Instantaneous Rate Research Articles

Motion process and failure mode of Pusa landslide, China based on dense optical flow method

ABSTRACT Unmanned aerial vehicle (UAV) is widely applied in geohazard monitoring with its high resolution and feasibility features, where UAV videos can record the whole landslide failure process. Previous studies can only provide the qualitative depiction of the landslide failure process, rather than the quantitative motion process, which makes it difficult to analyse the landslide dynamic characteristics and failure mode. In this letter, we take UAV video of Pusa landslide, China obtained on 28 August 2017 to retrieve the landslide motion process by using the dense optical flow method. Firstly, the landslide boundary can be clearly depicted by the cumulative landslide motion time series maps. Secondly, the maximum cumulative motion distance of the Pusa landslide was located in the middle of the slope body, with the maximum distance as 79 m, while the maximum instantaneous motion rate was around 42 m/s in the middle and lower part of the slope body. Finally, the failure mode of Pusa landslide can be characterized as ‘fissure zone in the middle, fissure extension to the top, rock bulges outward in the middle and landslide failure to high-speed runout debris flow’.

On the acceptance, commissioning, and quality assurance of electron FLASH units.

FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000Gy/s. We established a framework for the acceptance, commissioning, and periodic quality assurance (QA) of electron FLASH units and present an example of commissioning. A protocol for acceptance, commissioning, and QA of UHDR linear accelerators was established by combining and adapting standards and professional recommendations for standard linear accelerators based on the experience with UHDR at four clinical centers that use different UHDR devices. Non-standard dosimetric beam parameters considered included pulse width, pulse repetition frequency, dose per pulse, and instantaneous dose rate, together with recommendations on how to acquire these measurements. The 6- and 9-MeV beams of an UHDR electron device were commissioned by using this developed protocol. Measurements were acquired with a combination of ion chambers, beam current transformers (BCTs), and dose-rate-independent passive dosimeters. The unit was calibrated according to the concept of redundant dosimetry using a reference setup. This study provides detailed recommendations for the acceptance testing, commissioning, and routine QA of low-energy electron UHDR linear accelerators. The proposed framework is not limited to any specific unit, making it applicable to all existing eFLASH units in the market. Through practical insights and theoretical discourse, this document establishes a benchmark for the commissioning of UHDR devices for clinical use.

Design of a compact beam transport system for laser-driven proton therapy

Abstract We put forward a new design of a compact beam transport system for intense laser-driven proton therapy, where instead of using conventional pulsed solenoids, our design relies on a helical coil irradiated by a nanosecond laser pulse to generate strong magnetic fields for focusing protons. A pair of dipole magnets and apertures are employed to further filter protons with large divergences and low energies. Our numerical studies combine particle-in-cell simulations for laser-plasma interaction to generate high-energy monoenergetic proton beams, finite element analysis for evaluating the magnetic field distribution inside the coil, and Monte-Carlo simulations for beam transport and energy deposition. Our results show that with this design, a spread-out Bragg peak in a range of several centimeters to a deep-seated tumor with a dose of approximately 16.5 cGy and fluctuation around 2% can be achieved. The instantaneous dose rate reaches up to 109 Gy/s, holding the potential for future FLASH radiotherapy research.

The efficiency of synchronization dynamics and the role of network syncreactivity

Synchronization of coupled oscillators is a fundamental process in both natural and artificial networks. While much work has investigated the asymptotic stability of the synchronous solution, the fundamental question of the transient behavior toward synchronization has received far less attention. In this work, we present the transverse reactivity as a metric to quantify the instantaneous rate of growth or decay of desynchronizing perturbations. We first use the transverse reactivity to design a coupling-efficient and energy-efficient synchronization strategy that involves varying the coupling strength dynamically according to the current state of the system. We find that our synchronization strategy is able to synchronize networks in both simulation and experiment over a significantly larger (often by orders of magnitude) range of coupling strengths than is possible when the coupling strength is constant. Then, we characterize the effects of network topology on the transient dynamics towards synchronization by introducing the concept of network syncreactivity: A network with a larger syncreactivity has a larger transverse reactivity at every point on the synchronization manifold, independent of the oscillator dynamics. We classify real-world examples of complex networks in terms of their syncreactivity.

