Insertion Of Complete Dentures Research Articles

Impact of complete dentures treatment on Oral health-related quality of Life (OHRQoL) in edentulous patients: A descriptive case series study.

To evaluate the changes in oral health-related quality of life [OHRQoL] before and three months after complete denture oral rehabilitation using the Geriatric oral health assessment index [GOHAI] in Pakistani elderly edentulous patients. In this descriptive case series study a total of 80 edentulous patients were recruited from Islamic International Dental Hospital, Islamabad, Pakistan from November 2021 to April 2022. The OHRQoL was evaluated twice by using the GOHAI- Urdu version. First, before getting the complete denture, and subsequently after three months of using a prosthesis. The data were analysed using SPSS-23. Pre and post-comparison were done by t-test. Moreover, the ANOVA test was utilized to assess the socio-demographic variables-GOHAI score and association. The mean GOHAI scores increased significantly from 22.9 (SD = 3.01) at baseline to 28.1 (SD = 5.59) after three months (P = 0.001), reflecting an overall increase of 5.2 points. At baseline, the ability of the patient to swallow comfortably was found to have the highest mean GOHAI score of 3.02 (SD= 1.24) and after three months of complete denture insertion, the same questionnaire item further improved with the highest mean GOHAI score of 3.43 (SD=1.05). The socio-demographic characteristics-based comparison of mean pre and post-insertion GOHAI scores suggested a statistically significant difference (p=0.001). The OHRQoL in elderly edentulous patients improved after complete denture delivery, and a significant improvement was noted in most GOHAI domains.

Effect of Prosthetic Rehabilitation on Airway Space in Edentulous Patients with Obstructive Sleep Apnea- a Preliminary Observational Study.

The common causes of obstructive sleep apnea (OSA) are identified as anatomic and/or functional abnormality in the oral cavity, oropharynx, velopharynx, and hypopharynx leading to compromised airway space and increased collapsibility. This study was conducted to evaluate the effect of implant-supported mandibular complete denture in improving the airway space among completely edentulous patients with OSA and compare it with conventional complete denture. In this observational study, completely edentulous individuals were screened with snoring, tiredness, observed apnea, high blood pressure, body mass index, age, neck circumference, and gender (STOP-Bang) questionnaire to evaluate the incidence of OSA. Ten mild-moderate patients were included as study participants. Lateral cephalograms (L1) made at the edentulous state was considered baseline. They were rehabilitated with complete denture prosthesis. One week after denture insertion, two implants were placed in the edentulous mandibular arch. Delayed loading protocol was followed. Lateral cephalogram (L2) was made 6 months after complete denture insertion and 6 months after implant-supported prosthesis (L3). Cephalometric tracings were used to evaluate change in upper airway space (UAS), middle airway space (MAS), and lower airway space (LAS). Repeated measures ANOVA was used to evaluate statistical significance in the airway measurements made at the three intervals. Post hoc Tukey HSD and Bonferroni test were used to assess if the differences obtained were truly significant. Statistical analysis revealed significant differences in UAS, MAS and LAS between L1, L2 and L3 (p< 0.05). Post hoc Tukey HSD indicated that UAS increased significantly at all three intervals followed by LAS and MAS respectively (α=.05). Post hoc Bon-ferroni test indicated that implant-supported mandibular complete dentures had a significant improvement in airway space when compared to conventional complete dentures (α=.05). Implant-supported mandibular complete denture could be effective in edentulous patients with mild-moderate OSA.

Effect of Denture Wearing on Occurrence of Fungal Isolates: An Original Study.

The present study aimed to evaluate the effect of denture wearing on the occurrence of fungal isolates in the oral cavity before and after complete denture insertion. Fifty completely edentulous patients were selected. Swab samples were collected intraorally before the fabrication of complete dentures from the palatal mucosal surface and after complete denture fabrication (1 and 7 days after denture insertion). Further, these samples were inoculated and incubated. Results showed that in 48 patients, no isolate of fungus before denture insertion was found. In two subjects, results were false positive (contamination from the environment), and in six patients, there was an increase in growth, but not much significant increase of growth was seen (mild growth of fungus only after denture insertion). One of the major findings of this study was that the overall occurrence of fungal isolates (before and after denture insertion) in the oral cavity was not significant.

