Innovative Management Methods Research Articles

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol

Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming normal physical and social activities. However, several existing analgesics may carry unwanted side effects, such as ulcers, blood clotting issues, drowsiness, and more. The development of new analgesics is focused on creating drugs that are both effective and associated with fewer adverse effects. Considering the continuous rise in the number of patients dealing with neurological, oncological, and other conditions accompanied by chronic pain, there is a growing demand for innovative methods of treatment and pain management. The combination of two different heterocyclic fragments within one molecule makes it possible to use the possibilities of influencing such a molecule on various mechanisms of occurrence and development of various pathological conditions, including those accompanied by pain. Chemical modifications of pyrazole and 1,2,4-triazole structures, involving their incorporation into a single molecule, have the potential, as suggested by in silico predictions, to yield biologically active compounds with analgesic properties. The aim of this work was to determine the optimal conditions for the chemical transformation and properties of 4-amino-5-(3-methylpyrazol-5-yl)-1,2,4-triazole-3-thiol, 4-amino-5-(3-(3-fluorophenyl)pyrazol-5-yl)-1,2,4-triazole-3-thiol and their derivatives for the preparation of bioactive systems with analgesic activity. Materials and methods. The creation of a target series of compounds was implemented by consistently using well-known methods of organic synthesis. 4-Amino-5-(3-methylpyrazole-5-yl)-1,2,4-triazole-3-thiol and 4-amino-5-(3-(3-fluorophenyl)pyrazole-5-yl)-1,2,4-triazole-3-thiol were resynthesized as starting materials using acetone or 1-(3-fluorophenyl)ethane-1-one, diethyloxalate, and sodium methylate using step-by-step hydrazinolysis and carbon disulfide involvement in an alkaline medium. Further targeted functionalization involved the introduction of a 2,6-dichlorophenyl substitute, alkane acid residues, and esters based on them into the structure of the target compounds. The structure of all synthesized substances was determined by IR spectrophotometry, 1H NMR spectroscopy, and elemental analysis. The individuality of the compounds was confirmed by high-performance liquid chromatography-mass spectrometry. The analgesic properties were studied on two models: the “acetic acid-induced writhing test” and a formalin model of pain inflammation. Pharmacokinetic parameters were predictably calculated using the SwissADME online platform. Results. Based on the results of the synthetic part of the work, the structure of 4-amino-5-(3-methylpyrazole-5-yl)-1,2,4-triazole-3-thiol and 4-amino-5-(3-(3-fluorophenyl)pyrazole-5-yl)-1,2,4-triazole-3-thiol, as well as their derivatives, was successfully recreated. The presence of a beneficial effect of 2,6-dichlorophenyl substitute, as well as fragments of saturated carboxylic acids and their esters on the formation of antinociceptive activity has been proven. The quantitative indicators of pharmacokinetic parameters, as determined during ADME analysis, fall within acceptable ranges in nearly all instances. Conclusions. The optimal conditions for the synthesis and structural modification of 4-amino-5-(3-methylpyrazol-5-yl)-1,2,4-triazole-3-thiol, 4-amino-5-(3-(3-fluorophenyl)pyrazol-5-yl)-1,2,4-triazole-3-thiol were established, which allowed the preparation of 2-((4-amino-5-(3-methylpyrazol-5-yl)-1,2,4-triazol-3-yl)thio)alkanoic acids and their esters, as well as [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine systems. It has been shown that the combination of pyrazole derivatives of 1,2,4-triazol-3-thiol with 2,6-dichlorophenyl substituent and fragments of saturated carboxylic acids and their esters creates conditions for the formation of compounds with antinociceptive activity, which was confirmed in vivo by experimental data acetic acid-induced writhing test and formalin inflammation model.

