The national development strategy requires enterprises to take technological innovation as a tool to realize the transformation and upgrading of industrial structure and the transformation of development mode. Technological innovation is not only a weapon for enterprises to improve their competitive strength, but also a key means to stabilize themselves in the complex and severe living environment. High-tech enterprises are the key to improve the national innovation level. The performance of innovation input-output of different types of high-tech enterprises is different, which should be analyzed concretely. In order to explore the strongest driving force of enterprise technological innovation and analyze the effective input mode of enterprise technological innovation output maximization, this paper studies the micro data of enterprises in zhongguancun demonstration zone from 2009 to 2016 as samples. The research finds that: There is a significant positive correlation between innovation input and business profit growth. Second, the type of enterprise plays a moderating role in the relationship between independent innovation input and operating profit, but not in the relationship between government innovation input and operating profit.