Generally, two-phase (TP) flow inlet condition is not allowed for conventional microchannel heat exchangers, and a certain subcooled degree of liquid is strictly required to guarantee the efficient operation of system. To solve multi-heat sources cooling issue, a type of circular radial expanding minichannels heat sink (REMHS) utilizing flow boiling of deionized water is proposed in present work. Flow boiling heat transfer of REMHS is investigated with the inlet vapor mass qualities in the range of 0.01–0.53. Under TP flow inlet, slug-annular and annular flows are the main flow patterns observed in REMHS in this work, where the low-medium mass flux (22–132 kg/m2s) and medium-high heat flux (33.1–176.4 kW/m2) conditions are applied. The experimental results illustrate that the proposed REMHS under TP flow inlet maintains a stable and high flow boiling heat transfer performance without occurring heat deterioration. When xin increases from 0.04 to 0.53, the maximum local heat transfer coefficient increases by 22% from 42.5 to 51.9 kW/m2K. The flow distribution among the expanding channel array is relatively uniform and the heat transfer capability in the REMHS displays a good symmetry under TP flow inlet. The maximum discrepancy in heat transfer coefficient is below 19% within our experimental range. Six classic flow boiling heat transfer correlations are compared with the experimental results, and Li & Wu's correlation gives a good prediction on all the measured data with MAE of 21.1%. Besides, the thermal independence of REMHS connected in series is also examined, and the mutual interaction in heat transfer between the REMHS in series is trivial, the proposed REMHS is expected to be applied to multi-heat source cooling.