EVALUATION OF TRAUMATIC ULCERATIONS FREQUENCY AND SITE IN POST-INSERTION ADJUSTMENT RECALL VISITS IN COMPLETE DENTURE PATIENTS VISITING A DENTAL COLLEGE IN CHITWAN

Background: During the initial days after complete denture insertion, patients can face various difficulties like traumatic ulcerations, loss of retention, unstable denture, difficulty in mastication and speech etc. The aim of the study was to assess the site and number of traumatic ulcerations in maxillary and mandibular denture bearing area in post-insertion adjustment recall visits and also to find out the total number of adjustments recall visits required until the patients become comfortable with the denture. Methods: A cross-sectional study was conducted among 75 complete denture patients to look for the number and site of traumatic ulcerations and the number of post-insertion recall visits required until they became symptom free. Descriptive (frequency and percentage) statistical analysis was done using SPSS Statistical Software Package (version 21.0). Results: In the mandibular arch 49.33% (N=34) and in the maxillary arch 12.5% (N=9) patients required adjustment visits for traumatic ulcerations. In the first recall visit after 24 hrs, 34 patients showed traumatic ulcerations on mandibular arch while only 6 patients experienced traumatic ulcerations on the maxillary arch. Conclusions: The patients required more post insertion adjustments for traumatic ulcerations in the mandibular arch in comparison to maxillary arch. Traumatic ulcerations was most frequently found in distobuccal sulcus area in the maxillary arch and labial sulcus in the mandibular arch.

Comparison of retention and denture base adaptation between conventional and 3D-printed complete dentures.

Background. In recent years, complete denture construction has been revolutionized using computer-aided designing and computer-aided manufacturing (CAD-CAM) technology. This clinical study compared the retention and denture base adaptation of 3D-printed complete dentures fabricated using dimethacrylate-based resins with a photoinitiator versus conventional complete dentures. Methods. Ten completely edentulous patients were nominated for this study. Each patient received two complete dentures. One complete denture was conventionally fabricated, while the other was digitally fabricated through 3D printing of dimethacrylate-based resins with a photoinitiator. Denture base adaptation for both dentures was evaluated using surface matching software. Denture retention was also evaluated using a digital force meter at the time of complete denture insertion (T0 ), after three months (T3 ) and six months (T6 ) of denture use. Results. Regarding adaptation (mean misfit values), a statistically insignificant difference was detected between the two differently fabricated complete dentures. In addition, comparable satisfactory retention values were observed for both conventionally fabricated and 3D-printed dentures; however, there was an insignificant increase in retention over time. Conclusion. 3D-printed complete dentures fabricated using dimethacrylate-based resins could be a promising alternative to conventionally fabricated complete dentures with satisfactory denture base adaptation and retention.

Assessment of Changes in Oral Health-related Quality of Life and Nutritional Status of Edentulous Patients before and after Insertion of Complete Dentures

Assessment of Changes in Oral Health-related Quality of Life and Nutritional Status of Edentulous Patients before and after Insertion of Complete Dentures

Commonest location of traumatic ulcers in edentulous patients after denture insertion

Aim: To evaluate frequency of commonest location of traumatic oral ulcers after complete denture insertion and find out their association with age, gender and arch type. Study design: Cross sectional observational study Place and duration: Prosthodontic department of Islamic International Dental College, Riphah International University Islamabad, from 11th Feb.,2022 till 11th April 2022. Methodology: A sample of 150 completely edentulous patients were clinically checked for traumatic ulcer development after insertion of complete denture. Frequently involved anatomical sites were noted in both arches. Denture surfaces were assessed to find out the frequently existing denture problems responsible for ulcers. Results: Out of total 150 patients 37.3% with oral ulcers were males and 62.7 % were female. 61-70 years old age group reported with frequent ulcers 48.7%. Frequently observed oral ulcer site in maxilla was sulci 10.0% and in mandible was ridge 24.7%. Frequently observed denture problem responsible for ulcer formation was denture surface roughness 46.7%. Association with age, gender and arch type was significant; p&lt;0.05. Conclusion: Frequent ulcers develop in mandibular arch as compared to maxilla and commonest sites of ulcer developments are the ridges and sulci. Old age and female predisposition have been seen in ulcer development. Keywords: Complete dentures, Mandibular arch, Maxillary arch, oral ulcers, traumatic ulcers, post insertion complains

Campagna Technique: A Boon for Debilitated Dentition Patients

Immediate complete denture insertion followed by removal of teeth provides a positive emotional response to the patient by saving the embarrassment of being edentulous and minimal alteration in general appearance, muscle tone, and speech. The patient gets adjusted to the change more quickly; the healing period is faster and less painful. However, the fabrication of immediate denture requires different impression techniques to follow than routine conventional complete denture procedure. This case report presents the fabrication of conventional immediate denture using Campagna impression technique which appears to be more precise among all the techniques as it ensures a similar degree of accuracy of the borders in the dentulous as well as edentulous region of the maxillary dental arch. To provide optimum benefit from the constructed denture, a lingualized balanced occlusal scheme was given.

