Research Institute Research Articles

Genetic profile of Brazilian patients with LAMA2-related dystrophies.

LAMA2-related dystrophies (LAMA2-RD) constitute a rare neuromuscular disorder with a broad spectrum of phenotypic severity. Our understanding of the genotype-phenotype correlations in this condition remains incomplete, and reliable clinical data for clinical trial readiness is limited. In this retrospective study, we reviewed the genetic data and medical records of 114 LAMA2-RD patients enrolled at seven research centers in Brazil. We identified 58 different pathogenic variants, including 21 novel ones. Six variants were more prevalent and were present in 81.5% of the patients. Notably, the c.1255del, c.2049_2050del, c.3976 C>T, c.5234+1G>A, and c.4739dup variants were found in patients unable to walk and without cortical malformation. In contrast, the c.2461A>C variant was present in patients who could walk unassisted. Among ambulatory patients, missense variants were more prevalent (p < 0.0001). Although no specific hotspot regions existed in the LAMA2, 51% of point mutations were in the LN domain, and 88% of the missense variants were found within this domain. Functional analysis was performed in one intronic variant (c.4960-17C>A) and revealed an out-of-frame transcript, indicating that the variant creates a cryptic splicing site (AG). Our study has shed light on crucial phenotype-genotype correlations and provided valuable insights, particularly regarding the Latin American population.

Hotspots and trends of risk factors in gastric cancer: A visualization and bibliometric analysis

BACKGROUND The lack of specific symptoms of gastric cancer (GC) causes great challenges in its early diagnosis. Thus it is essential to identify the risk factors for early diagnosis and treatment of GC and to improve the survival rates. AIM To assist physicians in identifying changes in the output of publications and research hotspots related to risk factors for GC, constructing a list of key risk factors, and providing a reference for early identification of patients at high risk for GC. METHODS Research articles on risk factors for GC were searched in the Web of Science core collection, and relevant information was extracted after screening. The literature was analyzed using Microsoft Excel 2019, CiteSpace V, and VOSviewer 1.6.18. RESULTS A total of 2514 papers from 72 countries and 2507 research institutions were retrieved. China (n = 1061), National Cancer Center (n = 138), and Shoichiro Tsugane (n = 36) were the most productive country, institution, or author, respectively. The research hotspots in the study of risk factors for GC are summarized in four areas, namely: Helicobacter pylori (H. pylori ) infection, single nucleotide polymorphism, bio-diagnostic markers, and GC risk prediction models. CONCLUSION In this study, we found that H. pylori infection is the most significant risk factor for GC; single-nucleotide polymorphism (SNP) is the most dominant genetic factor for GC; bio-diagnostic markers are the most promising diagnostic modality for GC. GC risk prediction models are the latest current research hotspot. We conclude that the most important risk factors for the development of GC are H. pylori infection, SNP, smoking, diet, and alcohol.

Navigating an emerging innovation ecosystem: a case study of fuel cell innovation in Taiwan

ABSTRACT The Taiwanese government has actively promoted and established policies for developing fuel cell research and industrial activities since the early 2000s. The activities, including those of Taiwanese policy actors, private firms, and research institutions, are part of a fuel cell innovation ecosystem. Through an embedded case study, this paper examines past national policies, sectoral-level developments, and how a firm has navigated the environment. The analysis is based on the notion of an innovation ecosystem, which analytically covers micro, meso, and macro levels and has more porous boundaries than a national innovation system. Hence, the contribution of this paper relates to creating a deeper understanding of what is happening under the surface of government policy and what path firms can take. Thus, it contributes to studies on latecomer strategies in technology sectors of the dynamic interaction between policy, sectoral development, and firm strategy.

