. But, there is still a question of accuratepredictability, that is, how accurate can an institution be in predicting risk and granting credit levels. If an institutiongrants too low of a credit limit/loan for an individual, then the institution may lose business to competitors, butif the institution grants too high of a credit limit/loan, then the institution may lose money if that individual doesnot repay the credit/loan. The novelty of this work is that it shows how to improve the accuracy in predictingcredit limits/loan amounts using synthetic feature generation. By creating secondary groupings and includingboth the original binning and the synthetic bins, the classification accuracy and other statistical measures likeprecision and ROC improved substantially. Hence, our research showed that without synthetic feature generation,the classification rates were low, and the use of synthetic features greatly improved the classification accuracy andother statistical measures.

Intersectionality of Self-Reported Food Insecurity and Perceived Stress of College Students at a Land-Grant Southeastern Higher Education Institution during the COVID-19 Pandemic

College food insecurity (FI) and poor psychosocial health are prevalent public health issues in the U.S., yet often overlooked. Since the COVID-19 pandemic, repercussions on these critical inequity issues remain unclear. During the summer months of 2020, this cross-sectional survey examined associations between students’ self-reported FI and perceived stress (PSS-10), one aspect of poor psychosocial health. An anonymous online survey was distributed to a convenience sample of college students at a land grant institution of higher education in the southeastern U.S., and $10 e-gift card was provided to survey respondents. The survey response rate was 26.2% (n=235) and participants were predominantly female, White, and from upper-division including junior and senior students. Among respondents, 31.3% were food insecure and 37.8% were laid off or temporarily furloughed. Students who worked before the pandemic were 3.49 times more likely to continue working despite the pandemic; however, employment status was not significantly associated with since-PSS-10 scores or FI. In multiple linear regression models, pre-PSS-10 scores, age, and lower division were significant predictors of since-PSS-10 scores. Additionally, students experiencing FI and having higher pre-PSS-10 scores were predicted of having higher since-PSS-10 scores. This study adds important findings about college FI and perceived stress to the limited literature regarding college student health during the pandemic. A more rigorous study design with a larger, nationally or regionally representative sample is recommended for future studies. To address both complex issues of college FI and poor psychosocial health, a multi-faceted interdisciplinary approach, well-supported by college administrators, would be warranted.

Describing College Success Indicators for First-Generation College Students in Colleges of Agriculture

Earning a bachelor’s degree has been documented as a potential social equalizer in American society. Yet, it has also been documented that first-generation college students (FGCS) have incongruently accessed and earned college degrees. This phenomenon has potentially perpetuated life-long differences in social outcomes in American society. As research continues to explain the experiences of FGCS, little has been done to explore differences for FGCS by college major or affiliation. However, a small but growing body of researchers are examining the experiences and outcomes of college of agriculture and related sciences students, specifically those enrolled at land grant institutions. The researchers in this study sought to describe college success indicators including on-campus involvement, leadership, and sense of belonging by generational status, and college affiliation at a large, midwestern, public, research-intensive institution. Overall, it was found that no differences were reported by generational status or college affiliation for the investigated college success indicators. These findings are different than previous literature in that FGCS were not lesser than their peers. Consequently, these findings add to the understanding of FGCS college experiences insofar as college affiliation may be playing a mitigating role in disparities among FGCS.

3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma.

BACKGROUNDPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches to assay patient tumors before treatment and identify effective treatment regimens based on tumor sensitivities are lacking. We developed an organoid-based platform (OBP) to visually quantify patient-derived organoid (PDO) responses to drug treatments and associated tumor-stroma modulation for personalized PDAC therapy.METHODSWe retrospectively quantified apoptotic responses and tumor-stroma cell proportions in PDOs via 3D immunofluorescence imaging through annexin A5, α-smooth muscle actin (α-SMA), and cytokeratin 19 (CK-19) levels. Simultaneously, an ex vivo organoid drug sensitivity assay (ODSA) was used to measure responses to standard-of-care regimens. Differences between ODSA results and patient tumor responses were assessed by exact McNemar's test.RESULTSImmunofluorescence signals, organoid growth curves, and Ki-67 levels were measured and authenticated through the OBP for up to 14 days. ODSA drug responses were not different from patient tumor responses, as reflected by CA19-9 reductions following neoadjuvant chemotherapy (P = 0.99). PDOs demonstrated unique apoptotic and tumor-stroma modulation profiles (P < 0.0001). α-SMA/CK-19 ratio levels of more than 1.0 were associated with improved outcomes (P = 0.0179) and longer parental patient survival by Kaplan-Meier analysis (P = 0.0046).CONCLUSIONHeterogenous apoptotic drug responses and tumor-stroma modulation are present in PDOs after standard-of-care chemotherapy. Ratios of α-SMA and CK-19 levels in PDOs are associated with patient survival, and the OBP could aid in the selection of personalized therapies to improve the efficacy of systemic therapy in patients with PDAC.FUNDINGNIH/National Cancer Institute grants (K08CA218690, P01 CA117969, R50 CA243707-01A1, U54CA224065), the Skip Viragh Foundation, the Bettie Willerson Driver Cancer Research Fund, and a Cancer Center Support Grant for the Flow Cytometry and Cellular Imaging Core Facility (P30CA16672).