Assessment of pH level and uric acid in saliva before and after complete denture insertion

Background: Many factors influence the composition of saliva. The rate of secretion follows a circadian rhythm, decreasing during sleep and increasing during day. The present study was conducted to assess pH level and uric acid in saliva before and after complete denture insertion. Materials & Methods: 80 completely edentulous patients of both genders were divided into two groups of 40 each and each group was further divided into two groups of 20 each. Group I was age ranged 40-60 years contains two subgroups: group A1 for smokers and group A2 for non-smokers. Group II age ranged 61-80 years contains two subgroups: group B1 for smokers and group B2 for non-smokers. Saliva samples were collected from subjects immediately before the insertion of dentures and pH & uric acid estimation was done.Results: Out of 80 patients, males were 45 and females were 35. The mean pH of saliva before denture insertion was 6.7 and after denture insertion was 5.1. The difference was significant (P

Is the Number of Appointments for Complete Denture Fabrication Reduced with CAD-CAM? A Literature Review

One of the key arguments in favor of digitally produced complete dentures (CDs) is the requirement for less patient visits in comparison to the conventional workflow. However, it is not yet clear if this argument is accurate; nor, if indeed the insertion of the complete dentures is achieved in fewer appointments, how many are required. The purpose of this literature review was to investigate the reported number of required patient visits for the production of digitally fabricated CDs. An electronic search was performed in PubMed/MEDLINE using three groups of keywords: “complete dentures”, “CAD/CAM”, and “Appointments” with their alternative forms. Out of the initial 157 results, 36 articles were automatically selected utilizing exclusion keywords. After consensus between the two examiners, eight articles were finally analyzed and presented in a table. The majority (75%) of the reports came from institutions, and the average number of appointments up to complete denture insertion was 4.1, not always including try-in dentures. In this study, it can be concluded that, with a digital workflow, the insertion appointment is reached in fewer visits than the conventional five-visit procedure which is commonly taught in dental schools.

Salivary Flow Rate Before, During and After Insertion of Complete Denture in Different Age Group: a Comparative study

Background: Increase in salivary flow accompanying complete denture insertion is a well-known phenomenon. Complete dentures act as a mechanical stimulant, increasing salivary flow after insertion. This study compares unstimulated and stimulated salivary flow rates before, during, and after insertion of a complete denture in different age groups.Method: Forty subjects meeting inclusion criteria were selected. Unstimulated saliva was collected first. Stimulation was produced by chewing paraffin wax and collected of saliva in a graduated container. This procedure was carried out before insertion, during insertion, 24 hours after, and 7 days after insertion of complete dentures. The study data were entered, edited, and coded in Microsoft Excel. The unstimulated and stimulated salivary flow rate was compared at different time intervals.Result: Unstimulated salivary rate was lowest before denture insertion with mean values of 0.27ml/minute. The highest flow rate was recorded during denture insertion (mean values of 0.60 ml/minute). The mean unstimulated salivary flow rate 24 hours after denture insertion was higher than 7 days after denture insertion. The mean stimulated salivary rate was lowest before denture insertion (mean values of 0.59 ml/minute). The highest flow rate was recorded during denture insertion (mean values of 0.93 ml/minute). There was a declining trend in salivary flow rate after denture insertion i.e. 0.86 ml/minute to 0.75ml/min after 24 hours and 7 days of denture insertion. A gradual decrease in salivary flow rate with an increase in age was noted but the association of age with salivary flow rates was not statistically significant.Conclusion: There was an increase in both unstimulated and stimulated salivary flow rate after insertion of complete denture and age does not affect salivary flow rates before, during (immediately after), 24 hours after, and 7 days after denture insertion.

