Development Of Innovative Strategies Research Articles

Recombinant human cyclophilin A in combination with adoptive T cell therapy improves the efficacy of cancer immunotherapy in experimental models in vivot;

Adoptive T-cell therapy (ACT) is successfully applied in cancer treatment, however, its efficiency can be limited by a low viability, short persistence time, and loss of functional activity of T cells after adoptive transfer. The search for novel immunomodulators that can improve the viability, expansion, and functions of T cells after their infusion with the minimal side effects could contribute to the development of more efficient and safe ACT strategies. Recombinant human cyclophilin A (rhCypA) is of particular interest in this respect, as it exhibits pleiotropic immunomodulatory activity and stimulates both innate and adaptive anti-tumor immunity. Here, we evaluated the effect of rhCypA on the efficacy of ACT in the mouse EL4 lymphoma model. Lymphocytes from transgenic 1D1a mice with an inborn pool of EL4-specific T cells were used as a source of tumor-specific T cells for ACT. In models of immunocompetent and immunodeficient transgenic mice, the course (3 days) rhCypA administration was shown to significantly stimulate EL4 rejection and prolong the overall survival of tumor-bearing mice after adoptive transfer of lowered doses of transgenic 1D1a cells. Our studies showed that rhCypA significantly improved the efficacy of ACT by enhancing the effector functions of tumor-specific cytotoxic T cells. These findings open up the prospects for the development of innovative strategies of adoptive T-cell immunotherapy for cancer using rhCypA as an alternative to existing cytokine therapies.

Knowledge Management as a New Strategy of Innovative Development

Theoretical framework: The relevance of studying the growing role of knowledge management in the context of ensuring the innovative activity of enterprises is increasing. The results demonstrate a number of important conclusions that have made it possible to expand the existing theoretical and practical aspects of the knowledge management concept. Design/methodology/approach: The conducted study in service companies has revealed a low culture of using this concept in the Ukrainian context. In the course of the research, it has been established similar and different features of the influence of knowledge management on innovation of service companies, direct and indirect relationship between variables, complex structure and indirect impact of production, integration, application of information on the speed, quality and number of innovations in enterprises. Findings: The complex structure of the relationship between knowledge and innovative activity can be a consequence of insufficient level of personnel competencies, available information and data management technologies, methods and practices of production, integration and application. Therefore, the low innovativeness of the service companies under study in the context of system orientation and technological capabilities of the companies, in particular, in the practice of knowledge management, and the low impact of knowledge and information on the innovation of services and processes on the market of Ukraine have been revealed. Research, Practical & Social implications: This is precisely why the strategy of personalization significantly prevails in its use in knowledge management compared to the codification strategy, which is manifested in the limited practice of using systems and technologies for the generation, accumulation, storage, use, dissemination of knowledge. Originality/value: In addition, the use of the personalization strategy is explained by the fact that the service companies under consideration focus more on processes, the optimization of which significantly affects interaction with customers and the efficiency of operations.

The problem of the cultural crisis in today's information-digital society

The purpose of the paper is to highlight the crisis phenomena that are an integral part of the socio-cultural space and, together with elements of progress towards well-being, form civilizational progress. The crisis of culture has several manifestations, determining its existential and axiological dimensions. The purpose of scientific exploration is to characterize the crisis phenomena in modern culture in the information and digital section. The methodology that most fully reveals the content of the cultural crisis is scientific-philosophical dialectical and synergetic in nature. Consequently, man and society use informatization and digitalization of socio-cultural space as principles, revealing the problematic aspects of cultural development. The formation of innovative sociocultural development strategies, the main task of which is to promptly identify the crisis aspects of culture, should be considered as a novelty. It is the dynamism that is the main practically oriented criterion in the modern scientific and philosophical analysis of the cultural crisis. Conclusion. Thus, the information and digital society has developed the actual value constants of its development, which allow promptly recognizing the cultural processes that are potentially or presently in crisis.

