Insertion Of Methyl Group Research Articles

The effect of methyl group functionality on the host-guest interaction and sensor behavior in metal-organic frameworks

The strategy of MOFs functionalization by modifying ligands is a powerful platform among other ongoing researchs which is creating high-performance MOFs. Ligands modification through the addition of support groups (in helping of host–guest main interaction sites) has a key role in the increasing of host molecule adsorption capacity. To investigate this issue we synthesized two structures TMU-59 and TMU-6(RL1) and studied the effect of MOFs functionalization with functional groups such as methyl group in the vicinity of basic amine groups on the detection of guest molecules. The sensing ability of TMU-6(RL1) as parent structure and methyl functionalized TMU-59 has studied for the detection of TNP in aqueous solutions. Our results reveal that the insertion of methyl groups on pillaring linker can remarkably increase the hydrophobicity, stability and electron density of MOFs as well as maximizing the interaction with the nitro-aromatics guests by providing multiple adsorption mechanisms such as hydrogen bonds and π-π interactions. The detection limit for TNP in water solvent is 0.46 and 102 ppb for TMU-59 and TMU-6(RL), respectively. Present work as a comprehensive study reveals that how MOFs functionalization through the addition of relatively active group such as methyl would have influenced the overall sensing behavior.

Synthesis and anticancer properties of 1-(2-isopropyl-5-methylphenoxymethyl)-3R-4-aryl-5,6,7,8-tetrahydro-2,2а,8а-triazacyclopenta[cd]azulene derivatives

In recent years, attention to itself is attracted to the problem of treatment of cancer that is caused by increase in patients, especially of working age. Therefore, the enlargement of the arsenal of anticancer medicines of a wide spectrum of action is actual.
 The purpose of the study was to synthesize substances with potentially antitumor properties in a series 1-(2-isopropyl-5-methylphenoxymethyl)-3R-4-aryl-5,6,7,8-tetrahydro-2,2а,8а-triazacyclopenta[cd]azulene derivatives and to study the effect of synthesized compounds on inhibition of growth (or their destruction) of a wide range of cancer.
 The objects of the study were derivatives of 1-(2-isopropyl-5-methylphenoxymethyl)-3R-4-aryl-5,6,7,8-tetrahydro-2,2а,8а-triazacyclopenta[cd]azulene, which were synthesized by refluxing 3-(2-isopropyl-5-methylphenoxymethyl)-6,7,8,9-tetrahydro-5Н-[1,2,4]triazolo[4,3-a]azepine with с appropriate α-halogenketones in ethyl acetate and further cyclization in an alkaline medium. Использовали данные NMR 1Н spectroscopy data were used. The primary evaluation of anticancer activity was carried out National Cancer Institute of Health, USA within the Development Therapeutic Program.
 A series of new of 1-(2-isopropyl-5-methylphenoxymethyl)-3R-4-aryl-5,6,7,8-tetrahydro-2,2а,8а-triazacyclopenta[cd]azulene derivatives was synthesized, their structure and purity were confirmed by NMR 1Н spectroscopy. The anticancer activity of the synthesized compounds was studied both at a concentration of 10-5 mol/l and in a concentration gradient of 10-4‒10-8 mol/l in experiments in vivo on cancer cell lines. It is shown that insertion of methyl group into position 3 of heterocyclic system of the basic structure of 4-aryl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulene leads to an increase in the anticancer effect.
 It is found that the tested compounds showed high anticancer effect on all types of cancer cell lines investigated – leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer.

A quantum chemical study of the interaction of carbenes with 2-alkenylfurans and thiophenes

The study of the interaction mechanism of monoalkenyl-substituted furans and thiophenes with carbenes was performed by AM1 and MNDO methods. The energy profiles of two pathways were calculated, one leading to ylide formation and the second to cyclopropanation species. The insertion of methyl groups into the vinyl fragment does not change the energetic parameters of path 1. The reactivity of the exocyclic double bond was shown to depend on the degree of substitution. The calculations prove the presence of the intermediate ylide formation, based on experimental data. The stability of the ylides is determined by the heights of the cycloaddition barrier and the one of the reversed reaction 1 as shown by calculations.

Atypical Transfer RNA's And Their Origin In Neoplastic Cells

Publisher Summary This chapter focuses on the structure and synthesis of transfer RNA (tRNA) and discusses the biochemistry of tRNA methylases. Translation is the most complex molecular mechanism known in the living cell. It requires messenger RNA, which is the simplest of the structures involved, even though it is laden with information. The ribosomes are complex structures composed of RNA and at least a score of different proteins. Transfer RNA is the most complex biomacromolecule known. In addition to these major components, there are ancillary ones— enzymes that transfer amino acids to the transfer RNA. Moreover, there are at least 8 soluble protein factors needed for the completion of the synthesis of a protein. Any or all of these numerous components could be a regulatory factor in protein synthesis. There are three different lines of biological evidence that point to transfer RNA as a regulatory factor. Transfer RNA is a pivotal molecule in protein synthesis. It is the link between the amino acids and the message-bearing nucleic acids. The tRNA methylases are a complex family of enzymes that modify the structure of preformed tRNA by the insertion of methyl groups into specific positions in the four main bases of tRNA. The enzymes are species-specific, organ-specific, base-specific, and even site-specific for particular bases.

Viscosity B coefficients for some substituted anilinium cations in aqueous solution at 25° and 35°

The variation with concentration of the viscosity and density of aqueous solutions of anilinium chloride, and of some C- and N-methyl substituted anilinium chlorides, has been measured in the presence of sufficient hydrochloric acid to suppress hydrolysis. A suitable method of evaluating viscosity B coefficients for these organic cations from these data has been developed. It has been shown that the ratio of the B coefficient for the organic cation (B+) to its limiting apparent molar volume (Φ+°) increased slightly with increasing methyl substitution in the ring. For the N-methylated cations, on the other hand, B+/Φ+° fell rapidly as the number of substituent groups increased. This behaviour can be understood by assuming that increasing N-methyl substitution makes it progressively more difficult for a primary hydration shell to form around the charged nitrogen atom, and that insertion of methyl groups in the aromatic ring has little effect on this hydration process.