Based on research conducted with women injection drug users (WIDUs), I discuss the ethical conflicts that researchers and subcontractors face in gaining access to the life narratives of WIDUs. Foremost among these is the potentially exploitative nature of the study participant–researcher relationship. I suggest that federal and institutional guidelines for human subject research must incorporate additional safeguards to protect study populations such as WIDUs. Moreover, the ethical concerns related to health care research should be addressed in guidelines for ethical conduct with human subjects, research ethics seminars, and required training programs for researchers and subcontractors separately.