Evaluation of salivary stress biomarker changes after the insertion of complete dentures

Introduction/Objective. The purpose of this study was to assess the relationships between salivary stress markers [salivary ?-amylase (sAA) and pH], and patients? stress with new dentures. Methods. An intra-individual evaluation was done, in which 30 participants older than 65 years, both sexes, in good general health, first-time complete dentures (CDs) wearers, took part. Measuring of stress biomarkers was done in the unstimulated saliva collected by the so-called spitting method: (1) before any prosthetic treatment, (2) after insertion of a new pair of CDs, and (3) two months after CDs delivery. Results. Upon evaluating the obtained data it was observed that the sAA values steadily increased and by the end of the observation period sAA was higher in women but without statistical significance. The pH values increased until the second follow-up period, after which they dropped. The post-hoc test showed a statistically significant difference in pH values between the first vs. the second (p = 0.005) and the second vs. the third (p = 0.001) follow-up periods. Conclusion. There was a non-significant increase in sAA values during the adaptation period. The biggest difference in sAA values between men and women was at the moment of insertion of dentures. The highest pH level was after the insertion of dentures. Since sAA changes were of no statistical significance, the sAA and pH values cannot be used as a reliable biomarker in saliva for observing the patients? adaptation, psychological, and emotional issues.

Evaluation of oral stereognosis, masticatory efficiency, and salivary flow rate in complete denture wearers.

Aim:The aim of the present study was to evaluate the improvement in oral stereognostic ability, masticatory efficiency, and difference in salivary flow rate in nonexperienced denture wearers, before, after, and 6 months after rehabilitation with complete dentures.Settings and Design:Invivo – Observational study.Materials and Methods:Seventy edentulous subjects were selected who came for rehabilitation with complete dentures for the first time. The study was conducted in three stages–before denture insertion, after denture insertion, and 6 months after denture insertion. Oral stereognostic ability was evaluated by asking the subjects to identify six heat cured acrylic resin samples by oral manipulation without seeing it. The unstimulated salivary flow rate was estimated by measuring the time taken to collect 5 ml of the whole saliva. Masticatory efficiency of the subjects was assessed with the help of preweighed chewing gums. The chewing gums were desiccated after the chewing strokes and weighed again.Statistical Analyses Used:Data were tabulated and analyzed statistically using pairedt-test, one-way ANOVA test, and the post hoc test.Results:Oral stereognostic ability increased immediately on insertion of complete dentures and was still higher 6 months post insertion of dentures. Comparison of the means of masticatory efficiency after denture insertion and 6 months after denture usage gave highly significant values (p< 0.001). The salivary flow which increased immediately following denture insertion returned to almost normal 6 months after denture insertion.Conclusion:The study support the hypothesis that the presence of dentures improve oral sterognostic ability and masticatory efficiency.

Oral health related quality of life by means of functional changes in Geriatric Oral Health Assessment Index (GOHAI) before and after insertion of new conventional complete dentures in completely edentulous patients.

The oral health-related quality of life determines the quantity to which oral health disrupts the regular life and common functioning of an individual. To evaluate the oral health problems of older adults, Geriatric Oral Health Assessment Index (GOHAI) can be used. GOHAI was developed by Atchinson and Dolan3 before and after complete denture therapy”. Study Design: Cross sectional study. Setting: Department of Prosthodontics, Lahore Medical and Dental College, Lahore. Period: February 18, 2018 to August 17, 2018. Material &amp; Methods: Patients will be selected for the study according to the criteria. Patient history and clinical examination was undertaken. Upper and lower complete dentures was made-up for 30 patients (both male and female) using standardized clinical and laboratory methods. Conventional procedures were applied to complete denture construction. Complete dentures were constructed in the similar dental laboratory within the institution by compression moulding method. Laboratory and clinical remount procedures, beside with occlusal corrections were carried out using a semi-adjustable articulator. The GOHAI questionnaire was completed on two different appointments. First questionnaire was documented before denture insertion and second questionnaire was recorded after complete denture insertion. Results: Before treatment mean GOHAI score was 20.46 ± 2.85 and after treatment mean GOHAI score was improved and was 26.32 ± 2.34. The mean GOHAI score was statistically improved p-value &lt; 0.001. For male patients, before treatment mean GOHAI score was 21.61 ± 2.59 and after treatment mean GOHAI score was improved and was 26.31±2.14. The mean GOHAI score was statistically improved in male patient, p-value &lt; 0.001. For female, before treatment mean GOHAI score was 19.34 ± 2.70 and after treatment mean GOHAI score was improved and was 26.44 ± 2.49. The mean GOHAI score was statistically improved in female patients, p-value &lt; 0.001. Conclusion: According to patient’s information enhancement in functional changes after placement of complete dentures.