Применение инновационных подходов в антикризисном управлении интернет-платформами

The article is devoted to the study of innovative methods of crisis management of Internet platforms, which are becoming an important component of the modern economic environment. In the course of the research, various methods of analysis are used, including a detailed examination of modern crisis management strategies and an analysis of successful cases of integration of innovations into Internet platforms. The obtained results emphasize the importance of innovative approaches for effectively overcoming crisis situations and ensuring the sustainability of Internet platforms, and the analysis of practical examples shows that innovations contribute to improving competitiveness, optimizing user experience and increasing the financial performance of Internet platforms. The results of the study emphasize the importance of innovation for crisis management of Internet platforms, which also defines the main aspects of the theory, including the core and protective shell, and also shows the possibilities of its transformation based on the integration of the principles of the theories of disruptive innovation by K. Christensen and technological revolutions by K. Perez. The study demonstrates that changing the protective shell of the theory of crisis management under the influence of institutional changes caused by technological transformations is an important element of successful crisis management of Internet platforms. Thus, this article provides valuable practical recommendations and contributes to the expansion of the theory of crisis management of Internet platforms. The contribution made to the field of crisis management emphasizes that innovations are an important tool for effectively overcoming crisis situations, increasing competitiveness and ensuring the sustainability of Internet platforms.

Management tools for the public-private partnership model of construction enterprises

The article explores the mechanisms and challenges of applying public-private partnership (PPP) in strategic management of construction enterprises in Ukraine. It analyzes the impact of globalization and liberalization on the effectiveness of construction firms and seeks ways to optimize PPPs to ensure their adaptation to the changing market conditions. The article emphasizes the need to harmonize PPP practices with contemporary demands of sustainable development and to define a set of criteria that take into account economic, technical, organizational, and social aspects. Five main groups of criteria are proposed, aimed at improving PPP models and assessed through a wide range of indicators, including in line with the policy of the European Union. Expert interviews have been used to determine the relevance of the criteria, allowing for an objective assessment of the importance of each one. The essence of PPP as a tool for strategic management, providing a coordinated interaction between the state and private investors in the construction sector, is provided. The current state and prospects for the development of PPPs in Ukraine are analyzed, taking into account international experience and the specifics of the national market. The defined criteria and sub-criteria for innovative development should form the basis for creating an effective management model that considers all aspects of sustainable development and facilitates the implementation of strategic initiatives. The research results highlight the importance of technical-technological and organizational development as key elements of a successful PPP model. The proposed approaches and recommendations may serve as a foundation for improving the management of construction enterprises, including through the introduction of innovative technologies and management methods

Storage management optimization based on electrical consumption and production forecast in a photovoltaic system

Decentralized energy production, particularly from photovoltaic (PV) systems, is becoming increasingly prevalent, leading to a rise in the number of energy producers and consumers, or ”prosumers”. These prosumers, equipped with their own energy generation and storage systems, are not just passive consumers but active participants in the energy market. They generate their own electricity, often from renewable sources, and can feed excess power back into the grid, store it for later use, or share it within a local energy community. This evolving energy paradigm presents new opportunities and challenges in terms of energy management and optimization, necessitating innovative approaches to ensure efficient and sustainable use of energy resources. This paper introduces an innovative storage management method for grid-connected photovoltaic (PV) systems. The method is designed to minimize either the economic or ecological cost, or to find an optimal balance between the two, under various tariff scenarios. This is achieved while adhering to a full self-consumption constraint imposed by the distribution system operator. The control strategy is underpinned by forecasts of electrical consumption, production, and CO2 emissions, which are developed using feedforward neural network models. These models are trained on data from a real-scale smart-grid demonstrator at the Catholic University of Lille, France. The results of the study offer a comparative analysis of the economic and ecological benefits of the three proposed strategies, demonstrating that the best compromise is achieved when considering the off-peak tariff option. Furthermore, a real-time controller was implemented on the Energy Management System (EMS) of the demonstrator and tested over a 24-hour period, yielding satisfactory results. This paper, therefore, presents a significant advancement in the field of storage management for grid-connected PV systems.

