Trends caused by digital transformations in the economy have led to the formation of new forms of interaction between industrial enterprises, industries and complexes. Digital ecosystems are becoming a tool for ensuring sustainable economic development, requiring the development of conceptual foundations and methodological provisions for sustainable development in the context of the application of the ecosystem approach within the framework of spatial interaction of economic entities. The increasing role of digital assets and methods of their use within digital ecosystems is becoming an integral part of the formation of resource potential that ensures sustainable development with ecosystem interaction of participants, which indicates the development of competition not between individual companies, which is inherent in the traditional economy, but between the ecosystems being formed. Thanks to ecosystem interaction, participating companies focus more on external interaction, innovative priorities in management technologies, the creation of a rapidly adaptable value chain, the accumulation of knowledge and the build-up of digital assets. Territorial boundaries become conditional, competitive relations within the ecosystem become partner-oriented, aimed at increasing the return on network effects obtained through the interaction of digital platform participants. Ecosystems as more flexible structures have the property of rapid response to changes in the external environment and the ability to adjust to target requirements and tasks, rapid market coverage, technology adaptation and the creation of new business models. The structural changes taking place as a result of the digital transformation of the economy in various sectors of the economy show an increasing interest in the development of digital manufacturing enterprises and the transition to high-tech production. Digital transformation of activity is inextricably linked with ensuring sustainability of development, and such components of the ecosystem as flexibility and adaptability, as well as complementarity of assets, allow optimizing the sustainability of the socio-economic system.