Development and Validation of a Portable EIT System for Real-Time Respiratory Monitoring.

This work contributes to the improvement of novel medical technologies for the prevention and treatment of diseases. Electrical impedance tomography (EIT) has gained attention as a valuable tool for non-invasive monitoring providing real-time insights. The purpose of this work is to develop and validate a novel portable EIT system with a small form factor for respiratory monitoring. The device uses a 16-electrode architecture with adjacent stimulation and measurement patterns, an integrated circuit current source and a single high-speed ADC operating with multiplexers to stimulate and measure across all electrodes. Tests were conducted on 25 healthy subjects who performed a pulmonary function test with a flowmeter while using the EIT device. The results showed a good performance of the device, which was able to recognize all respirations correctly, and from the EIT signals and images, correlations of 96.7% were obtained for instantaneous respiratory rate and 96.1% for tidal volume prediction. These results validate the preliminary technical feasibility of the EIT system and demonstrates its potential as a reliable tool for non-invasive respiratory assessment. The significance of this work lies in its potential to democratize advanced respiratory monitoring technologies, making them accessible to a wider population, including those in remote or underserved areas.

Phylogeographic Analysis for Understanding Origin, Speciation, and Biogeographic Expansion of Invasive Asian Hornet, Vespa velutina Lepeletier, 1836 (Hymenoptera, Vespidae)

The Asian hornet, Vespa velutina, is an invasive species that has not only expanded its range in Asia but has also invaded European countries, and it incurs significant costs on local apiculture. This phylogeographic study aims to trace the evolutionary trajectory of V. velutina and its close relatives; it aims to identify features that characterize an invasive species. The last successful invasion of Vespa velutina into France occurred in late May, 2002, and into South Korea in early October, 2002, which were estimated by fitting a logistic equation to the number of observations over time. The instantaneous rate of increase is 1.3667 for V. velutina in France and 0.2812 in South Korea, which are consistent with the interpretation of little competition in France and strong competition from local hornet species in South Korea. The invasive potential of two sister lineages can be compared by their distribution area when proper statistical adjustments are made to account for differences in sample size. V. velutina has a greater invasive potential than its sister lineage. The ancestor of V. velutina split into two lineages, one found in Indonesia/Malaysia and the other colonizing the Asian continent. The second lineage split into a sedentary clade inhabiting Pakistan and India and an invasive lineage colonizing much of Southeast Asia. This latter lineage gave rise to the subspecies V. v. nigrithorax, which invaded France, South Korea, and Japan. My software PGT version 1.5, which generates geophylogenies and computes geographic areas for individual taxa, is useful for understanding biogeography in general and invasive species in particular. I discussed the conceptual formulation of an index of invasiveness for a comparison between sister lineages.

Dynamics of cardio-muscular networks in exercise and fatigue.

A fundamental question in cardiovascular and muscle physiology is how the heart operates in synchrony with distinct muscles to regulate homeostasis, enable movement and adapt to exercise demands and fatigue. Here we investigate how autonomic regulation of cardiac function synchronizes and integrates as a network with the activity of distinct muscles during exercise. Further, weestablish how the network of cardio-muscular interactions reorganizes with fatigue. Thirty healthy young adults performed two body weight squat tests until exhaustion. Simultaneous recordings were taken of a 3-lead electrocardiogram (EKG) along with electromyography (EMG) signals from the left and right vastus lateralis, and left and right erector spinae. We first obtained instantaneous heart rate (HR) derived from the EKG signal and decomposed the EMG recordings in 10 frequency bands (F1-F10). We next quantified pair-wise coupling (cross-correlation) between the time series for HR and all EMG spectral power frequency bands in each leg and back muscle. We uncovered the first profiles of cardio-muscular network interactions, which depend on the role muscles play during exercise and muscle fibre histochemical characteristics. Additionally, we observed a significant decline in the degree of cardio-muscular coupling with fatigue, characterized by complex transitions from synchronous to asynchronous behaviour across a range of timescales. The network approach we utilized introduces new avenues for the development of novel network-based markers, with the potential to characterize multilevel cardio-muscular interactions to assess global health, levels of fatigue, fitness status or the effectiveness of cardiovascular and muscle injury rehabilitation programmes. KEY POINTS: The heart operates in synchrony with muscles to regulate homeostasis, enable movement, and adapt to exercise demands and fatigue. However, the precise mechanisms regulating cardio-muscular coupling remain unknown. This study introduces a pioneering approach to assess cardio-muscular network interactions by examining the synchronization of cardiac function with muscle activity during exercise and fatigue. We uncover the first profiles of cardio-muscular interactions characterized by specific hierarchical organization of link strength. We observe a significant decline in the degree of cardio-muscular coupling with fatigue, marked by complex transitions from synchronous to asynchronous behaviour. This network approach offers new network-based markers to characterize multilevel cardio-muscular interactions to assess global health, levels of fatigue, fitness status or the effectiveness of cardiovascular and muscle injury rehabilitation programmes.

