Injection System Research Articles

Automated Injectors versus Manual Administration: A Comparative Analysis of Radiation Exposure Reduction in 18F-FDG Delivery

Abstract Background Despite the presence of safety protocols, the manual manipulation of radiopharmaceuticals continues to pose a significant occupational radiation risk. Health care professionals in nuclear medicine are at risk of radiation exposure, particularly to their hands and eyes. Despite existing protective measures, manual handling of radiopharmaceuticals remains a significant source of occupational radiation. Objective This study evaluates the effectiveness of automated injectors in reducing radiation exposure among health care workers during fluorine-18 fluorodeoxyglucose (18F-FDG) administrations, compared with traditional manual injection methods. Methods We assessed radiation exposure levels associated with manual versus automated 18F-FDG injection techniques using specialized dosimeters. Measurements focused on whole-body, extremity, and eye-lens radiation doses to evaluate the potential benefits of automation in minimizing exposure. Results Findings reveal that automated injectors significantly reduce radiation exposure, with decreases of 97.97 and 98.96% in left- and right-hand extremity doses, respectively, 43.24% in eye-lens dose, and 91.66% in whole-body dose compared with manual methods. Conclusion Automated injection systems offer considerable advantages in reducing health care worker radiation exposure in nuclear medicine. The substantial reduction in staff doses underscores the necessity of transitioning to such technology to promote safer clinical environments. This study highlights the critical role of automation in enhancing occupational safety standards within diagnostic radiology settings.

Commissioning of the tracer-encapsulated solid pellet (TESPEL) injection system for Wendelstein 7-X and first results for OP1.2b

Abstract A new tracer-encapsulated solid pellet (TESPEL) injection system was successfully commissioned for the stellarator fusion experiment Wendelstein 7-X (W7-X) during its OP1.2b operational campaign. TESPELs are polystyrene encapsulated solid pellets loaded with tracer impurities that have been employed in other stellarator devices for impurity transport studies. During the OP1.2b campaign approximately 140 pellet injections were performed with a successful delivery rate of 89%, thus this system has proven to be very reliable. Here, the experimental set-up and methodology are described first. In addition, it is outlined how, through the analysis of TESPEL time-of-flight signals and of the temporal evolution of line emissions originating from shell and tracer species as well as comparisons with ablation models, the radial localization of the deposited tracer is determined. This contribution also provides a general overview of the TESPEL injector performance during OP1.2b, discusses the global effects of TESPEL injections on W7-X plasmas and reports on first results in terms of a summary of TESPEL injections, plasma response to TESPELs, the post-deposition evolution of tracer spectral emission lines and soft x-ray emissions.

Microenvironment‐Responsive Injectable Conductive Hydrogel for Spinal Cord Injury Repair

AbstractSpinal cord injury (SCI) represents a severe neurological condition often coupled with a drastic secondary inflammatory response, which further exacerbates the damage in most cases. Due to their unique electrical and mechanical compatibilities with the spinal cord, the utilization of conductive hydrogels through injection for SCI repair, particularly in scenarios involving non‐uniform and large gaps, has emerged as a promising approach. Herein, leveraging the acidic microenvironment characteristic of acute SCI sites, an injectable conductive hydrogel with pH‐responsive immunoregulation is engineered for SCI repair. Based on the dynamic Schiff base chemistry and covalent photo‐crosslinking, this composite hydrogel, composed of gelatin methacryloyl, oxidized dextran, and MoS2, exhibits adjustable mechanical and conductive properties, enabling a customized match with the natural spinal cord's attributes. Additionally, the incorporation of Wnt5a and its selective release in acidic conditions prompt the immediate suppression of inflammatory factors and enhances neural differentiation and regeneration. In the 2‐mm hemisection mouse SCI model, the optimized conductive hydrogel can effectively bridge the injury gap, establish nerve connections and signal, mitigate inflammatory response, and promoted recovery of mobility. This novel injectable conductive hydrogel system offers a promising advance in therapeutic materials for SCI repair.