Development of innovative strategies to evaluate teaching-learning processes in public health

Development of innovative strategies to evaluate teaching-learning processes in public health

TRIZ inventive principle in healthcare quality and innovation development

PurposeThis research aimed to create inventive principles in managing quality and innovation systems that can be used as a guide for the development of effective innovation projects in hospitals.Design/methodology/approachTotal quality and innovation management in healthcare (TQIM-H) framework and theory of inventive problem-solving (TRIZ) were integrated with results from in-depth interviews with 30 healthcare experts, resulting in TQIM-H inventive principle. The developed inventive principle was validated using 50 effective innovation projects from one of the largest healthcare conglomerates in Southeast Asia.FindingsThe TQIM-H inventive principle consisted of 7 dimensions and 72 procedures for creating innovation in hospitals under the medical quality framework. The principle effectively helps innovators develop innovative solutions that still strictly comply with medical guidelines.Originality/valueInnovation is recognized as a critical factor that helps organizations adapt to global changes and increases the potential for competition, especially in hospitals. However, creating innovation in hospitals has a lower success rate than in other industries because, in general, ineffective innovation development strategies are used and the created innovation is not aligned with regulations and restrictions regarding healthcare quality in the healthcare system.

Photogenerated Carrier-Assisted Electrocatalysts for Efficient Water Splitting

Electrocatalysts are the core component of electrocatalytic water splitting for improving its overall energy conversion efficiency and reducing the energy input. At present, the design of efficient electrocatalysts mainly focuses on optimizing their electronic structure and local reaction microenvironment to improve the adsorption of reaction intermediates. Although many effective strategies (such as heteroatom doping, vacancy, heterojunction construction, strain engineering, and phase transformation) have been developed, the improvement in catalytic activity has been very limited. Hence, the development of innovative strategies to enhance the optimization of photoelectroactivity is desirable. Inspired by the strategy of applying a potential field to reduce carrier radiation recombination in traditional photoelectrocatalysis, photogenerated carrier-assisted electrocatalysis, based on the synergy effect of light and electric energy, provides a new strategy to enhance the intrinsic activity of water splitting. The essence of the photo-assisted strategy can be attributed to the injection of hot carriers and photogenerated electron–hole pairs or the accelerated reaction kinetics caused by local temperature rises. The photogenerated carrier-assisted strategy has received wide attention due to its simplicity and efficiency. In this review, we focus on the recent advances in photogenerated carrier-assisted strategies (PCAS) for enhancing the performance of HER, OER, and overall water splitting. The possible mechanisms are addressed and the basic composition and latest progress in photo-assisted electrocatalysts using PCAS are summarized. Finally, the challenges and development prospects of PCAS will be detailed.

Strategy and challenge of innovative drug research and development from clinically effective ingredients of traditional Chinese medicine

Novel drug discovery from the active ingredients of traditional Chinese medicine is the most distinctive feature and advantageous field of China, which has provided an unprecedented opportunity. However, there are still problems such as unclear functional substance basis, action targets and mechanism, which greatly hinder the clinical transformation of active ingredients in traditional Chinese medicine. Based on the analysis of the current status and progress of innovative drug research and development in China, this paper aimed to explore the prospect and difficulties of the development of natural active ingredients from traditional Chinese medicine, and to explore the efficient discovery of trace active ingredients in traditional Chinese medicine, and obtain drug candidates with novel chemical structure, unique target/mechanism and independent intellectual property rights, in order to provide a new strategy and a new model for the development of natural medicine with Chinese characteristics.

CONCEPTUAL APPROACHES TO EVALUATING THE EFFECTIVENESS OF INNOVATION IMPLEMENTATION AT ENTERPRISES

The article analyzes the peculiarities of the methods of evaluating the innovative development of the enterprise. It was determined that the main factors affecting the choice and combination of methods for assessing the innovative state of the enterprise for the purpose of developing a strategy for its innovative development and forming the management components of the mechanism for its implementation are: certain difficulties in determining the indicators that are included in the innovative enterprise development strategies; planning and forecasting terms; information security regarding the assessment of the possible influence of internal and external environmental factors on the further innovative activity of the enterprise; the results of the analysis of the relevant indicators in the retrospective, that is, in the previous period. It has been studied that to evaluate the development of innovative processes at enterprises, they are widely used analytical methods, in particular – statistical, expert assessment, including the method of morphological analysis. This is explained not only by the simplicity in the application of analytical methods, but also by the fact that thanks to these methods, on the one hand, it is possible to single out the characteristics of the studied component as part of a single whole in the general system, and on the other – to concentrate precisely on the study of the most important task in accordance with the set goal, taking into account the maximum possibilities for using all analytical approaches at the same time. It was found that for the analysis of internal and external environments, sub under the influence of which the enterprise functions, methods already known and effective in practical use can be involved – these are SWOT-analysis and PEST-analysis methods.