(In)stability of de Sitter quasinormal mode spectra

We consider how the quasinormal spectrum for the conformal wave operator on the static patch of de Sitter changes in response to the addition of a small potential. Since the quasinormal modes and co-modes are explicitly known, we are able to give explicit formulae for the instantaneous rate of change of each frequency in terms of the perturbing potential. We verify these exact computations numerically using a novel technique extending the spectral hyperboloidal approach of Jaramillo et al. (2021). We propose a definition for a family of pseudospectra that we show capture the instability properties of the quasinormal frequencies.

Speckle Vibrometry for Contactless Instantaneous Heart Rate and Respiration Rate Monitoring on Mechanically Ventilated Patients.

Objective: Contactless monitoring of instantaneous heart rate and respiration rate has a significant clinical relevance. This work aims to use Speckle Vibrometry (i.e., based on the secondary laser speckle effect) to contactlessly measure these two vital signs in an intensive care unit. Methods: In this work, we propose an algorithm for the estimation of instantaneous heart rate and respiration rate from mechanically ventilated patients. The algorithm uses multiple regions, principal component analysis, and dominant angle analysis. A semi-automated peak detection method is implemented to precisely label the aortic valve opening peak within the cardiac waveform. Results: Compared with electrocardiography, the present work achieves limits of agreement of [-2.19, 1.73] beats per minute of instantaneous heart rate. The measurement spot is on the chest covered with two to three layers of duvet blankets. Compared with the airway flow signal measured by the mechanical ventilator, the present work achieves limits of agreement of [-0.68, 0.46] respirations per minute of instantaneous respiration rate. Conclusions: These results showcased Speckle Vibrometry's potential in vital sign monitoring in a clinical setting. Significance: This is the first human clinical study for Speckle Vibrometry.

Supercritical carbon dioxide as solvent for manufacturing of ibuprofen loaded gelatine sponges with enhanced performance

Supercritical carbon dioxide was used as the solvent for manufacturing of ibuprofen loaded gelatine sponges with high loading capacity and fast release performance toward healthcare materials in the treatment of postoperative dental pain. The solubility of ibuprofen in supercritical CO2 was first determined at 313 K under different pressure conditions. The micronisation of ibuprofen drugs were successfully adsorbed onto the surface of network pore system of gelatine sponges via supercritical CO₂ processing. The loading capacity of ibuprofen in gelatine sponges obtained by using supercritical CO₂ as the solvent can be up to 19.86 wt%, which was double that of the sample prepared by direct soaking in ethanol. The dissolution of ibuprofen was determined and higher instantaneous dissolution rate was observed for the ibuprofen loaded gelatine sponges synthesized by supercritical CO₂ processing.

Event-triggered nonlinear state estimation with quantized innovations

This paper proposes an event-triggered (ET) estimator with quantization mechanism to relieve the bandwidth and energy limitations of wireless sensors, where the ET strategy reduces the overall communication rate of the system, and the quantization mechanism mitigates the instantaneous bit rate constraint. Then, Gaussian approximation is applied to derive the analytical form of the minimum mean squared error (MMSE) estimator under the event-triggered strategy and quantization mechanism. Furthermore, the relationship between event-triggered parameter and communication rate is explicitly established. Finally, theoretical results are validated through some simulations on a target tracking system.

