Tannin-fluoride preparations were applied on to the dentin surface exposed by the preparation of the vital teeth for artificial crowns or inlays and the decrease in the sensibility of the dentin was observed clinically. The results obtained were as follows: 1) In the case of the crown preparation, tannin-fluoride preparations were markedly effective in reducing the dentin hyperesthesia in 50.0% of the cases, effective in 31. 3% and not effective in 18.7%. In the cases of the inlay preparation, the preparations were markedly effective in 57.1% of the cases, effective in 32.8% and not effective in 10.1%. 2) The effect of tannin-fluoride preparations on the hypoesthesia of the dentin was more distinct to the mechanical stimulation than to the thermal stimulation 3) Reapplication of the tannin-fluoride preparations showed a considerable hypoesthetic effect on the non-effective cases of the first application of the mixture. 4) There was no significant difference between the two tannin-fluoride preparations mixed with water and with glycerin.