Initial Zone Research Articles

Symmetry-preserving discretizations in Lagrangian cell-centered hydrodynamics

This paper discusses constructing discretizations in Lagrangian cell-centered hydrodynamics (CCH) that preserve cylindrical symmetry on unequal-angle-zoned grids in two-dimensional Cartesian geometry. We achieve this by modifying the nodal solver (Corot and Mercier, 2018) and updating the total and internal energy equations. The method is a unique solution to the challenging problem of ensuring symmetry in vectors. A criterion is established for determining whether or not this symmetry correction should be applied. We prove that both nodal and zonal quantities maintain a symmetry distribution. Numerical illustrations using unequal-angle initial zoning are presented to demonstrate the efficiency of the scheme.

Crack failure behaviors of Ti–6Al–4V dovetail joints subjected to fretting fatigue and effect of laser shock dimple-textured surface coated with diamond-like carbon film

Fretting damage can lead to a reduction in fatigue strength by more than half, due to the increased stress on the fretting surface, which accelerates crack initiation and propagation. Laser shock peening (LSP) technology is an advanced method for protecting against fretting fatigue, which reduces the effective stress on the fretting surface of components by introducing a deeper compressive residual stress field. In this work, LSP was utilized to create regularly arranged dimples on the surface of titanium alloy dovetail joints, and followed by diamond-like carbon (DLC) coating to alter fretting friction. Five surface treatment samples including as-machined, conv-LSP, LSP dimple-textured, DLC, LSP dimple-textured + DLC, were prepared for fretting fatigue tests on dovetail joints. The experimental results showed that the fatigue performance of specimens treated with LSP dimple-textured + DLC is better. Furthermore, it is found that wear debris from fretting surface was discharged into crack source area during fretting fatigue, leading to the formation of a fracture debris area forms in the crack initiation zone. The crack initiation zone displays the protrusion morphology characteristics due to the friction effect induced by contact loads. There is an internal correlation between the size of fracture debris area and surface wear resistance. Fracture debris area and the protrusion morphology vary with surface treatments and applied load. This research further reveals that the variation characteristics of the crack initiation area including the fracture debris area, have a positive influence on observing and analyzing failure behavior of fretting fatigue damage.

Debris‐flow fan channel avulsions: An important secondary erosional process along the Ichino‐sawa torrent, Japan

AbstractSediment transported from debris‐flow initiation zones is typically stored in a topographic feature called a debris‐flow fan, the formation process of which governs secondary sediment transport further downstream. Although sediment transport from debris‐flow fans can impact sediment regimes and change landforms, the determinants of progressive fan formation are not well constrained. To identify such determinants, this study monitored debris flows and performed topographic surveys of debris‐flow fans in the Ichino‐sawa torrent (Japan) during 2016–2017. In this period, eight debris flows occurred, two of which eroded the existing fan and formed a new channel with a short recurrence interval (~40 days). Consequently, these two cases induced substantial sediment transport further downstream from the fan. The examined rainfall indices did not provide a threshold for diagnosing the occurrence of such sediment transport. Debris flows with a large flow depth and a long duration led to changes in the runout direction and subsequently formed new channels. Before these processes, the existing channel was backfilled and plugged by previous debris flows, forming a steep fan surface around the fan apex. The results suggest that increasing the magnitude and the duration of debris flows potentially triggers sediment transport from fans coupled with channel plugging. The annual sediment transport from the fan exceeded almost all sediment yields of the world rivers and was found comparable with that linked with volcanic eruptions and their aftermath. Thus, the fan‐formation process can induce substantial sediment transport, independent of volcanic perturbations and extreme climatic events, and is dependent on the sediment supply from repeated occurrence of debris flows in the initiation zones.