The triple helix collaboration: lessons from a Chinese provincial innovation ecosystem

Purpose Innovation is vital for sustainable regional development. Government is generally not a source of innovation per se, but the authors shows that by establishing and funding an industrial innovation ecosystem, it can create fertile conditions for research institutions to introduce innovative technologies into industry and for industry to introduce its gaps and needs to motivate and direct academic research. This paper aims to present a case study of the Jiangsu Industrial Technology Research Institute (JITRI) as a “triple helix” collaboration model engaging Industry-University-Research (IUR) institutions. The authors aim to provide a fresh perspective on constructing innovation ecosystems, promoting value creation and advancing the adoption of industrial technology. Design/methodology/approach Taking JITRI as a case study, this research examines its innovative approaches to interfacing with IUR organizations within China’s Yangtze Delta region. The authors propose a multilayered framework where JITRI serves as the core, facilitating the formation of a robust innovation ecosystem with diverse IUR entities. Findings This framework comprises three layers: core, platform and support. JITRI acts as the central nexus, binding these elements together and fostering a cohesive innovation ecosystem. By analyzing the operational mechanisms of the Jiangsu Provincial innovation system, the authors gain valuable insights into how JITRI bridges the gap between academia and industry. This facilitates the efficient commercialization of technologies. The success of the JITRI approach presents a compelling model for emulation by other provincial innovation ecosystems seeking to enhance their innovation capabilities. Research limitations/implications This study enriches the ongoing conversation on innovation ecosystems, proposing novel avenues for further research. However, the field requires continuous monitoring through longitudinal studies. Given the long-term nature of such initiatives, the full impact of this approach might only be realized over several decades. Practical implications JITRI aims to create a robust and innovative provincial innovation ecosystem through its focus on IUR collaboration. This unique approach offers valuable insights and ideas for fostering the development of thriving innovation ecosystems in other provinces. These insights encompass new perspectives on innovation ecosystem development, value creation and industrial advancement. Originality/value This study pioneers the use of the JITRI system as a case study, offering valuable insights with potential application to innovation ecosystems across China and globally.

A Study on Prescription Pattern of Drugs in Orthopaedics Inpatient Department of Navodaya Medical College Hospital and Research Centre in Raichur

A Study on Prescription Pattern of Drugs in Orthopaedics Inpatient Department of Navodaya Medical College Hospital and Research Centre in Raichur

First Report of Agroathelia rolfsii Causing Southern Blight on Lippia (Phyla canescens) in Guangzhou, China.

Lippia (Phyla canescens) is a fast-growing, mat-forming, and prostrate perennial plant well adapted to infertile, high-saline, and drought environments (Leigh, et al. 2004). It arrived in China from Japan as a flowering ground cover in 2001 (Cai, et al. 2004). In June 2022, southern blight appeared in our nursery of the Floriculture Research Institute of Guangdong Academy of Agricultural Sciences. High temperature and damp environment are major factors for this disease. The symptoms of top-layer plants were not easily detected, but they were slightly yellowed. A yellowish-brown water-soak lesion appeared on the stems and lowest leaves exposed to soil. White mycelium appeared in the middle stage. Finally, the surface plants showed water-soak decay, and a mass of beige to black-brown rapeseed-shaped sclerotia appeared on the residue and surrounding soil; these plants died. Sclerotia and mycelia were collected from disease tissue, and after surface sterilization, sclerotia was cultured on potato dextrose agar (PDA) at 28±2°C in an incubator without light. Eight fungal isolates with similar colony morphologies were consistently isolated by purifying from different sampling areas. The isolates exhibited obvious septa and a clamp connection structure within the white mycelium. The average growth rate was 26.86±0.06 mm/day. Numerous white granular sclerotia were produced on the mycelium 6 days later. The sclerotia with a diameter of 1.24±0.07mm (n=189) gradually changed from diage to yellow to brown. A typical strain B1 was selected for further identification, targeting its 18S rRNA and LSU rRNA sequences (Yang, et al. 2011; Xue, et al. 2019). Its 18S rRNA sequence (GenBank Accession No. OR517233, 1626 bp) is 99.63% and 99.57% identical to Athelia rolfsii (AY665774, 1179bp; KC670714, 1775bp; JF819726, 1781bp). Its LSU rRNA sequence (OR539570, 757 bp) is 99.87% identical to Agroathelia rolfsii (OR526537, 904 bp). For Athelia rolfsii, a synonym of Agroathelia rolfsii, by combining the morphological characteristics and molecular identification, the isolate pathogen B1 was confirmed to be Agroathelia rolfsii (the teleomorph of Sclerotium rolfsii). To fullfill Koch's postulates, we inoculated the mycelial plugs to healthy lippia stems and leaves which has grown for one year, with PDA plugs free of mycelium as the control. All the plants were kept in a greenhouse at 28±2°C with a 14-h photoperiod and 80% relative humidity. Each treatment was repeated thrice and vaccinated with 6 points. At 7 d following inoculation, all plants inoculated with B1 showed typical symptoms, but the control group was asymptomatic, and sclerotia appeared 17d after inoculation. Using the same protocol mentioned above, pathogenic fungal was reisolated only from treated groups, but not from the control group. Chose three of the pathogens for 18S rRNA and LSU rRNA sequencing, the results showed 100% identity to B1, the same as its microstructure. There are few reports about the disease on P. canescens. Sosa (2007) investigated the pathogens on P. canescens in Argentina, 16 fungi were found but no A. rolfsii. Sclerotium rolfsii were identified on P. nodiflora or P. lanceolata (Michaux) Greene in America (Farr, et al. 1989). To our knowledge, this is the first report in China. Because this pathogen has wide-ranging hosts and causes serious damage, the results from this study will offer guidance for the prevention and treatment of this disease.