Анализ и перспективы инновационного развития предприятий общественного питания

Public catering has become an important healthy food provider in Russia. As a rule, this sphere is represented by small businesses with no experience in innovation. Their prospects for innovative development depend on the form of ownership, size, and target audience. The present research objective was to develop recommendations on how to restructure a public catering enterprise as part of an innovative development strategy.
 The study featured public catering enterprises together with their innovative potential, activities, and factors that contribute to or hinder their development. The innovative restructuring scenarios were based on the synthesis method.
 The authors developed a goal-centered classification which includes commercial and socially oriented public catering enterprises with their own advantages and disadvantages. The list of disadvantages includes decentralization, overstaffing, and multi-format, which make it difficult to introduce innovations and strategizing. The restructuring process requires a new management system optimized by specialists competent in the field of innovation, as well as a new matrix of strategic resources.
 An audit of public catering enterprises makes it possible to assess their competitiveness and strategic prospects. The current lack of personnel with experience in innovations hinders the development of the industry. Universities and regional innovation infrastructure should provide public catering with specialists in innovation management.

Comparative Analysis of Innovative Development Strategies of Fuel and Energy Complex of Ukraine and the EU Countries: International Experience

The European Union is pursuing an ambitious energy policy to reduce the emission of pollutants into the environment and achieve complete decarbonization by 2050. According to the approved Green Deal, each European state had to introduce its own energy strategy based on its own economic, social, climatic, and climatic conditions. In the process of European integration, Ukraine has developed its own strategies that meet the principles of European government policy. The analysis of the experience of implementation of energy strategies of different member states of the European Union will have a positive impact on the process of implementation of the new energy policy in Ukraine. According to this, a comparative analysis of strategies and the state of the fuel and energy complex of France, Austria, Poland, which have common features with the energy system of Ukraine. As a result of the study, it was found that the process of decarbonization should be gradual. Abrupt changes can lead to negative consequences in economic and social aspects. The information obtained can be useful for energy reforms in Ukraine.

Research on Tourism Marketing Strategy Innovation in New Media Era

The new media environment is accepted and loved by an increasing number of audiences for its characteristics of media individuation, diversified forms and dynamic information dissemination. Tourism destination publicity and marketing are the traditional core functions of competent departments. However, with the background of the rapid development of new media, there is a problem that how to adapt to and effectively use new media channels needs to be faced at present. Relying on new media to carry out marketing strategy innovation of tourist destinations, which is of great help to do a good job in the promotion of tourist destinations, improve their reputation and influence. In terms of this, this paper starts with the elaboration of new media and tourism destination marketing, discusses the characteristics of tourism marketing under the new media environment and the main marketing forms of new media, hoping to find effective innovative development strategies for the publicity and marketing of tourism destinations.

Innovative development strategy of a risk-averse firm considering product unreliability under competition

This paper aims to seek the innovative development strategy for a leading firm in a competitive market when considering product unreliability and risk behavior. A higher innovation level may bring about better product performance. Nevertheless, it may cause some unreliability events which might incur serious negative outcomes (e.g., products recall). Facing uncertain outcomes, the innovative firm may care more about the risk of innovation when making decisions, especially in a competitive market. We build a Stackelberg game model for a competitive market consisting of a leading firm and a competitor. The Conditional Value-at-Risk (CVaR) is used to measure the firm’s risk attitude. The optimal innovation strategy of the leading firm and the response strategy of the competitor is obtained. We find that the optimal innovation strategy takes three different forms depending on the risk attitude and the development cost of innovation. i.e., no innovation, complete innovation and partial innovation. In addition, different from most existing literature on risk-averse players’ pricing decisions, we find that a risk-averse innovative firm may set a higher price to focus on only tech-savvy consumers. Moreover, the effects of innovation are also investigated. We find that the two competing firms can achieve a win–win result by adopting an appropriate innovation strategy.

Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection.

Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infectionAcinetobacter baumannii is a gram-negative multidrug-resistant nosocomial pathogen and a major cause of hospital acquired infetions. Carbapenem resistant A. baumannii has been categorised as a Priority1 critial pathogen by the World Health Organisation. A. baumannii is responsible for infections in hospital settings, clinical sectors, ventilator-associated pneumonia, and bloodstream infections with a mortality rates up to 35%. With the development of advanced genome sequencing, molecular mechanisms of manipulating bacterial genomes, and animal infection studies, it has become more convenient to identify the factors that play a major role in A. baumannii infection and its persistence. In the present review, we have explored the mechanism of infection, virulence factors, and various other factors associated with the pathogenesis of this organism. Additionally, the role of the innate and adaptive immune response, and the current progress in the development of innovative strategies to combat this multidrug-resistant pathogen is also discussed.

