Inoculation Of Cancer Cells Research Articles

Enhancing effect of thoracotomy and/or laparotomy on the growth of ascitic tumor in rats.

To evaluate the effect of operative stress on a tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the intraperitoneal inoculation of Sato lung cancer cells in Donryu rats. The survival time and the spread of the tumor were examined. Thoracotomy and laparothoracotomy reduced significantly the survival time of the inoculated rats as compared with the control but no significant difference was observed between the two test groups subjected to operative stress. No difference was observed in the spread of the tumor between the test groups and the control. These results indicated that the operative stress increased only the number of metastatic foci and did not change the characteristics of the tumor cells.

Enhancing effect of thoracotomy and/or laparotomy on the development of the lung metastases in rats after intravenous inoculation of tumor cells.

To evaluate the effect of operative stress on the tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the inoculation of Sato lung cancer cells in Donryu rats. The survival time, the number of metastatic foci on the surface of the lung and the per cent-area of metastatic foci in the frontal section through the pulmonary hilus were observed. Thoracotomy and laparothoracotomy reduced significantly the survival time as compared with the control but no significant difference was found between the two test groups subjected to operative stress. The number of percent-area of metastatic foci found were inversely related to the length of the survival time.

TRANSPLANTABLE LUNG CANCER IN RATS. EFFECT OF TREATMENT.

The presence of cancer cells in the blood of patients with malignant tumors has been reported repeatedly.^6,15Lung carcinoma produces distant metastases early in its course in a high percentage of patients. In spite of this and the frequent vascular invasion by lung cancer⁹the reported incidence of cancer cells in the blood with carcinoma of the lungs is surprisingly small.¹⁴ It has been suggested that adjuvant chemotherapy may be of value in minimizing the dissemination of cancer cells especially at time of surgery. Mechlorethamine hydrochloride (a nitrogen mustard, HN₂)⁶and thio-tepa¹⁵have been found to be of some value, but the complications with lung cancer have been quite frequent and severe. In experimental animals it was shown that with the administration of mechlorethamine hydrochloride the inoculated cancer cells disappeared from the circulation soon after the injection of the mustard; even so a relatively

ヘマトポルフィリン水銀錯塩 (MH) のEhrlich固型癌に対する抗癌性

An antitumor substance, mercury-hematoporphyrin complex (MH), now being tested for clinical use in Japan, was retested for antitumor activity in animals employing solid-type of Ehrlich ascites tumor cells. In Method I, a slight modification of Sugiura's method, MH showed no antitumor activity, while in Method II where the drug was given beginning at 7 days after the inoculation of cancer cells, it showed a marked effect. MH gave no effect against Ehrlich ascites cells.

Role of operative stress on the resistance of the experimental animal to inoculated cancer cells.

Role of operative stress on the resistance of the experimental animal to inoculated cancer cells.