In the context of the need to reduce technological dependence and structural changes in the economy, it is important to solve the problems of ensuring technological sovereignty by enhancing the innovative activity of enterprises and the growth of innovative activity in the context of industries and regions. The expediency of identifying innovative activities is justified by the opportunity to evaluate the activity of the enterprise as a result. In this work, a complex of factors has been identified and the functional dependencies of their influence on the innovative activities of enterprises have been determined. Groups of indicators characterizing the innovative activities of enterprises have been developed, defined, formalized and classified. A methodology and methods for assessing the influence of factors on the results of an enterprise’s innovative activities have been developed. The assessment of the results of an enterprise’s innovative activity in the presented work is associated with the grouping of indicators of innovative activity based on the obtained mathematical generalized indicator. An assessment is made of the contribution of the enterprise’s innovative activities to ensuring the technological sovereignty of the national economy.