High-Precision Analysis Using μPMU Data for Smart Substations

This paper proposes a correction technique for bad data and high-precision analysis based on micro-phasor measurement unit (μPMU) data for a stable and reliable smart substation. First, a high-precision wide-area monitoring system (WAMS) with 35 μPMUs installed at Korea’s Yeonggwang substation, which is connected to renewable energy sources (RESs), is introduced. Time-synchronized μPMU data are collected through the phasor data concentrator (PDC). A pre-processing program is implemented and utilized to integrate the raw data of each μPMU into a single comma-separated values (CSV) snapshot file based on the Timetag. After presenting the technique for identification and correction of event, duplicate, and spike bad data of μPMU, causal relationships are confirmed through the voltage and current fluctuations for a total of five states, such as T/L fault, tap-up, tap-down, generation, and generation shutdown. Additionally, the difference in active power between the T/L and the secondary side of the M.Tr is compared, and the fault ride through (FRT) regulations, when the fault in wind power generation (WP), etc., occurred, is analyzed. Finally, a statistical analysis, such as boxplot and kernel density, based on the instantaneous voltage fluctuation rate (IVFR) is conducted. As a result of the simulation evaluation, the proposed correction technique and precise analysis can accurately identify various phenomena in substations and reliably estimate causal relationships.

Trend in agricultural growth and cassava productivity in Nigeria (1961 – 2020)

This study analyzed the trend in agricultural growth and cassava productivity in Nigeria (1961 – 2020). Time series on variables of interest were sourced from the Central Bank of Nigeria (CBN) statistical bulletin, the National Bureau of Statistics (NBS), and FAOSTAT. The secondary data obtained were analysed using trend analysis, instability index, compound growth rate model, and the Granger causality test. The results showed that Nigeria’s agricultural output generally experienced an upward trend from 1960-2020. The findings also revealed a general increase in the output of cassava produced in an area in the country within the study period. The yield however experienced some relatively stable trend with mild fluctuations and a noticeable decline in 2013. Across the major policy line considered in this study, the pre-SAP era (1961 – 1985) had the lowest mean output, while the SAP and post-SAP era had the highest mean output of 24772.15 and 45181.94 respectively. The values of instability of production and land put under cassava cultivation are more pronounced in Period II [1986–1998] and Period III [1999–2020]. During period I, (Pre – SAP; 1961 – 1985), the compound growth rate (CGR) for production accelerated while yield stagnated with a CGR of 0.2%. In period II, (CGR for production (6.2%) and area (6.3%) for cassava accelerated; both CGR and instantaneous growth rate for yield experienced stagnation. For period III, there was an acceleration in output and area. There was unidirectional causality between production (output) and area under cultivation, agricultural growth and cassava production, agricultural growth and area under cassava cultivation at a 5% level of significance; while area under cassava cultivation and cassava productivity, productivity and area under cultivation exhibited a bi-directional causality at 5% significant level. The findings are compelling reasons for encouraging cassava production for sustainable food production in Nigeria as it is a versatile staple to address food security.

Integrated Analysis Reveals Genetic Basis of Growth Curve Parameters in an F2 Designed Pig Population Based on Genome and Transcriptome Data

