Insect Juvenile Hormone Activity Research Articles

Aromatic ethers with the insect juvenile hormone activity

In the literature, numerous morphogenetically active mixed ethers have been reported, containing phenyl and epoxidated terpenoid groupings1'2. In view of the juvenile activity of those juvenile hormone analogues in which the oxirane ring of the parent hormone is replaced by the more stable oxolane ring3'4, attention has been now paid to the preparation** of some alkyl aryl ethers containing an oxolane ring in the aliphatic portion of the molecule instead of the oxirane ring. Some of these ethers have been so far reported in a Czechoslovak Patent Application only5. The present bioanalogues have been prepared by alkylation of 4-chloropheno l (I), 4-methylphenol {II), 4-ethylphenol (ill) or 4-methoxycarb onylphenol (IV) with 1 -bromo-3-methyl-5-(2-oxolanyl)pentane3 (V), l-bromo-3-methyl-5-(2-oxolanyl)-2-pentene3 (VI) or 2-bromo-4-(2- oxolanyl)butane4 (VII).

Compounds with insect juvenile hormone activity. I. Some 4-oxa-farnesane insect juvenile hormone mimics.

Compounds with insect juvenile hormone activity. I. Some 4-oxa-farnesane insect juvenile hormone mimics.

Insect juvenile hormone activity of the stereoisomers of ethyl 3,7,11-trimethyl-2,4-dodecadienoate.

Insect juvenile hormone activity of the stereoisomers of ethyl 3,7,11-trimethyl-2,4-dodecadienoate.

Penetration and persistence of an insect growth regulator in the pupa of the stable fly, Stomoxys calcitrans

An insect growth regulator, ( E)-6,7-epoxy-1-( p-ethylphenoxy)-3,7-dimethyl-2-octene (Stauffer R-20458) with insect juvenile hormone activity readily penetrated the puparium of white pharate pupae of Stomoxys calcitrans. The quantity and the persistence of the chemical in the puparium and in the developing pharate adult were determined over a 168 hr post-treatment period. The loss of chemical from the pharate stage was almost total within 168 hr, but over 20 per cent of the applied dose was still present in the puparium after the same interval.

Synthesis of mono- and sesquiterpenoids—II : (±)-Sesquicarene and a mixture of (±)-sirenin and its C-7 epimer

The title compounds were synthesized by the application of the intramolecular α-ketocarbene olefin addition. Some intermediates for the synthesis of (±)-sirenin showed insect juvenile hormone activity.