Influence of adhesives usage in complete dentures during adaptation period varying the degree of resorption of mandibular ridges

PurposeThis study evaluated the effect of the use of a powder-type adhesive on masticatory performance and oral health related quality of life (OHRQoL) in patients with normal and resorbed mandibular ridges during adaptation period with complete dentures. MethodsForty-two edentulous subjects (12 men, 30 women) were distributed in four groups: normal mandibular ridges with adhesive, n = 10; normal mandibular ridges without adhesive, n = 10; resorbed mandibular ridges with adhesive, n = 11; resorbed mandibular ridges without adhesive, n = 11. Masticatory performance was evaluated by sieving method and OHRQoL by Oral Health Impact Profile in Edentulous Adults (OHIP-EDENT) inventory at 30, 60 and 90 days after the insertion of new complete dentures. Data were analyzed using 2-way ANOVA test and Generalized Estimating Equations (GEEs), α = 0.05. ResultsThe use of adhesive resulted in better masticatory performance at 30 (35.76 ± 12.63%) and 60 days (30.06 ± 10.54%) after the insertion of the dentures and did not influence on OHRQoL in participants with normal ridges during the adaptation period. The use of adhesive did not interfere on masticatory performance during adaptation period and had a negative effect on masticatory discomfort/disability subscale OHRQoL at 30-day period [5.2(3.6, 6.8)] for resorbed mandibular ridges with new complete dentures. ConclusionsThe use of adhesive can improve masticatory performance of new complete dentures users with normal mandibular ridges in the initial adaptation period up to 60 days after insertion. For resorbed ridges subjects, the use of adhesive had a negative impact on masticatory discomfort/disability OHRQoL at 30 days after insertion.

Comparison of nonscheduled, postinsertion adjustment visits for complete dentures fabricated with conventional and CAD-CAM protocols: A clinical study

Statement of problemUnscheduled denture-adjustment visits may disrupt both patients and clinicians. Denture-adjustment visits have not been correlated with denture-processing methods. PurposeThe purpose of this clinical study was to identify differences in the number of unscheduled postinsertion-adjustment visits of patients with complete dentures fabricated by injection molding (IM) versus dentures fabricated by computer-aided design and computer-aided manufacturing (CAD-CAM). Material and methodsOne hundred six participants were evaluated in the study. They were consecutively treated in a private practice setting and followed up for 1 year after the insertion of new complete dentures. The first 33 received dentures fabricated using an IM system, and the other 73 were milled using a CAD-CAM system. All participants had been edentulous for at least 1 year. Participant ages ranged from 29 to 83 years. IM dentures were fabricated by a commercial dental laboratory; CAD-CAM dentures were milled by a commercial manufacturer. All participants were scheduled for 1- or 2-week postinsertion office visits. Further adjustment visits were scheduled according to participant request. The results were tabulated, and univariable tests of association were performed including chi-square and the Fisher exact tests for categorical comparisons and the Wilcoxon rank sum test for comparison of ordinal continuous data. A multivariable logistic regression model was used to control for the influence of multiple predictor variables on the outcome of interest. ResultsEdentulous years ranged from 1 to 60. Approximately one half (n=56) of all participants returned for scheduled postinsertion visits approximately 1 to 2 weeks after insertion of the dentures. No significant demographic or clinical differences were noted between participants receiving CAD-CAM or conventional dentures. Return visits for unscheduled adjustments were not associated with the method of denture fabrication or any other demographic features (P=.55). ConclusionsBased on the results of this study, there were no significant differences in the number of unscheduled, postinsertion visits for participants whose dentures were fabricated following IM or CAD-CAM milling protocols. Clinicians may choose to fabricate complete dentures with either protocol and expect similar clinical results in terms of the number of unscheduled postinsertion visits.

Structural equation modeling of the impact of mandibular ridge form and denture quality on oral health-related quality of life in complete denture wearers

PurposeTo examine the effect of mandibular ridge form and denture quality on oral health-related quality of life (OHRQoL) in complete denture wearers by using structural equation modeling (SEM) analysis of data before and after new complete denture insertion. MethodsFour hundred thirty-two edentulous patients who visited the Dental Hospital of Tokyo Medical and Dental University for new complete dentures were recruited. An intervention study design was conducted, including complete denture fabrication with SEM analysis. Mandibular ridge form, mandibular denture stability, accuracy of jaw relation record, and the Oral Health Impact Profile for edentulous subjects (OHIP-EDENT-J) total score before and after new complete denture insertion were used in the hypothesized model. ResultsTwo hundred and thirty-seven participants completed the research. SEM analysis demonstrated adequate model fit. Path coefficients of mandibular ridge form to OHIP-EDENT-J before and after insertion, and mandibular denture stability to OHIP-EDENT-J before insertion, were significant. ConclusionsThis study demonstrated that mandibular denture stability and mandibular ridge form are important to ensure successful complete denture therapy.