Bioethanol sacrifice zones and environmental/ epistemic injustice. A case study in Argentina.

This paper presents a case of environmental conflict caused by a corn-based bioethanol plant in Argentina- one of the world's most important agro-industrial economies. The aim is to illustrate how epistemic inequality is a transversal aspect of environmental injustice. Many of the environmental impacts of this production have been denounced by the affected peoples living next to the plant, which functions in a densely populated area. Their knowledges about health, air pollution and the risk of explosions have been systematically excluded from legal proceedings and policy-making in the case. Additionally, they have demanded the intervention of public universities and research centers in the case, but instead the scientific sector has offered its capacities to advance the agro-industrial complex rather than research the damages and risks made to environmental and human health. Thus, these peoples seem to be confined to a "sacrifice zone" where the protection of the rights to health and a clean environment are systematically violated, along with the denial of their status of legitimate knowers. This paper describes situations in which the knowledge of those affected is disregarded and/or excluded in the process of evidence-making. It also makes visible the co-responsibility of the scientific community in this case regarding the inequality between "production" and "impact" science related to the environmental sustainability of bioethanol. The empirical data of the case is presented within an Environmental/Epistemic Justice and STS framework. In order to overcome the devastating effects of agro-industrial sacrifice zones, this work contributes to the reflection on the interconnectedness of environmental sciences, affected people’s knowledge, and politics.

Research on Business Contracts and Legal Regulations

In todays business environment, commercial contracts serve as important tools for regulating business activities, and their binding force and enforcement mechanisms are essential for the stability of business transactions. However, the complexity of commercial contracts often leads to various challenges, including contract interpretation, performance, and dispute resolution. Against this background, the research centers on the following questions. What are the challenges in drafting and enforcing commercial contracts? How effective are legal rules in constraining and protecting commercial contracts? What are the legal protection and risk management strategies of parties involved in commercial contracts? By conducting an in-depth study of these questions, this study examines the relationship between commercial contracts and laws and regulations, with a particular focus on the complexity of commercial contracts. As such, the paper aims to provide practical recommendations for strengthening the legal framework of commercial contracts and promoting the effective protection of the interests of all parties in business transactions.

Automated Power Source Selection System for Uninterrupted Supply: Integration of Main Power, Solar Energy, and Generator Power

A consistent power supply is indispensable across various sectors, spanning from households to critical institutions like research facilities, hospitals, and financial institutions. This study endeavors to ensure uninterrupted power provision to a load through an automated selection process among three primary power sources: main power, solar energy, and generator power, with main power being the primary preference. Implemented using an 8051 microcontroller, the system is linked to three switches representing each power source for simulation purposes. Upon detection of a switch release or deactivation, signifying the absence of that particular power source, the microcontroller promptly deactivates the corresponding relay driver. This relay driver then switches the relevant relay, facilitating seamless power continuity to the load if any switch is activated. A lamp or bulb serves as a demonstrative load powered by the primary source. In the event of a power outage, the system seamlessly transitions to the next available source, such as solar energy, and if required, to generator power. An LCD is employed to indicate the currently active power source, ensuring operational transparency and facilitating swift troubleshooting when necessary.