Synergistic adsorption and oxidation of trivalent antimony from groundwater using biochar supported magnesium ferrite: Performances and mechanisms

Antimony (Sb) pollution is considered an environmental problem, since Sb is toxic and carcinogenic to humans. Here, a novel biochar supported magnesium ferrite (BC@MF) was adopted for Sb(III) removal from groundwater. The maximum adsorption capacity was 77.44 mg g−1. Together with characterization, batch experiments, kinetics, isotherms, and thermodynamic analyses suggested that inner-sphere complexation, H–bonding, and electrostatic interactions were the primary mechanisms. C–C/CC, C–O, and O–CO groups and Fe/Mg oxides might have acted as adsorption sites. The adsorbed Sb(III) was oxidized to Sb(V). The generation of reactive oxygen species, iron redox reaction, and oxidizing functional groups all contributed to Sb(III) oxidation. Furthermore, the fixed-bed column system demonstrated a satisfactory Sb removal performance; BC@MF could treat ∼6060 BV of simulated Sb-polluted groundwater. This research provides a promising approach to sufficiently remove Sb(III) from contaminated groundwater, providing new insights for the development of innovative strategies for heavy metal removal.

Public Service Innovation in the Era of the Covid-19 Pandemi in Tangerang District, Banten

The government has a big responsibility for the best and quality services in all public service sectors to the community. However, during COVID-19, the government imposed strict health protocols that affected the quality of service. This condition requires the Tangerang Regency Government to innovate digital-based public services or information and communication technology. The theory of innovation in research uses the theory developed by Rogers, Everett M in his book Diffusion of Innovations, which looks at innovation from the dimensions of Relative Advantages, Compatibility, Complexity, Trialability and Observability. The research design used is qualitative with a narrative or descriptive study approach. Data collection techniques used triangulation techniques by means of observation, interviews and document review. Meanwhile, data analysis used techniques developed by Miles and Huberman, namely data reduction, data display, and conclusion drawing/verification. The results of the study show that during COVID-19, the Tangerang Regency Government has developed e-government-based public service innovations, including; the Population Administration Service Information System application (SIPENDUK), the Integrated Licensing Service Information System application (SIPINTER), the Integrated Online PBB Print Information System application (siCEPOT) and the Online Medical Check-Up Booking Information System application (Si BOMCU). Public service innovation development strategies that need to be used are; compiling and establishing a blueprint for an integrated e-government application system and creating an ideal institutional model in e-government management.

Evolution of Russian and foreign approaches to defining the content of industrial cooperation

Aim. The presented study aims to analyze and substantiate practical recommendations for the formation and application of controlled interaction technologies, the development of importdependent and export-oriented enterprises, as well as systems comprising a unified business space at the meso, macro, and global levels within the framework of inter-firm cooperation during import substitution and localization.Tasks. The authors substantiate their original approach to the formation and development of inter-firm network interaction, which involves integrating the management of the internal and external environment of an import-dependent and export-oriented enterprise of the real sector of the economy at the global, macro, meso and micro levels into a unified business space; consider an important component of strategic management as a function of the formation of managed interaction systems by a unified business environment that determines the sustainable development of enterprises, industries, and regions.Methods. This study uses general scientific and special methods of cognition to investigate the process of finding and applying new forms of enterprise management within the framework of inter-firm cooperation in the context of maximum environmental fluctuations.Results. It is found that scientific interest in cooperation is spiral in nature and each subsequent whorl reflects the realization of the opportunities provided by cooperation with regard to the current and future waves of innovation (for example, as it happens in the current historical period exhibiting the signs of transformation of inter-firm industrial cooperation into cybersocial networks organizing the interaction between man and machine). According to the authors, as industrial cooperation evolves based on a capacious base of theoretical and applied scientific research in the field of formation and management of network entities, it requires additional study of the possibility of development through the implementation of interaction in the systems of a unified business space.Conclusions. The study shows that the systems of a unified business space are a specific and promising form of implementation and management of the development of industrial cooperation that is in demand within the framework of the strategy of innovative development of production and products during the implementation of the policy of import substitution and industrial localization.