Managing Creative Skills to Increase the Economic Efficiency of Industrial Organizations

Economic variations have generated the need for the request of innovative management and management methods and approaches that would advance employees’ different thinking "problem solving ability" and mobilize their original potential. Creativity becomes one of the main managerial abilities. Therefore, the article deals with the concept of creative skills management systems of industrial enterprises. The main goal and tasks in the management of creative skills, and the ways of management decisions .also, the model of an industrial enterprise's creative skills management subsystem is presented. In order to evaluate the administrative system of creative skills in the Iraqi Cement state Company, management, Management Functional Assessment Model (MFAM) was used, and the sample was 173 employees. We also consider the main indicators for evaluating the effectiveness of the creative skills management system in order to ensure efficiency growth in the conditions of innovative economic development. After conducting the tests, it became clear the importance of creative skills management in order to increase the economic efficiency of companies and its role in developing the performance of employees. Also, companies gain a continuous and increasing competitive advantage by owning innovative employees. In addition, the study recommends paying attention to creative skills and developing them in order to increase the performance of employees and raise the economic efficiency of companies and possess a competitive advantage.

Problems and innovative approaches in student management in universities: focusing on students with autism as the core

Background Students with autism have unique characteristics in social interaction, emotional management, and learning styles, which may be overlooked in the larger environment of universities and affect their learning and life. Therefore, from a psychological perspective, exploring the problems and innovative approaches in student management in universities, with a focus on autistic students, has important theoretical and practical significance.Subjects and MethodsThe subjects of this study were 206 college students studying at a certain university, all of whom had varying degrees of autism. These students were equally divided into an experimental group and a control group. The experimental group conducted innovative management based on the management innovation pathways collected through expert surveys, while the control group only managed in traditional ways. The management experiment lasted for 60 days. Before and after the experiment, each group of students needs to be tested with the Autism Behavior Checklist (ABC).ResultsThe experimental results showed that there was no significant difference in any baseline data between the two groups before the start of the experiment, and there was no significant difference in ABC scores. After the experiment, the total ABC scores of the experimental group and control group students were 33.6 ± 2.9 and 42.2 ± 3.1, respectively, with lower scores and significant differences in the experimental group.ConclusionsThe expert group members found that managing college students through multiple innovative university management methods that focus on students and balance humanization and institutionalization can help improve the symptoms of students with autism.

Urban waste water management paradigm evolution: Decentralization, resource recovery, and water reclamation and reuse

AbstractThe growing urban population, increasing income per capita, and significant rise in the number of people living in cities are all placing a strain on the nation's water supply and calling for innovative methods of urban water management. Water stress, excessive resource consumption, nutrient discharge into aquatic ecosystems, and financially unstable utilities are all consequences of the traditional linear “take, make, waste” approach to water management. Many strategies are required to achieve economic, environmental, and social sustainability. More closed‐loop urban wastewater and resource management systems can be developed and implemented with the help of a toolkit that includes stormwater management/rainwater harvesting, water conservation, water reclamation and reuse, energy management, nutrient recovery, and source separation. Water conservation, water reclamation, and wastewater reuse are becoming the norm in many water‐poor regions. This shift is hastened by decentralization, made possible by dispersed stormwater management/rainwater collection and innovative high‐performance treatment technologies. Similar changes are occurring in conventional methods of residual management due to the need for more energy recovery and nutrient recovery and reuse. Finding the most outstanding long‐term solutions requires an economic study done well. The practice of stove‐piping must be eradicated from urban wastewater and resource management. These novel techniques for managing urban wastewater and resources can produce more long‐term, financially stable, resource‐efficient, environmentally friendly, nutrient‐sensitive, and sanitary outcomes.

Innovation and Technology Application in Tourism Management

Under the national planning, investment, and guidance, China's tourism industry has developed rapidly in recent years, effectively driving social and economic growth. In order to adapt to the macro development trend of the information age, when planning the future development of the tourism industry in China, it is clearly pointed out and emphasized to strengthen the deep integration with information technology, empower the tourism industry with new technologies, upgrade the traditional tourism industry market structure, and further enhance the development momentum of the tourism industry, so that the tourism industry can meet the people's pursuit of high-quality living quality Play a greater role in driving socio-economic growth. As a new form of media, new media can break through the limitations of time and space with the assistance of mobile devices such as smartphones, digital televisions, and computers, providing users with diversified information services. With the increasing degree of social networking, new media has become a commonly used way of information dissemination and communication. Applying it to tourism management not only helps to diversify the channels of tourism information dissemination, but also helps to improve the speed of tourism information dissemination. This article studies innovative methods of tourism management in the context of new media, in order to promote the healthy and sustainable development of the tourism industry.