Clinical pharmacology considerations for first-in-human clinical trials for enzyme replacement therapy.

Inborn errors of metabolism (IEM) such as lysosomal storage disorders (LSDs) are conditions caused by deficiency of one or more key enzymes, cofactors, or transporters involved in a specific metabolic pathway. Enzyme replacement therapy (ERT) provides an exogenous source of the affected enzyme and is one of the most effective treatment options for IEMs. In this paper, we review the first-in-human (FIH) protocols for ERT drug development programs supporting 20 Biologic License Applications (BLA) approved by the Center for Drug Evaluation and Research (CDER) at the US Food and Drug Administration (FDA) in the period of May 1994 to September 2023. We surveyed study design elements across these FIH protocols including study population, dosage form, dose selection, treatment duration, immunogenicity, biomarkers, and study follow-up. A total of 18 FIH trials from 20 BLAs were identified and of those, 72% (13/18) used single ascending dose (SAD) and/or multiple ascending dose (MAD) study design, 83% (15/18) had a primary objective of assessing the safety and tolerability, 72% (13/18) included clinical endpoint assessments, and 94% (17/18) included biomarker assessments as secondary or exploratory endpoints. Notably, the majority of ERT products tested the approved route of administration and the approved dose was tested in 83% (15/18) of FIH trials. At last, we offer considerations for the design of FIH studies.

A scientometrics study and its practical implications for fused deposition modeling

This study presents a scientometric analysis focusing on fused deposition modeling (FDM), highlighting key findings such as the top contributing nations, prevalent publication types, and prominent publishers. It tracks changes in FDM research over time, noting a significant increase in publications, and identifies popular keywords indicating recurring topics in the field. Additionally, the analysis explores highly cited journals and their burst rates, concluding with an examination of research categories and institutes involved in FDM research. These insights offer valuable guidance for researchers, institutions, and stakeholders interested in advancing FDM technology, with practical implications discussed. The detailed examination of the scholarly landscape in FDM contributes to a deeper understanding of the field's dynamics and potential avenues for future research and innovation.

Correlation between Rice Weevil Infestation Sitophilus oryzae (Linnaeus) and Seed Quality Parameters of Maize (Zea mays. L) Seed

The experiment was conducted at the Seed Research and Technology Centre, PJTSAU, Rajendranagar, Hyderabad, to investigate the impact of Sitophilus oryzae on the seed quality parameters of maize. Samples weighing 500g of maize variety DHM-117 were placed in plastic jars in three replications S. oryzae adults of 0, 5, 10, 15, and 20 pairs were separately released into each replicate of the maize seeds then these jars were placed in an incubator set at 25°C and 75% humidity. These jars were covered with lids equipped with aeration facilities. The adult emergence, germination percentage and moisture content were evaluated every two months six months. An inverse correlation was observed between adult emergence with germination percentage and seedling vigour index while, adult emergence showed a positive correlation with moisture content.

Master resilience trainer course quality improvement evaluation

ABSTRACT The Master Resilience Training (MRT) course is the U.S. Army’s resilience program of record to develop soldiers as resilience trainers within their home units. The Walter Reed Army Institute of Research (WRAIR) recently conducted an MRT Quality Improvement Evaluation (QIE) to understand perceptions of the MRT course, determine the effectiveness of the course, and provide revision recommendations for the next iteration of the course. Soldiers who were completing the MRT course were invited to take surveys and participate in interviews. Results from quantitative and qualitative data suggest that most participants felt satisfied with the training and that it was relevant for soldiers. Most participants also agreed that the training would help them become better soldiers and leaders. Along with positive feedback about the course, participants also identified areas that could be improved. Soldier feedback along with program evaluators’ observation informed recommendations for improving the overall MRT course and its implementation. Program evaluators recommend MRT participants learn fewer and less complex skills, focus on coach education throughout the course, and highlight leader development by promoting motivation and enhancing effective communication. Program evaluators recommendations for ways to improve buy-in from leaders and graduated MRTs are also discussed.