Appropriate growth curves can reflect more sophisticated growth patterns of animals than body weight, and thus, the identification of genes and variants related to the growth curve parameter traits contributes to revealing the fine growth and development characteristics of livestock. However, the ability of single genome-wide association analysis (GWAS) and transcriptome analyses to identify valuable genes and variants is limited. In this study, based on genome and transcriptome data, the growth curve parameter traits of hybrid pigs were analyzed, and a set of genes and variants were identified. The Gompertz–Laird growth curve model was optimized to reveal the growth pattern of F2 individuals of Duroc × Erhualian pigs over four time points. Five growth parameters were estimated, including initial body weight (W0), instantaneous growth rate per day (L), coefficient of relative growth or maturing index (k), body weight at inflection point (Wi), and average growth rate (GR). These five parameters were subjected to a genome-wide association study, differential gene expression analysis, and weighted gene co-expression network analysis (WGCNA). In the study, 336 pigs were genotyped, and 39,494 SNP markers were used for each pig in the analysis. Thirty of these pigs were also included in the transcriptomics analysis. Based on genome and transcriptome data, the integrated analyses identified five putative SNPs (including INRA0056460 on chromosome X, DRGA0004151 on chromosome 3, INRA0056460 on chromosome X, H3GA0049324 on chromosome 17, and H3GA0037747 on chromosome 13) and 15 candidate genes (PDGFA, VEGFD, CSPP1, EFHC1, PIK3C3, ZZZ3, GCC2, MAPK14, ZPR1, ISG15, ANG, CEBPD, ZHX3, CTBP2, and MYNN). The functional analysis indicated that these candidate genes played important roles in cell division and differentiation, development and aging, and skeletal muscle and fat formation. Our results provide insight into the genetic mechanisms underlying the growth and development of hybrid pigs and offer a theoretical basis for genomic breeding.

Side effects of semi-synthetic insecticide spinetoram on the whitefly parasitoid Encarsia formosa.

Insecticide risk assessment for biological control agents is essential for implementing integrated pest management (IPM) programs. Spinetoram is a naturally derived insecticide used to control a variety of agricultural sap-sucking insect pests, and Encarsia formosa Gahan (Hymenoptera: Aphelinidae) plays a key role in the biocontrol of greenhouse whiteflies. Despite its presumed safe ecotoxicological profile, the side effects of spinetoram on E. formosa are partially unknown, especially at sublethal doses. In the laboratory, we estimated the lethal concentrations (LC) of spinetoram on E. formosa by topical exposure of pupae and 48 h residual contact exposure of emerged adults. Afterwards, we assessed the impact of spinetoram LCs on the life history traits (juvenile development, adult longevity, parasitism, adult emergence) and population growth parameter (the instantaneous rate of increase, ri) of the parasitoid. Probit analysis allowed the estimation of LC10 = 0.10 mg/L, LC50 = 0.56 mg/L, and LC90 = 3.28 mg/L. Spinetoram at LC10 had no impact on the observed parameters of E. formosa. Conversely, spinetoram at LC50 and LC90 significantly reduced adult longevity by 19.2% and 40.6%, total parasitism by 33.4% and 38.7%, and total adult emergence by 29.6% and 39.1%, respectively. Also, the ri of E. formosa was significantly affected by spinetoram LC50 and LC90 with a reduction of 8.17 and 29.83%, respectively. Our results suggested that spinetoram significantly threatens the effectiveness of E. formosa when applied at the field recommended rate. However, further validation of spinetoram under greenhouse conditions is required for a comprehensive risk assessment for E. formosa in IPM programs. © 2024 Society of Chemical Industry.

Short-term temperature changes affected the predation ability of Orius similis on Bemisia tabaci nymphs

Abstract Bemisia tabaci (Gennadius), a major pest that can adversely affect economies and agriculture globally, is particularly sensitive to climate change-induced temperature fluctuations, which can intensify its outbreaks. Orius similis Zheng, a primary natural predator of B. tabaci, also experiences temperature-related effects that influence its biocontrol efficacy. Thus, understanding the response of O. similis to temperature changes is pivotal for optimizing its biocontrol potential. Herein, our investigations showed that the functional response of O. similis to both high- and low-instar nymphs of B. tabaci adheres to the type II model at temperatures of 19, 22, 25, 28, and 31 °C. At 28 °C, O. similis exhibits the highest instantaneous attack rate (high-instar: 1.1580, low-instar: 1.2112), and the shortest handling time per prey (high-instar: 0.0218, low-instar: 0.0191). The efficacy of O. similis in controlling B. tabaci nymphs follows the sequence: 28 °C > 25 °C > 31 °C > 22 °C > 19 °C. Additionally, search efficiency inversely correlates with prey density. Simulations using the Hessell–Varley interference model indicate that increased density of O. similis under any temperature condition leads to reduced predation rates. Moreover, O. similis shows a predation preference for low-instar nymphs of B. tabaci, with higher predation level observed at the same temperature. In conclusion, for effective control of B. tabaci in field releases, O. similis should be optimally released at temperatures between 25 and 28 °C to preferably target the egg or early nymph stages of B. tabaci and determining the appropriate number of O. similis is important to minimize interference among individuals and enhance biocontrol efficacy.