Adaptive institutional change in municipal waste management

Purpose. The paper proposes a new trajectory of institutional change that integrates economic (fiscal) and technical solutions in managing municipal waste.
 Methodology / approach. The study adopts a model for the study of institutional change. A retrospective, quantitative analysis of institutional change, a legal-historical analysis of formal institutions, and a comparative-institutional analysis are used to substantiate the link between municipal waste quantities and Gross domestic product (GDP) growth. Using correlation and regression analysis, we examine the relationship between institutional change in municipal waste management and recycling.
 Results. The study proves the impact of institutional change on municipal waste management in the EU and Bulgaria. It can change the relationship between GDP and the amount of waste and stimulate the implementation of more efficient and innovative waste management methods. The relationship between institutional change in municipal waste management are studied. The main idea is that more legal acts regulating municipal waste management and a higher human development index, wich reflects better and more efficient municipal waste management, will lead to higher recycling rates. The study discusses how institutional change aimed at effective municipal waste management can contribute to increased revenues and reduced costs for the government by promoting innovation in the sector, introducing more efficient waste collection and treatment technologies, and encouraging recycling.
 Originality / scientific novelty. The study highlights the lack of a unified direction in rules and policies for municipal waste management in Bulgaria and its impact on the system’s efficiency. It aims to present a new approach to solving the problems related to municipal waste management in Bulgaria that focuses on the importance of institutional change.
 Practical value / implications. The paper identifies differences between the municipal waste management systems in the EU and Bulgaria. The proposed financial and technical solutions help central and municipal administrations to create new institutions. These actions can be joint and better coordinated. All this should lead to changes in the regulatory framework. The new rules will contribute to stability and less need to change regulations, clarity for individuals and organisations to the optimal solutions for reducing municipal waste costs, and “pressure” on the central and local administration to take the necessary actions for such a change.

РОЗВИТОК НОВИХ ПІДХОДІВ ДО МОДЕЛЮВАННЯ ПРОЦЕСІВ ДІАГНОСТИКИ ТА АНАЛІЗУ РИЗИКІВ В ІТ КОМПАНІЯХ

The article considers the topical issue of developing new approaches to modeling the processes of diagnostics and risk analysis in IT companies. The rapid technological progress of recent years necessitates innovative risk management methods. The authors highlight that conventional risk assessment methods often fail to account for the swift changes within the IT sector and may prove inadequate for dynamic environments. Consequently, the task at hand involves formulating and adapting new risk modeling approaches that consider the specific nature of the IT industry and propose enhancements to risk management. The article underscores that one of the primary sources of risk for IT companies is the rapid technological progress within the IT realm. Novel technologies frequently employed by IT companies can be less predictable and stable compared to those utilized by traditional businesses. Conventional risk models, founded on historical statistical data, may be ill-suited for such dynamic environments, necessitating fresh approaches to modeling technological and innovative risks. Within the article, three key risk sources within the IT domain are examined: rapid technological progress, cybersecurity threats, and the need to handle extensive data volumes. The main risks associated with these factors are described, highlighting the need for developing new approaches to their modeling. Emphasis is placed on cybersecurity and cyberattacks, which present significant threats to IT companies. Thus, particular attention is dedicated to the economic-mathematical modeling of cyber risks, avenues of research in this field, and effective risk management. The authors underscore the importance of leveraging cutting-edge technologies, notably artificial intelligence, in modeling risks for IT companies. The article demonstrates how the utilization of new risk modeling methods can assist in identifying potential threats and devising effective measures for prevention. As a result of this research, it is affirmed that the development of innovative risk modeling approaches in IT companies holds substantial potential for ensuring business resilience.