Comparison of the Clinical Utility of Two Insulin Resistance Indices: IRI-HOMA and IRI-Belfiore in Diagnosing Insulin Resistance and Metabolic Complications in Children Based on the Results Obtained for the Polish Population

Background: Recognizing insulin resistance (IR) in children remains challenging due to uncertain IRI-HOMA cut-offs and unclear recommendations for evaluating IR based on OGTT. In our study, we compare the effectiveness of IRI-HOMA and IRI-Belfiore (OGTT-based) in detecting IR and its metabolic complications in children. Methods: The analysis included 553 children who were hospitalized at the Department of Endocrinology and Metabolic Diseases of the Polish Mother’s Memorial Hospital Research Institute (PMMH-RI) in Lodz, Poland, between 2002 and 2018 due to various reasons—of these, 67.5% were girls. All underwent OGTT for glucose and insulin assessment. IR diagnosis relied on IRI-HOMA and IRI-Belfiore. IR based on IRI-HOMA was evaluated using three criteria: (A) &gt;2.5; (B) &gt;2.67 in boys and &gt;2.22 in girls before puberty and &gt;5.22 and &gt;3.82 during puberty, respectively; (C) &gt;95th percentile according to charts for IRI-HOMA in children. Results: Prepubertal children exhibited significantly lower IRI-HOMA and IRI-Belfiore than their pubertal counterparts (p &lt; 0.00005). IRI-HOMA and IRI-Belfiore values positively correlated with age and BMI SDS value (p &lt; 0.000001 for all calculations). As many as 26% to 46.9% of children with normal IRI-HOMA showed elevated IRI-Belfiore, with notably higher levels of triglycerides, a lower HDL cholesterol fraction, and a lower HDL/total cholesterol ratio in this subgroup. Conclusions: A notable proportion of children exhibited elevated IRI-Belfiore levels despite having normal IRI-HOMA values. This suggests the possibility of peripheral IR preceding hepatic IR in children—omitting an OGTT may therefore lead to overlooking cases of IR. Children diagnosed with IR via OGTT displayed significantly poorer lipid profiles compared to those without IR (characterized by normal values in both IRI-HOMA and IRI-Belfiore). This underscores the ability of OGTT-derived IR indices to identify individuals at risk of developing complications associated with obesity and IR before the onset of metabolic syndrome (MS) symptoms. If IR is already detected in children based on fasting glucose and insulin levels (IRI-HOMA), further evaluation may not be warranted, as OGTT results often simply confirm the diagnosis.

Global research progress of gut microbiota and epigenetics: bibliometrics and visualized analysis

BackgroundGut microbiota is an important factor affecting host health. With the further study of the mechanism of gut microbiota, significant progress has been made in the study of the link between gut microbiota and epigenetics. This study visualizes the body of knowledge and research priorities between the gut microbiota and epigenetics through bibliometrics.MethodsPublications related to gut microbiota and epigenetics were searched in the Web of Science Core Collection (WoSCC) database. Vosviewer 1.6.17 and CiteSpace 6.1.R2 were used for bibliometric analysis.ResultsWoSCC includes 460 articles from 71 countries. The number of publications on gut microbiota and epigenetics has increased each year since 2011. The USA, PEOPLES R CHINA, and ITALY are at the center of this field of research. The University of California System, Harvard University, and the University of London are the main research institutions. Li, X, Yu, Q, Zhang, S X are the top authors in this research field. We found that current research hotspots and frontiers include short-chain fatty acids (SCFA) play an important role in gut microbiota and epigenetic mechanisms, gut microbiota and epigenetics play an important role in host obesity, diet, and metabolism. Gut microbiota and epigenetics are closely related to colorectal cancer, breast cancer, and inflammatory bowel disease. At the same time, we found that gut microbiota regulates epigenetics through the gut-brain axis and has an impact on psychiatric diseases. Therefore, probiotics can regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases.ConclusionThis is the first comprehensive and in-depth bibliometric study of trends and developments in the field of gut microbiota and epigenetics research. This study helps to guide the direction of research scholars in their current field of study.

