Innovative Vehicle Research Articles

Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges.

The discovery of novel and innovative therapeutic strategies for cancer treatment and management remains a major global challenge. Exosomes are endogenous nanoscale extracellular vesicles that have garnered increasing attention as innovative vehicles for advanced drug delivery and targeted therapy. The attractive physicochemical and biological properties of exosomes, including increased permeability, biocompatibility, extended half-life in circulation, reduced toxicity and immunogenicity, and multiple functionalization strategies, have made them preferred drug delivery vehicles in cancer and other diseases. Small interfering RNAs (siRNAs) are remarkably able to target any known gene: an attribute harnessed to knock down cancer-associated genes as a viable strategy in cancer management. Extensive research on exosome-mediated delivery of siRNAs for targeting diverse types of cancer has yielded promising results for anticancer therapy, with some formulations progressing through clinical trials. This review catalogs recent advances in exosome-mediated siRNA delivery in several types of cancer, including the manifold benefits and minimal drawbacks of such innovative delivery systems. Additionally, we have highlighted the potential of plant-derived exosomes as innovative drug delivery systems for cancer treatment, offering numerous advantages such as biocompatibility, scalability, and reduced toxicity compared to traditional methods. These exosomes, with their unique characteristics and potential for effective siRNA delivery, represent a significant advancement in nanomedicine and cancer therapeutics. Further exploration of their manufacturing processes and biological mechanisms could significantly advance natural medicine and enhance the efficacy of exosome-based therapies.

The Eighth Agria Conference on Innovative Vehicle Technologies and Automation Solutions, InnoVeTAS2024

Even though the last few years were filled with all kinds of challenges for companies and universities; we are happy to host once again, the Eighth Agria Conference on Innovative Vehicle Technologies and Automation Solutions, also known as InnoVeTAS2024. This conference series was started as a subset event of the International Pneumobile competition, in order to make it more attractive to students and professors from a wide range of universities in Europe. Today, the InnoVeTAS conference has become an independent scientific forum, which is traditionally held in May. This being the eigtht conference in the series; our event has become one of the major technical and scientific talks in Heves County! Additionally, we are now visible on the venue of Hungarian national conferences! In cooperation with IÓP Publishing, this year’s conference proceedings will also be the third time, that it will have been listed in the Scopus index, which is useful for high level researchers. List of Honorary chairs, Scientific Committee, Editorial Committee, Organizing Committee, Invited Speakers, Organization Institution and Sponsor are available in this Pdf.

Skin Delivery and Innovative Carrier’s Effectiveness

The skin serves as the body first protecting barrier against the external attacks of chemicals and microorganisms. On the other hand, it is an obstacle to penetration and transdermal delivery of any substance applied on its surface. Thus, a need to report some news on the skin composition for a better understanding of the transdermal delivery mechanisms of topical products applied on its surface. Therefore, due to the actual increased use of topical drugs, cosmetics, and diet supplement treatments, further feasibility research studies have been carried out to extend the knowledge of the percutaneous absorption ‘rules and means. These studies are retained necessary to control the release through the skin layers of various selected active ingredients, loaded and carried out by different vehicles. The paper will focus on the effectiveness of innovative tissue carriers that, are able to deliver active ingredients throughout the skin layers, are made by a very low consumption of water, and are free of chemicals also. In conclusion, these novel eco-sustainable carriers, resulting skin- and environmentally friendly, might be used as innovative vehicles in substitution of the normal emulsions that, made by the use of preservatives, emulsifiers, fragrances, and other chemicals may often cause allergic and/or sensitization phenomena, consuming a great quantity of water also.

Skin Delivery and Innovative Carrier’s Effectiveness

The skin serves as the body first protecting barrier against the external attacks of chemicals and microorganisms. On the other hand, it is an obstacle to penetration and transdermal delivery of any substance applied on its surface. Thus, a need to report some news on the skin composition for a better understanding of the transdermal delivery mechanisms of topical products applied on its surface. Therefore, due to the actual increased use of topical drugs, cosmetics, and diet supplement treatments, further feasibility research studies have been carried out to extend the knowledge of the percutaneous absorption ‘rules and means. These studies are retained necessary to control the release through the skin layers of various selected active ingredients, loaded and carried out by different vehicles. The paper will focus on the effectiveness of innovative tissue carriers that, are able to deliver active ingredients throughout the skin layers, are made by a very low consumption of water, and are free of chemicals also. In conclusion, these novel eco-sustainable carriers, resulting skin- and environmentally friendly, might be used as innovative vehicles in substitution of the normal emulsions that, made by the use of preservatives, emulsifiers, fragrances, and other chemicals may often cause allergic and/or sensitization phenomena, consuming a great quantity of water also.