A comparative evaluation of border molding using two different materials in mandibular edentulous arches- an in-vivo study

Brief Background The purpose was to compare and evaluate border moulding using two different materials on mandibular edentulous arches. Materials and Methods This clinical study was performed on 15 healthy edentulous subjects who reported to the department of Prosthodontics. All the subjects were first given complete dentures, fabricated with low fusing compound as the border moulding material, followed by complete dentures with putty as the border moulding material. Retention was measured at 3 stages: Border moulding; Complete denture insertion; 6 weeks follow up. Patient’s satisfaction was measured with a 10 point visual analogue scale for both the dentures pre treatment and at the follow up visit. Results Putty border moulding showed higher retention as compared to low fusing compound border moulding with significant difference at all stages- stage 1 (p=0.011), stage 2 (p=0.009) and stage 3 (p=0.0054). The time taken for border moulding was significantly lower in Group 2 than Group 1(P=1.6E-48). According to VAS scores, in terms of aesthetic and comfort parameters, patients were satisfied in both groups without any significant difference, however, retention in Group 2 was higher as compared to group 1(P=0.05) Summary and Conclusions There was a statistically significant difference in the retention, between the groups. Group 2( Putty) had higher retention compared to Group 1(low fusing compound).Time taken for border moulding was significantly lower for Group 2( putty). No significant difference in patient’s satisfaction was observed for aesthetic and comfort parameters. In functional parameter, retention was better in Group 2(putty) subjects. Key Words: Low fusing compound, PVS (putty), border molding, mandibular edentulous arch.

A clinical evaluation on the effect of astringent on keratinization of oral mucosa before and after the insertion of complete denture.

Conventional complete dentures still remain a viable method of treatment for many patients in this era of fixed prosthesis like dental implants. All patients undergoing complete denture treatment need nonsurgical preprosthetic treatment for the preparation of healthy denture bearing mucosa as well-keratinized healthy mucosa is desirable for a complete denture. To evaluate and compare the keratinization before and after denture insertion at intervals of 1 week and 1 month. The present study was conducted on 24 completely edentulous male subjects divided into control and study groups. Each patient in study group was asked to massage with astringent on the denture bearing mucosa over a 4-week period. Exfoliative cytology was used to collect the surface cells from the palatal mucosa and buccal mucosa. The first smear was taken before the denture insertion. The second and third smears were taken after the stimulation treatment with astringent gel for each patient after 1 week and after 4 weeks. Each smear was stained with the Papanicolaou's technique. The number of basal cells, intermediate cells, and superficial cells were recorded to calculate the degree of keratinization. Descriptive statistics, paired samples t-test, independent t-test, and repeated-measures analysis of variance. The result showed statistically significant increase in the keratinization of palatal mucosa after 4 weeks of astringent therapy and no effect was noted in the keratinization of buccal mucosa. Astringent has shown to increase keratinization of palatal mucosa, and so it can be used to increase the quality of the denture bearing mucosa; moreover, the astringent stimulation has no effect on the keratinization of buccal mucosa.

Determination of Salivary Myeloperoxidase, Immunoglobulin E, and Tumor Necrosis Factor-α after Complete Denture Insertion

Objective: To detect activities of salivary myeloperoxidase (MPO) and concentrations of salivary tumor necrosis factor (TNF)-α as indicators of inflammatory reaction and salivary immunoglobulin E as an indicator of allergic reaction after complete insertion of acrylic dentures. Subjects and Methods: Complete dentures were made for a uniform group of elderly patients, and saliva samples were taken immediately before they were given to the patients, as well as 2, 3, 7, and 30 days after insertion of the dentures, with simultaneous monitoring of changes in the oral mucosa. Results: After 7 and 30 days of wearing upper and lower complete dentures, nonsignificant increases in salivary MPO and TNF-α were proven to be indicators of inflammation. No changes were observed in the values of salivary immunoglobulin E during a 30-day observational period, which excluded the appearance of allergic reactions to acrylic materials in the tested group of patients. Conclusion: A nonsignificant increase in the levels of MPO was observed on day 7; it decreased after 30 days. TNF-α also tended to increase in a nonsignificant manner.