Fatigue assessment of directionally solidified superalloy thin plates under bimodal random processes

During actual service, aviation aircraft often experience multiple complex alternating loads coupled with each other. If the frequency range of the excitation load spectrum covers the first two resonance frequencies of the structure, it can significantly impact the vibration fatigue life of the structure. In this study, bimodal random vibration fatigue tests were conducted on thin plates composed of DZ125L directionally solidified superalloy. The impact of low-frequency and high-frequency vibration signal intensities on the vibration fatigue behavior of DZ125L alloy thin plates was investigated separately during bimodal random processes. The crack propagation mechanism of bimodal random vibration fatigue was proposed based on the fracture morphology observed in DZ125L alloy thin plates that failed due to vibration fatigue. The study findings indicate that the number and location of crack initiation zones can influence the mechanism of fatigue crack propagation. Additionally, a new model was developed in this study to enhance the sensitivity of the frequency domain method to the intensity of low-frequency and high-frequency vibration signals in bimodal random processes. Compared to traditional frequency domain methods used for broadband and bimodal processes, the new model can effectively describe the variation characteristics of bimodal fatigue life with different component process intensities. Furthermore, it has broader applicability for predicting the vibration fatigue life of bimodal random processes with varying vibration signal intensities.

Effect of direct-quenching and tempering on hydrogen-induced delayed fracture resistance of high-strength bolt steel

This investigation attempts to explore the potential significance of controlled forging, i.e., direct-quenching at two different finish-forging temperatures of ∼930 °C (B8H sample) and ∼780 °C (B8L sample), and tempering at 600 °C in improving the hydrogen-induced delayed fracture (HIDF) resistance of a 1300-MPa-grade high-strength bolt steel by constant load tensile testing using circumferentially notched round bar specimens and hydrogen thermal analysis. The microstructural characteristics of the tested samples were analyzed and their influences on HIDF were discussed. The results showed that the B8L sample demonstrated a considerably increased HIDF resistance expressed by critical notch delayed fracture stress of 1825 MPa and a decreased hydrogen embrittled index of as low as 21% compared with those of 1675 MPa and 27% for the B8H sample, although the former exhibited slightly higher strength and absorbed hydrogen content. Scanning electron microscopy observation of the fracture surface demonstrated that the B8L sample prevented the brittle intergranular fracture with smaller quasi-cleavage facet and decreased area fraction of the brittle crack initiation zone compared with the B8H sample. The increased resistance to HIDF of the B8L sample is primarily because of its fine microstructure with increased number of finely distributed V-rich nanoscale MC precipitates and decreased dislocation density. It is proposed that controlled forging coupled with V-microalloying is a feasible and economical way to further increase the HIDF resistance of high-strength bolt steel.

Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function.

Models of nuclear genome organization often propose a binary division into active versus inactive compartments, yet they overlook nuclear bodies. Here we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nuclear locales: the nuclear lamina, nuclear speckles, and nucleoli. Whereas gene expression correlates mostly with nuclear speckle proximity, DNA replication timing correlates with proximity to multiple nuclear locales. Speckle attachment regions emerge as DNA replication initiation zones whose replication timing and gene composition vary with their attachment frequency. Most facultative LADs retain a partially repressed state as iLADs, despite their positioning in the nuclear interior. Knock out of two lamina proteins, Lamin A and LBR, causes a shift of H3K9me3-enriched LADs from lamina to nucleolus, and a reciprocal relocation of H3K27me3-enriched partially repressed iLADs from nucleolus to lamina. Thus, these partially repressed iLADs appear to compete with LADs for nuclear lamina attachment with consequences for replication timing. The nuclear organization in adherent cells is polarized with nuclear bodies and genomic regions segregating both radially and relative to the equatorial plane. Together, our results underscore the importance of considering genome organization relative to nuclear locales for a more complete understanding of the spatial and functional organization of the human genome.

Soil-water characteristic curve of expansive soils considering cumulative damage effects of wetting and drying cycles

A novel experimental program was undertaken to explore crack development inside an expansive soil column under cyclic Wetting and Drying (W-D) and its influences on the Soil-Water Characteristic Curve (SWCC). Experimental investigations revealed that in the first drying cycle, fine and evenly distributed cracks developed from initial defects in the upper surface. In the subsequent drying cycles, the unhealed cracks during the wetting cycle further grow in width, length and depth while the initiation zone of new cracks was limited. The crack development characteristics within the soil column were described using fractal dimensions. The cracking degree of soil cross-sections gradually reduced with increasing depth. Also, each W-D cycle process contributed to a similar increment in the crack fractal dimension of soil at the same depth. In addition, the saturated water content, air-entry value and residual suction of cracked expansive soils gradually reduced with an increase in the number of W-D cycles. An obvious bimodal phenomenon was only observed in the SWCC of soil samples after the third W-D cycle. In order to quantify the damage induced by crack development to the soils, the damage variable was proposed based on the crack fractal dimensions. Furthermore, the Damage Impact Factor (DIF), as a function of the volume damage variable and soil plasticity index, was introduced into the traditional Fredlund and Xing (F-X) model to estimate the SWCC of cracked expansive soil. The form of modified F-X model is relatively simple and can be conveniently extended into geotechnical engineering practice applications.