Innovative Vehicle Design Processes Based on the Integrated Framework for Abstract Physics Modeling (IF4APM)

In industrial vehicle design processes, most companies have implemented model-based systems engineering (MBSE). As a consequence, design processes are nowadays not driven by documents, but by digital models of the vehicle to be developed and its components. These models exist on different levels of abstraction. The models on the requirements level are already well defined as well as the models of the defined product behavior and product properties. In recent years, the specification of models on the level of product functions was largely clarified, and elaborate frameworks already exist. However, this is not yet true for the level between functions and definite properties; this level can be referred to as "abstract physics". The enormous importance of this level, which, amongst others, can represent the physical effect chains which allow a vehicle component to function, is expressed by several researchers. Several research works aim at specifying models on this level, but, until now, no general consensus can be identified, and the existing model specifications are less appropriate for the early stages of vehicle design. This paper explains an Integrated Framework for Abstract Physics Modeling (IF4APM), which incorporates different perspectives of abstract physics and is suited for the early phases. The explanation is based on typical components of several kinds of vehicles. The main advantages of the proposed approach are the consistent interconnection of abstract product models, the clearness and understandability of the resulting matrices, and the aptitude to be used in the early phases of a vehicle design process.

Information Communication Technology (ICT) Integration in Teaching and Learning in Selected Rural Secondary School in Burera District, Rwanda

Studies conducted on the use of information and communication technology (ICT) in education posit its importance in all life domains, without exception to education. ICT has been a vehicle for aspiration, innovation, and quality academic achievement. This paper aimed to investigate the use of information and communication technology in the teaching and learning process at Ecole Secondaire Kagogo in Burera District, Rwanda. The study had two objectives: (1) to assess the benefits of using ICT in rural secondary schools, and (2) to examine the challenges preventing effective ICT integration in secondary schools. The study is descriptive, adopting a mixed-methods approach. Guided by the Diffusion of Innovations Theory (DOI), the study involved a population of 114 participants with a purposive sample size of 52 respondents. Data were collected through a questionnaire and interviews with teachers and school leaders. Findings revealed that ICT enables teachers to share assessments with students and deliver the lessons; helps learners engage in peer assessments and independent learning; and that school leaders use ICT to share resources. Reports identified inadequate infrastructure and a lack of professional development as barriers to the effective integration of ICT into schools. It was recommended that the required facilities, resources, and ICT gadgets be supplied for rural secondary schools so they would not still lag behind in the use of ICT in teaching and learning.

High performance Cu sintering joint for power devices enabled by in-situ generation of Cu particles with multi-level hierarchical structures

Copper (Cu) particle sintering is widely regarded as one of the most ideal interconnect technologies for wide band gap semiconductors owing to its potential for low-temperature curing while withstanding a higher working temperature. Nevertheless, the strict requirements for sintering conditions and high costs limit the widespread application of Cu sintering technology. In this paper, a simple vehicle was introduced into Cu paste formulation to achieve an effective sinter bonding even using commercially available sub-micron or even micrometer Cu particles (C-Cu particles) with the in-situ generation of composite Cu particles. This innovative vehicle comprises Cu salt, a combination of capping agents and reducing agents. The addition of the hybrid capping agent binds Cu atoms to the surface of the C-Cu particles and allows the generated Cu particles (G-Cu particles) produced from the vehicle to grow on their surface, resulting in the in-situ generation of composite Cu particles. Based on the in-situ generated composite Cu particles, sintering experiments were conducted at designated temperatures (200 °C, 225 °C, 250 °C) for various durations (3 min, 5 min, 10 min) in a N2 atmosphere under different pressures (10 MPa, 15 MPa, 20 MPa). A reliable Cu sintered joint with a high shear strength of 41.3 MPa can be achieved at a low temperature (200 °C) using 500 nm C-Cu particles. Moreover, the joints sintered with large size (>3 μm) particles at 250 °C could also reach 43.3 MPa. The in-situ generated composite Cu particles accomplish the transformation of low-energy interfaces of C-Cu/C-Cu to high-energy interfaces of G-Cu/G-Cu, which in turn facilitates low-temperature sintered connection of C-Cu particles and reliable sintered joints formed of large size C-Cu particles. These findings improve the feasibility of Cu sinter bonding in practical applications.