Management of an organisation’s accounting department: Overcoming the challenges of martial law in Ukraine

The study of accounting personnel management is relevant since the modern accounting service as a structural unit of an organisation with specific administrative functions is constantly transforming and adapting in response to the pressure of an aggressive environment. Effective management of accounting personnel makes the transformation process manageable, which has a positive impact on the functioning, productivity, and sustainability of the entire company. The purpose of the study was to summarise the practical experience and current trends in the management of the accounting service of a company in the conditions of war. The study is based on scientific works on the organisation of accounting and personnel management, statistical and analytical studies, and legislative acts in the field of accounting. The study employed traditional theoretical methods of cognition (generalisation, deduction, grouping, analysis, synthesis); empirical methods (observation, description of personal experience), and the graphic method. The paper focused on the interaction of managers with the accounting department as a team. It was demonstrated how the unfavourable conditions of martial law forced accountants and managers to join forces to adapt the organisation to the new realities. Specifically, the most difficult issues that have arisen in the field of accounting management at Ukrainian enterprises since the beginning of the war were considered. The study investigated such aspects of accounting service management as: staffing, creation of appropriate working conditions for accountants, digitalisation of accounting business processes as a tool for enhancing security, psychological factors of work efficiency. Particular attention was paid to new manifestations of loyalty of accountants and managers in extreme conditions. The problem of social responsibility of managers and the influence of moral and ethical principles on organisational decision-making by accountants was raised. The authors suggested personnel strategies that have proven to be the best in managing an organisation’s accounting department in times of war. This study is important and has practical value, as it suggests that organisational managers should pay attention to the needs of accounting staff, as well as apply both conventional and innovative methods of personnel management adapted to martial law conditions to the accounting service

Management Method Evaluation for Innovation and Entrepreneurship in College with Multi-Scale Feature Convolutional Network

ABSTRACT Since the full implementation of the innovation-driven development strategy in the country, all regions and departments have placed great emphasis on the work of mass entrepreneurship and innovation, resulting in a significant increase in innovation and entrepreneurship. The national focus on mass entrepreneurship and innovation has shifted from quantitative to qualitative improvements, with greater attention being paid to improving substance rather than expanding scope. There is a growing trend among colleges to recognize innovation and entrepreneurial management as a significant achievement in college education and teaching. By prioritizing innovation and entrepreneurship management and professional education, the aim is to cultivate college students with an entrepreneurial spirit, and to develop inventive and entrepreneurial talent. Cultivating innovative talent is one way to apply the innovation-driven development plan and build a creative country. However, the implementation of the innovation and entrepreneurship development plan in the country has posed both new opportunities and challenges to the management of innovation and entrepreneurship education in colleges across the country. As a result, innovation and entrepreneurship have become increasingly important tasks that can help improve the management of innovation and entrepreneurship in these institutions. In order to address this issue, this paper proposes a neural network for evaluating innovation and entrepreneurship management methods in colleges, which combines convolutional neural networks with these tasks. Specifically, a multi-scale convolutional neural network is designed to more efficiently extract innovation and entrepreneurship management features in colleges, ultimately leading to improved model performance.

Conceptual basis of state policy in the sphere of museum affair

The purpose of the study is the analysis of the conceptual bases and directions of implementation of state policy in the museum sphere, as well as the definition of practical state management concepts in the sphere of museum affairs in Ukraine. The methodology is based on the use of problem-oriented approaches, which are based on the systematic and legal analysis of normative legal acts with the aim of improving state-management decisions as the main direction of the state’s regulatory activity. The following methods were used: interpretative-analytical, comparative-historical analysis, theoretical generalization, historical-comparative, historical-typological, historical-legal, statistical. Scientific novely. The article, based on the analysis of existing scientific works, defines the main directions of state policy in the museum sphere in general, and in the direction of preservation of monuments of material culture in particular. Prospects for improving state support for the educational activities of modern museums are also determined; attention is also focused on the positive experience of organizing cultural and educational activities of foreign museums in the context of preserving the cultural self-identification of society. Conclusions. It is emphasized that in order to ensure state management of socio-cultural processes in the context of museum development, Ukraine should focus on the implementation of innovative forms and methods of state management of the museum industry, which are based on world experience. The conceptual foundations of state policy in the field of museum affairs should be: analysis of the work of museum institutions with the determination of measures to improve their activities; development of measures to ensure the protection of monuments of museum funds; prevention of theft of historical and cultural values located in museums; replacement of security guards with technical ones; provision of financial resources for the creation of new exhibitions in museums; equipping museums with alarm systems and video surveillance; creation of a list of measures regarding the initiative of new expositions and exhibitions that will show the heroism of the defenders of the sovereignty of Ukraine.