A natural polyphenolic nanoparticle--knotted hydrogel scavenger for osteoarthritis therapy

Exploring highly efficient and cost-effective biomaterials for osteoarthritis (OA) treatment remains challenging, as current therapeutic strategies are difficult to eradicate the excessive reactive oxygen species (ROS) and nitric oxide (NO) at damaged sites. Tea polyphenol (TP) nanoparticles (NPs), a nature-inspired antioxidant in combination with 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), a NO scavenger, could provide maximized positive therapeutic effects on OA by eradicating both ROS and NO. Notably, this combination not only improves the half-life of the TP monomer and the drug loading efficiency of carboxy-PTIO but also prevents nitrite from being harmful to tissue. Moreover, the protonation ability of carboxy-PTIO allows smart acid-responsive release in response to environmental pH, which provides conditioned treatment strategies for OA. In in vitro experiments, TP/PTIO NPs downregulated proinflammatory cytokine release via synergistic removal of ROS and NO and suppression of ROS/NF-κB and iNOS/NO/Caspase-3 signaling. For in vivo experiments, NPs were cross-linked with 4-arm-PEG-SH to form an injectable hydrogel system. The release of TP and carboxy-PTIO from the system efficiently prevents cartilage inflammation and damage via similar signaling pathways. Overall, the proposed system provides an efficient approach for OA therapy.

PELATIHAN SERVIS RINGAN KENDARAAN SEPEDA MOTOR BAGI MASYARAKAT DESA RIDOGALIH

Motorbikes are a means of transportation that is often used in daily activities, the development of increasingly sophisticated technology has begun to be combined with the help of electronic control circuits such as injection systems to control combustion in the motorcycle combustion chamber or indicators to show hot engine temperatures that make it easier for motorcycle owners to carry out vehicle maintenance. Therefore, due to the lack of workshops or vehicle service services, here the author will share information about motorcycle maintenance that can be done by yourself to save costs and can be developed as a form of business, such as a workshop. With this lack of information, most people only use motorbikes for their daily needs and ignore motorcycle maintenance. Here the author will educate the community on how to maintain their two-wheeled vehicles in Citeureup 1 hamlet by socializing the importance of maintaining two-wheeled vehicles, training on maintaining two-wheeled vehicles, and evaluation to ensure that the community can maintain their own motorbikes. This program also has the aim that the people of Sirnajaya Village, Serang Baru District, Bekasi Regency are able to maintain their own motorbikes and can be developed as a form of business, namely a workshop. Based on the light service training, there are several impacts, among others can increase understanding related to light service procedures such as engine oil change, axle oil, CVT maintenance and replacement of front brake lining and understand about safety riding and have understood how to drive properly.

Investigation of unswept ramp system with lobe shape nozzle for fuel mixing of hydrogen jet at a scramjet engine

The role of efficient fuel mixing and a stable flame holder is crucial in enhancing the performance and capabilities of scramjet engines for high-speed flight. The present research paper has tried to disclose the fuel mixing efficiency of 3-lobe annular nozzle on the mixing mechanism of the fuel jet behind the strut. In addition, using internal air jet flow for increasing the circulation strength and fuel mixing behind the strut is also examined in this study. Numerical simulation of the flow and fuel jet behind the strut is done to reveal the main physics related to the mechanism of fuel mixing inside the combustor with the proposed injection system. The results of our simulation show that using annular 3-lobe fuel jet improve the fuel mixing via production of the multiple vortex pairs within the combustor behind the strut. The use of internal air jet also enhances the fuel mixing efficiency up to 90% in combustor of scramjet engine.

Injectable Magnetic Hydrogel Incorporated with Anti-Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis.

Endometriosis is a prevalent gynecological condition characterized by chronic pelvic pain, dysmenorrhea, and infertility, affecting ≈176 million women of reproductive age worldwide. Current treatments, including pharmacological and surgical interventions, are often associated with significant side effects and high recurrence rates. Consequently, there is an urgent need for innovative and safer therapeutic approaches. In this study, an injectable magnetic hydrogel nanosystem is developed designed for the dual-purpose magnetothermal and anti-inflammatory treatment of endometriosis. This hydrogel incorporates Fe3O4 nanoparticles alongside an anti-inflammatory peptide. Upon magnetic activation, the Fe3O4 nanoparticles induce a localized hyperthermic response, raising the temperature of endometriotic lesions to 63.3°C, effectively destroying endometriotic cells. Concurrently, the thermally responsive hydrogel facilitates the controlled release of the anti-inflammatory peptide, thus modulating the inflammatory milieu. The biocompatibility and complete in vivo degradability of the hydrogel further enhance its therapeutic potential. The in vivo studies demonstrated that this injectable magnetic hydrogel system achieved a 90% reduction in the volume of endometriotic lesions and significantly decreased inflammatory markers, offering a promising non-invasive treatment modality for endometriosis. By integrating precise lesion ablation with the modulation of the inflammatory microenvironment, this system represents a novel approach to the clinical management of endometriosis.