Lattice light sheet microscopy reveals 4D force propagation dynamics and leading-edge behaviors in an embryonic epithelium in Drosophila

How pulsed contractile dynamics drive the remodeling of cell and tissue topologies in epithelial sheets has been a key question in development and disease. Due to constraints in imaging and analysis technologies, studies that have described the invivo mechanisms underlying changes in cell and neighbor relationships have largely been confined to analyses of planar apical regions. Thus, how the volumetric nature of epithelial cells affects force propagation and remodeling of the cell surface in three dimensions, including especially the apical-basal axis, is unclear. Here, we perform lattice light sheet microscopy (LLSM)-based analysis to determine how far and fast forces propagate across different apical-basal layers, as well as where topological changes initiate from in a columnar epithelium. These datasets are highly time- and depth-resolved and reveal that topology-changing forces are spatially entangled, with contractile force generation occurring across the observed apical-basal axis in a pulsed fashion, while the conservation of cell volumes constrains instantaneous cell deformations. Leading layer behaviors occur opportunistically in response to favorable phasic conditions, with lagging layers "zippering" to catch up as new contractile pulses propel further changes in cell topologies. These results argue against specific zones of topological initiation and demonstrate the importance of systematic 4D-based analysis in understanding how forces and deformations in cell dimensions propagate in a three-dimensional environment.

Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?

Eukaryotic DNA replication is a tightly controlled process that occurs in two main steps, i.e., licensing and firing, which take place in the G1 and S phases of the cell cycle, respectively. In Saccharomyces cerevisiae, the budding yeast, replication origins contain consensus sequences that are recognized and bound by the licensing factor Orc1–6, which then recruits the replicative Mcm2–7 helicase. By contrast, mammalian initiation sites lack such consensus sequences, and the mammalian ORC does not exhibit sequence specificity. Studies performed over the past decades have identified replication initiation sites in the mammalian genome using sequencing-based assays, raising the question of whether replication initiation occurs at confined sites or in broad zones across the genome. Although recent reports have shown that the licensed MCMs in mammalian cells are broadly distributed, suggesting that ORC-dependent licensing may not determine the initiation sites/zones, they are predominantly located upstream of actively transcribed genes. This review compares the mechanism of replication initiation in yeast and mammalian cells, summarizes the sequencing-based technologies used for the identification of initiation sites/zones, and proposes a possible mechanism of initiation-site/zone selection in mammalian cells. Future directions and challenges in this field are also discussed.

Fatigue response of wire-arc additive manufactured nickel-aluminum bronze (NAB) in the post-annealed condition

Nickel-aluminum bronze (NAB) is chosen for critical applications like marine propellers, pump components, and offshore structures due to its exceptional mechanical properties and corrosion resistance. Considering the utmost importance of the fatigue performance of NAB in such applications, this study investigates the fatigue performance of wire arc additive manufactured (WAAM) NAB in the annealed (675 °C for 6 h then furnace cooling) condition. To this end, static mechanical properties were evaluated using uniaxial tensile testing, while fatigue properties were assessed through fully reversed tests conducted at ambient temperature. Electron backscatter diffraction (EBSD) was utilized for the examination of the texture, and grain size distribution in annealed WAAM NAB. Additionally, scanning electron microscopy was employed to inspect fatigue-fractured specimens, while the analysis of EBSD was conducted to examine the deformation behavior beneath the crack initiation zone. The results provide insights into the fatigue life, crack initiation, and propagation characteristics of WAAM NAB relative to the cast counter material. The findings of this research provide valuable insights into the mechanical properties, microstructural characteristics, and fatigue response of WAAM NAB, informing the design of fatigue-resistant components and supporting the reliable utilization of WAAM NAB in demanding applications such as the marine and naval industries.