Prospects and directions of digital transformation in foundry

The time of information technology determines its priorities, which are a prerequisite for building a competitive production and economy. The ubiquitous spread of digitalization is one of the basic principles of new economy, a new type of socio–economic structure that is gradually being formed in the modern world through the introduction of scientific and technological progress and innovative methods of management, intellectualization and capitalization of human knowledge, the use of advanced new information and material technologies, accelerated development of knowledge-intensive sectors of the economy, the formation of creative, efficient, rational information and material production. Currently, at large foundries with mass and large-scale production of castings, the task of automating the control of technological processes using digital control systems was solved in general. They implement algorithms for controlling technological processes of casting in closed circuits (locally). The systems under consideration allow to implement optimal control strategies and automatically perform sequences of operations (start and stop of equipment; calculation and input of metal charge; calculation of formulations, dosing and mixing of molding and core mixtures) of multi-stage periodic casting processes. Digital transformation can significantly change the established practice of foundry production (from direct control and management of technological processes to business planning and document management). The transformation will have an impact on all parameters of the enterprise: economic efficiency of production (productivity, operating costs); reliability (operational readiness); safety (number of incidents); compliance with legislative norms on ecology. The technological criterion for success of the digital transformation of foundry production will be the release of a nomenclature of castings with a minimum level of defect, commercial – the release of a nomenclature of castings in demand on the market (machine parts and mechanisms), with a minimum self-cost, which is determined by the technological level of preparation of the production and its implementation and, as a consequence, low costs and optimal quality of molds, metal and castings.

Epigenetics: an innovative lever for grapevine breeding in times of climatic changes

Climate change imposes numerous threats to viticulture. Different strategies have been developed to mitigate these effects that range from innovative vineyard management methods and precision viticulture to the breeding of new varieties and rootstocks better adapted to environmental challenges. Epigenetics refer to heritable changes in genome functioning that are not mediated by DNA sequence variations. The recent discovery that epigenetic memories can mediate acclimation and adaptation of plants to their environment now provides new levers for plant improvement facing climate changes without significant impact on the genetic information. This can be mediated either by using the epigenetic memories of stresses and/or by creating epigenetic diversity in the form of new epialleles without changing the genetic information. Indeed, grapevine is a perennial grafted clonally propagated plant, and as such, presents epigenetic specificities. These specificities require adapting strategies that have already been developed in model plants but also offer opportunities to explore how epigenetic memories and diversity can be a major source of rapid adaptation to the environment for plants bearing similar properties. Among these strategies, both annual and trans-annual plant priming with different types of elicitors might provide efficient ways to better face (a)biotic stresses. The use of epigenetic exchanges between scion and rootstocks and/or the creation of non-targeted epigenetic variations at a genome-wide scale, or targeted using epigenetic editing, may provide innovative and promising avenues for grapevine improvement to face challenges imposed by climate changes.

THE NEED TO REFORM THE MANAGEMENT SYSTEM OF HIGHER EDUCATION INSTITUTIONS AND IMPLEMENT NEW PRINCIPLES TO IT

When we covered the topic "The need to reform the management system of higher education institutions and introduce new principles to it" in the article, we presented the need and important principles of developing and updating the management system of higher education institutions. These principles can be: Orientation to central goals: The importance of orientation to central goals is shown in the management system of higher education institutions. The management system should include support for goal setting, instructional design, student achievement of goals, and performance evaluation. Discussion and management transparency: In the reform of the management system, it is necessary to follow the principles of discussion and management transparency[1]. Effective and mutual cooperation between the administration, teachers, students and parents, establishment of high-level relations between governing bodies and organizations is important. Establishing a broad framework of management: In reforming the management system of higher education institutions, the principle of establishing a broad framework of management is important. This is to support changing and innovative methods of strategic management, monitor learning processes, enable efficient and cost-effective use of resources, ensure quality, improve the quality of education and learn to adopt innovations. contains z.