Using Support Networks as a Predictor of Success for STEM Degrees: Preliminary Results Detailing a Selection Process for Test Subjects Engaged in a Longitudinal Study of Low Socio-Economic Status American Undergraduate Students

This study follows the selection process for participants in a National Science Foundation S-STEM grant program for low socio-economic students. State land grant institution were created to provide states with technical universities for mid- to lower-class citizens, but they have generally failed to deliver successful instruction to residential, low-socioeconomic status, underrepresented minority students. There is a need for more research on additional predictors to assess the potential of non-traditional students in the admissions process. The primary research question in this work is whether students from low-SES backgrounds possessing lower incoming metrics can still have success earning a STEM degree with the help of a web of support adults. This metrics-based selection process was generated from a five-year study of underrepresented minority (URM) students who had previously succeeded in earning an engineering degree, even though they were not originally admitted into engineering. The selection process also asked students to identify the members of their support network, how they used this support to succeed in life, and culminated in an on-campus interview. The high school metrics for these students were found to be significantly lower than their engineering peers, but the average number of anchor/mentors that were identified was 6.2. These 21 students are currently performing well and will be compared against other residential students for retention, performance, and graduation through their time at the institution.

Efficacy of Intra-articular, intra-osseous Injections of Platelet-Rich Plasma in Osteoarthritis Knee: A Randomized Clinical Trial

<h3>Research Objectives</h3> To evaluate the efficacy of intra-articular, intra-osseous Injections of platelet-rich plasma (PRP) and compare its efficacy with intra-articular injection of PRP in OA Knee. <h3>Design</h3> A parallel 2 group, prospective randomized clinical trial. <h3>Setting</h3> A tertiary care teaching hospital in India. <h3>Participants</h3> A total of 64 persons with OA knee with a Kellgren-Lawrence score of 3 were randomized into two groups. <h3>Interventions</h3> Persons in Group-I received 8ml of single intra-articular PRP injection, and persons in Group II received 18 ml of PRP (two-intra-osseous injections (5ml each in femoral-condyle and tibia plateau) and one intra-articular injection (8ml) of PRP (total 18 ml of PRP, for single joint)) the in the target knee joint under fluoroscopic guidance. All persons (n=64) were followed up at 3 and 6 months. <h3>Main Outcome Measures</h3> Clinical outcomes were evaluated using the visual analog (VAS) pain intensity scores and knee injury and osteoarthritis outcome score (KOOS) questionnaire. <h3>Results</h3> There was no disparity between the two groups in baseline demographic and clinical parameters. Both groups demonstrated statistically significant improvement in VAS pain scores and KOOS scores (pain, symptoms, ADL, sport/recreation, and quality of life) at baseline, 3- and 6 months. However, comparing the two groups revealed no significant difference in VAS scores and KOOS scores at six months. Persons in Group-II reported increased injection-associated pain following interventions. Except for injection-associated pain, no other adverse events were reported in any person. <h3>Conclusions</h3> Though both groups showed significant improvement following PRP injections, additional injections of PRP in the subchondral region did not provide additional benefits (pain-relief and KOOS scores) than intra-articular-PRP injections at 6 months. <h3>Author(s) Disclosures</h3> The institutional intramural research grant supported the study.

Risk Stratifying Febrile Children in the Emergency Department: An Ongoing Challenge.

1 Division of Pediatric Emergency Medicine and Pediatric Sepsis Program, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine; Children's Hospital of Philadelphia, Philadelphia, PA 2 Division of Emergency Medicine, Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Lurie Children's Hospital, Evanston, IL *See also p. 980. Dr. Balamuth’s institution received funding from several federal, foundational, and institutional grants to study sepsis and other infectious emergencies unrelated to this study. Dr. Florin’s institution received funding from the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases.

3 Oral - Matching adjusted indirect comparison of PFS & OS comparing ribociclib + letrozole vs palbociclib + letrozole as first-line treatment of HR+/HER2− ABC: Analysis based on updated PFS & final OS results of MONALEESA-2 & PALOMA-2

3 Oral - Matching adjusted indirect comparison of PFS & OS comparing ribociclib + letrozole vs palbociclib + letrozole as first-line treatment of HR+/HER2− ABC: Analysis based on updated PFS & final OS results of MONALEESA-2 & PALOMA-2

Frederick Watts and the Founding of Penn State

Frederick Watts and the Founding of Penn State

Echocardiographic diversity associated with exercise capacity in heart failure precursor stage B: the Project Baseline Health Study

