2248 children of Bukhara and Zarafshan are examined. Results of research have revealed, that in a Zarafshan Toothmaxillary anomalies, illnesses paradontes meet twice more, than in a Bukhara. We recommend treatment-and-prophylatic action to begin as soon as possible, i.e. to begin with embryo the period of development of the child. In recent years, studies have been conducted to study the prevalence of dental caries, periodontal disease, and dentofacial anomalies among children and adults. However, some key points of this problem, such as the relationship between the level of pollution of others in different territories, differing in the degree of pollution of environmental objects, have not yet been clarified.[2, 4] The state of hard tissues of teeth was also studied taking into account changes in the surface of tooth enamel in the form of spots, hypoplasia, fluorosis and spalls. Depending on the number of decayed, missing and filled teeth, 5 degrees of caries were determined: very low (0.0–0.1), low (1.2–2.6), moderate (2.7–4.4), high (4.6–6.5), very high (4.5–6.5), very high (6.6 or more). The results obtained indicate that the highest levels of contamination with the studied harmful substances in the atmosphere of Zarafshan in 2013–2017. ranged from 0.3 to 19.6 mg/m, which exceeded the MPC by 10.6–13.5 times, and were assessed as “causing concern” and “dangerous”. In Bukhara, pollution was less pronounced and was assessed as “permissible” and “causing concern”. More dysfunctional is Zarafshan. Common air pollutants-dust, sulfur dioxide, nitrogen dioxide, carbon monoxide, hydrocarbon-in this area are added aggressive substances such as phenol ethyl acetate, formaldehyde. It should be noted that the leading ingredient in the level of air pollution in both Zarafshan and Bukhara was inorganic dust, suspended solids, the presence of which is a consequence of dust storms characteristic of these regions of the republic.