Management of the development of a metallurgical company on the basis of the algorithm of the pre-investment analysis

The article is devoted to the development of methodological approaches to assessing the effectiveness of investments in innovations and repairs of Russian metallurgical companies based on an analysis of the state of innovation and technological potential in order to maintain competitiveness in the face of tougher sanctions. The analysis of sources and directions of investments and comparison of the current internal rate of return in the leading companies in the metallurgical sector were carried out: Severstal, MMK, NLMK, EVRAZ; their investment activity was studied and the predominant selfinvestment in the development of companies and interest in financial parameters and global trends were confirmed to the detriment of the material component of production. The problem of disunity of owners, managers of the main production, repair facilities and top management in making investment decisions is detailed and methods for its solution are proposed through the use of a company's preinvestment analysis algorithm based on the methodology of predictive analysis of large data arrays. The methodological basis is the theory of strategic management and investment analysis. Methods: classification, comparison, grouping, economic and mathematical modeling, predictive analysis and algorithms. The methodology for evaluating investment projects using the modified internal rate of return (MIRR) has been refined. An algorithm for analyzing the investment environment of metallurgical companies is proposed based on taking into account the service life of equipment and ranking it depending on the need for repair or renewal. The updated analytical tools will be of interest to industry enterprises, corporations and government agencies in substantiating the strategy of innovative development. The developed approaches are of scientific interest in the study of contradictions between production, top management, owners of metallurgical companies and the state.

Comparative Analysis of Strategies for Innovative Development of the Fuel and Energy Complex: The Experience of the EU Countries

Most European countries do not have large reserves of natural resources and depend on imported energy resources. In this regard, the government of the European Union has approved a new energy policy aimed at developing a “green” economy and combating dependence on non-renewable resources. Currently, the European Union is a leader in the development of renewable energy sources. Many states have achieved success in this industry, their experience can be used in other countries where alternative energy is not so widespread. This study analyzes and compares existing strategies for the innovative development of the fuel and energy complex of EU member states. The process of formation of the EU energy policy and its distinctive features were studied. The example of Italy, Germany, Poland, Spain, and Finland was used to study in detail the impact of the new energy policy approved by the EU government. The prospects for the introduction of alternative energy sources in the geographical and climatic conditions of Kazakhstan have been assessed. Synthesizing the information obtained, a list of tips for the successful development of alternative energy in the Republic of Kazakhstan was proposed.

НАУКОВО-МЕТОДИЧНИЙ ПІДХІД ДО ФОРМУВАННЯ МЕХАНІЗМУ УПРАВЛІННЯ РОЗВИТКОМ ІННОВАЦІЙНОГО ПОТЕНЦІАЛУ ПІДПРИЄМСТВА

The paper substantiates the relevance of problems regarding the formation and development of the enterprise innovative potential as a system indicator that characterizes the level of its efficiency in the implementation of the innovative development strategy. In order to determine the specific features of the formation of the business entity’s innovative potential, the article examines the main approaches of domestic and foreign scientists regarding the definition of this concept essence. The work summarized the approaches of foreign researchers to defining the essence of the innovative potential concept in three groups. Based on the results of the analysis and generalization of existing approaches to determining the essence of innovation potential, as well as from the standpoint of the statement that the constant development of innovation potential enables the business entity to obtain competitive advantages, solve production problems and take a stable competitive position on the market, the work improved the conceptual and terminological apparatus by defining the essence of the enterprise innovative potential, as a system of interconnected scientific and technical, technological, personnel, financial, material, human resources and intangible components (the readiness and ability of the enterprise and its management potential), which allows to ensure creation and implementation of innovations, and their further transformation into the final innovative product or service, which, in turn, comprehensively ensures sustainable innovative development of the enterprise. On the basis of the study of the formation peculiarities of the enterprise innovative potential in the conditions of a dynamic environment, the article develops the conceptual foundations of managing the development of innovative potential in the part of the development of a scientific and methodological approach, which provides for the presence of a flexible system of adaptation to changes in external and internal conditions in the process of developing and implementing innovations, and also takes into account the dependence and interrelationship of the development goals of innovative potential from the development and operation goals of the enterprise and the set of tasks, methods and tools and methodical and information management support for the development of the innovative enterprise potential.

Optimization model planning of sustainable innovation development of the electric power industry enterprise

The high scientific and practical significance of the problem of ensuring the sustainable development of electric power enterprises determined the topic, subject of research, purpose and tasks. The research purpose is connected with improving the tools of strategy for innovative development of the production field of the electric power industry enterprise. In the course of solving the set goal, the method of collective expert assessments, the method of morphological analysis based on successive approximations was used. The results of the research were substantiated methodological principles and methodology for planning the innovative development of an electric power industry enterprise. The elements of this methodology are the system of indicators of sustainable innovative development and the optimization model for the formation of a strategy for sustainable innovative development of an electric power enterprise.