XUV irradiation of young planetary atmospheres. Results from a joint XMM-Newton and HST observation of HIP67522

The evaporation and the chemistry of the atmospheres of warm and hot planets are strongly determined by the high-energy irradiation they receive from their parent stars. This is more crucial among young extra-solar systems because of the high activity of stars at early ages. In particular, the extreme-ultraviolet (EUV) part of the stellar spectrum drives significant processes of photo-chemical interaction, but it is not directly measurable because of strong interstellar absorption and a lack of sufficiently sensitive instrumentation. An alternative approach is to derive synthetic spectra from the analysis of far-ultraviolet (FUV) and X-ray emission lines, which allow us to estimate the missed flux in the EUV band. We performed joint and simultaneous spectroscopy of with and the Hubble Space Telescope (HST) in order to reconstruct the full high-energy spectrum of this 17\,Myr-old solar-type (G0) star, which is the youngest transiting multiplanet system known to date. We performed a time-resolved spectral analysis of the observations, including quiescent emission and flaring variability. We then derived the emission measure distribution (EMD) versus temperature of the chromospheric and coronal plasma from the high-resolution spectra obtained in X-rays with RGS and in FUV with COS. We derived broad-band X-ray and EUV luminosities from the synthetic spectrum based on the EMD, which allowed us to test alternative EUV versus\ X-ray scaling laws available in the literature. We also employed the total X--EUV flux received by the inner planet of the system to estimate its instantaneous atmospheric mass-loss rate. We confirm that is a very active star with a hot corona, reaching plasma temperatures above 20\,MK even in quiescent state. Its EUV/X-ray flux ratio falls in between the predictions of the two scaling laws we tested, indicating an important spread in the stellar properties, which requires further investigation.

Dispersal of optimal foragers in a patchy environment: Simulations with a mathematical model and tests of predictions in field experiments

To predict the effect of density on the dispersal of foraging parasitoids, we developed a spatially explicit individual-based model in which parasitoids move among host patches at random but use an optimal decision-rule about when to leave these patches. We used a simple decision rule where an individual forager exploits a patch as long as the instantaneous attack rate is higher than the average attack rate it has experienced in the environment. Such a rule implies that foragers compute and remember attack rates as they forage. Simulations with different combinations of patch distribution, host density, mutual interference, and parasitoid density predicted that dispersal distance should increase with parasitoid density. To test this prediction, we used data from two field experiments in which we released either few or many adults of the aphid parasitoid Aphelinus asychis in replicated sites, and subsequently assessed dispersal from the spatial distribution of parasitoid offspring. In the first experiment, we did not to detect a relation between the number released and dispersal distance, but in the second experiment, dispersal distance increased with initial density, as predicted by our model. We propose two hypotheses to explain the discrepancy between the experiments. Different levels of environmental variability among experiments, resulting from differences in experimental designs, could cause differences in statistical conclusions. However, there could be a threshold density below which dispersal is not density-dependent, and this threshold may have been exceeded in the second experiment where large releases involved many more individuals than in the first experiment. In any case, our approach linked individual behavior and spatial distribution, and our results show that the insect distributions in the field can be predicted, qualitatively, from theory about individual behavior.