Probabilistic safety analysis of the large primary circuit leakages accident scenarios in the VVER-reactor

Probabilistic safety analysis of the loss of coolant accidents in the VVER-type reactor plant has been performed taking into account the internal initiating events of the reactor primary circuit large leakages. Swedish program code RiskSpectrum PSA was used for probabilistic safety analysis. Logical probabilistic models of the accident scenarios of the large primary circuit leakages in the VVER-type reactor were developed taking into account different operation modes of the power plant unit. Critical paths and probabilities of the accident scenarios occurrence of the large leakages were identified. The critical path of development of the reactor primary circuit large leakages accident with large leakages of 140–346 mm diameters is the accident sequence with a leak in the pipeline to the reactor pressurizer vessel. It has been established that the greatest contribution to the failure of safety functions during this initiating event is made by the failures due to common causes of the supporting systems (cooling and ventilation systems), critical consumers cooling circuit, emergency injection system. The critical path of the accident with large leakages of 346–850 mm diameters is the accident sequence with the rupture of any of the four primary circuit loops. The greatest contribution to the failure of safety functions during this initiating event is made by the failures due to common causes of the emergency injection system elements. Based on the accident analysis, recommendations for increase of performance reliability of safety functions during the large leakages accidents under all operation states of the nuclear power plant unit were given. In order to increase reliability of safety systems, it is necessary to eliminate failures due to common causes of equipment, increase the reliability of operation of supporting systems, change the maintenance and checking equipment procedures.

Progress Toward Biocarbon Utilization in Electric Arc Furnace Steelmaking: Current Status and Future Prospects

AbstractSteel is an essential material in modern infrastructure and industry, but its production is associated with significant carbon dioxide emissions. Biocarbon utilization in electric arc furnace (EAF) steelmaking represents a promising pathway toward reducing the carbon footprint of steel production. This review draws new perspectives on the current state of biocarbon utilization in EAF steelmaking by collectively examining the literature from multiple scales of testing, from laboratory experiments to industrial trials. The scientific insights from each scale are defined and the results are collectively pooled to give a comprehensive understanding of biocarbon’s performance for EAF applications. Several recent progressions are identified along with critical limitations, such as biocarbon’s high reactivity or low density. However, solution pathways like agglomeration are established from the thorough understanding developed by this study. These insights aim to enhance the progression of biocarbon utilization in the EAF process, ultimately facilitating the development of more efficient and sustainable steelmaking. The proposed areas for future research, such as optimizing key biocarbon properties or improved injection systems, are expected to have significant impact on the next phase of biocarbon adoption. Graphical Abstract

Status Monitoring System of Reciprocating Hydrogen Compressor Based on Hilbert−Huang Transform

ABSTRACTA reciprocating hydrogen compressor status monitoring system for predictive maintenance is developed based on HHT (Hilbert−Huang Transform) with multiple functions, strong applicability, and high accuracy to address the problem of difficulty in identifying fault signals and failure to provide advance warning before faults occur in the reciprocating hydrogen compressor state monitoring system. Design framework of monitoring system is confirmed, and function modules are designed based on LabView platform. HHT is applied to monitor the status of reciprocating hydrogen compressor based on LabView platform. A reciprocating hydrogen compressor is selected as research object, status monitoring analysis is carried out. Five working states of reciprocating hydrogen compressor are collected, which conclude normal state, filler malfunction, cross‐head malfunction, air valve malfunction, and piston rod malfunction. HHT is carried out for five signals, and results show that HHT marginal spectrum of five signals has different characteristics. Based on comparison results, precision of HHT ranges from 0.757 to 0.784, recall of HHT ranges from 0.738 to 0.766, F1‐score of HHT ranges from to 0.788 to 0.804, HHT has better performance than other two methods. Proposed monitoring system designed in this study provides a comprehensive and efficient online monitoring and data analysis solution for reciprocating hydrogen compressors, which can achieve fault prediction of reciprocating hydrogen compressor, reduce failure rate, and effectively improve the reliability of the compressor oil injection system.

