Insecticidal Metabolites Research Articles

The chemistry of prasinons A and B. Identification of the nitrogen-containing moiety

Hydrogenolysis of prasinon B, an insecticidal metabolite of Streptomyces prasinus, gave N-2-(1,3-dioxocyclopentyl)-succinamic acid, the methyl ester of which (dihydroflavensomycinic acid) is a known degradation product of the antibiotic flavensomycin. The relationship between flavensomycin and the prasinons is discussed.

Isolation and identification of nigragillin as a insecticidal metabolite produced by a Aspergillus niger.

Isolation and identification of nigragillin as a insecticidal metabolite produced by a Aspergillus niger.

Structure of aspochracin, an insecticidal metabolite of [formula omitted

Structure of aspochracin, an insecticidal metabolite of [formula omitted

Aspochracin, a New Insecticidal Metabolite of Aspergillus ochraceus

A new insecticidal substance named aspochracin was isolated from the culture filtrate of Aspergillus ochraceus, a pathogenic fungus causing muscardine on insects. The compound was found to be a novel cyclotripeptide, composed of N-methyl-l-alanine, N-methyl-l-valine and l-ornithine, containing an octatrienoic acid side chain. Isolation procedure, structural elucidation and biological activities are described in detail.Hexahydroaspochracin (II) derived on hydrogenation of aspochracin (I), an insecticidal metabolite of Aspergillus ochraceus, was synthesized by cyclization of N-methyl-l-valyl-N- methyl-l-alanyl-α-caprylyl-l-ornithine (XIV). In addition to II, isohexahydroaspochracin (XV) was isolated from the reaction mixture.