Screening of mungbean germplasm for resistance against Cercospora leaf spot under natural field conditions

Mung bean is an excellent protein source pulse crop grown throughout the world. Punjab province accounts for 80% area and production of mung bean in Pakistan. Mung bean is cultivated on a large scale for its green manuring ability and grain consumption. Mungbean is prone to economically important fungal, bacterial, and viral diseases. Cercospora leaf spot (CLS) caused by Cercospora canescens is one of the most serious disease concerns in Pakistan. The pulses program at the National Agriculture Research Centre, Islamabad is trying hard to get the resistant germplasm against CLS. Sixty-eight advance lines/approved varieties were evaluated in the augmented design under natural field conditions. Forty-one advance lines/approved varieties were found resistant and twenty-five advance lines/approved varieties were found moderately resistant. Two advanced lines/approved varieties did not perform well and were susceptible to CLS infection. This data indicates that the germplasm at pulses program is excellent in resistance against CLS under natural field conditions in the Arid Zone and can serve as potential future varieties.

Students as co-producers

To engage students with academic research is recognised as a high-impact activity that supports the development of valuable critical thinking skills. Various approaches have been developed to promote student research both in and outside the curriculum. By incorporating the perspectives of both students and academics, this qualitative study evaluates the extent to which a research partnership is formed through an institutional research scheme called the Junior Research Associate. Our findings indicate that it is critical to move beyond the entrenched academic hierarchies of supervisor/supervisee to develop a negotiated research relationship. Challenges identified include the short timeframe to establish the conditions for successful partnership and differential expectations of partners at the outset of the scheme. It is also important to safeguard against such initiatives being instrumentalised by academics seeking to further their personal research agenda. The findings help to inform strategies to scale up such initiatives.

Imagination as a catalyst for Relational Leadership: Educational leaders’ perspectives.

This research examines the role of imagination in relational leadership. Specifically, the following question was explored through a case study of a unique offering of an imagination-focused MEd program in Educational Leadership in a large, public research institution in British Columbia, Canada: How do participants understand imagination’s role in leadership after completing a two-year imagination-focused MEd leadership program? The 13 participants—all aspiring and emerging leaders in their professional settings—shared their developing conceptions of leadership, imagination, and the role of imagination in educational leadership. Participants articulated how imagination contributes to understanding themselves as leaders, engaging others with empathy, and building connections. The relational role of imagination was a dominant theme. According to participants, imagination is necessary for forming and enriching relationships, and reciprocally, relationships enhance imagination. Participants indicated how imagination supports their sense of belonging; imagination allowed participants to see themselves as potential leaders, and to feel they belonged “at the leadership table.” According to these preliminary findings, imagination may also create more opportunity in leadership. Overall, imagination emerges in this study as promoting not only relational, but humanizing leadership practices. This research contributes to understandings of relational leadership and highlights directions for future research. It identifies new directions for supporting equity and diversity in educational leadership and has clear implications for leadership education.

Driving innovation in energy and telecommunications: next-generation energy storage and 5G technology for enhanced connectivity and energy solutions

