It is convenient to use the semi-empirical model (SEM), developed by the authors earlier and describing the relation of the electron density at heights of the middle ionosphere (120–200 km) to the parameters of the thermosphere and the integral flux of the ionizing solar radiation, to estimate the gas composition characteristics using the data of ionospheric measurements [Shchepkin et al., 2008]. The ratios of the concentrations of oxygen atoms and nitrogen molecules to those of oxygen molecules and atoms at a height of 120 km are compared using two SEM versions. The first version is based on the usage of the coefficients obtained from the measurements of N(h) profiles at Moscow observatory. The electron densities at heights of 120–200 km, obtained at the Institute of Solar-Terrestrial Physics in 2003–2006 using the digisonde, were the experimental data for the second version.