Influence of type of vehicle on dermal penetration efficacy of hydrophilic, amphiphilic, lipophilic model drugs

The influence of the vehicle on the dermal penetration efficacy of three different active ingredient (AI) surrogates (hydrophilic, amphiphilic, lipophilic model drugs), that were incorporated into these vehicles, was investigated with the ex vivo porcine ear model, which allowed to assess time and space resolved dermal penetration profiles of the AI. Fifteen different vehicles, including classical vehicles (hydrogel, oleogel, o/w cream, w/o ointment, amphiphilic cream) and innovative vehicles were included into the study. Results show tremendous differences in the penetration efficacy of the AI among the different vehicles. The differences in the total amounts of penetrated AI between lowest and highest penetration were about 3-fold for the hydrophilic AI surrogate, 3.5-fold for the amphiphilic AI and almost 5-fold for the lipophilic AI. The penetration depth was also affected by the type of vehicle. Some vehicles allowed the AI to penetrate only into the upper layers of the stratum corneum, whereas others allowed the penetration of the AI into deeper layers of the viable dermis. Data therefore demonstrate that the vehicles in compounding medications cannot be exchanged against each other randomly if a constant and safe medication is desired. The data obtained in the study provide first information on which types of vehicles are exchangeable and which types of vehicles can be used for enhanced dermal penetration of AI, thus providing a first base for a science-based selection of vehicles that can provide both, efficient dermal drug delivery and skin barrier function maintenance/strengthening at the same time.

Assessing and mapping water-energy-food nexus smart innovations and practices in Vhembe District Municipality, Limpopo Province, South Africa

Water, energy, and food and their interactions (commonly referred to as the WEF nexus) are critical pillars to resolving the intractable global challenges such as poverty, hunger, malnutrition, poor sanitation, climate, and health crises. The nexus approach, practices, and innovations at the household level are critical determinants of whether resource use efficiency, co-benefits, basic rights to water and food, and sustainability governance are attained. In particular, smart WEF innovations can contribute to the current generations' economic, social, and environmental needs without compromising the needs of the future generation. The study aimed to identify smart innovations, practices, and factors influencing their adoption to inform policy and decision-making processes. The study intends to support scaling up the adoption of innovations and practices that enhance sustainability and resource security in support of the sustainable development goals (SDGs). Semi-structured interviews and key informant interviews (KII) supplemented with observational checklists were used to identify the WEF nexus smart technologies, innovations, and practices in Vhembe District Municipality, Limpopo Province, South Africa. Data were collected from a sample size of 128 households in the study area. Our findings revealed synergistic smart innovation practices across WEF resource use and management practices. Though indigenous knowledge (IK) practices were widely evident in the study area, non-existent WEF smart knowledge support systems existed in the study area. Indigenous knowledge practices were the most elicited innovation by 99.2% of households, suggesting it is critical to advancing WEF smart innovations and practices and needs to be integrated into any policy and governance interventions. A proportion of households recycle water (27%), whilst 53% use untreated water. Furthermore, the knowledge systems on smart WEF innovations were fragmented despite their potential to synergize sustainability objectives. Exploring innovation platforms (IPs) as vehicles for dissemination, innovation, and extension and advisory service delivery, as well as validation of Indigenous Knowledge Systems (IKS), has the potential to contribute to the diffusion, uptake, and scaling of existing innovation and practices with significant spill-over effects on WEF resource security and sustainability outcomes both at local and extra local scales.

Power Requirement Study of Bus KITe PHEB in Kuala Terengganu

Air pollution and the depletion of fossil fuel are both made worse by the increasing number of vehicles on the road. Conventional vehicles never fulfil future regulations for emission and fuel usage. In addition to this, diesel-powered vehicles are quickly becoming one of the most significant sources of particulate matter (PM) and nitrogen oxides (NOx) in the atmosphere. Electric vehicles (EV), hybrid electric vehicles (HEV), and plug-in hybrid electric vehicles (PHEV) are only a few examples of the innovative vehicle topologies that have emerged in recent years. The battery pack in a PHEV is more substantial than that of a HEV. Plus, it gets the same mileage as regular cars while using a combination of fuel and electricity as its propulsion source. The power requirement for the BUS KITe plug-in hybrid electric bus (PHEB) powertrain has been determined in this work by employing a steady-state velocity and the Kuala Terengganu driving cycle in accordance with the bus parameter, specification, and performance requirement. The power requirements of the bus can be used to determine the appropriate dimensions for the electric machine, internal combustion engine, and energy storage system that make up the BUS KITe PHEB model in MATLAB/SIMULINK environment.