DIGITALIZATION AS A POWERFUL FACTOR IN ENSURING HIGH COMPETITIVENESS OF THE ENTERPRISE

DIGITALIZATION AS A POWERFUL FACTOR IN ENSURING HIGH COMPETITIVENESS OF THE ENTERPRISE

Treatment of Biowaste for Electrodes in Energy Storage Applications: A Brief Review

Proper and innovative waste management methods still pose a major concern in our present world. Continuous accumulation of biowaste from bio-processing industries, household, organic residues and so on makes the environment polluted and endangers the health of man and other animals. The common waste management methods which include direct dumping into water bodies, open-air combustion, and as land fillers are obsolete and are the major causes of environmental pollution. Conversion of biowastes into valuable materials aids proper waste management, and helps to attain a cleaner environment, in addition to the fact that wastes are turned into wealth. Biowastes are rich in carbon and can serve as excellent precursors for the synthesis of important carbon materials such as activated carbon, graphene, carbon nanotubes etc. Three important methods of converting biowastes into carbon materials are discussed in this review. The electrochemical, adsorption, and electrocatalytic properties of the materials and the applications in electrochemical energy storage devices are also discussed in brief. This review focuses on the synthesis of carbon materials from biowaste residues and their use in developing electrode materials for batteries and supercapacitors. Future perspectives on the need to exploit greener technology for the conversion of biowastes into important carbon materials should be considered.

Application of SWOT analysis to justify the strategy of hotel business enterprises

One of the important areas of action in Ukraine is the restoration of the sphere of activity of hotels with the reduction of restrictions after COVID-19 in the conditions of the russian federation's war against Ukraine. Using the experience of hotels in other countries will be useful in restoring the tourism industry in Ukraine. Disadvantages in the operation of hotels arise from the fact that management decisions are sometimes made intuitively, modern innovative management methods, such as SWOT analysis, are not used. The object of the research is the influence of the owner and management on the review of the business strategy in the critical use of the hotel's capabilities with the help of SWOT analysis. The problem of improving business management was solved at the stage of considering options for improving the hotel's operations. The results were to show the chance of choosing the optimal business strategy when systematically considering options for management decisions regarding the future of the hotel using SWOT analysis techniques. When applying a SWOT analysis, the weaknesses and strengths of the hotel are modeled; but it requires special statistical knowledge. In the paper, based on the processing of studied of the hospitality industry, examples of SWOT analysis experience for the implementation of business strategy by hotels in countries with a developed tourism market are indicated. Consolidated information is formed on the components of a SWOT analysis of a hotel business strategy according to the authors' proposals. The process of SWOT analysis in improving the activity of Ukrainian hotels at the stage of planning and implementation of strategic directions is revealed. The formation of an information base is outlined with an integrated approach in the process of implementation. Organizational measures for implementing the hotel strategy according to SWOT analysis are indicated. Conclusions are drawn and directions for further research are shown. The obtained results are the process of making management decisions based on a set of market data, which determines the application of a certain sequence of recognized stages (algorithm). A SWOT analysis, which was prepared by eliminating all the ideas of the participants and ranking them in order of importance, will combine a large problem into a report that is more understandable to individuals and must be put into practice by them.

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain

Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which exhibit some symptom similarities and are thus considered to share a common etiology. The calcitonin gene-related peptide (CGRP) has gained credit as a target for migraine management; nevertheless, the efficacy and the applicability of CGRP modifiers warrant the search for more effective therapeutic targets for pain management. This scoping review focuses on human studies of common pathogenic factors in migraine and NP, with reference to available preclinical evidence to explore potential novel therapeutic targets. CGRP inhibitors and monoclonal antibodies alleviate inflammation in the meninges; targeting transient receptor potential (TRP) ion channels may help prevent the release of nociceptive substances, and modifying the endocannabinoid system may open a path toward discovery of novel analgesics. There may exist a potential target in the tryptophan-kynurenine (KYN) metabolic system, which is closely linked to glutamate-induced hyperexcitability; alleviating neuroinflammation may complement a pain-relieving armamentarium, and modifying microglial excitation, which is observed in both conditions, may be a possible approach. Those are several potential analgesic targets which deserve to be explored in search of novel analgesics; however, much evidence remains missing. This review highlights the need for more studies on CGRP modifiers for subtypes, the discovery of TRP and endocannabinoid modulators, knowledge of the status of KYN metabolites, the consensus on cytokines and sampling, and biomarkers for microglial function, in search of innovative pain management methods for migraine and NP.