Direct numerical simulation (DNS) of a droplet-laden, turbulent Couette airflow over a waved water surface is performed modeling the marine atmospheric boundary (MABL) layer carrying idealized spume droplets. Both the instantaneous and mean flow properties, the characteristics of the vortex structures and the momentum exchange between air turbulence and waved water surface and droplet-mediated momentum transfer are investigated. A Eulerian–Lagrangian approach is employed in DNS where full, 3D Navier–Stokes equations for the carrier air are solved in a Eulerian frame, and the trajectories of individual droplets are simultaneously tracked in a Lagrangian frame. The impact of the droplets on the carrier air flow is modeled via a point force approximation. The droplets size is considered in the range of spume droplet sizes observed in MABL. Various water surface roughness and droplet injection scenarios are considered, and both instantaneous and phase-averaged flow fields, the Reynolds stresses and the eigenvalues of the local air velocity gradient tensor are evaluated in DNS. Numerical results show a strong dependence of the droplet-mediated airflow modification on-the-droplet injection mechanism. Droplets injected with the surrounding air velocity effectively mitigate the vortex structures by reducing their swirling strength and suppress the momentum flux from air turbulence to water surface by weakening both ejections and sweeping events, and thus accelerating the mean flow as compared to the droplet-free flow. On the other hand, droplets injected with the velocities of the Lagrangian particles of the water surface enhance both the swirling strength of the vortex structures and air-flow turbulent stresses and decelerate the mean wind. The results also show that these effects of droplet-mediated flow modification become less pronounced as the water surface wave steepness increases.