DIGITAL REVOLUTION: TECHNOLOGICAL ADVANCEMENTS SHAPING AZERBAIJAN-TURKEY LOGISTICS

The digital revolution has become an integral and transformative force that is reshaping every aspect of human existence worldwide. The digital revolution in communication and connectivity has fueled unprecedented global connectivity. The advent of the Internet and social media platforms enabled instant communication, breaking down geographic barriers and facilitating the rapid dissemination of information. It not only revolutionized personal interactions but also redefined the nature of business and politics. Economically, the digital revolution has ushered in a new era of innovation and efficiency. Technologies such as artificial intelligence, big data, and blockchain have caused a paradigm shift in industries, optimizing processes and opening up new opportunities. E-commerce has taken off, fundamentally changing consumer behavior and the traditional retail landscape. Moreover, the gig economy has flourished, providing new opportunities for employment and labor dynamics. Despite its many benefits, the digital revolution has also raised ethical concerns, including questions about data privacy, cybersecurity, and the digital divide. As societies grapple with these challenges, it is clear that the digital revolution is an ongoing and dynamic process with far-reaching consequences that require ongoing adaptation and thoughtful regulation. In managing this digital landscape, societies must strike a balance between embracing innovation and addressing ethical implications to ensure a future where the benefits of the digital revolution are maximized for all. The onset of the Digital Revolution has ushered in a new era for the logistics industry, fundamentally changing the way goods and information flow in the global supply chain. In an era where technological advancements are the backbone of progress, logistics has emerged as a vehicle for innovation that adapts and evolves to meet the demands of an increasingly interconnected world. This brief explores the key role digital technologies are playing in shaping the logistics landscape.

Role of Functionalized Peptides in Nanomedicine for Effective Cancer Therapy.

Peptide-functionalized nanomedicine, which addresses the challenges of specificity and efficacy in drug delivery, is emerging as a pivotal approach for cancer therapy. Globally, cancer remains a leading cause of mortality, and conventional treatments, such as chemotherapy, often lack precision and cause adverse effects. The integration of peptides into nanomedicine offers a promising solution for enhancing the targeting and delivery of therapeutic agents. This review focuses on the three primary applications of peptides: cancer cell-targeting ligands, building blocks for self-assembling nanostructures, and elements of stimuli-responsive systems. Nanoparticles modified with peptides improved targeting of cancer cells, minimized damage to healthy tissues, and optimized drug delivery. The versatility of self-assembled peptide structures makes them an innovative vehicle for drug delivery by leveraging their biocompatibility and diverse nanoarchitectures. In particular, the mechanism of cell death induced by self-assembled structures offers a novel approach to cancer therapy. In addition, peptides in stimuli-responsive systems enable precise drug release in response to specific conditions in the tumor microenvironment. The use of peptides in nanomedicine not only augments the efficacy and safety of cancer treatments but also suggests new research directions. In this review, we introduce systems and functionalization methods using peptides or peptide-modified nanoparticles to overcome challenges in the treatment of specific cancers, including breast cancer, lung cancer, colon cancer, prostate cancer, pancreatic cancer, liver cancer, skin cancer, glioma, osteosarcoma, and cervical cancer.

How Artificial Intelligence Drives Sustainable Frugal Innovation: A Multitheoretical Perspective

Recent globalization and industrialization efforts have pushed many companies to seriously consider innovation efficiency and its effectiveness. Industries seek to integrate innovation thinking in the company, resulting in different innovation theories. However, these theories become mostly ineffective when disruptions such as pandemics, political instability, or other natural events occur. In response to such disruptions, frugal innovation has been adopted in recent years because it can maximize efficiency with fewer resources. While frugal thinking is effective from an economic perspective, not enough attention has been devoted to exploring this innovative thinking method from the perspective of other pillars of sustainability (environment and society). This article focuses on this gap to deepen the understanding of sustainable frugal innovation in a recent business environment under various theoretical perspectives (triple bottom line, diffusion of innovation, and critical success factor theories). Technology is a vehicle for innovation, so this article integrates the technological advantages of AI with sustainable frugal innovation as a driving force for its effective implementation; other existing studies are limited. Integrating AI with sustainable frugal innovation requires precise actions that can be the result of understanding AIs critical success factors from the perspectives of sustainable frugal thinking. Therefore, this article analyzes the critical success factors for AI through grey DEMATEL. A research framework has been proposed and validated with a Danish case study context. Among 24 overall common critical success factors, “understanding the concept of AI” and “level of AI investment” in sustainable frugal innovation are identified as the most influential success factors. In addition, influential connections among other overall common success factors are presented. These findings could motivate industries to explore different options for successfully integrating AI with their sustainable frugal thinking, which may increase their business competitiveness during disruptions in a more sustainable way.