Failure Causes Analysis of Circumferential Cracking on Gathering Pipeline in M Oil and Gas Field

The gathering and transportation pipeline experienced corrosion cracking failure after 2 years of operation. This paper conducted an analysis on the reasons for the pipeline failure by integrating background information on its usage, as well as observations, analyses, and detection of the morphology of failure samples. The results indicated that the fracture originated from the inner wall of the pipeline and extended to the outer wall along the wall thickness until complete fracture occurred. Based on microstructure analysis of the fracture and original microcracks at the top of the pipeline, it was determined that the fracture was a multi-source brittle fracture, spreading in both inter-granular and trans-granular forms with obvious radial quasi-cleavage fractures accompanied by secondary cracks. EDS analysis revealed that the element S was present in all zones related to fracture initiation, spreading, and transient zones. XRD analysis showed that corrosion products on the fracture surface were mainly composed of FeS, indicating the presence of H2S in the service environment leading to sulfide stress corrosion cracking characteristics in line with pipeline failure. It is recommended to confirm the source of H2S in the service medium and test residual stress within the same pipeline for potential risk assessment regarding cracking in other areas.

Impact of Intermediate Species in Simulating Oblique Detonation with Pre-Vaporized N-Decane/air Mixtures Substituting for Kerosene/Air Mixtures

ABSTRACT A renewed two-step n-decane mechanism is presented to improve reliable and robust simulation results, substituting for kerosene. This mechanism demonstrates that effective control of ignition delay time and heat release, based on the Chapman – Jouguet condition, enables successful simulation of oblique detonation waves. Chain reactions influence the overall reaction heat and explosion temperature, especially in simplified mechanisms with few steps. Therefore, carbon monoxide (CO) generation is crucial for balancing the overall reaction heat and reducing species sensitivity to pressure, a factor previously not discussed in simplified models. The computational time for solving detailed chemical kinetics increases exponentially with species count, driving the pursuit for further reduction in kinetic mechanism size. The sensitive interaction between density and temperature during the fuel/air mixture explosion process affects initiation zone formation and cellular structure. Analyzing the distribution of CO can provide insights into structural details. The study considers applying the Rankine – Hugoniot curve to confirm detonation speeds, temperatures, and kinetic energy changes induced by chemical reactions.

Multi-source remote sensing-based landslide investigation: the case of the August 7, 2020, Gokseong landslide in South Korea

Landslides pose a growing concern worldwide, emphasizing the need for accurate prediction and assessment to mitigate their impact. Recent advancements in remote sensing technology offer unprecedented datasets at various scales, yet practical applications demand further case studies to fully integrate these technologies into landslide analysis. This study presents a case study approach to fully leverage variety of multi-source remote sensing technologies for analyzing the characteristics of a landslide. The selected case is a landslide with a long runout debris flow that occurred in Gokseong County, South Korea, on August 7, 2020. The chosen multi-source technologies encompass digital photogrammetry using RGB and multi-spectral imageries, 3D point clouds acquired by light detection and ranging (LiDAR) mounted on an unmanned aerial vehicle (UAV), and satellite interferometric synthetic aperture radar (InSAR). The satellite InSAR analysis identifies the initial displacement, triggered by rainfall and later transforming into a debris flow. The utilization of digital photogrammetry, employing UAV-RGB and multi-spectral image data, precisely delineates the extent affected by the landslide. The landslide encompassed a runout distance of 678 m, featuring an initiation zone characterized by an average slope of 35°. Notably, the eroded and deposited areas measured 2.55 × 104 m2 and 1.72 × 104 m2, respectively. The acquired UAV-LiDAR data further reveal the eroded and deposited landslide volumes approximately measuring 5.60 × 104 m3 and 1.58 × 104 m3, respectively. This study contributes a valuable dataset on a rainfall-induced landslide with a long runout debris flow, underscoring the effectiveness of multi-source remote sensing technology in monitoring and comprehending complex landslide events.

Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS.

