Three isomers (nongeminal cis-2,4,6 ( 2); nongeminal trans-2,4,6 ( 3); geminal 2,2,4 ( 4)) were isolated from the reaction of hexachlorocyclotriphosphazatriene (trimer) ( 1) with diethylene glycol monobutyl ether (DEGBE). The substitution reactions of cis-tris isomer ( 2) with 3-amino-1-propanol were investigated under different solutions conditions to provide amphiphilic phosphazene ( 5). All of compounds were characterized by using elemental analysis, 31P NMR and mass spectroscopies. Thermosensitive properties of compound 5 were studied. The compound 5 is soluble in both water and organic media. This indicates that compound 5 is an amphiphilic molecule. Concentration-dependent LCST (Lower Critical Solution Temperature) behavior of 5 was measured in water. Compound 5 exhibited a reversible and thermosensitive phase transition in aqueous medium, from soluble to insoluble states. Compound 5 showed LCST at 37 °C (for 7 wt.% concentration) which is near to body temperature.