How to raise consumer awareness of the environmental impact of vehicle attributes? A big data analysis

The introduction of the Euro 7 emission standard is expected to significantly change the typology of the European passenger car. This study analyzes the environmental impact resulting from future trends in fleet composition and proposes an innovative vehicle classification system focused on raising consumer awareness of the importance of their choices with regard to key attributes such as body type, engine power and vehicle weight. A sensitivity analysis of the fleet's greenhouse gas emissions to deviations in their composition is carried out, considering the preferences expressed by the consumers in 2022 and the vehicle's specifications reported by the automotive industry on European digital platforms embodying Industry 4.0 principles. The findings show that internal combustion fleet emissions are expected to rise 0.30% per 1% increase in engine power and 0.44% to 0.69% per 1% increase in weight, according to the Worldwide Harmonised Light Vehicle Test Procedure (WLTP). The plug-in electric vehicle (PHEV) segment is the fastest growing in terms of market share. This trend will continue in the future, as this is the segment best suited to comply with the emissions targets imposed on manufacturers. Another relevant conclusion is that the environmental impact of PHEV vehicles is potentially very negative if the drivers' charging habits do not reflect the manufacturer's design intention. Thus, the development of consumer environmental awareness tools is urgent. This is the study's main motivation: to develop a tool in the scope of the Industry 4.0 while promoting the emergent concept of Industry 5.0, sustainability based and human-centered.

Trackless Trams: An Emerging Transformative Opportunity

Trackless trams are a Chinese innovation that provide net zero opportunities, which are also transformative for cities. They have not yet been used outside China. They are battery-based vehicles with sensors that guide them down roads and have rail-like ride quality with potential to carry the equivalent of six lanes of traffic. This means they can enable net zero transformative potential for reducing car dependence while creating urban regeneration opportunities around stations, thus enabling other social and economic benefits for a city. The personal and research story is outlined of how urban leaders, developers and finance groups, are now discovering how trackless trams can be applied to their cities. Issues are being raised that need answers, but the immediate appeal of a new technology that can compete with cars and help provide a net zero transport solution is real. Significant steps forward in certifying this innovative vehicle are happening in 2023 and ongoing policy discussions are starting to resolve how best to demonstrate the technology so it becomes transformative. The opportunity is suggested to create a new model in cities on how to integrate such transit with urban regeneration in net zero corridors, using procurement with partnerships between private investment and public agencies.

Stakeholder expectations and contributions to creating a market for automated, connected, electric and shared vehicles

An increasing number of companies develop innovative vehicle solutions to further sustainable transportation. One promising direction is the combination of automated, connected, electric and shared (ACES) vehicles. Due to the multitude of stakeholders involved in such an undertaking and their diverging interests, capabilities and roles, a shared vision is essential to foster productive collaboration. This study takes a brand development perspective and evaluates the degree to which stakeholders align regarding the ambition, potential and strategic pathway of the ACES brand. An expert survey involving 28 ACES stakeholders identifies numerous themes on which stakeholders agree, for example, the potential social and environmental benefits of ACES, but also a number where they disagree, for example, the legitimacy of different stakeholders in managing the stakeholder network or the degree to which all four technologies are necessary to create more sustainable mobility solutions. Consequently, the research proposes a shared brand understanding for ACES to help align the often conflicting expectations of different stakeholders. The key recommendation is to ask consumers and cities to play a central role in fostering stronger co-creation and cooperation within the stakeholder network. While the former group is essential to motivate technology providers to continue research efforts, the latter plays a decisive role in creating a regulatory framework that enhances the appeal of ACES in comparison to alternative modes of transport. Further research is necessary to understand the most appealing incentives (whether economic, social or moral) to leverage joint efforts in shaping the ACES brand.