DNA topoisomerase I can contribute to cancer genome instability. During catalytic activity, topoisomerase I forms a transient intermediate, topoisomerase I-DNA cleavage complex (Top1cc) to allow strand rotation and duplex relaxation, which can lead to elevated levels of DNA-RNA hybrids and micronuclei. To comprehend the underlying mechanisms, we have integrated genomic data of Top1cc-triggered hybrids and DNA double-strand breaks (DSBs) shortly after Top1cc induction, revealing that Top1ccs increase hybrid levels with different mechanisms. DSBs are at highly transcribed genes in early replicating initiation zones and overlap with hybrids downstream of accumulated RNA polymerase II (RNAPII) at gene 5'-ends. A transcription factor IIS mutant impairing transcription elongation further increased RNAPII accumulation likely due to backtracking. Moreover, Top1ccs can trigger micronuclei when occurring during late G1 or early/mid S, but not during late S. As micronuclei and transcription-replication conflicts are attenuated by transcription factor IIS, our results support a role of RNAPII arrest in Top1cc-induced transcription-replication conflicts leading to DSBs and micronuclei.

Scaling of damage mechanism for additively manufactured alloys at very high cycle fatigue

A comparative analysis of fracture mechanisms in high- and very high- cycle fatigue (HCF, VHCF) regimes was carried out based on the results of multifractal analysis of the fracture surfaces of additively manufactured 316L stainless steel samples. In terms of scale invariants, the morphology of fracture surfaces in HCF and VHCF regimes inside and outside the fine granular area is shown. The analysis demonstrated that chaotic patterns of relief formation prevail in the crack initiation zone of VHCF samples. However, there is a self-similar relief with a pronounced correlation in the crack propagation area. The relief of the crack growth areas for HCF and VHCF samples are similar to each other.

Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap.

Based on experimentally determined average inter-origin distances of ~100 kb, DNA replication initiates from ~50,000 origins on human chromosomes in each cell cycle. The origins are believed to be specified by binding of factors like the origin recognition complex (ORC) or CTCF or other features like G-quadruplexes. We have performed an integrative analysis of 113 genome-wide human origin profiles (from five different techniques) and five ORC-binding profiles to critically evaluate whether the most reproducible origins are specified by these features. Out of ~7.5 million union origins identified by all datasets, only 0.27% (20,250 shared origins) were reproducibly obtained in at least 20 independent SNS-seq datasets and contained in initiation zones identified by each of three other techniques, suggesting extensive variability in origin usage and identification. Also, 21% of the shared origins overlap with transcriptional promoters, posing a conundrum. Although the shared origins overlap more than union origins with constitutive CTCF-binding sites, G-quadruplex sites, and activating histone marks, these overlaps are comparable or less than that of known transcription start sites, so that these features could be enriched in origins because of the overlap of origins with epigenetically open, promoter-like sequences. Only 6.4% of the 20,250 shared origins were within 1 kb from any of the ~13,000 reproducible ORC-binding sites in human cancer cells, and only 4.5% were within 1 kb of the ~11,000 union MCM2-7-binding sites in contrast to the nearly 100% overlap in the two comparisons in the yeast, Saccharomyces cerevisiae. Thus, in human cancer cell lines, replication origins appear to be specified by highly variable stochastic events dependent on the high epigenetic accessibility around promoters, without extensive overlap between the most reproducible origins and currently known ORC- or MCM-binding sites.

Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

Based on experimentally determined average inter-origin distances of ~100 kb, DNA replication initiates from ~50,000 origins on human chromosomes in each cell cycle. The origins are believed to be specified by binding of factors like the origin recognition complex (ORC) or CTCF or other features like G-quadruplexes. We have performed an integrative analysis of 113 genome-wide human origin profiles (from five different techniques) and five ORC-binding profiles to critically evaluate whether the most reproducible origins are specified by these features. Out of ~7.5 million union origins identified by all datasets, only 0.27% (20,250 shared origins) were reproducibly obtained in at least 20 independent SNS-seq datasets and contained in initiation zones identified by each of three other techniques, suggesting extensive variability in origin usage and identification. Also, 21% of the shared origins overlap with transcriptional promoters, posing a conundrum. Although the shared origins overlap more than union origins with constitutive CTCF-binding sites, G-quadruplex sites, and activating histone marks, these overlaps are comparable or less than that of known transcription start sites, so that these features could be enriched in origins because of the overlap of origins with epigenetically open, promoter-like sequences. Only 6.4% of the 20,250 shared origins were within 1 kb from any of the ~13,000 reproducible ORC-binding sites in human cancer cells, and only 4.5% were within 1 kb of the ~11,000 union MCM2-7-binding sites in contrast to the nearly 100% overlap in the two comparisons in the yeast, Saccharomyces cerevisiae. Thus, in human cancer cell lines, replication origins appear to be specified by highly variable stochastic events dependent on the high epigenetic accessibility around promoters, without extensive overlap between the most reproducible origins and currently known ORC- or MCM-binding sites.