Artificial intelligence‐driven sustainability: Enhancing carbon capture for sustainable development goals– A review

AbstractArtificial intelligence (AI) and environmental points are equally important components within the response to local weather change. Therefore, based on the efforts of reducing carbon emissions more efficiently and effectively, this study tries to focus on AI integration with carbon capture technology. The urgency of tackling climate change means we need more advanced carbon capture, and this is an area where AI can make a huge impact in how these technologies are operated and managed. It will minimize manufacturing emissions and improve both resource efficiency as well as our planet's environmental footprint by turning waste into something of value again. Artificial intelligence could be leveraged to analyze huge data sets from carbon capture plants, searching for optimal system settings and more efficient ways of identifying patterns in the available information at a larger scale than currently possible. In addition, AI incorporated sensors and monitoring mechanisms in the supply chain can identify any operational failure at reception itself allowing for timely action to protect those areas. Artificial intelligence also helps generative design for carbon capture materials, which allows researchers to explore new types of carbon‐absorbing material, including metal–organic frameworks and polymeric materials that are important in industrial CO2, such as moisture. In addition, it increases the accuracy of reservoir simulations and controls CO2 injection systems for storage or enhanced oil recovery. Through applying AI algorithms on reservoir geology, production performance and real‐time data this study would like to facilitate the optimization of injection processes as well as minimize CO2 emissions while assuring a maximum efficiency. Artificial intelligence integrates with renewable‐based carbon capture efforts that can be employed by AI‐driven smart grid systems to improve carbon capture methods.

A procedure for estimating mitigation effect of air injection on ship underwater radiated noise

Increasing evidence exists that underwater radiated noise (URN) from ships has a negative impact on marine ecosystems. This has led to numerous initiatives aimed at monitoring and mitigating ambient sound levels generated by shipping. Within the European Union, noise abatement is being addressed by a wide range of stakeholders, with activities focused on developing procedures and thresholds for evaluating noise impact as well as knowledge on the effectiveness of a range of mitigation measures. In the SATURN project, MARIN is studying air injection systems for mitigation of both propeller cavitation and machinery noise; the so-called "Prairie" and "Masker" systems. Model-scale tests have been performed in order to quantify performance in terms of sound level reductions for a range of test conditions. In this paper we elaborate a procedure for applying the processed measurement data to ship-scale URN predictions for assessing mitigation potential during the early design stage. Data reduction of the model test results is explained, leading to a model for estimating the mitigation effect and power requirement of the two systems. We subsequently apply the model to a number of test cases, covering both measured and calculated source levels. Limitations of the approach will also be discussed.

Floating Liquefied CO<sub>2</sub> Injection Systems into Reservoir below Seabed

Floating Liquefied CO<sub>2</sub> Injection Systems into Reservoir below Seabed

Recycling industrial waste polymer as a binder system for ceramic injection molding feedstock

Recycling industrial waste polymer as a binder system for ceramic injection molding feedstock

Plasma discharge experiments of a Faraday shieldless driver for high-power and long-pulse radio frequency ion source for NBI application.

Due to the high stability and less maintenance, the radio frequency (RF) driven ion source is preferred for the neutral beam injection (NBI) system. In a popular design of the RF ion source for NBI application, a Faraday shield (FS) is installed inside the RF plasma driver to protect the discharge tube. However, the FS also brings some drawbacks, such as lowering the RF power transfer and increasing the processing difficulty. A prototype of the RF plasma driver without FS and with mature manufacturing technology has been developed by using a water-cooled discharge tube. After basic testing, this prototype was further tested under the RF plasma discharge experiments in views of high power, long pulse, and long term. The reliability and its plasma characteristics were the focus of these experiments, also for the hidden issues. The results show that the prototype could generate stable and high-density plasma without any damage or sputtering mark. An RF plasma discharge of 50 kW and 20s has been achieved. The expected frequency tuning was equally effective on the prototype. Moreover, compared to the RF plasma driver with FS, the prototype could produce higher electron density in the extraction region under the same RF power. Of course, some of the shortcomings of the prototype have also been exposed in the experiments and will be improved in subsequent experiments.