Study of loading of an improved container design during transportation by railway

The object of research. The object of research is the processes of occurrence, perception and redistribution of loads in the design of a container with a frame made of square pipes and lining made of smooth sheets.
 Investigated problem. Under operating conditions, damage to containers may occur due to the loads acting on them during transportation by various modes of transport. One of the most determining among such loads are dynamic loads, which are experienced not only by the container structure, but also by the cargo placed in it. As a result, there may be damage to the structure of the container, as well as to the cargo, which necessitates additional costs, both for the repair of containers and for reimbursement of expenses for damage to the transported cargo. In addition, this situation is unfavorable from an environmental point of view. In this regard, there is a need to conduct research to improve the design of a universal container in order to reduce its load, as well as increase operational efficiency.
 The main scientific results. A scientific substantiation of the use of square pipes as components of the frame of a universal container has been carried out.
 The area of practical use of research results. The sphere of practical use of the obtained results is the engineering industry, in particular railway transport.
 Innovative technological product. The concept of a universal container with a frame made of square pipes and a lining made of smooth sheets.
 Scope of the innovative technological product. The developments proposed as part of the study will be useful recommendations for creating innovative vehicle designs, including modular ones.

Getting the pieces to fit: NHS and third sector collaboration to enhance crisis mental health service provision for young people

BackgroundThe increase in demand for young people’s mental health services has been met by a growth of co-located mental health service provision in the NHS and third sector. This research explores the benefits and challenges of the NHS collaborating with a charity to provide a step-down crisis mental health service for young people in Greater Manchester, and suggests how the collaboration between the NHS and third sector may be improved for future projects.MethodsWorking from a critical realist paradigm, this qualitative case study utilised thematic analysis of 9 in-depth interviews with operational stakeholders from 3 operational layers, to explore insiders’ perspectives of the benefits and challenges of collaboration between the NHS and third sector in the context of the ‘Safe Zones’ initiative.ResultsThemes relating to perceived benefits of collaboration were: doing things differently, flexibility, a hybrid approach, shared expertise, and shared learning. These were counterbalanced by perceived challenges: getting the pieces to fit, obtaining a shared vision, geography, lack of referrals, and timing. The importance of effective communication (e.g. of shared vision, standard operating procedures, key performance indicators) was noted as central to addressing challenges and reaping benefits.ConclusionsNHS and third sector collaboration can yield a range of benefits, some of which can mitigate against the perceived inflexibility and restrictive nature of usual mental health service provision, thereby providing a vehicle for innovation in step-down crisis care for young people.

Sustainable Business Model Design: A Multi-Case Approach Exploring Generic Strategies and Dynamic Capabilities on the Example of German Wine Estates

Business model design needs to encounter increasing and highly dynamic challenges due to counter-caesural environmental changes. Empirical research on strategic sustainability is expected to provide guidance for needed dynamic transformation and sustainability. The reported research builds on a multi-case research of four German wine estates. The cases each represent a specific generic strategic grouping and distinct business models and are thereby suited to analyse sustainability by leaning on the concept of dynamic capabilities. Sustainability was examined as a strategic vehicle for innovation in the wine industry and a nuanced view of dynamic capabilities. Premium strategist turned out to strongly engage and profile in sustainability with aligned dynamic capabilities as a building block to generate premium products. Quality leadership also leverages product quality with comprehensive dynamic capabilities aiming for sustainability by building on size and a professional structure but less on environmental profiling. The price–value strategy approaches sustainability primarily from a market-based and circular economy view. Niche strategist’s dynamic capabilities in the analysed population illustrated an entrepreneurial and effectuation-based approach with specific dynamic capabilities fine-tuned to exploit market opportunities. The multi-case analyses thereby allowed us to identify strategy-specific and business-model-suiting capabilities.

Editorial.

The Journal of Consulting and Clinical Psychology (JCCP) has been one of the core scientific journals in clinical psychology for decades, with high-quality, innovative, and cutting-edge research that has shaped the science and practice of the field as it currently stands. It is a great honor to have been selected as the new Editor of JCCP for the next 5 years, starting with this issue. As the new editor, I will first build on the excellent work previous editors have done in making JCCP what it is now, a vehicle for innovation and improvement in the science and practice of clinical psychology. I am proud to lead an excellent team of highly qualified associate and consulting editors (CEs) to preserve and to further strengthen the journal's position. However, innovation also means change and establishing new opportunities that have the potential to further science and practice. In the following, I will describe some ideas and views that will guide the content, structure, and format of JCCP in the coming years. (PsycInfo Database Record (c) 2023 APA, all rights reserved).