Introduction. The Cooperation of Cooperation in Higher Education Institutions is becoming the most important component of the innovation process. For regional politicians, it is a vital component of regional innovation policy, as the successful use of R&D results of local free economic zones is important for the competitiveness not only of the region but also of the country as a whole.
 There is a clear shift towards regionalization in higher education innovation policy and technologies. One of its consequences is the expectation from universities to create networks and establish regional connections. It is also important to create broad shared cluster networks, although most clusters focus on weak local networks. Nevertheless, network members are responsible for more patent applications than others. Moreover, it seems that the quality of patents is not reduced in cooperation with the universities of one regional cluster.
 The hypothesis of the research is to substantiate the methodological recommendations and proposals to increase the effectiveness of the interaction of free economic zones in the management system of cooperation of higher education institutions.
 The purpose of the study is to substantiate the features and effectiveness of the interaction of free economic zones in the management system of cooperation of higher education institutions.
 The methodology of scientific research is general and special research methods: logical and comparative analysis in revealing the principles of forming the scientific essence of cooperation
 of higher education institutions; the method of induction was used to make formal-logical generalizations, which allows the formulation of a general conclusion based on the analysis of individual facts and phenomena, the method of deduction was used to obtain intermediate (partial) conclusions based on the analysis of the general process, the method of abstraction was used to identify processes due to the neglect of random phenomena, For modeling and calculations used special software and hardware: MS Excel, RSPSS, programming language "R".
 Conclusions and prospects for further research. Theoretical and methodological provisions for managing the development of cooperation of international higher education institutions, based on maximizing resource complementarity and minimizing institutional incompatibility, and whose main goal is to ensure the development of cooperation of international higher education institutions as a way to improve areas (education, research, technology transfer).
 The scientific and methodological provisions of ensuring the management of the development of cooperation of international higher education institutions, which are based on selected key areas and strategic opportunities from the cooperation of international free economic zones, which allows to ensure the effectiveness of their international activities and provides a basis for leveling economic opportunism.
 Keywords: institutions of higher education (HEI); interaction of HEIs; cooperation; integration; innovation policy of HEIs; management system of HEIs.