Development and Application of Integrated Injection System for Injection and Profile Control in Dagang Oilfield

Abstract Dagang Oilfield is a heterogeneous, multi-layered, and structurally complex fault block oil reservoir. During the production process, the contradictions between layers and within layers are becoming increasingly prominent. Split injection and profile control are two important development processes for ensuring production and increasing production in current oilfield development. However, during the construction process of split injection wells for profile control, there are often problems with plugging agents, which affect the effectiveness of split injection and the success rate of testing and adjustment, and even require well repair operations. This has become a key quality control production link that affects the efficiency of oil recovery construction and the improvement of quality, cost, and efficiency. The idea of developing a new type of integrated water distributor for injection and profile control has been proposed, which can achieve dual functions of layered water injection and profile control using a set of pipe columns. Through several years of technological breakthroughs, technological breakthroughs have been made in various aspects such as main structure design, anti backflow structure design, and water nozzle optimization design. Innovative proposals have been made and the integrated water distribution device structure design for injection and profile control has been successfully developed, fundamentally solving the pain points and difficulties of low measurement and adjustment rate after injection well profile control construction, significantly improving the qualification rate of measurement and adjustment, and significantly improving work efficiency and construction quality.

The Pvc15 ATPase selectively associates effector proteins with the Photorhabdus virulence cassette.

The Photorhabdus virulence cassette (PVC) is an extracellular contractile injection system. In the producing bacterium, N-terminal signal peptides enable effector 'payloads' to be loaded into the PVC's hollow tube-facilitated by the 'ATPases associated with diverse cellular activities' (AAA) ATPase, Pvc15-ready for injection of the toxin or virulence factor into eukaryotic cytosols. Pvc15's function and its interaction with the signal peptide were unclear. This study describes the signal peptide diversity in extracellular contractile injection system clades and interrogates the Pvc15-signal peptide interaction using ATPase assays, cell respiratory assays and western blot quantification of Escherichia coli lysates and co-purifications of PVCs with their payloads. This study found that extracellular contractile injection system signal peptides can be grouped according to sequence alignment, owing to potentially homologous loading mechanisms. Pvc15 contains three domains, including tandem AAA domains D1 and D2. By constructing Pvc15 mutants, we found that while each domain is necessary for PVC-payload loading, domain D2 is the sole bioactive ATPase domain and rescues unstable payloads via the signal peptide. Finally, truncating the signal peptide abolishes Pvc15-dependent PVC loading and has varying effects on payload stability. This study provides crucial insights into extracellular contractile injection system effector loading mechanisms and their ATPase chaperones, and suggests that these devices could be bioengineered for injection of therapeutic proteins into human cells.

Innovation and application of integrated management mechanism of chemical flooding in extra-high water cut sandstone oilfield

Abstract Daqing oilfield chemical flooding technology is mature and matching, enhanced oil recovery, strongly support the development of oil fields, in order to ensure the national strategic security of energy plays a pivotal role. Since the 13th five-year plan, aiming at the problems of poor quality reservoir condition, poor development benefit and increasing difficulty of stable production, the target of high-efficiency development has been set, innovative Management mode, the construction of “Key research, continuous improvement, promotion and application” closely linked to the new mechanism of integrated scientific research and production management; A new dynamic management mechanism of chemical flooding development is established, and a new management model of injection system is established. Since 2016, the development efficiency of chemical flooding has improved markedly, with annual oil production remaining stable at over 10 million tons and an additional 2.55 million tons of oil production. The tonnage of polymer-enhanced oil has increased from 47.4 tons to 57.2 tons, saving 126,000 tons of polymer and generating 5.503 billion yuan in economic benefits, Daqing Field has made important contributions to the revitalization and development of the country in the new era and ensuring national energy security.

Analysis of Corrosion Causes and Optimization of Corrosion Evaluation Methods for Water Injection System in Changqing JY Oilfield

Abstract Based on the corrosion characteristics of the water injection system in Changqing Oilfield, an experimental study was conducted on the corrosion of the water injection system caused by carbon dioxide, hydrogen sulfide, bacteria, and water treatment agents in the produced liquid. The main influencing factors of corrosion in the water injection system were analyzed, and it was clarified that the corrosion of the water injection system in Changqing Oilfield was mainly caused by oxygen corrosion, which also had an impact on the water quality of the injection. Combining static corrosion analysis with the introduction of pitting and dynamic corrosion rate testing methods, the average corrosion rate of JY oilfield water injection system has a positive correlation with pitting corrosion, while the average corrosion rate of clean water has a stronger correlation with pitting corrosion. The corrosion evaluation method has been optimized, providing technical basis for formulating effective anti-corrosion measures for the oilfield.

Automatic High-Throughput Injection System for Zebrafish Larvae Based on Precise Positioning of Injection Target

Automatic High-Throughput Injection System for Zebrafish Larvae Based on Precise Positioning of Injection Target