The article provides a scientific justification of the importance of ensuring and increasing the level of economic security of the business sector, which implies positive and progressive changes in the development of the national economy. It is emphasized that when forming the economic security management system of the business sector, it is necessary to take into account that ensuring economic security includes determining the types and causes of negative impacts on its level. A number of elements of the economic security management system of the entrepreneurial sector of the national economy, which form the methodological basis for its formation and improvement, are highlighted. It is proposed to consider the economic security management system of the entrepreneurial sector as the ability of enterprises to effectively carry out economic activities, use resource opportunities, realize economic interests and innovative development potential, ensure competitiveness. As a result, it is proposed to divide the economic security management system of the business sector into subject-object (subjects and objects) and management (functions, goals, directions) levels. An essential characteristic of managing the economic security of the entrepreneurial sector of the national economy is the stability and stability of functioning, the presence of “compensatory functioning”, which means the ability to maintain the stability of activity under the conditions of the realization of external and internal threats. It was concluded that the methodological foundations of economic security management of the business sector relate, on the one hand, to the substantiation of the processes of preserving the commercial secret of the enterprise, and on the other hand, to the preparation of enterprises to conduct economic activity under the influence of the external environment and to adapt to it while maintaining a sufficient level of economic efficiency and security.