Ratcheting Effect of 304 Stainless Steel Manufactured by Laser Metal Deposition Under Uniaxial Cyclic Stress

Laser metal deposition (LMD) is an advanced manufacturing technology which has become increasingly popular in recent years. The cyclic tests of 304 austenitic stainless steel (SS304) manufactured by LMD are conducted under symmetrical and asymmetrical cyclic stress. In the results, it is shown that SS304 manufactured by LMD exhibits cyclic softening/hardening and ratcheting effect under symmetrical cyclic stress. The ratcheting strain and ratcheting strain rate of the smooth specimen both increase as the cyclic stress amplitude under the asymmetric cyclic stress. The ratcheting strain and ratcheting strain rate of the smooth specimen change non‐monotonously as the mean stress increases. As the stress amplitude increases, the area of fatigue fracture becomes smaller until no fatigue crack initiation zone can be observed. In this case, only the characteristic of plastic fracture is significant. Park et al.'s model has the worst predicted accuracy. Modified Goodman equation and Smith–Watson–Topper model have the similar predicted accuracy.

Identification of the complete particle size distribution of landslide debris by the combined method of scaled image analysis, line-grid analysis and laboratory sieve analysis

BackgroundGround failures in a slope due to gravity, are commonly known as landslides. Depend on the compositional, geological, and structural characteristics of the unstable initiation zone and the erosional composition of the propagation zone decide the complete particle size distribution of the moving mass and its gradation. This information is most important for the study of downslope movement. Only laboratory sieve analysis cannot fulfil this target because the natural debris contains a wide range of particle sizes, especially boulders. The combined method of scaled image analysis and laboratory sieve analysis or the combined method of line-grid analysis and laboratory sieve analysis was proposed to fulfil the requirement. To study the proposed combined methods, five different locations within the downslope propagation zone from the Aranayake landslide in Sri Lanka were surveyed and analyzed. In image analysis, the high-resolution scaled image of deposited debris was analyzed by computer-based image analysis for particle sizes. Small particles were addressed by the laboratory sieve analysis using the representative debris sample taken from the same location. If the boulder sizes within the debris are too big to address this method, then the Line-grid method was performed. The particles in every 0.5 m along a measured line of debris deposition were measured in this method. If the selected location contains small particles that cannot measured manually, the representative sample was used for the laboratory sieve analysis to fulfil this range.ResultsThe results of three locations indicated a 40% distribution of < 10 mm and a 60% distribution of > 10 mm representing the general distribution of the debris. Two distributions deviated from the general distribution that was surveyed and analyzed from special locations of the “near boundary of flow path” and “slope change zone” of the landslide.ConclusionsThe combined methodology yielded successful results of complete particle size distribution for the wide range of particle sizes in debris. The variation of the particle size distribution curves of debris along the downslope depositions is planned to be used for the study of downslope propagation, damage zone assessment studies, and predicting the representative composition of future failures.

Anticipatory coarticulation of the Spanish alveolar fricative /s/ in adults with apraxia versus dysarthria

This acoustic study compares anticipatory coarticulation characteristics of the Spanish alveolar sibilant fricative /s/ when in utterance-initial position followed by a vowel in adults with dysarthria and apraxia of speech. Three groups of participants (28 individuals with no speech disorder, 20 with dysarthria, and 8 with apraxia of speech) produced 12 monosyllabic words that included the five vowel sounds of central-peninsular Spanish. The acoustic measurements compared within and between groups were frequency of the spectral intensity peak (FreqMid) in different zones of fricative execution, magnitude of the change in frequency of the spectral intensity peak (ΔFreq) in the end zone compared to the average of the initial and middle zones, first three spectral moments, and the difference in spectral center of gravity between the middle and end zones (DiffM-E CoG). Several of these measures were able to differentiate between dysarthric and healthy speech, especially when /s/ was followed by an unrounded vowel, and the same occurred for apraxia, but this time when the adjacent vowel was rounded. While both disorders showed similar spectral patterns, the two motor speech disorders differed in terms of the measures FreqMid and DiffM-E CoG. Possible explanations for these differences are here discussed within the framework of motor control models.