Implementation of sprinkling location with restructure-monochrome-dot on diffusivity mutational-status of fabricated function agent on porous

The recognition technology that determines the sprinkling mutation status in simple squamous epithelium cells produces a monochromatic dot pattern in an echo state using the instantaneous recognition rate (MPR) and vacuum recognition rate (VPR). The diffusivity echo system was created in the form of sprinkler recognition to control recognition rate conditions. The mutation status of simple squamous epithelium cells is displayed as a sprinkling porous value according to the sprinkling location layer by a diffusivity-down structure to search as a jagged monochrome-dot pattern. In the sprinkling porous, the perception rate concept is verified by referencing the instantaneous rate and vacuum rate to the mutant state signal through the sprinkling echo conformation. The jagged mutation state of MPR-VPR appears from a sprinkling porous to a maximum-minimum sprinkling-echo conformation. Sprinkling echo locations are found in the sprinkling porous values of the mutant state. Wr-af-FA-τMED is far mutational-status of 18.12±5.16 units, Wr-af-CO-τMED is convenient mutational-status of 6.89±0.30 units, Wr-af-FL-τMED is flank mutational-status of 2.34±1.53 units, Wr-af-VI-τMED is vicinage mutational-status of 0.48±0.20 units. Diffusivity echo calculates the jagged momentary vacuum conformation that appears through the perception rate system in simple squamous epithelium cells, and the ability to estimate the sprinkling-echo conformation for the jagged degree perception rate of MPR-VPR can be confirmed. We can estimate the shape through the vacuum signal in the sprinkling porous and estimate the diffusion data of the diffusivity echo rate through the diffusivity perception system.

A microscopic oxygen transport model for ultra-high dose rate radiotherapy in vivo: The impact of physiological conditions on FLASH effect.

Ultra-high dose rate irradiation (≥40Gy/s, FLASH) has been shown to reduce normal tissue toxicity, while maintaining tumor control compared to conventional dose-rate radiotherapy. The radiolytic oxygen (O2) depletion (ROD) resulting from FLASH has been proposed to explain the normal tissue protection effect; however, in vivo experiments have not confirmed that FLASH induced global tissue hypoxia. Nonetheless, the experiments reported are based on volume-averaged measurement, which have inherent limitations in detecting microscopic phenomena, including the potential preservation of stem cells niches due to local FLASH-induced O2 depletion. Computational modeling offers a complementary approach to understand the ROD caused by FLASH at the microscopic level. We developed a comprehensive model to describe the spatial and temporal dynamics of O2 consumption and transport in response to irradiation in vivo. The change of oxygen enhancement ratio (OER) was used to quantify and investigate the FLASH effect as a function of physiological and radiation parameters at microscopic scale. We considered time-dependent O2 supply and consumption in a 3D cylindrical geometry, incorporating blood flow linking the O2 concentration ([O2]) in the capillary to that within the tissue through the Hill equation, radial and axial diffusion of O2, metabolic and zero-order radiolytic O2 consumption, and a pulsed radiation structure. Time-evolved distributions of [O2] were obtained by numerically solving perfusion-diffusion equations. The model enables the computation of dynamic O2 distribution and the relative change of OER (δROD) under various physiological and radiation conditions in vivo. Initial [O2] level and the subsequent changes during irradiation determined δROD distribution, which strongly depends on physiological parameters, i.e., intercapillary spacing, ultimately determining the tissue area with enhanced radioresistance. We observed that the δROD/FLASH effect is affected by and sensitive to the interplay effect among physiological and radiation parameters. It renders that the FLASH effect can be tissue environment dependent. The saturation of FLASH normal tissue protection upon dose and dose rate was shown. Beyond ∼60Gy/s, no significant decrease in radiosensitivity within tissue region was observed. In turn, for a given dose rate, the change of radiosensitivity became saturated after a certain dose level. Pulse structures with the same dose and instantaneous dose rate but with different delivery times were shown to have distinguishable δROD thus tissue sparing, suggesting the average dose rate could be a metric assessing the FLASH effect and demonstrating the capability of our model to support experimental findings. On a macroscopic scale, the modeling results align with the experimental findings in terms of dose and dose rate thresholds, and it also indicates that pulse structure can vary the FLASH effect. At the microscopic level, this model enables us to examine the spatially resolved FLASH effect based on physiological and irradiation parameters. Our model thus provides a complementary approach to experimental methods for understanding the underlying mechanism of FLASH radiotherapy. Our results show that physiological conditions can potentially determine the FLASH efficacy in tissue protection. The FLASH effect may be observed under optimal combination of physiological parameters, not limited to radiation conditions alone.