The results of research work for the period from 2018 to 2023 on the use of early non-invasive functional ultrasound screening for the purpose of targeted formation of highly productive mature-brood stocks of Siberian sturgeon of the Ob, Yenisei, Baikal, Lena populations, European sterlet of the Kama population, Siberian sterlet of the Ob, Yenisei, Irtysh populations on main full-cycle industrial fish-breeding farms of Eastern and Western Siberia using water recirculation systems are presented in the article. Biotechnological methods for the formation of highly productive mature stocks using ultrasound monitoring are described. The number of individuals with pathologies and anomalies in the development of the reproductive system, liver, gallbladder and other internal organs were estimated; treatment methods were proposed. For the first time studies on the use of ultrasound for visualizing the gonads, determining the stages of maturity, detecting diseases of the heart, liver, gallbladder in salmon fish (trout, Atlantic salmon) grown in aquaculture have been carried out. For the first time ultrasound and histological studies were carried out to study the nature of “ink spots” on the skin of Siberian sturgeon Lena population from natural habitat. It was found that in the skin of sturgeon during pathology there was a growth of epidermal cells. Melanin melanocytes increased in both epidermis and dermis. At the same time there were no elastic fibers of the epidermis after painted according to Van-Gison. All these changes may indicate melanoma.
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