Helicobacter pylori infection is one of the most commonly treated infections in gastroenterology. In the last three decades, due to recurrent or repeated infection, the incidence of this complex health problem has been constantly increasing. Studies have shown that successful treatment of this infection can prevent the occurrence of numerous complications, such as ulcer disease, dyspepsia or gastric cancer. Interventions in the prevention of Helicobacter pylori infection are numerous, they are carried out at all levels of health care and are of great importance for reducing the number of patients, but also for the occurrence of complications related to the infection. The aim of this paper is to evaluate innovations in medical treatment and prevention of Helicobacter pylori infection.