The performance of building sound insulation is an important parameter for evaluating the quality of construction projects. So far, the sound insulation performance testing of building walls requires the installation of large-dimensioned wall samples in specialized sound insulation laboratories, which is time-consuming and costly. If small-dimensioned components of the wall panels can be applied and quickly tested at the project site, it could significantly improve efficiency and reduce costs. To address this issue, this paper investigates a method for estimating the random incidence sound transmission loss of wall panels based on the measurement of the normal incidence sound transmission loss of corresponding small samples. Initially, the sound transmission loss of single-layer and composite structures is theoretically analyzed based on the theories of Equivalent Single Layer method and Layer-Wise method. Subsequently, the random incidence sound transmission loss is estimated by the normal incidence sound transmission loss. The methodology for estimating the random incidence sound transmission loss of wall panels proposed in this study offers both a practical approach and theoretical support for the rapid assessment of the sound insulation performance of building walls. This study is of great significance for improving the quality of construction projects and inspection efficiency.