Driving innovation in energy and telecommunications involves leveraging next-generation energy storage and 5G technology to enhance connectivity and energy solutions. This review explores the intersection of these two domains, highlighting the importance of advancements in energy storage and 5G technology for a sustainable and connected future. Energy storage is crucial for balancing the supply and demand of electricity in modern power systems. Traditional energy storage methods, such as batteries and pumped hydro, have limitations in terms of scalability, efficiency, and cost-effectiveness. Next-generation energy storage technologies, including advanced batteries, hydrogen storage, and thermal storage, offer promising solutions to overcome these limitations. These technologies enable efficient energy storage at scale, facilitating the integration of renewable energy sources like solar and wind into the grid. By storing excess energy generated during periods of low demand, next-generation energy storage systems ensure a reliable and stable power supply, reducing the reliance on fossil fuels and lowering greenhouse gas emissions. In parallel, the evolution of telecommunications technology, particularly the advent of 5G networks, is revolutionizing connectivity and communication. 5G technology offers significantly higher data transfer speeds, lower latency, and increased network capacity compared to its predecessors. These capabilities are essential for supporting emerging technologies such as the Internet of Things (IoT), autonomous vehicles, and smart grids. With 5G-enabled IoT devices, utilities can monitor energy consumption in real-time, optimize grid operations, and detect and respond to faults more efficiently. Moreover, 5G connectivity enhances the efficiency and reliability of energy storage systems by enabling seamless communication between distributed energy resources and grid operators. The convergence of next-generation energy storage and 5G technology presents numerous opportunities for driving innovation in both energy and telecommunications sectors. One of the key areas of innovation is the development of smart energy storage systems equipped with 5G connectivity. These systems can autonomously adjust their operation based on grid conditions, weather forecasts, and energy demand patterns, optimizing energy storage and distribution in real-time. Furthermore, advanced energy management algorithms leveraging artificial intelligence (AI) and machine learning (ML) algorithms can optimize energy usage and storage, further improving the efficiency and reliability of the grid. Another area of innovation lies in the integration of renewable energy resources with 5G-enabled microgrids. Microgrids are localized energy systems that can operate independently or in conjunction with the main grid. By combining renewable energy sources with energy storage and 5G-enabled communication, microgrids can provide reliable, clean, and resilient power to remote or urban areas. These microgrids can also facilitate peer-to-peer energy trading, allowing consumers to buy and sell excess energy within their communities, fostering energy independence and sustainability. Furthermore, advancements in battery technology, such as solid-state batteries and flow batteries, are enhancing the performance and reliability of energy storage systems. Solid-state batteries offer higher energy density, faster charging rates, and improved safety compared to conventional lithium-ion batteries. Flow batteries, on the other hand, provide scalability and long-duration storage capabilities, making them suitable for grid-scale applications. Integrating these advanced battery technologies with 5G-enabled monitoring and control systems enhances the overall resilience and flexibility of the energy infrastructure. In addition to technological advancements, driving innovation in energy and telecommunications requires collaboration among various stakeholders, including policymakers, regulators, industry players, and research institutions. Policies and regulations should incentivize the deployment of next-generation energy storage and 5G infrastructure, promote interoperability standards, and ensure data privacy and security. Public-private partnerships can facilitate the investment and deployment of innovative solutions, while research and development initiatives can spur further technological advancements. Driving innovation in energy and telecommunications through next-generation energy storage and 5G technology is essential for building a sustainable, connected, and resilient future. By leveraging advanced energy storage systems, smart grids, and 5G-enabled communication networks, we can optimize energy usage, reduce carbon emissions, and enhance the reliability and efficiency of our energy infrastructure. Collaboration and investment across various sectors are key to unlocking the full potential of these transformative technologies and achieving a brighter, more sustainable future for generations to come. Keywords: Innovation, Energy, Telecommunications, Next-Generation, 5G technology, Enhanced connectivity.

PROJECT OF A DASHBOARD FOR BRAZILIAN CENTERS AFFILIATED WITH CENTER FOR INTERNATIONAL BLOOD AND MARROW RESEARCH

Since the first hematopoietic stem cell transplantation (HSCT) was performed at the Federal University Hospital (Curitiba, PR) in 1979, the number of centers offering this modality of treatment has increased. However, accessing comprehensive HSCT outcomes has become a challenge due to lack of an official Brazilian registry. The partnership between the Brazilian Cellular Therapy and Bone Marrow Transplant Society (SBTMO) and the Center for International Blood and Marrow Research (CIBMTR) was an important milestone in the establishment of the HSCT Brazilian registry (HSCTBR). By using CIBMTR’s Data Back to Center (DBtC) tool, we have gained insights into HSCT outcomes through the Brazilian Summary Slides. While understanding the country's transplant scenario is crucial, it is equally important for each center to assess their own outcomes. In order to help the Brazilian centers with the CIBMTR, the data manager of SBTMO working group has developed a business tool solution to facilitate this important task.