Abstract Background The current paradigm to stage heart failure (HF) defines precursor stage B (or “pre-HF”) as having any subclinical change in cardiac structure or function. Yet, HF risk factors and type of cardiac abnormality may induce clinically relevant heterogeneity in HF stage B. Therefore, we assessed clinical and echocardiographic heterogeneity within stage B HF and its association with exercise capacity in a large community-based sample. Methods 2071 participants to the Baseline Health Study (50.4±17.0 years, 56.2% women, 37.8% hypertensive) underwent echocardiography and physical performance testing including 6-minute walk (6MWT) and treadmill exercise test. We defined echocardiographic profiles of left and right heart remodeling and dysfunction using sex-specific internal reference values. We assessed HF stages (0-A-B-C-D) following HF societies recommendations. stage B participants were stratified according to presence/absence of HF risk factors and to the most severe echocardiographic abnormality present (reduced ejection fraction (EF), left ventricular (LV) hypertrophy/diastolic dysfunction or other abnormalities). We reported associations between physical performance metrics and HF (sub)stages. Results Stage B HF was present in 516 participants (24.9%). Within stage B HF, we observed a large diversity in echocardiographic profiles. Yet, stage B participants without HF risk factors (n=96, 18.6% of stage B) predominantly presented echo abnormalities other than LV diastolic dysfunction, hypertrophy and reduced EF, while their physical performance profile resembled that of people with normal echocardiography without HF risk factors. In contrast, stage B participants with HF risk factors (n=420) were characterized by LV diastolic dysfunction, hypertrophy or reduced EF, three phenotypes associated with lower 6MWT distance and lower exercise capacity. Concomitant presence of HF risk factors and LV dysfunction/hypertrophy was associated with worst physical performance. Conclusions We observed a wide clinical and echocardiographic diversity affecting physical performance in HF precursor stage B when defined by the current staging paradigm. Concomitant presence of HF risk factors and LV dysfunction/hypertrophy may mark individuals at highest risk for progression towards overt HF. Funding Acknowledgement Type of funding sources: Other. Main funding source(s): This research was made supported by an institutional research grant from Verily Inc. (CA, USA) and by the Research Foundation Flanders (Belgium).

Comparative validation of the HAS-BLED and the GARFIELD-AF bleeding risk scores in Asian patients with atrial fibrillation: a report from the COOL-AF registry

Abstract Introduction There have been conflicting comparative data on the predictive value of the HAS-BLED and the GARFIELD-AF bleeding risk scores. Furthermore, there are limited data in Asian patients with atrial fibrillation (AF) who are at higher risk of bleeding compared to non-Asians. We compared the performance of the HAS-BLED score with the GARFIELD-AF score in predicting major bleeding in AF patients treated with OAC in the Cohort of antithrombotic use and Optimal INR Level in patients with non-valvular AF in Thailand (COOL-AF) registry. Since the sex and body weight seem to impact bleeding events in Asians, we explored an update of the HAS-BLED risk score by incorporating sex and body weight. Methods The COOL-AF registry was a nationwide study enrolling AF patients from 27 hospitals in Thailand between 2014 and 2017. The registry aimed to assess antithrombotic patterns, quality of oral anticoagulant (OAC) control and clinical outcomes. Data were collected every 6 months and until 3 years. AF patients treated with oral anticoagulants (OAC, either warfarin or non-vitamin K antagonist OAC (NOAC)) were included into the present study. We fitted the variables of the HA-SBLED and GARFILED-AF score to major bleeding in Cox regression model. We also explored a modified HAS-BLED by addition of two additional predictors (sex and body weight). Discrimination, calibration, net reclassification index and decision curve analysis were used to compare the predictive performance of the three models. Results Of 3,402 patients in the COOL-AF registry, 2,568 patients (mean age 68.4 years; 43.4% female) who received OAC at baseline were studied. The proportion of patients with prior bleeding was 10.6%. Majority of patients (68.7%) received warfarin. The incidence rate of major bleeding was 2.11 (1.79–2.48) per 100 person-years. The C-indexes of the GARFIELD-AF, HASBLED and modified HASBLED score were 0.65 (95% CI 0.63–0.67), 0.66 (95% CI 0.64–0.68) and 0.69 (95% CI 0.67–0.71) respectively. Calibration plot showed good agreement between predicted and observed bleeding in the deciles of original HAS-BLED and GARFIELD-AF scores, while the modified HAS-BLED score overestimated the risk in the last decile (Figure 1). The modified HASBLED score has superior NRI than the original HASBLED score (26.9%, 95% CI 9.7% to 42.2%). The NRI between the modified HASBLED and GARFIELD score was similar (20%, 95% CI −1.2% to 40.4%). The net benefit curve of the three models were overlapping among different risk thresholds (Figure 2). Conclusion The clinical utility for bleeding prediction GARFIELD-AF, HAS-BLED and modified HAS-BLED scores were similar in Asian patients with AF participating in the COOL-AF registry. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): This study was funded by the Health Systems Research Institute (HSRI) (grant no. 59-053), the HeartAssociation of Thailand under the Royal Patronage of H.M. the King.

50P Transcriptomic profiles of CD32b in breast cancer predict outcome and are associated with immune activation

50P Transcriptomic profiles of CD32b in breast cancer predict outcome and are associated with immune activation