Introduction and Aim: Supraglottic airway devices are increasingly being used as an excellent alternative to mask ventilation and tracheal intubation with least complications. The present randomized, prospective study was conducted to compare the I-Gel with LMA-Supreme with respect to time taken for insertion, insertion success rate, ease of insertion of gastric tube, hemodynamic changes before and after insertion and post-operative airway morbidity. Materials and Methods: Fifty American Society of Anaesthesiologist (ASA) grade-I and II patients between 20-60 years age, of either sex, were randomly assigned to two groups of 25 patients each. Group A: LMA- supreme was inserted and Group B: I-gel was inserted Hemodynamic responses were recorded before induction and at the intervals after insertion of LMA Supreme/I-Gel. Time taken for insertion, insertion success rate and ease of insertion of gastric tube was noted. Patients were inspected for any trauma immediately, sore throat and hoarseness of voice 24 hours after the surgery. Statistical analysis was carried out with student’s t-test and chi-square test and value of P Results: Insertion time of I-Gel (11.24 ± 1.94 seconds) was faster than the LMA-Supreme (15.44 ± 2.48 seconds) and the results were statistically significant (P = 0.03). Ease of insertion of gastric tube was more in LMA Supreme (25/25) as compared to I Gel (23 / 25). The two groups were comparable as far as the insertion success rate, hemodynamics and post-operative airway morbidity were concerned. Conclusion: I-Gel is better than LMA-Supreme in terms of faster insertion time. Insertion success rate, ease of insertion of gastric tube, hemodynamics and post-operative airway morbidity is comparable in both the groups. Keywords: LMA SUPREME, I-GEL, SGA, Gastric drainage tube, Endotracheal intubation, Haemodyanamic response.